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Protein

Phosphatidate cytidylyltransferase

Gene

Cds2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.UniRule annotation

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 4 (Gpat4), Glycerol-3-phosphate acyltransferase 3 (Gpat3), Glycerol-3-phosphate acyltransferase 2, mitochondrial (Gpat2)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (Agpat2), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (Agpat1), Lysocardiolipin acyltransferase 1 (Lclat1), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (Agpat5), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4)
  3. Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 2 (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 1 (Cds1)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotation, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferaseUniRule annotation (EC:2.7.7.41UniRule annotation)
Gene namesi
Name:Cds2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1332236. Cds2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei106 – 123HelicalUniRule annotationAdd BLAST18
Transmembranei150 – 168HelicalUniRule annotationAdd BLAST19
Transmembranei175 – 197HelicalUniRule annotationAdd BLAST23
Transmembranei203 – 229HelicalUniRule annotationAdd BLAST27
Transmembranei241 – 263HelicalUniRule annotationAdd BLAST23
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiA2AMQ5.
PaxDbiA2AMQ5.
PeptideAtlasiA2AMQ5.
PRIDEiA2AMQ5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058793.
ExpressionAtlasiA2AMQ5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2AMQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1440. Eukaryota.
COG0575. LUCA.
GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.

Family and domain databases

InterProiView protein in InterPro
IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiView protein in PROSITE
PS01315. CDS. 1 hit.

Sequencei

Sequence statusi: Complete.

A2AMQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESESEAKLD GETASDSESR AETAPLPTSV DDTPEVLNRA LSNLSSRWKN
60 70 80 90 100
WWVRGILTLA MIAFFFIIIY LGPMVLMMIV MCVQIKCFHE IITIGYNVYH
110 120 130 140 150
SYDLPWFRTL SWYFLLCVNY FFYGETVTDY FFTLVQREEP LRILSKYHRF
160 170 180 190 200
ISFALYLTGF CMFVLSLVKK HYRLQFYMFG WTHVTLLIVV TQSHLVIHNL
210 220 230 240 250
FEGMIWFIVP ISCVICNDIM AYMFGFFFGR TPLIKLSPKK TWEGFIGGFF
260 270 280 290 300
ATVVFGLLLS YVMSGYRCFV CPVEYNNDTN SFTVDCEPSD LFRLQEYNIP
310 320 330 340 350
GVIQSAIGWK TVRMYPFQIH SIALSTFASL IGPFGGFFAS GFKRAFKIKD
360 370 380 390 400
FANTIPGHGG IMDRFDCQYL MATFVNVYIA SFIRGPNPSK LIQQFLTLRP
410 420
DQQLHIFNTL KSHLTDKGIL TSALEDE
Length:427
Mass (Da):49,294
Last modified:February 20, 2007 - v1
Checksum:iF67EF48633FAF3E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807793 Genomic DNA. No translation available.
RefSeqiNP_001277968.1. NM_001291039.1.
UniGeneiMm.284503.

Genome annotation databases

EnsembliENSMUST00000089461; ENSMUSP00000086886; ENSMUSG00000058793.
GeneIDi110911.
UCSCiuc029ueu.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiA2AMQ5_MOUSE
AccessioniPrimary (citable) accession number: A2AMQ5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported