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Protein

Filensin

Gene

Bfsp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • cell maturation Source: MGI
  • lens fiber cell development Source: MGI

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Filensin2 Publications
Alternative name(s):
Beaded filament structural protein 1
Lens fiber cell beaded-filament structural protein CP 95
Short name:
CP95
Gene namesi
Name:Bfsp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:101770 Bfsp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Intermediate filament, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002858541 – 669FilensinAdd BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AMT1
PaxDbiA2AMT1
PRIDEiA2AMT1

PTM databases

iPTMnetiA2AMT1
PhosphoSitePlusiA2AMT1

Expressioni

Tissue specificityi

Detected in eye lens fiber cells (at protein level) (PubMed:21745462).1 Publication

Gene expression databases

BgeeiENSMUSG00000027420
CleanExiMM_BFSP1
GenevisibleiA2AMT1 MM

Interactioni

Subunit structurei

Associates with BFSP2 to form long fibrils (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (PubMed:21745462).By similarity1 Publication

Protein-protein interaction databases

BioGridi198340, 1 interactor
STRINGi10090.ENSMUSP00000028907

Structurei

3D structure databases

ProteinModelPortaliA2AMT1
SMRiA2AMT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 318IF rodPROSITE-ProRule annotationAdd BLAST286

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 33HeadAdd BLAST33
Regioni34 – 68Coil 1AAdd BLAST35
Regioni69 – 77Linker 19
Regioni78 – 177Coil 1BAdd BLAST100
Regioni178 – 194Linker 12Add BLAST17
Regioni195 – 318Coil 2Add BLAST124
Regioni319 – 669TailAdd BLAST351

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IHW9 Eukaryota
ENOG410ZJHK LUCA
GeneTreeiENSGT00390000016976
HOGENOMiHOG000095201
HOVERGENiHBG050684
InParanoidiA2AMT1
KOiK10378
OMAiDLYTKGR
OrthoDBiEOG091G044T
PhylomeDBiA2AMT1
TreeFamiTF331671

Family and domain databases

InterProiView protein in InterPro
IPR039008 IF_rod_dom
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AMT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRRSYVFQA RQERYERAQP AGPAAQPGGT APGLAALQAL GERVAVQVQR
60 70 80 90 100
ARALQQRHAG LRRQLDAFQR LGEQPGPEDA LARHVEANLQ RARDLTAEHA
110 120 130 140 150
RLERQEAEAQ RALDEFRSKY ENECECQLVL KEMLERLNKE ADEALLRNLH
160 170 180 190 200
LQLEAQFLQA DISVAKDRYK KNLLEIQTYI TVLQQIVQTA PQVSLVTGMR
210 220 230 240 250
ESGLLMQEKL FTEREVAALQ NQLEEGREAV THLQAQKAEL QAQTTALEQA
260 270 280 290 300
IKHAHECYDE ELQLYNEQIE NLRKEIEEAE RSLERSSYDC RQLAVAQQTL
310 320 330 340 350
RNELDRYHRI IEIEGSRLSS VFIETPISLI TPSHGAPLSL GSSVKDLARA
360 370 380 390 400
VQDITAAKPR QKALPKSLPK RKEIIAQDKV EETLEDAPLK PPQEPKALQV
410 420 430 440 450
ERKAEGGSQP GAGGGHGVSP TQEGGPEDVP DGGQISKAFG KLCKVVKERV
460 470 480 490 500
SGHKEPEPEP PTDLFTKGRH VLVTGESSFV DPEFYSSSIP ARGGVVISIE
510 520 530 540 550
EDSMHHDGHV EPSPGQPMPP VENGQGVPQG REGDHSNHQQ GTDKNGLRAK
560 570 580 590 600
EPKDLEEKDD DGKKEAEGSR RPCPVIIPGP DEPSTSHSQT SGSNQGGPVG
610 620 630 640 650
PASKSSSLLA KGPSKALSIK KVEVVESIEK ISTESIQTYE ETSVIVETLI
660
GKSKGNKKLG EKSLPDTRA
Length:669
Mass (Da):73,669
Last modified:February 20, 2007 - v1
Checksum:i32DFEEC7F1098996
GO
Isoform 2 (identifier: A2AMT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-207: Missing.

Show »
Length:663
Mass (Da):73,039
Checksum:iBF2CD28E57E8BB88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185Q → H in BAA24139 (PubMed:9409766).Curated1
Sequence conflicti291R → S in BAA24139 (PubMed:9409766).Curated1
Sequence conflicti337P → S in BAA24139 (PubMed:9409766).Curated1
Sequence conflicti394 – 395EP → TR in BAA24139 (PubMed:9409766).Curated2
Sequence conflicti440G → R in BAE25294 (PubMed:16141072).Curated1
Sequence conflicti463D → N in BAA24139 (PubMed:9409766).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024920202 – 207Missing in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003147 mRNA Translation: BAA24139.1
AK143180 mRNA Translation: BAE25294.1
AK053766 mRNA Translation: BAC35514.1
AL807801 Genomic DNA Translation: CAM18251.1
AL807801 Genomic DNA Translation: CAM18252.1
BC057580 mRNA Translation: AAH57580.1
AB010375 Genomic DNA Translation: BAA28377.1
CCDSiCCDS16811.1 [A2AMT1-2]
CCDS71154.1 [A2AMT1-1]
RefSeqiNP_001277990.1, NM_001291061.1 [A2AMT1-1]
NP_033881.2, NM_009751.2 [A2AMT1-2]
UniGeneiMm.275937

Genome annotation databases

EnsembliENSMUST00000028907; ENSMUSP00000028907; ENSMUSG00000027420 [A2AMT1-2]
ENSMUST00000099296; ENSMUSP00000096899; ENSMUSG00000027420 [A2AMT1-1]
GeneIDi12075
KEGGimmu:12075
UCSCiuc008mqh.1 mouse [A2AMT1-2]
uc012cfe.1 mouse [A2AMT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBFSP1_MOUSE
AccessioniPrimary (citable) accession number: A2AMT1
Secondary accession number(s): O54770
, Q3UPV0, Q6PFF8, Q8BKB1, Q9QWM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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