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Protein

Phosphatidate cytidylyltransferase

Gene

Cds2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.UniRule annotation

Pathway:iCDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 4 (Agpat6), Glycerol-3-phosphate acyltransferase 3 (Agpat9), Glycerol-3-phosphate acyltransferase 2, mitochondrial (Gpat2)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (Agpat2), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (Agpat1), Lysocardiolipin acyltransferase 1 (Lclat1), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (Agpat5), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4)
  3. Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 2 (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 1 (Cds1)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferaseUniRule annotation (EC:2.7.7.41UniRule annotation)
Gene namesi
Name:Cds2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1332236. Cds2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiA2AMQ5.

Expressioni

Gene expression databases

BgeeiA2AMQ5.
ExpressionAtlasiA2AMQ5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099470.

Structurei

3D structure databases

ProteinModelPortaliA2AMQ5.
SMRiA2AMQ5. Positions 56-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
KOiK00981.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AMQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESESEAKLD GETASDSESR AETAPLPTSV DDTPEVLNRA LSNLSSRWKN
60 70 80 90 100
WWVRGILTLA MIAFFFIIIY LGPMVLMMIV MCVQIKCFHE IITIGYNVYH
110 120 130 140 150
SYDLPWFRTL SWYFLLCVNY FFYGETVTDY FFTLVQREEP LRILSKYHRF
160 170 180 190 200
ISFALYLTGF CMFVLSLVKK HYRLQFYMFG WTHVTLLIVV TQSHLVIHNL
210 220 230 240 250
FEGMIWFIVP ISCVICNDIM AYMFGFFFGR TPLIKLSPKK TWEGFIGGFF
260 270 280 290 300
ATVVFGLLLS YVMSGYRCFV CPVEYNNDTN SFTVDCEPSD LFRLQEYNIP
310 320 330 340 350
GVIQSAIGWK TVRMYPFQIH SIALSTFASL IGPFGGFFAS GFKRAFKIKD
360 370 380 390 400
FANTIPGHGG IMDRFDCQYL MATFVNVYIA SFIRGPNPSK LIQQFLTLRP
410 420
DQQLHIFNTL KSHLTDKGIL TSALEDE
Length:427
Mass (Da):49,294
Last modified:February 20, 2007 - v1
Checksum:iF67EF48633FAF3E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807793 Genomic DNA. No translation available.
RefSeqiNP_001277968.1. NM_001291039.1.
UniGeneiMm.284503.

Genome annotation databases

EnsembliENSMUST00000089461; ENSMUSP00000086886; ENSMUSG00000058793.
GeneIDi110911.
KEGGimmu:110911.
UCSCiuc029ueu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807793 Genomic DNA. No translation available.
RefSeqiNP_001277968.1. NM_001291039.1.
UniGeneiMm.284503.

3D structure databases

ProteinModelPortaliA2AMQ5.
SMRiA2AMQ5. Positions 56-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099470.

Proteomic databases

PRIDEiA2AMQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089461; ENSMUSP00000086886; ENSMUSG00000058793.
GeneIDi110911.
KEGGimmu:110911.
UCSCiuc029ueu.2. mouse.

Organism-specific databases

CTDi8760.
MGIiMGI:1332236. Cds2.

Phylogenomic databases

GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
KOiK00981.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Miscellaneous databases

ChiTaRSiCds2. mouse.
NextBioi35543703.
SOURCEiSearch...

Gene expression databases

BgeeiA2AMQ5.
ExpressionAtlasiA2AMQ5. baseline and differential.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AMQ5_MOUSE
AccessioniPrimary (citable) accession number: A2AMQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.