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A2ANY6

- A2ANY6_MOUSE

UniProt

A2ANY6 - A2ANY6_MOUSE

Protein

Midasin

Gene

Mdn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.UniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein complex assembly Source: InterPro

    Keywords - Molecular functioni

    ChaperoneUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MidasinUniRule annotation
    Gene namesi
    Name:Mdn1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1926159. Mdn1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    PTM / Processingi

    Proteomic databases

    MaxQBiA2ANY6.
    PaxDbiA2ANY6.
    PRIDEiA2ANY6.

    Expressioni

    Gene expression databases

    ArrayExpressiA2ANY6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the midasin family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG5271.
    GeneTreeiENSGT00550000074802.
    HOGENOMiHOG000231719.
    HOVERGENiHBG031706.
    InParanoidiA2ANY6.
    KOiK14572.
    OMAiRIFLTMD.
    OrthoDBiEOG7S4X6J.
    PhylomeDBiA2ANY6.
    TreeFamiTF300488.

    Family and domain databases

    Gene3Di3.40.50.300. 8 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011704. ATPase_dyneun-rel_AAA.
    IPR012099. Midasin.
    IPR027417. P-loop_NTPase.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF07728. AAA_5. 8 hits.
    [Graphical view]
    PIRSFiPIRSF010340. Midasin. 1 hit.
    SMARTiSM00382. AAA. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 8 hits.
    SSF53300. SSF53300. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2ANY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHLSVELVS GPLRLIAAKN EKSSGELNRF LAKSVWTPQD RQCILDSLAQ     50
    LLLDKDYTLL LGRQLRPILL DLLERNAKAI KTGGQVNHDL HERLSVSMSK 100
    LIGSHPDVLP FALRYFKDTY PVFQRLFLES SDANPVRYGR RRMKLRDLME 150
    AANIFLQHRQ TVFRELWDWS VCVPLLRSHD ALVRWHTANC LALVTCMNEE 200
    HKLSFLRKIF SSDELVHFRL RLLEEAQLQD LEKALVLANP EVSLWHKGEE 250
    PQYIQGHLVS ADLSSSVAAV CGVVLPKLSS SPGEQASDRS SSLEQELALK 300
    SFVLVESVCK NLQLLAVSVA SQNAVLLEGP IGSGKTSLVE HLAAVTGRTK 350
    PPQLLKVQLG DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATKGYWILL 400
    EDIDYAPLDV VSVLIPLLEH GELLIPGHGD CLKVAPTFQL FATRRLLSCG 450
    GSWYRPMNSH ATMLDKYWTK IHLHNLNKKD LNEVLQSKYP SLLAATDHLL 500
    DIYIELTGEK HCCPSVAYDK APQEVSEAER ENRRVVLEGR ELSLRDLLNW 550
    CNRVAHGFDP TSSTALLHIF QEAMDCFTAM LSEQTKKLRM AEVIGSRLNI 600
    SKKKAEFYCK LYKPEIVINE LDVQVGRVRL LRKQSEVVRI QKEKCTFAAT 650
    RPSSVLLEQL AVCVSQGEPV LLVGETGTGK TSAVQYLAYA TGQHLRVVNM 700
    NQQSDTADLL GGFKPVDHKL IWLPLRETFE ELFVQTFSKK QNFTFLGHIQ 750
    TCYRQKRWHD LLKLMLHVQK SASTKGGEQS QPGLLKEKWE AFGLRLNHAQ 800
    QQMKMTENAL LFAFVEGTLA QAIKKGEWIL LDEINLAAPE TLECLSGLLE 850
    GSSGSLVLLD RGDTEPLVRH PDFRLFACMN PATDVGKRNL PPGIRNRFTE 900
    LYVEELESKE DLQILIVDYL KGLNVSKNTV QGIVNFYTAL RKESGTKLVD 950
    GTGHRPHYSL RTLCRALRFA ASNPCGSIQR SLYEGFCLGF LTQLDRASHP 1000
    VVQKLICQHI ISGNVKSLLK QPIPEPKGGR LIQVEGYWIS VGDKEPKIDE 1050
    TYVLTPSVKL NLRDIARVVS AGTYPVLIQG ETSVGKTSLI RWLAAASGNH 1100
    CVRINNHEHT DIQEYIGCYT SDTSGKLVFN EGVLIDAMRK GYWIVLDELN 1150
    LAPTDVLEAL NRLLDDNREL LITETQEVVR AHPRFMLFAT QNPPGLYGGR 1200
    KVLSRAFRNR FVELHFDELP SSELETILHK RCSLPPSYCS KLVKVMLDLQ 1250
    SYRRRSSVFA GKQGFIALRD LFRWAERYRL AEQTQEDYDW LQHLANDGFM 1300
    LLAGRVRKQE EADVIQEVLE KHFKKKLCPQ SLFSKENVLK LLGKSSTQTT 1350
    VLESKFSHVV WTESMRRLAV LVGRALEFGE PVLLVGDTGC GKTTVCQMFS 1400
    ALANQKLYSV NCHLNMETSD FLGGLRPVRQ KPNDKDELDT RLFEWHDGPL 1450
    VLAMKEDSFF LLDEISLADD SVLERLNSVL EVEKCLVLAE KGSPESKDNE 1500
    VELLTAGKHF RILATMNPGG DFGKKELSPA LRNRFTEIWC PQSTKREDLI 1550
    QIINHNLRPG LSLAGVGHKG AGVAEVMLAF ITWLTRQEFG RKCVVSIRDI 1600
    LSWVNFMNSM AEDAAVKRPE AISTVTSFVH AACLVYIDGI GSGVTSSGFG 1650
    TALLAREECL KFLIKKLSKV VRLTQRQKDE LKIYDRLRHK EFTSIDDFWG 1700
    VHPFFIPRGP VLDGHNTGDY ALTAGTTAMN AQRLLRAAKL NKPILLEGSP 1750
    GVGKTSLVAA LAKASGNTLV RINLSEQTDI TDLFGADLPV EGGRGGEFAW 1800
    CDGPLLAALK AGHWVVLDEL NLASQSILEG LNACFDHRGE IYVPELGMSF 1850
    QVQHEKTRIF GCQNPFRQGG GRKGLPKSFL NRFTQVFVDP LTVVDMEFIA 1900
    STLFPTIDKD IVKKMVAFNN HIDHEVTVEK KWGQKGGPWE FNLRDLFRWC 1950
    QLILVDQSPG CYDPGQHVFL VYGERMRTRE DKEKVVAVFK DVFASNSMPY 2000
    IGTRQFHITP YDIQIGYSVL SRSSYVPHPS RRPLSLLHQS FQSLEPIMKC 2050
    VQMNWMVILV GPASVGKTSL VQLLAHLTGH TLKIMAMNSA MDTTELLGGF 2100
    EQVDIIRPWR LLLEKVERTV RVLLRDSLLI NSVDTEVVLQ AWSHFLLTYK 2150
    PKCLGEDGKG VTIEIVNKLE AVLLLMQRLN NKINSYSKAD FAKLVEDFRS 2200
    FGVKLLQSAS GRSHGSFEWV DSMLVQALKS GDWLLMDNVN FCNPSVLDRL 2250
    NALLEPGGVL TINERGMVDG STCTVTPNPN FRLFLSMDPI HGEISRAMRN 2300
    RGLEIYISGE EDGSIQDNLD LKVLLHSLGL VGDSVCNILL ALHTEIQSLV 2350
    RGSPASSVST LSHTAILIVQ YLQRGLSLHK AFFEACWEVY VCSQHSAANQ 2400
    KLVQDLLESH TASLQARETW GHSILATGLW PDSVPSALFA TEDSRLSVVR 2450
    SEGQILAYCL NRMSLKTSSW TRSQPLTLQD LENIMQTCSP DDLTFNAVEV 2500
    DTCWVDEPEV LATAVKLLIE RATNQDWMLR VKWLCHLAKN IPQGLESVRV 2550
    HLEASATALR KFYSTSLSAG VSNVLKILQT NITDDFVIPL DPRWNMQALD 2600
    IIRNSLDFDP QSDQAKQLFA LLESVANKTF IYLDREKRIF TEANLVSVGS 2650
    KKLRSSVLRM SFEFHKDPEN YHSPPHEIVA NLAAFFELID GLILLWVQSP 2700
    QGVVPDAHIN KILGSVQWRD RFWTVADTVT VDASGLALLA LHWHWVSKHL 2750
    IYQIPQLLVN QENKYYKELQ TVSEHIHSCL GSPADSFAGV KKLQAFLGRP 2800
    FPFKDKLVVD CFLQLQALNR ALAIGEQLPV FGECGWQEDI NRLQVVASEW 2850
    NLKKSLLQAW GLILRANILE DVNLDELKNL VSTQCSELKS RGLSRGFLEK 2900
    AHDASSPSQP DLSSLVHLTR RVQLWPAAEY LAMLWQYRVT ADFIAQACLR 2950
    RSSKHDQMDE EISHHIAFCL KHTPIAPQKL WNLWSLLHIE MLSAQEVSCL 3000
    WSELFTSTFG SSWSSPVTTA PECWLAWSPL PNIQQQEVPR SRWDSTLKGP 3050
    GSLCRAVFSK CCFGVLTNSS RASYWDVSGL PLLSSSHVTL GEWVERAQQL 3100
    QDISSLLWTN MAVPSVAEFR RTDSRLQGLV LCRYLLGLTE LLPAHQRQEY 3150
    MQNCEHLLLG NTQAFHHVDQ TMGNIGGQEA LPKELLCLLL TSLHYFIGEG 3200
    EGKQNLPEAA RRGRLWVSLG LLQIQTWLPR ARFDPAVKKA YKLRYAQDEL 3250
    RQLQCELKTR NLLSHLQTGR DLEDDIITSH SHPHIKLLPQ RISQLESLVH 3300
    SLSKKQAFRP HLPSYETLVQ EIHHYVTSIA KVTAVQDLLM RLLQALHTDG 3350
    PKSAQVLQNL LKEEASWQQS HHQFRKRLVE EYALYPDTVA PLLASILQLQ 3400
    HGMRLVASEV HASLHSGVLC AENLGALAMA VLAFPSVGPS FPTYHAHADA 3450
    LCSVNAAEAL RSLGKLMVKR AARKEEAKSQ QAYPTREQLL MNALLYLRSH 3500
    VLCKGELDQR ALLLFRHLCQ EIINEWDEQE RIAQEKAEQE SSLYRYRSRS 3550
    GRTALSEEEE EELELRKLFP LHEKDFADIL MEPTLEEKKK VSDGREEEAA 3600
    PDPTLLCQSS MQAVMLIHQQ LCLSFARSLW YQQAVPPHEA KHYLSLFLSC 3650
    YQTGASLVTH FYPLMGVELN DQLLGSQLLA CTLSSNTLCG EATSDLMMRP 3700
    DGPYDFYQHP NVAEARQCQP VLQGFSEAVS QLLQDWPEHP VLQQLLVVMD 3750
    RIRGFPLSSP ISKFLNGLEI LLAKAQDWEE NASRVLSLRK HLDLVSQMII 3800
    RWRKLELNCW SMSLDNTMIR HTEKSTKHWF SIYQMLEKHM QERTEEQEDD 3850
    KQMTLMLLVS TLQAFIEGSS LGEFHVRLQM LLVFHCHVLL MPQVEGKDSL 3900
    CSVLWNLYHF YKQFLDPVKA KIMELRSPIE KELKEFVKIS KWNDVSFWSI 3950
    KQSVEKTHRT LFKFMKKFEA VLSEPCQSCL VESDKEEQPD CLPKPTEEAT 4000
    METSPIQGLN NALRETLLAQ PVEWKPSGTE QCQDASPLSV EGELLRRLPR 4050
    LSKRMRKMCL VFMKESPLPH LVESLDQFTG GVISSVSELQ SLKVDPSAEK 4100
    EKQHSEAKHI LLQKHRALSD LFKHLANIGL SYRKGLAWAR SKSPQELLHL 4150
    HPLDLRSALS IVSSTREADS RLLTEISSLW DGCQKYFYRS LARHTRLTAA 4200
    LATPVKEVSM GTIERCKGFS AHLMKLLIRQ RHSLTTLTEQ WIILRNLLSC 4250
    VQEIHSRLTG PPVYPVAFPP QDSVQQWTER LQHLAMQSQI LLEQFSWLFQ 4300
    CCPSAEPTVG HRDAQVQEHP SASHLENIDF KETIAGVMPD LLSSDLSYPS 4350
    PVPTSQLPSA CRMRRQDQLW QQSTAGLTEM LKTIKTMKAG VDKIRQQSCE 4400
    TLFHTWEDFE VCSSGLNCLS QVSAHLQGLA SLFILPGIEV EQTDSRMALV 4450
    ESLDYLRGEV SKAIDDFTAW KARLFVAHKQ EGNQMVEESF VEDFSEQVET 4500
    AIRAILCTIQ NLAERNNKKA EDSAVDKRLQ EEDGGKEEEA SFKSLQPGHL 4550
    TKLLEDDFWA SVSTLHVQKI ISSVSELLER LKSCSEDGNT TKHKVFSQSC 4600
    GLLVRLIPIL CGFSDLVLFF LTVSLATHRS TAKLLSVLAQ TFTELSQKGF 4650
    CLPKELMEDS AGEGATQFHD YEGGGIGDGE GMKDVSDRIE NEEQVEDTFQ 4700
    KGQEKDEEDL DSKPDTKGED NAIEMSEDFD GKMHDGELEQ EEDDEKSDSE 4750
    DGDLDKQMGN LNGEEADKLD ERLWGDDEEE DEDGDGRAEE TGPGVDEEDS 4800
    ELVAKDDSLD AGNLNKNKKH QDEKEDSEPE DVEQGQEKIN EQIDEREYDE 4850
    NEVDPYHGNQ EKLPEPEALD LPDDLKLDSE DKSGGEDTDN EEAEEENPLE 4900
    IKEKTVDMEE TDHEIEEPGA GQDEGESPHE PEEGPSEDKE NMDMDTGADD 4950
    QDRDTSSHAE EHSLEEEAEE EEEKGEKEED KATTDGGGES GVNPVDQGLQ 5000
    PQKEEEEEGE QSDAEEQVPE ATERKEHATC GQTGVDNVQS AQAVELAGAA 5050
    PEKEQGKEEH GSGAADANQA EGHESNLIAR LSSQQHTNKN TQSFKRRPGQ 5100
    ADNERSVGDY NERVRKRLRT VGTDRETEQE PTQAQVEDAD AFEHVKQGSD 5150
    AYDAQTYDVA SSEQQQTAKA SGQDQEEEEI EDILMDTEEE LMRAEDTEQL 5200
    KPEAVQSETA ATSGSSEMEV DMQTLKTKED QDPRTTTPHQ ETENERPERS 5250
    RDSTIHTLRQ FLVDSVFQPI LKDISELRQE MERQLETWQA HDYGNAEEEK 5300
    AAAEMWQNYL VLTASLSQQL CEQLRLLLEP TQAAKLRGDY RTGKRLNMRK 5350
    IIPYIASQFR KDRIWLRRTK PSKRQYQICL AIDDSSSMVD NHTKQLAFES 5400
    LAVIGNALTL LEVGQIAVCS FGESVKLLHP FHEQFNDSSG THILRLCTFQ 5450
    QRKTKIAQFL ETVAKMFAAA QKLSQNVSPE TAQLLLIVSD GRGLFLEGKD 5500
    RVLAAVQAAQ NANIFVIFVV LDNPNSRDSI LDIKVPIFKG PGEMPEIRSY 5550
    MEEFPFPFYI ILRDVNALPE TLSDALRQWF ELVTASDHS 5589
    Length:5,589
    Mass (Da):630,342
    Last modified:February 5, 2008 - v1
    Checksum:iCE58B46C42EA157A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL805973 Genomic DNA. No translation available.
    AL831774 Genomic DNA. No translation available.
    RefSeqiXP_006537539.1. XM_006537476.1.
    UniGeneiMm.24627.

    Genome annotation databases

    EnsembliENSMUST00000071642; ENSMUSP00000071569; ENSMUSG00000058006.
    GeneIDi100019.
    KEGGimmu:100019.
    UCSCiuc008sfa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL805973 Genomic DNA. No translation available.
    AL831774 Genomic DNA. No translation available.
    RefSeqi XP_006537539.1. XM_006537476.1.
    UniGenei Mm.24627.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi A2ANY6.
    PaxDbi A2ANY6.
    PRIDEi A2ANY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071642 ; ENSMUSP00000071569 ; ENSMUSG00000058006 .
    GeneIDi 100019.
    KEGGi mmu:100019.
    UCSCi uc008sfa.1. mouse.

    Organism-specific databases

    CTDi 23195.
    MGIi MGI:1926159. Mdn1.

    Phylogenomic databases

    eggNOGi COG5271.
    GeneTreei ENSGT00550000074802.
    HOGENOMi HOG000231719.
    HOVERGENi HBG031706.
    InParanoidi A2ANY6.
    KOi K14572.
    OMAi RIFLTMD.
    OrthoDBi EOG7S4X6J.
    PhylomeDBi A2ANY6.
    TreeFami TF300488.

    Miscellaneous databases

    ChiTaRSi MDN1. mouse.
    NextBioi 35543779.
    PROi A2ANY6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2ANY6.

    Family and domain databases

    Gene3Di 3.40.50.300. 8 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011704. ATPase_dyneun-rel_AAA.
    IPR012099. Midasin.
    IPR027417. P-loop_NTPase.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF07728. AAA_5. 8 hits.
    [Graphical view ]
    PIRSFi PIRSF010340. Midasin. 1 hit.
    SMARTi SM00382. AAA. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 8 hits.
    SSF53300. SSF53300. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2ANY6_MOUSE
    AccessioniPrimary (citable) accession number: A2ANY6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3