ID   A2AMS0_MOUSE            Unreviewed;       192 AA.
AC   A2AMS0;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=Sigma non-opioid intracellular receptor 1 {ECO:0000256|ARBA:ARBA00020208, ECO:0000256|RuleBase:RU368083};
DE   AltName: Full=Sigma 1-type opioid receptor {ECO:0000256|ARBA:ARBA00033467, ECO:0000256|RuleBase:RU368083};
GN   Name=Sigmar1 {ECO:0000313|MGI:MGI:1195268};
GN   Synonyms=Oprs1 {ECO:0000313|EMBL:AAR27306.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAR27306.1};
RN   [1] {ECO:0000313|EMBL:AAR27306.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CD-1 {ECO:0000313|EMBL:AAR27306.1};
RA   Pan L.P., Pasternak G.W., Pan Y.;
RT   "Identification and characterization of five new splice variants from the
RT   mouse sigma 1 receptor gene (Oprs1).";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in lipid transport from the endoplasmic reticulum
CC       and is involved in a wide array of cellular functions probably through
CC       regulation of the biogenesis of lipid microdomains at the plasma
CC       membrane. Regulates calcium efflux at the endoplasmic reticulum.
CC       {ECO:0000256|RuleBase:RU368083}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000256|RuleBase:RU368083}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC       {ECO:0000256|ARBA:ARBA00004541, ECO:0000256|RuleBase:RU368083}.
CC       Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU368083}.
CC       Membrane {ECO:0000256|RuleBase:RU368083}; Single-pass membrane protein
CC       {ECO:0000256|RuleBase:RU368083}. Nucleus envelope
CC       {ECO:0000256|ARBA:ARBA00004259, ECO:0000256|RuleBase:RU368083}. Nucleus
CC       inner membrane {ECO:0000256|ARBA:ARBA00004540,
CC       ECO:0000256|RuleBase:RU368083}. Nucleus outer membrane
CC       {ECO:0000256|RuleBase:RU368083}. Postsynaptic density membrane
CC       {ECO:0000256|ARBA:ARBA00034112}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- DOMAIN: The C-terminal helices form a flat, hydrophobic surface that is
CC       probably tightly associated with the cytosolic surface of the
CC       endoplasmic reticulum membrane. {ECO:0000256|RuleBase:RU368083}.
CC   -!- SIMILARITY: Belongs to the ERG2 family. {ECO:0000256|ARBA:ARBA00007141,
CC       ECO:0000256|RuleBase:RU368083}.
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DR   EMBL; AY390764; AAR27306.1; -; mRNA.
DR   RefSeq; NP_001273468.1; NM_001286539.1.
DR   AlphaFoldDB; A2AMS0; -.
DR   SMR; A2AMS0; -.
DR   PeptideAtlas; A2AMS0; -.
DR   TopDownProteomics; A2AMS0; -.
DR   Antibodypedia; 2756; 284 antibodies from 34 providers.
DR   DNASU; 18391; -.
DR   GeneID; 18391; -.
DR   UCSC; uc008sjl.2; mouse.
DR   AGR; MGI:1195268; -.
DR   CTD; 10280; -.
DR   MGI; MGI:1195268; Sigmar1.
DR   VEuPathDB; HostDB:ENSMUSG00000036078; -.
DR   HOGENOM; CLU_085469_0_0_1; -.
DR   OrthoDB; 168990at2759; -.
DR   BioGRID-ORCS; 18391; 5 hits in 79 CRISPR screens.
DR   ChiTaRS; Sigmar1; mouse.
DR   ExpressionAtlas; A2AMS0; baseline and differential.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-UniRule.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-UniRule.
DR   InterPro; IPR006716; ERG2_sigma1_rcpt-like.
DR   PANTHER; PTHR10868; SIGMA 1-TYPE OPIOID RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR10868:SF1; SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1; 1.
DR   Pfam; PF04622; ERG2_Sigma1R; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle {ECO:0000256|RuleBase:RU368083};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU368083};
KW   Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW   Lipid transport {ECO:0000256|RuleBase:RU368083};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368083};
KW   Nucleus {ECO:0000256|RuleBase:RU368083};
KW   Receptor {ECO:0000256|RuleBase:RU368083, ECO:0000313|EMBL:AAR27306.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU368083};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU368083}; Transport {ECO:0000256|RuleBase:RU368083}.
FT   TRANSMEM        9..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368083"
SQ   SEQUENCE   192 AA;  21633 MW;  6C75160BF446D3BC CRC64;
     MPWAAGRRWA WITLILTIIA VLIQAAWLWL GTQNFVFSRE EIAQLARQYA GLDHELAFSR
     LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCILHASL SEYVLLFGTA LGSHGHSGET
     VVHGPGEATA LEWGPNTWMV EYGRGVIPST LFFALADTFF STQDYLTLFY TLRAYARGLR
     LELTTYLFGQ DS
//