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Protein
Submitted name:

Protein Gabre

Gene

Gabre

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: MGI

GO - Biological processi

  • chloride transport Source: MGI
  • gamma-aminobutyric acid signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Protein GabreImported
Gene namesi
Name:GabreImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1330235. Gabre.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei753 – 77725HelicalSequence analysisAdd
BLAST
Transmembranei896 – 91217HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • GABA-A receptor complex Source: GO_Central
  • integral component of plasma membrane Source: MGI
  • synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2094133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 916894Sequence analysisPRO_5002642716Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiA2AMW3.
PeptideAtlasiA2AMW3.
PRIDEiA2AMW3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031340.
GenevisibleiA2AMW3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066543.

Structurei

3D structure databases

ProteinModelPortaliA2AMW3.
SMRiA2AMW3. Positions 483-786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini483 – 687205Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini696 – 78590Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOVERGENiHBG051707.
InParanoidiA2AMW3.
KOiK05185.
OMAiRGRICIH.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008099. GABAAe_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01723. GABAAREPSLON.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AMW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPKVLLMLL NMFLALQWRV GPHVNLENKP PAQDKVVFGP QPQPVPQPLT
60 70 80 90 100
PPESPAGDTV VFGPQPQPQA ESPGHDDVVF SSQPQPMPQP QPMPEPQPQP
110 120 130 140 150
EPEPEPQPQP QPQPLAGRQP LPQPLPWPMP QPQPEPEPEP EPEPEPEPEP
160 170 180 190 200
EPEPEPEPEP QPEPQPQPLA GRQPLPQPLP WPLPLPLPEP QPEPQPDPQP
210 220 230 240 250
EPQPEPQPEP QPEPQPEPQT PGQVQAGRQP RPRPQPEPQP QPEPQPEPQP
260 270 280 290 300
EPQPQPEPEP EPQPEPEPQP EPEPQPEPQP EPQPEPKPEP EPQPEPEPQP
310 320 330 340 350
EPQPEPQPEP QPEPKPEPEP QPEPKPEPEP QPEPEPEPEP EPEPQPEPEP
360 370 380 390 400
KPEPQPEPEP EPEPEPEPEP EPEPEPEPEP EPESESELDL EPEPEPHPHP
410 420 430 440 450
HPHPHPHPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EMKSEPQSQL
460 470 480 490 500
EPQPSGKKLP AKEPELTVDC MTERPGGKLT RASRILNTIL SNYDHKLRPG
510 520 530 540 550
IGEKPTVVTV EVIVNSLGPI STPDMEYSID IIFHQTWYDE RLRYNDTFET
560 570 580 590 600
LILHGNVVSQ LWIPDTFFRN SKRTQEYDIT IPNQMALIHK DGKVLYSVRM
610 620 630 640 650
TIDARCSLHM LNFPMDSHSC PLSFSSFSYD DSEMIYKWEN FKLEINAKNT
660 670 680 690 700
WKLLEFDFTG VNNKTEIIST PFGDFMVMTF FFNVSRRFGF IVFQNYVPSS
710 720 730 740 750
VTTMLSWVSF WIKIEAAAAR ASVGVSSVLT MATLGTLSCK NFPRVSYLTA
760 770 780 790 800
LDFYIAICFV LCFCTLLEFA VLNFLTYNNI KRQASLKVYQ LPTNSRANAR
810 820 830 840 850
TRARARTRAR ARARARQQQE VFVCEIVTYE ENAEEGYQWS PRSRRPQCPW
860 870 880 890 900
RRCGRSYVCF RVLRKYFCMA PGCEGGSWQR GRICIHVYRL DNYSRVLFPI
910
TFFFFNVLYW LICLNL
Length:916
Mass (Da):104,508
Last modified:February 20, 2007 - v1
Checksum:iBBDE0E88BA03C587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807816 Genomic DNA. No translation available.
RefSeqiNP_059065.2. NM_017369.2.
UniGeneiMm.391288.

Genome annotation databases

EnsembliENSMUST00000064780; ENSMUSP00000066543; ENSMUSG00000031340.
GeneIDi14404.
KEGGimmu:14404.
UCSCiuc009tkm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807816 Genomic DNA. No translation available.
RefSeqiNP_059065.2. NM_017369.2.
UniGeneiMm.391288.

3D structure databases

ProteinModelPortaliA2AMW3.
SMRiA2AMW3. Positions 483-786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066543.

Chemistry

ChEMBLiCHEMBL2094133.

Proteomic databases

PaxDbiA2AMW3.
PeptideAtlasiA2AMW3.
PRIDEiA2AMW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064780; ENSMUSP00000066543; ENSMUSG00000031340.
GeneIDi14404.
KEGGimmu:14404.
UCSCiuc009tkm.1. mouse.

Organism-specific databases

CTDi2564.
MGIiMGI:1330235. Gabre.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOVERGENiHBG051707.
InParanoidiA2AMW3.
KOiK05185.
OMAiRGRICIH.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031340.
GenevisibleiA2AMW3. MM.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008099. GABAAe_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01723. GABAAREPSLON.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2AMW3_MOUSE
AccessioniPrimary (citable) accession number: A2AMW3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.