Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2ANY6

- A2ANY6_MOUSE

UniProt

A2ANY6 - A2ANY6_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Midasin

Gene

Mdn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.UniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein complex assembly Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MidasinUniRule annotation
Gene namesi
Name:Mdn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1926159. Mdn1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. intermediate filament cytoskeleton Source: Ensembl
  3. membrane Source: Ensembl
  4. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiA2ANY6.
PaxDbiA2ANY6.
PRIDEiA2ANY6.

Expressioni

Gene expression databases

ExpressionAtlasiA2ANY6. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the midasin family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5271.
GeneTreeiENSGT00550000074802.
HOGENOMiHOG000231719.
HOVERGENiHBG031706.
InParanoidiA2ANY6.
KOiK14572.
OMAiRIFLTMD.
OrthoDBiEOG7S4X6J.
PhylomeDBiA2ANY6.
TreeFamiTF300488.

Family and domain databases

Gene3Di3.40.50.300. 8 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR002035. VWF_A.
[Graphical view]
PfamiPF07728. AAA_5. 8 hits.
[Graphical view]
PIRSFiPIRSF010340. Midasin. 1 hit.
SMARTiSM00382. AAA. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 8 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ANY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHLSVELVS GPLRLIAAKN EKSSGELNRF LAKSVWTPQD RQCILDSLAQ
60 70 80 90 100
LLLDKDYTLL LGRQLRPILL DLLERNAKAI KTGGQVNHDL HERLSVSMSK
110 120 130 140 150
LIGSHPDVLP FALRYFKDTY PVFQRLFLES SDANPVRYGR RRMKLRDLME
160 170 180 190 200
AANIFLQHRQ TVFRELWDWS VCVPLLRSHD ALVRWHTANC LALVTCMNEE
210 220 230 240 250
HKLSFLRKIF SSDELVHFRL RLLEEAQLQD LEKALVLANP EVSLWHKGEE
260 270 280 290 300
PQYIQGHLVS ADLSSSVAAV CGVVLPKLSS SPGEQASDRS SSLEQELALK
310 320 330 340 350
SFVLVESVCK NLQLLAVSVA SQNAVLLEGP IGSGKTSLVE HLAAVTGRTK
360 370 380 390 400
PPQLLKVQLG DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATKGYWILL
410 420 430 440 450
EDIDYAPLDV VSVLIPLLEH GELLIPGHGD CLKVAPTFQL FATRRLLSCG
460 470 480 490 500
GSWYRPMNSH ATMLDKYWTK IHLHNLNKKD LNEVLQSKYP SLLAATDHLL
510 520 530 540 550
DIYIELTGEK HCCPSVAYDK APQEVSEAER ENRRVVLEGR ELSLRDLLNW
560 570 580 590 600
CNRVAHGFDP TSSTALLHIF QEAMDCFTAM LSEQTKKLRM AEVIGSRLNI
610 620 630 640 650
SKKKAEFYCK LYKPEIVINE LDVQVGRVRL LRKQSEVVRI QKEKCTFAAT
660 670 680 690 700
RPSSVLLEQL AVCVSQGEPV LLVGETGTGK TSAVQYLAYA TGQHLRVVNM
710 720 730 740 750
NQQSDTADLL GGFKPVDHKL IWLPLRETFE ELFVQTFSKK QNFTFLGHIQ
760 770 780 790 800
TCYRQKRWHD LLKLMLHVQK SASTKGGEQS QPGLLKEKWE AFGLRLNHAQ
810 820 830 840 850
QQMKMTENAL LFAFVEGTLA QAIKKGEWIL LDEINLAAPE TLECLSGLLE
860 870 880 890 900
GSSGSLVLLD RGDTEPLVRH PDFRLFACMN PATDVGKRNL PPGIRNRFTE
910 920 930 940 950
LYVEELESKE DLQILIVDYL KGLNVSKNTV QGIVNFYTAL RKESGTKLVD
960 970 980 990 1000
GTGHRPHYSL RTLCRALRFA ASNPCGSIQR SLYEGFCLGF LTQLDRASHP
1010 1020 1030 1040 1050
VVQKLICQHI ISGNVKSLLK QPIPEPKGGR LIQVEGYWIS VGDKEPKIDE
1060 1070 1080 1090 1100
TYVLTPSVKL NLRDIARVVS AGTYPVLIQG ETSVGKTSLI RWLAAASGNH
1110 1120 1130 1140 1150
CVRINNHEHT DIQEYIGCYT SDTSGKLVFN EGVLIDAMRK GYWIVLDELN
1160 1170 1180 1190 1200
LAPTDVLEAL NRLLDDNREL LITETQEVVR AHPRFMLFAT QNPPGLYGGR
1210 1220 1230 1240 1250
KVLSRAFRNR FVELHFDELP SSELETILHK RCSLPPSYCS KLVKVMLDLQ
1260 1270 1280 1290 1300
SYRRRSSVFA GKQGFIALRD LFRWAERYRL AEQTQEDYDW LQHLANDGFM
1310 1320 1330 1340 1350
LLAGRVRKQE EADVIQEVLE KHFKKKLCPQ SLFSKENVLK LLGKSSTQTT
1360 1370 1380 1390 1400
VLESKFSHVV WTESMRRLAV LVGRALEFGE PVLLVGDTGC GKTTVCQMFS
1410 1420 1430 1440 1450
ALANQKLYSV NCHLNMETSD FLGGLRPVRQ KPNDKDELDT RLFEWHDGPL
1460 1470 1480 1490 1500
VLAMKEDSFF LLDEISLADD SVLERLNSVL EVEKCLVLAE KGSPESKDNE
1510 1520 1530 1540 1550
VELLTAGKHF RILATMNPGG DFGKKELSPA LRNRFTEIWC PQSTKREDLI
1560 1570 1580 1590 1600
QIINHNLRPG LSLAGVGHKG AGVAEVMLAF ITWLTRQEFG RKCVVSIRDI
1610 1620 1630 1640 1650
LSWVNFMNSM AEDAAVKRPE AISTVTSFVH AACLVYIDGI GSGVTSSGFG
1660 1670 1680 1690 1700
TALLAREECL KFLIKKLSKV VRLTQRQKDE LKIYDRLRHK EFTSIDDFWG
1710 1720 1730 1740 1750
VHPFFIPRGP VLDGHNTGDY ALTAGTTAMN AQRLLRAAKL NKPILLEGSP
1760 1770 1780 1790 1800
GVGKTSLVAA LAKASGNTLV RINLSEQTDI TDLFGADLPV EGGRGGEFAW
1810 1820 1830 1840 1850
CDGPLLAALK AGHWVVLDEL NLASQSILEG LNACFDHRGE IYVPELGMSF
1860 1870 1880 1890 1900
QVQHEKTRIF GCQNPFRQGG GRKGLPKSFL NRFTQVFVDP LTVVDMEFIA
1910 1920 1930 1940 1950
STLFPTIDKD IVKKMVAFNN HIDHEVTVEK KWGQKGGPWE FNLRDLFRWC
1960 1970 1980 1990 2000
QLILVDQSPG CYDPGQHVFL VYGERMRTRE DKEKVVAVFK DVFASNSMPY
2010 2020 2030 2040 2050
IGTRQFHITP YDIQIGYSVL SRSSYVPHPS RRPLSLLHQS FQSLEPIMKC
2060 2070 2080 2090 2100
VQMNWMVILV GPASVGKTSL VQLLAHLTGH TLKIMAMNSA MDTTELLGGF
2110 2120 2130 2140 2150
EQVDIIRPWR LLLEKVERTV RVLLRDSLLI NSVDTEVVLQ AWSHFLLTYK
2160 2170 2180 2190 2200
PKCLGEDGKG VTIEIVNKLE AVLLLMQRLN NKINSYSKAD FAKLVEDFRS
2210 2220 2230 2240 2250
FGVKLLQSAS GRSHGSFEWV DSMLVQALKS GDWLLMDNVN FCNPSVLDRL
2260 2270 2280 2290 2300
NALLEPGGVL TINERGMVDG STCTVTPNPN FRLFLSMDPI HGEISRAMRN
2310 2320 2330 2340 2350
RGLEIYISGE EDGSIQDNLD LKVLLHSLGL VGDSVCNILL ALHTEIQSLV
2360 2370 2380 2390 2400
RGSPASSVST LSHTAILIVQ YLQRGLSLHK AFFEACWEVY VCSQHSAANQ
2410 2420 2430 2440 2450
KLVQDLLESH TASLQARETW GHSILATGLW PDSVPSALFA TEDSRLSVVR
2460 2470 2480 2490 2500
SEGQILAYCL NRMSLKTSSW TRSQPLTLQD LENIMQTCSP DDLTFNAVEV
2510 2520 2530 2540 2550
DTCWVDEPEV LATAVKLLIE RATNQDWMLR VKWLCHLAKN IPQGLESVRV
2560 2570 2580 2590 2600
HLEASATALR KFYSTSLSAG VSNVLKILQT NITDDFVIPL DPRWNMQALD
2610 2620 2630 2640 2650
IIRNSLDFDP QSDQAKQLFA LLESVANKTF IYLDREKRIF TEANLVSVGS
2660 2670 2680 2690 2700
KKLRSSVLRM SFEFHKDPEN YHSPPHEIVA NLAAFFELID GLILLWVQSP
2710 2720 2730 2740 2750
QGVVPDAHIN KILGSVQWRD RFWTVADTVT VDASGLALLA LHWHWVSKHL
2760 2770 2780 2790 2800
IYQIPQLLVN QENKYYKELQ TVSEHIHSCL GSPADSFAGV KKLQAFLGRP
2810 2820 2830 2840 2850
FPFKDKLVVD CFLQLQALNR ALAIGEQLPV FGECGWQEDI NRLQVVASEW
2860 2870 2880 2890 2900
NLKKSLLQAW GLILRANILE DVNLDELKNL VSTQCSELKS RGLSRGFLEK
2910 2920 2930 2940 2950
AHDASSPSQP DLSSLVHLTR RVQLWPAAEY LAMLWQYRVT ADFIAQACLR
2960 2970 2980 2990 3000
RSSKHDQMDE EISHHIAFCL KHTPIAPQKL WNLWSLLHIE MLSAQEVSCL
3010 3020 3030 3040 3050
WSELFTSTFG SSWSSPVTTA PECWLAWSPL PNIQQQEVPR SRWDSTLKGP
3060 3070 3080 3090 3100
GSLCRAVFSK CCFGVLTNSS RASYWDVSGL PLLSSSHVTL GEWVERAQQL
3110 3120 3130 3140 3150
QDISSLLWTN MAVPSVAEFR RTDSRLQGLV LCRYLLGLTE LLPAHQRQEY
3160 3170 3180 3190 3200
MQNCEHLLLG NTQAFHHVDQ TMGNIGGQEA LPKELLCLLL TSLHYFIGEG
3210 3220 3230 3240 3250
EGKQNLPEAA RRGRLWVSLG LLQIQTWLPR ARFDPAVKKA YKLRYAQDEL
3260 3270 3280 3290 3300
RQLQCELKTR NLLSHLQTGR DLEDDIITSH SHPHIKLLPQ RISQLESLVH
3310 3320 3330 3340 3350
SLSKKQAFRP HLPSYETLVQ EIHHYVTSIA KVTAVQDLLM RLLQALHTDG
3360 3370 3380 3390 3400
PKSAQVLQNL LKEEASWQQS HHQFRKRLVE EYALYPDTVA PLLASILQLQ
3410 3420 3430 3440 3450
HGMRLVASEV HASLHSGVLC AENLGALAMA VLAFPSVGPS FPTYHAHADA
3460 3470 3480 3490 3500
LCSVNAAEAL RSLGKLMVKR AARKEEAKSQ QAYPTREQLL MNALLYLRSH
3510 3520 3530 3540 3550
VLCKGELDQR ALLLFRHLCQ EIINEWDEQE RIAQEKAEQE SSLYRYRSRS
3560 3570 3580 3590 3600
GRTALSEEEE EELELRKLFP LHEKDFADIL MEPTLEEKKK VSDGREEEAA
3610 3620 3630 3640 3650
PDPTLLCQSS MQAVMLIHQQ LCLSFARSLW YQQAVPPHEA KHYLSLFLSC
3660 3670 3680 3690 3700
YQTGASLVTH FYPLMGVELN DQLLGSQLLA CTLSSNTLCG EATSDLMMRP
3710 3720 3730 3740 3750
DGPYDFYQHP NVAEARQCQP VLQGFSEAVS QLLQDWPEHP VLQQLLVVMD
3760 3770 3780 3790 3800
RIRGFPLSSP ISKFLNGLEI LLAKAQDWEE NASRVLSLRK HLDLVSQMII
3810 3820 3830 3840 3850
RWRKLELNCW SMSLDNTMIR HTEKSTKHWF SIYQMLEKHM QERTEEQEDD
3860 3870 3880 3890 3900
KQMTLMLLVS TLQAFIEGSS LGEFHVRLQM LLVFHCHVLL MPQVEGKDSL
3910 3920 3930 3940 3950
CSVLWNLYHF YKQFLDPVKA KIMELRSPIE KELKEFVKIS KWNDVSFWSI
3960 3970 3980 3990 4000
KQSVEKTHRT LFKFMKKFEA VLSEPCQSCL VESDKEEQPD CLPKPTEEAT
4010 4020 4030 4040 4050
METSPIQGLN NALRETLLAQ PVEWKPSGTE QCQDASPLSV EGELLRRLPR
4060 4070 4080 4090 4100
LSKRMRKMCL VFMKESPLPH LVESLDQFTG GVISSVSELQ SLKVDPSAEK
4110 4120 4130 4140 4150
EKQHSEAKHI LLQKHRALSD LFKHLANIGL SYRKGLAWAR SKSPQELLHL
4160 4170 4180 4190 4200
HPLDLRSALS IVSSTREADS RLLTEISSLW DGCQKYFYRS LARHTRLTAA
4210 4220 4230 4240 4250
LATPVKEVSM GTIERCKGFS AHLMKLLIRQ RHSLTTLTEQ WIILRNLLSC
4260 4270 4280 4290 4300
VQEIHSRLTG PPVYPVAFPP QDSVQQWTER LQHLAMQSQI LLEQFSWLFQ
4310 4320 4330 4340 4350
CCPSAEPTVG HRDAQVQEHP SASHLENIDF KETIAGVMPD LLSSDLSYPS
4360 4370 4380 4390 4400
PVPTSQLPSA CRMRRQDQLW QQSTAGLTEM LKTIKTMKAG VDKIRQQSCE
4410 4420 4430 4440 4450
TLFHTWEDFE VCSSGLNCLS QVSAHLQGLA SLFILPGIEV EQTDSRMALV
4460 4470 4480 4490 4500
ESLDYLRGEV SKAIDDFTAW KARLFVAHKQ EGNQMVEESF VEDFSEQVET
4510 4520 4530 4540 4550
AIRAILCTIQ NLAERNNKKA EDSAVDKRLQ EEDGGKEEEA SFKSLQPGHL
4560 4570 4580 4590 4600
TKLLEDDFWA SVSTLHVQKI ISSVSELLER LKSCSEDGNT TKHKVFSQSC
4610 4620 4630 4640 4650
GLLVRLIPIL CGFSDLVLFF LTVSLATHRS TAKLLSVLAQ TFTELSQKGF
4660 4670 4680 4690 4700
CLPKELMEDS AGEGATQFHD YEGGGIGDGE GMKDVSDRIE NEEQVEDTFQ
4710 4720 4730 4740 4750
KGQEKDEEDL DSKPDTKGED NAIEMSEDFD GKMHDGELEQ EEDDEKSDSE
4760 4770 4780 4790 4800
DGDLDKQMGN LNGEEADKLD ERLWGDDEEE DEDGDGRAEE TGPGVDEEDS
4810 4820 4830 4840 4850
ELVAKDDSLD AGNLNKNKKH QDEKEDSEPE DVEQGQEKIN EQIDEREYDE
4860 4870 4880 4890 4900
NEVDPYHGNQ EKLPEPEALD LPDDLKLDSE DKSGGEDTDN EEAEEENPLE
4910 4920 4930 4940 4950
IKEKTVDMEE TDHEIEEPGA GQDEGESPHE PEEGPSEDKE NMDMDTGADD
4960 4970 4980 4990 5000
QDRDTSSHAE EHSLEEEAEE EEEKGEKEED KATTDGGGES GVNPVDQGLQ
5010 5020 5030 5040 5050
PQKEEEEEGE QSDAEEQVPE ATERKEHATC GQTGVDNVQS AQAVELAGAA
5060 5070 5080 5090 5100
PEKEQGKEEH GSGAADANQA EGHESNLIAR LSSQQHTNKN TQSFKRRPGQ
5110 5120 5130 5140 5150
ADNERSVGDY NERVRKRLRT VGTDRETEQE PTQAQVEDAD AFEHVKQGSD
5160 5170 5180 5190 5200
AYDAQTYDVA SSEQQQTAKA SGQDQEEEEI EDILMDTEEE LMRAEDTEQL
5210 5220 5230 5240 5250
KPEAVQSETA ATSGSSEMEV DMQTLKTKED QDPRTTTPHQ ETENERPERS
5260 5270 5280 5290 5300
RDSTIHTLRQ FLVDSVFQPI LKDISELRQE MERQLETWQA HDYGNAEEEK
5310 5320 5330 5340 5350
AAAEMWQNYL VLTASLSQQL CEQLRLLLEP TQAAKLRGDY RTGKRLNMRK
5360 5370 5380 5390 5400
IIPYIASQFR KDRIWLRRTK PSKRQYQICL AIDDSSSMVD NHTKQLAFES
5410 5420 5430 5440 5450
LAVIGNALTL LEVGQIAVCS FGESVKLLHP FHEQFNDSSG THILRLCTFQ
5460 5470 5480 5490 5500
QRKTKIAQFL ETVAKMFAAA QKLSQNVSPE TAQLLLIVSD GRGLFLEGKD
5510 5520 5530 5540 5550
RVLAAVQAAQ NANIFVIFVV LDNPNSRDSI LDIKVPIFKG PGEMPEIRSY
5560 5570 5580
MEEFPFPFYI ILRDVNALPE TLSDALRQWF ELVTASDHS
Length:5,589
Mass (Da):630,342
Last modified:February 5, 2008 - v1
Checksum:iCE58B46C42EA157A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805973 Genomic DNA. No translation available.
AL831774 Genomic DNA. No translation available.
RefSeqiXP_006537539.1. XM_006537476.1.
UniGeneiMm.24627.

Genome annotation databases

EnsembliENSMUST00000071642; ENSMUSP00000071569; ENSMUSG00000058006.
GeneIDi100019.
KEGGimmu:100019.
UCSCiuc008sfa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805973 Genomic DNA. No translation available.
AL831774 Genomic DNA. No translation available.
RefSeqi XP_006537539.1. XM_006537476.1.
UniGenei Mm.24627.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi A2ANY6.
PaxDbi A2ANY6.
PRIDEi A2ANY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071642 ; ENSMUSP00000071569 ; ENSMUSG00000058006 .
GeneIDi 100019.
KEGGi mmu:100019.
UCSCi uc008sfa.1. mouse.

Organism-specific databases

CTDi 23195.
MGIi MGI:1926159. Mdn1.

Phylogenomic databases

eggNOGi COG5271.
GeneTreei ENSGT00550000074802.
HOGENOMi HOG000231719.
HOVERGENi HBG031706.
InParanoidi A2ANY6.
KOi K14572.
OMAi RIFLTMD.
OrthoDBi EOG7S4X6J.
PhylomeDBi A2ANY6.
TreeFami TF300488.

Miscellaneous databases

ChiTaRSi Mdn1. mouse.
NextBioi 35543779.
PROi A2ANY6.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi A2ANY6. baseline and differential.

Family and domain databases

Gene3Di 3.40.50.300. 8 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF07728. AAA_5. 8 hits.
[Graphical view ]
PIRSFi PIRSF010340. Midasin. 1 hit.
SMARTi SM00382. AAA. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 8 hits.
SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2ANY6_MOUSE
AccessioniPrimary (citable) accession number: A2ANY6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3