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Protein

E3 ubiquitin-protein ligase UBR4

Gene

Ubr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1655 – 172874UBR-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Calmodulin-binding, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR4 (EC:6.3.2.-)
Alternative name(s):
N-recognin-4
Zinc finger UBR1-type protein 1
p600
Gene namesi
Name:Ubr4
Synonyms:Kiaa0462, Zubr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916366. Ubr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 51805180E3 ubiquitin-protein ligase UBR4PRO_0000286862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781PhosphoserineCombined sources
Modified residuei181 – 1811PhosphoserineCombined sources
Modified residuei212 – 2121PhosphoserineCombined sources
Modified residuei370 – 3701PhosphotyrosineCombined sources
Modified residuei905 – 9051PhosphothreonineBy similarity
Modified residuei1083 – 10831N6-acetyllysineBy similarity
Modified residuei1401 – 14011PhosphoserineBy similarity
Modified residuei1646 – 16461PhosphoserineBy similarity
Modified residuei1651 – 16511PhosphoserineBy similarity
Modified residuei1746 – 17461PhosphoserineBy similarity
Modified residuei1753 – 17531PhosphoserineBy similarity
Modified residuei1876 – 18761PhosphoserineBy similarity
Modified residuei1902 – 19021PhosphoserineBy similarity
Modified residuei2712 – 27121PhosphothreonineBy similarity
Modified residuei2716 – 27161PhosphoserineBy similarity
Modified residuei2719 – 27191PhosphoserineCombined sources
Modified residuei2721 – 27211PhosphothreonineCombined sources
Modified residuei2941 – 29411PhosphothreonineBy similarity
Modified residuei2949 – 29491PhosphoserineBy similarity
Isoform 5 (identifier: A2AN08-5)
Modified residuei2603 – 26031PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA2AN08.
MaxQBiA2AN08.
PaxDbiA2AN08.
PeptideAtlasiA2AN08.
PRIDEiA2AN08.

PTM databases

iPTMnetiA2AN08.
PhosphoSiteiA2AN08.
SwissPalmiA2AN08.

Expressioni

Tissue specificityi

Widely expressed in adult and embryonic stages with highest levels in testis and brain.1 Publication

Gene expression databases

BgeeiA2AN08.
ExpressionAtlasiA2AN08. baseline and differential.
GenevisibleiA2AN08. MM.

Interactioni

Subunit structurei

Interacts with RB1 and calmodulin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
E7P069332EBI-4285947,EBI-7730971From a different organism.

Protein-protein interaction databases

BioGridi213238. 3 interactions.
DIPiDIP-61499N.
IntActiA2AN08. 5 interactions.
MINTiMINT-4114797.
STRINGi10090.ENSMUSP00000095433.

Structurei

3D structure databases

ProteinModelPortaliA2AN08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 157Poly-Ala
Compositional biasi608 – 62619Pro-richAdd
BLAST
Compositional biasi811 – 8166Poly-Leu
Compositional biasi2725 – 273511Poly-AspAdd
BLAST

Sequence similaritiesi

Belongs to the UBR4 family.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1655 – 172874UBR-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1776. Eukaryota.
ENOG410XPP8. LUCA.
GeneTreeiENSGT00600000084471.
HOVERGENiHBG058328.
InParanoidiA2AN08.
KOiK10691.
OMAiEGDVHTS.
OrthoDBiEOG7288QF.
PhylomeDBiA2AN08.
TreeFamiTF314406.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR025704. E3_Ub_ligase_UBR4.
IPR017986. WD40_repeat_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF13764. E3_UbLigase_R4. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AN08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP
60 70 80 90 100
QLVASVIESE SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV
110 120 130 140 150
AAACKVLIEF SLLRLENPDE ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT
160 170 180 190 200
FTAMMKSAKL PQTVKTLSDV EDQKELASPV SPELRQKEVQ MNFLNQLTSV
210 220 230 240 250
FNPRTVPSPP ISPQALVEGE NDEQSSPDQV SAAKTKSVFI AQNVASLQEL
260 270 280 290 300
GGSEKLLRVC LNLPYFLRYI NRFQDAVVAN SFFIMPATVA DATAVRNGFH
310 320 330 340 350
SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL
360 370 380 390 400
HVGSAQQVRT GSTSSKEDDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG
410 420 430 440 450
EHFQNFQLLG AWCLLNSLFL ILNLSPTALA DKGKEKDPLA ALRVRDILSR
460 470 480 490 500
TKEGVGSPKL GPGKGHQGFG VLSVILANHA IKLLASLFQD LQVEALHKGW
510 520 530 540 550
ETDGPPAVLS IMAQSTSTQR IQRLIDSVPL TNLLLTLLST SYRKACVLQR
560 570 580 590 600
QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS
610 620 630 640 650
PSKEKAAPPP PPPPPPLESS PRVKSPNKQA SGEKGNILAS RKDPELFSGL
660 670 680 690 700
ASNILNFITT SMLNSRNSFI RSYLSASLSE HHMATLASII KEVDKDGLKG
710 720 730 740 750
SSDEDFAAAL YHFNHSLVTS DLQSPNLQNT LLQQLGVAPF SEGPWPLYIH
760 770 780 790 800
PQGLSVLSRL LLIWQHKAGA QGDPDVPECL KVWDRFLTTM KQNALQGVVP
810 820 830 840 850
SETEDLNVEH LQLLLLIFHS FSEKGRRAIL TMLVQSIQEL SVNMEVQMRT
860 870 880 890 900
APLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSSS
910 920 930 940 950
RRANTPLYHG FKEVEENWSK HFSSDAAPQP RFYCVLSTEA SEEDLNRLDS
960 970 980 990 1000
EACEVLFSKP VKYDELYSSL TTLLAAGSQL DTTRRKEKKN VTALEACALQ
1010 1020 1030 1040 1050
YYFLILWRIL GILPPSKTYM NQLAMNSPEM SECDILHTLR WSSRLRISSY
1060 1070 1080 1090 1100
VSWIKDHLIK QGMKPEHAGS LIELAASKCS SVKYDVEIVE EYFARQISSF
1110 1120 1130 1140 1150
CSIDCTAVLQ LHEIPSLQSI YTLDAAVSKV QVSLDEHFSK MAAETDPHKS
1160 1170 1180 1190 1200
SEITKNLLPA TLQLIDTYAS FTRAYLLQNL NEEGSTEKPS QEKLHGFAAV
1210 1220 1230 1240 1250
LAIGSSRCKA NTLGPTLVQN LPSSVQSVCE SWNNINTNEF PNIGSWRNAF
1260 1270 1280 1290 1300
ANDTIPSESY ISAVQAAHLG TLCGQSLPLA ASLKHTLLSL VRLTGDLIVW
1310 1320 1330 1340 1350
SDEMNPAQVI RTLLPLLLES STESAAEISS NSLERILGPA ESDEFLARVY
1360 1370 1380 1390 1400
EKLITGCYNI LANHADPNSG LDESILEECL QYLEKQLESS QARKAMEEFF
1410 1420 1430 1440 1450
SDGGELVQIM MATANEDLSA KFCNRVLKFF TKLFQLTEKS PNPSLLHLCG
1460 1470 1480 1490 1500
SLAQLACVEP VRLQAWLTRM TTSPPKDSDQ LEVIQENRQL LQLLTTYIVR
1510 1520 1530 1540 1550
ENSQVGEGVC AVLLGTLTPM ATDMLANGDG TGFPELMVVM ATLASAGQGA
1560 1570 1580 1590 1600
GHLQLHNAAV DWLGRCKKYL SQKNVVEKLN ANVMHGKHVM VLECTCHIMS
1610 1620 1630 1640 1650
YLADVTNALS QSNGQGPSHL SVDGEERAIE VDSDWVEELA VEEEDSQAED
1660 1670 1680 1690 1700
SDEDSLCNKL CTFTITQKEF MNQHWYHCHT CKMVDGVGVC TVCAKVCHKD
1710 1720 1730 1740 1750
HEISYAKYGS FFCDCGAKED GSCLALVKRT PSSGMSSTMK ESAFQSEPRV
1760 1770 1780 1790 1800
SESLVRHAST SPADKAKVTI SDGKVTDEEK PKKSSLCRTV EGCREELQNQ
1810 1820 1830 1840 1850
ANFSFAPLVL DMLSFLMDAI QTNFQQASAV GSSSRAQQAL SELHTVDKGV
1860 1870 1880 1890 1900
EMTDQLMVPT LGSQEGAFEN VRMNYSGDQG QTIRQLISAH VLRRVAMCVL
1910 1920 1930 1940 1950
SSPHGRRQHL AVSHEKGKIT VLQLSALLKQ ADSSKRKLTL TRLASAPVPF
1960 1970 1980 1990 2000
TVLSLTGNPC KEDYLAVCGL KDCHVLTFSS SGSVSDHLVL HPQLATGNFI
2010 2020 2030 2040 2050
IKAVWLPGSQ TELAIVTADF VKIYDLSIDA LSPTFYFLLP SSKIRDVTFL
2060 2070 2080 2090 2100
FNEEGKNIIV IMSSAGYMYT QLMEEASSAQ QGPFYVTNVL EINHEDLKDS
2110 2120 2130 2140 2150
NSQVAGGGVS VYYSHVLQML FFSYSQGRSF AATVSRSTLE VLQLFPINIK
2160 2170 2180 2190 2200
SSNGGSKTSP ALCQWSEVMN HPGLVCCVQQ TTGVPLVVMV KPGTFLIQEI
2210 2220 2230 2240 2250
KTLPAKAKIQ DMVAIRHTAC NEQQRTTMIL LCEDGSLRIY MANVENTSYW
2260 2270 2280 2290 2300
LQPSLQPSSV ISIMKPVRKR KTATITARTS SQVTFPIDFF EHNQQLTDVE
2310 2320 2330 2340 2350
FGGNDLLQVY NAQQIKHRLN STGMYVANTK PGGFTIEISN NSSTMVMTGM
2360 2370 2380 2390 2400
RIQIGTQAIE RAPSYIEIFG RTMQLNLSRS RWFDFPFTRE EALQADRKLS
2410 2420 2430 2440 2450
LFIGASVDPA GVTMIDAVKI YGKTKEQFGW PDEPPEDFPS ASVSNICPPN
2460 2470 2480 2490 2500
LNQSNGTGES DSAAPATTSG TVLERLVVSS LEALESCFAV GPIIEKERNK
2510 2520 2530 2540 2550
HAAQELATLL LSLPAPASVQ QQSKSLLASL HSSRSAYHSH KDQALLSKAV
2560 2570 2580 2590 2600
QCLNTSSKEG KDLDPEVFQR LVITARSIAV TRPNNLVHFT ESKLPQMETE
2610 2620 2630 2640 2650
GADEGKEPQK QEGDGCSFIT QLVNHFWKLH ASKPKNAFLA PACLPGLTHI
2660 2670 2680 2690 2700
EATVNALVDI IHGYCTCELD CINTASKIYM QMLLCPDPAV SFSCKQALIR
2710 2720 2730 2740 2750
VLRPRNKRRH VTLPSSPRSN TPMGDKDDDD DDDADEKMQS SGIPDGGHIR
2760 2770 2780 2790 2800
QESQEQSEVD HGDFEMVSES MVLETAENVN NGNPSPLEAL LAGAEGFPPM
2810 2820 2830 2840 2850
LDIPPDADDE TMVELAIALS LQQDQQGSSS SALGLQSLGL SGQAPSSSSL
2860 2870 2880 2890 2900
DAGTLSDTTA SAPASDDEGS TAATDGSTLR TSPADHGGSV GSESGGSAVD
2910 2920 2930 2940 2950
SVAGEHSVSG RSSAYGDATA EGHPAGPGSV SSSTGAISTA TGHQEGDGSE
2960 2970 2980 2990 3000
GEGEGEAEGD VHTSNRLHMV RLMLLERLLQ TLPQLRNVGG VRAIPYMQVI
3010 3020 3030 3040 3050
LMLTTDLDGE DEKDKGALDN LLAQLIAELG MDKKDVSKKN ERSALNEVHL
3060 3070 3080 3090 3100
VVMRLLSVFM SRTKSGSKSS ICESSSLISS ATAAALLSSG AVDYCLHVLK
3110 3120 3130 3140 3150
SLLEYWKSQQ SDEEPVAASQ LLKPHTTSSP PDMSPFFLRQ YVKGHAADVF
3160 3170 3180 3190 3200
EAYTQLLTEM VLRLPYQIKK IADTSSRIPP PVFDHSWFYF LSEYLMIQQT
3210 3220 3230 3240 3250
PFVRRQVRKL LLFICGSKEK YRQLRDLHTL DSHVRGIKKL LEEQGIFLRA
3260 3270 3280 3290 3300
SVVTASSGSA LQYDTLISLM EHLKACAEIA AQRTINWQKF CIKDDSVLYF
3310 3320 3330 3340 3350
LLQVSFLVDE GVSPVLLQLL SCALCGSKVL AALAASTGSS SVASSSAPPA
3360 3370 3380 3390 3400
ASSGQATTQS KSSTKKSKKE EKEKEKEGES SGSQEDQLCT ALVNQLNRFA
3410 3420 3430 3440 3450
DKETLIQFLR CFLLESNSSS VRWQAHCLTL HIYRNSNKAQ QELLLDLMWS
3460 3470 3480 3490 3500
IWPELPAYGR KAAQFVDLLG YFSLKTAQTE KKLKEYSQKA VEILRTQNHI
3510 3520 3530 3540 3550
LTNHPNSNIY NTLSGLVEFD GYYLESDPCL VCNNPEVPFC YIKLSSIKVD
3560 3570 3580 3590 3600
TRYTTTQQVV KLIGSHTISK VTVKIGDLKR TKMVRTINLY YNNRTVQAIV
3610 3620 3630 3640 3650
ELKNKPARWH KAKKVQLTPG QTEVKIDLPL PIVASNLMIE FADFYENYQA
3660 3670 3680 3690 3700
STETLQCPRC SASVPANPGV CGNCGENVYQ CHKCRSINYD EKDPFLCNAC
3710 3720 3730 3740 3750
GFCKYARFDF MLYAKPCCAV DPIENEEDRK KAVSNINTLL DKADRVYHQL
3760 3770 3780 3790 3800
MGHRPQLENL LCKVNEAAPE KPQEDSGTAG GISSTSASVN RYILQLAQEY
3810 3820 3830 3840 3850
CGDCKNSFDE LSKIIQKVFA SRKELLEYDL QQREAATKSS RTSVQPTFTA
3860 3870 3880 3890 3900
SQYRALSVLG CGHTSSTKCY GCASAVTEHC ITLLRALATN PALRHILVSQ
3910 3920 3930 3940 3950
GLIRELFDYN LRRGAAAIRE EVRQLMCLLT RDNPEATQQM NDLIIGKVST
3960 3970 3980 3990 4000
ALKGHWANPD LASSLQYEML LLTDSISKED SCWELRLRCA LSLFLMAVNI
4010 4020 4030 4040 4050
KTPVVVENIT LMCLRILQKL IKPPAPTSKK NKDVPVEALT TVKPYCNEIH
4060 4070 4080 4090 4100
AQAQLWLKRD PKASYEAWKK CLPIRGVDGN GKSPSKSELH RLYLTEKYVW
4110 4120 4130 4140 4150
RWKQFLSRRG KRTTPLDLKL GHNNWLRQVL FTPATQAARQ AACTIVEALA
4160 4170 4180 4190 4200
TVPSRKQQVL DLLTSYLDEL SVAGECAAEY LALYQKLIAS CHWKVYLAAR
4210 4220 4230 4240 4250
GVLPYVGNLI TKEIARLLAL EEATLSTDLQ QGYALKSLTG LLSSFVEVES
4260 4270 4280 4290 4300
IKRHFKSRLV GTVLNGYLCL RKLVLQRTKL IDETQDMLLE MLEDMTTGTE
4310 4320 4330 4340 4350
SETKAFMAVC IETAKRYNLD DYRTPVFIFE RLCSIIYPEE NEVTEFFVTL
4360 4370 4380 4390 4400
EKDPQQEDFL QGRMPGNPYS SNEPGIGPLM RDIKNKICQD CDLVALLEDD
4410 4420 4430 4440 4450
SGMELLVNNK IISLDLPVAE VYKKVWCATN EGEPMRIVYR MRGLLGDATE
4460 4470 4480 4490 4500
EFIESLDSTT DEEEDEEEVY RMAGVMAQCG GLQCMLNRLA GVKDFKQGRH
4510 4520 4530 4540 4550
LLTVLLKLFS YCVKVKVNRQ QLVKLETNTL NVMLGTLNLA LVAEQESKDS
4560 4570 4580 4590 4600
GGAAVAEQVL SIMEIILDES NAEPLSEDKG NLLLTGDKDQ LVMLLDQINS
4610 4620 4630 4640 4650
TFVRSNPSVL QGLLRIIPYL SFGEVEKMQI LVERFKPYCS FEKYDEDHSG
4660 4670 4680 4690 4700
DDKVFLDCFC KIAAGIKNNS NGHQLKDLIL QKGITQNALD YMKKHIPSAK
4710 4720 4730 4740 4750
NLDADIWKKF LSRPALPFIL RLLRGLAMQH PATQVLIGTD SITSLHKLEQ
4760 4770 4780 4790 4800
VSSDEGIGTL AENLLEALRE HPDVNKKIDA ARRETRAEKK RMAMAMRQKA
4810 4820 4830 4840 4850
LGTLGMTTNE KGQVVTKTAL LKQMEELIEE PGLTCCICRE GYKFQPTKVL
4860 4870 4880 4890 4900
GIYTFTKRVA LEEMENKPRK QQGYSTVSHF NIVHYDCHLA AVRLARGREE
4910 4920 4930 4940 4950
WESAALQNAN TKCNGLLPVW GPHVPESAFA TCLARHNTYL QECTGQREPT
4960 4970 4980 4990 5000
YQLNIHDIKL LFLRFAMEQS FSADTGGGGR ESNIHLIPYI IHTVLYVLNT
5010 5020 5030 5040 5050
TRATSREEKN LQGFLEQPKE KWTESAFDVD GPHYFTILAL HVLPPEQWKA
5060 5070 5080 5090 5100
IRVEILRRLL VASHARAVAP GGATRLTDKA VKDYSAYRSS LLFWALVDLI
5110 5120 5130 5140 5150
YNMFKKVPTS NTEGGWSCSL AEYIRHNDMP IYEAADKALK TFQEEFMPVE
5160 5170 5180
TFSEFLDAAG LLSEITDPES FLKDLLNSVP
Length:5,180
Mass (Da):572,290
Last modified:February 20, 2007 - v1
Checksum:i5F4238194DF88EE0
GO
Isoform 2 (identifier: A2AN08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3159: Missing.

Show »
Length:2,021
Mass (Da):227,773
Checksum:iF6AD243037D80A83
GO
Isoform 3 (identifier: A2AN08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2474-2474: E → ESSETESLTKLD
     2827-2861: Missing.

Show »
Length:5,156
Mass (Da):570,301
Checksum:i2D7221BA3112D680
GO
Isoform 4 (identifier: A2AN08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-474: HQGFGVLSV → CVSACKLHF
     475-5180: Missing.

Show »
Length:474
Mass (Da):51,162
Checksum:i9C77086D2F5886E0
GO
Isoform 5 (identifier: A2AN08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2599-2599: T → TDCFSPRCACWNLGIVGILIGAPLETPSA

Show »
Length:5,208
Mass (Da):575,176
Checksum:iDE8A38E5894270F6
GO

Sequence cautioni

The sequence BAC39609.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4451R → K in BAC39609 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 31593159Missing in isoform 2. 1 PublicationVSP_025210Add
BLAST
Alternative sequencei466 – 4749HQGFGVLSV → CVSACKLHF in isoform 4. 1 PublicationVSP_025211
Alternative sequencei475 – 51804706Missing in isoform 4. 1 PublicationVSP_025212Add
BLAST
Alternative sequencei2474 – 24741E → ESSETESLTKLD in isoform 3. 1 PublicationVSP_025213
Alternative sequencei2599 – 25991T → TDCFSPRCACWNLGIVGILI GAPLETPSA in isoform 5. CuratedVSP_025214
Alternative sequencei2827 – 286135Missing in isoform 3. 1 PublicationVSP_025215Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044277 mRNA. Translation: BAC31850.1.
AK080556 mRNA. Translation: BAC37944.1.
AK082231 mRNA. Translation: BAC38442.2. Sequence problems.
AK083644 mRNA. Translation: BAC38980.2. Sequence problems.
AK086097 mRNA. Translation: BAC39609.1. Different initiation.
AL807833 Genomic DNA. Translation: CAM22428.1.
AL807833 Genomic DNA. Translation: CAM22429.1.
AL807833 Genomic DNA. Translation: CAM22430.1.
AL807833 Genomic DNA. Translation: CAM22431.1.
AB093242 mRNA. Translation: BAC41426.2.
BC040468 mRNA. Translation: AAH40468.1.
BC051096 mRNA. Translation: AAH51096.1.
BC057625 mRNA. Translation: AAH57625.1.
BC059890 mRNA. Translation: AAH59890.1.
BC094329 mRNA. Translation: AAH94329.1.
CCDSiCCDS51340.1. [A2AN08-1]
RefSeqiNP_001153791.1. NM_001160319.1. [A2AN08-1]
UniGeneiMm.271956.

Genome annotation databases

EnsembliENSMUST00000097822; ENSMUSP00000095433; ENSMUSG00000066036. [A2AN08-1]
ENSMUST00000165860; ENSMUSP00000125800; ENSMUSG00000066036. [A2AN08-3]
GeneIDi69116.
KEGGimmu:69116.
UCSCiuc008vmj.2. mouse. [A2AN08-4]
uc008vmm.2. mouse. [A2AN08-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044277 mRNA. Translation: BAC31850.1.
AK080556 mRNA. Translation: BAC37944.1.
AK082231 mRNA. Translation: BAC38442.2. Sequence problems.
AK083644 mRNA. Translation: BAC38980.2. Sequence problems.
AK086097 mRNA. Translation: BAC39609.1. Different initiation.
AL807833 Genomic DNA. Translation: CAM22428.1.
AL807833 Genomic DNA. Translation: CAM22429.1.
AL807833 Genomic DNA. Translation: CAM22430.1.
AL807833 Genomic DNA. Translation: CAM22431.1.
AB093242 mRNA. Translation: BAC41426.2.
BC040468 mRNA. Translation: AAH40468.1.
BC051096 mRNA. Translation: AAH51096.1.
BC057625 mRNA. Translation: AAH57625.1.
BC059890 mRNA. Translation: AAH59890.1.
BC094329 mRNA. Translation: AAH94329.1.
CCDSiCCDS51340.1. [A2AN08-1]
RefSeqiNP_001153791.1. NM_001160319.1. [A2AN08-1]
UniGeneiMm.271956.

3D structure databases

ProteinModelPortaliA2AN08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213238. 3 interactions.
DIPiDIP-61499N.
IntActiA2AN08. 5 interactions.
MINTiMINT-4114797.
STRINGi10090.ENSMUSP00000095433.

PTM databases

iPTMnetiA2AN08.
PhosphoSiteiA2AN08.
SwissPalmiA2AN08.

Proteomic databases

EPDiA2AN08.
MaxQBiA2AN08.
PaxDbiA2AN08.
PeptideAtlasiA2AN08.
PRIDEiA2AN08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097822; ENSMUSP00000095433; ENSMUSG00000066036. [A2AN08-1]
ENSMUST00000165860; ENSMUSP00000125800; ENSMUSG00000066036. [A2AN08-3]
GeneIDi69116.
KEGGimmu:69116.
UCSCiuc008vmj.2. mouse. [A2AN08-4]
uc008vmm.2. mouse. [A2AN08-1]

Organism-specific databases

CTDi23352.
MGIiMGI:1916366. Ubr4.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1776. Eukaryota.
ENOG410XPP8. LUCA.
GeneTreeiENSGT00600000084471.
HOVERGENiHBG058328.
InParanoidiA2AN08.
KOiK10691.
OMAiEGDVHTS.
OrthoDBiEOG7288QF.
PhylomeDBiA2AN08.
TreeFamiTF314406.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiUbr4. mouse.
PROiA2AN08.
SOURCEiSearch...

Gene expression databases

BgeeiA2AN08.
ExpressionAtlasiA2AN08. baseline and differential.
GenevisibleiA2AN08. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR025704. E3_Ub_ligase_UBR4.
IPR017986. WD40_repeat_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF13764. E3_UbLigase_R4. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-4461 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2599-5180 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Embryo, Head and Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-3369 (ISOFORM 3).
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4020-5180.
    Strain: C57BL/6J and FVB/N-3.
    Tissue: Brain, Eye and Mammary tumor.
  5. "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons."
    Tasaki T., Mulder L.C.F., Iwamatsu A., Lee M.J., Davydov I.V., Varshavsky A., Muesing M., Kwon Y.T.
    Mol. Cell. Biol. 25:7120-7136(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding."
    DeMasi J., Huh K.-W., Nakatani Y., Muenger K., Howley P.M.
    Proc. Natl. Acad. Sci. U.S.A. 102:11486-11491(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-181; SER-212; TYR-370; SER-2719 AND THR-2721, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2603 (ISOFORM 5), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiUBR4_MOUSE
AccessioniPrimary (citable) accession number: A2AN08
Secondary accession number(s): A2AN07
, A2AN09, A2AN10, A2AN11, Q52KI4, Q6PB49, Q6PFC7, Q80Y11, Q8BGB9, Q8C3E8, Q8C4W5, Q8C8X7, Q8CGE0, Q8CHF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.