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Protein
Submitted name:

Gamma-aminobutyric acid (GABA) A receptor, subunit epsilon

Gene

Gabre

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: MGI

GO - Biological processi

  • chloride transport Source: MGI
  • gamma-aminobutyric acid signaling pathway Source: MGI

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-aminobutyric acid (GABA) A receptor, subunit epsilonImported
Gene namesi
Name:GabreImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1330235 Gabre

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei753 – 777HelicalSequence analysisAdd BLAST25
Transmembranei896 – 912HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094133

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500264271623 – 916Sequence analysisAdd BLAST894

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiA2AMW3
PeptideAtlasiA2AMW3
PRIDEiA2AMW3

Expressioni

Gene expression databases

BgeeiENSMUSG00000031340
GenevisibleiA2AMW3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066543

Structurei

3D structure databases

ProteinModelPortaliA2AMW3
SMRiA2AMW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini483 – 687Neur_chan_LBDInterPro annotationAdd BLAST205
Domaini696 – 785Neur_chan_membInterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOVERGENiHBG051707
InParanoidiA2AMW3
KOiK05185
OMAiRGRICIH
OrthoDBiEOG091G0805
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008099 GABAAe_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01723 GABAAREPSLON
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

A2AMW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPKVLLMLL NMFLALQWRV GPHVNLENKP PAQDKVVFGP QPQPVPQPLT
60 70 80 90 100
PPESPAGDTV VFGPQPQPQA ESPGHDDVVF SSQPQPMPQP QPMPEPQPQP
110 120 130 140 150
EPEPEPQPQP QPQPLAGRQP LPQPLPWPMP QPQPEPEPEP EPEPEPEPEP
160 170 180 190 200
EPEPEPEPEP QPEPQPQPLA GRQPLPQPLP WPLPLPLPEP QPEPQPDPQP
210 220 230 240 250
EPQPEPQPEP QPEPQPEPQT PGQVQAGRQP RPRPQPEPQP QPEPQPEPQP
260 270 280 290 300
EPQPQPEPEP EPQPEPEPQP EPEPQPEPQP EPQPEPKPEP EPQPEPEPQP
310 320 330 340 350
EPQPEPQPEP QPEPKPEPEP QPEPKPEPEP QPEPEPEPEP EPEPQPEPEP
360 370 380 390 400
KPEPQPEPEP EPEPEPEPEP EPEPEPEPEP EPESESELDL EPEPEPHPHP
410 420 430 440 450
HPHPHPHPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EMKSEPQSQL
460 470 480 490 500
EPQPSGKKLP AKEPELTVDC MTERPGGKLT RASRILNTIL SNYDHKLRPG
510 520 530 540 550
IGEKPTVVTV EVIVNSLGPI STPDMEYSID IIFHQTWYDE RLRYNDTFET
560 570 580 590 600
LILHGNVVSQ LWIPDTFFRN SKRTQEYDIT IPNQMALIHK DGKVLYSVRM
610 620 630 640 650
TIDARCSLHM LNFPMDSHSC PLSFSSFSYD DSEMIYKWEN FKLEINAKNT
660 670 680 690 700
WKLLEFDFTG VNNKTEIIST PFGDFMVMTF FFNVSRRFGF IVFQNYVPSS
710 720 730 740 750
VTTMLSWVSF WIKIEAAAAR ASVGVSSVLT MATLGTLSCK NFPRVSYLTA
760 770 780 790 800
LDFYIAICFV LCFCTLLEFA VLNFLTYNNI KRQASLKVYQ LPTNSRANAR
810 820 830 840 850
TRARARTRAR ARARARQQQE VFVCEIVTYE ENAEEGYQWS PRSRRPQCPW
860 870 880 890 900
RRCGRSYVCF RVLRKYFCMA PGCEGGSWQR GRICIHVYRL DNYSRVLFPI
910
TFFFFNVLYW LICLNL
Length:916
Mass (Da):104,508
Last modified:February 20, 2007 - v1
Checksum:iBBDE0E88BA03C587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807816 Genomic DNA No translation available.
RefSeqiNP_059065.2, NM_017369.2
UniGeneiMm.391288

Genome annotation databases

EnsembliENSMUST00000064780; ENSMUSP00000066543; ENSMUSG00000031340
GeneIDi14404
KEGGimmu:14404
UCSCiuc009tkm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA2AMW3_MOUSE
AccessioniPrimary (citable) accession number: A2AMW3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health