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Protein

Protein AF-9

Gene

Mllt3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-112387. Elongation arrest and recovery.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AF-9
Alternative name(s):
Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog
Gene namesi
Name:Mllt3
Synonyms:Af9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917372. Mllt3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051241 – 569Protein AF-9Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei413PhosphoserineCombined sources1
Modified residuei420PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiA2AM29.
MaxQBiA2AM29.
PaxDbiA2AM29.
PeptideAtlasiA2AM29.
PRIDEiA2AM29.

PTM databases

iPTMnetiA2AM29.
PhosphoSitePlusiA2AM29.
SwissPalmiA2AM29.

Expressioni

Tissue specificityi

Ubiquitously expressed. Strong expression in the spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000028496.
ExpressionAtlasiA2AM29. baseline and differential.
GenevisibleiA2AM29. MM.

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ALKBH4 and BCOR (By similarity). Interacts with CBX8.By similarity1 Publication

Protein-protein interaction databases

BioGridi213873. 8 interactors.
DIPiDIP-60099N.
STRINGi10090.ENSMUSP00000077232.

Structurei

3D structure databases

ProteinModelPortaliA2AM29.
SMRiA2AM29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 112YEATSPROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi296 – 301Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 194Poly-SerAdd BLAST46
Compositional biasi384 – 392Poly-Ser9
Compositional biasi467 – 470Poly-Pro4

Sequence similaritiesi

Contains 1 YEATS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00440000039936.
HOGENOMiHOG000033834.
HOVERGENiHBG004191.
InParanoidiA2AM29.
KOiK15187.
OMAiPNRSVHT.
OrthoDBiEOG091G06LN.
PhylomeDBiA2AM29.
TreeFamiTF314586.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AM29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK
60 70 80 90 100
VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPKKVRF
110 120 130 140 150
DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS
160 170 180 190 200
SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS TSFSKPHKLM
210 220 230 240 250
KEHKEKPSKD SREHKSAFKE PSRDHNKSSK DSSKKPKENK PLKEEKIVPK
260 270 280 290 300
MAFKEPKPMS KEPKADSNLL TVTSGQQDKK APSKRPPASD SEELSAKKRK
310 320 330 340 350
KSSSEALFKS FSSAPPLILT CSADKKQIKD KSHVKMGKVK IESETSEKKK
360 370 380 390 400
SMLPPFDDIV DPNDSDVEEN MSSKSDSEQP SPASSSSSSS SSFTPSQTRQ
410 420 430 440 450
QGPLRSIMKD LHSDDNEEES DEAEDNDNDS EMERPVNRGG SRSRRVSLSD
460 470 480 490 500
GSDSESSSAS SPLHHEPPPP LLKTNNNQIL EVKSPIKQSK SDKQIKNGEC
510 520 530 540 550
DKAYLDELVE LHRRLMTLRE RHILQQIVNL IEETGHFHIT NTTFDFDLCS
560
LDKTTVRKLQ SYLETSGTS
Length:569
Mass (Da):63,375
Last modified:February 20, 2007 - v1
Checksum:i120A0604B13675EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157S → G in AAK28536 (PubMed:11439343).Curated1
Sequence conflicti164S → G in AAK28536 (PubMed:11439343).Curated1
Sequence conflicti172S → N in AAK28536 (PubMed:11439343).Curated1
Sequence conflicti176S → G in AAK28536 (PubMed:11439343).Curated1
Sequence conflicti179 – 190Missing in AAH21420 (PubMed:15489334).CuratedAdd BLAST12
Sequence conflicti352M → T in AAH21420 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831756, AL806533, AL929524 Genomic DNA. Translation: CAM20202.1.
AL929524, AL806533, AL831756 Genomic DNA. Translation: CAM24441.1.
AL806533, AL831756, AL929524 Genomic DNA. Translation: CAM25293.1.
BC021420 mRNA. Translation: AAH21420.1.
AF333960 mRNA. Translation: AAK28536.1.
CCDSiCCDS38796.1.
RefSeqiNP_081602.3. NM_027326.3.
UniGeneiMm.288898.
Mm.472285.

Genome annotation databases

EnsembliENSMUST00000078090; ENSMUSP00000077232; ENSMUSG00000028496.
GeneIDi70122.
KEGGimmu:70122.
UCSCiuc008tmp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831756, AL806533, AL929524 Genomic DNA. Translation: CAM20202.1.
AL929524, AL806533, AL831756 Genomic DNA. Translation: CAM24441.1.
AL806533, AL831756, AL929524 Genomic DNA. Translation: CAM25293.1.
BC021420 mRNA. Translation: AAH21420.1.
AF333960 mRNA. Translation: AAK28536.1.
CCDSiCCDS38796.1.
RefSeqiNP_081602.3. NM_027326.3.
UniGeneiMm.288898.
Mm.472285.

3D structure databases

ProteinModelPortaliA2AM29.
SMRiA2AM29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213873. 8 interactors.
DIPiDIP-60099N.
STRINGi10090.ENSMUSP00000077232.

PTM databases

iPTMnetiA2AM29.
PhosphoSitePlusiA2AM29.
SwissPalmiA2AM29.

Proteomic databases

EPDiA2AM29.
MaxQBiA2AM29.
PaxDbiA2AM29.
PeptideAtlasiA2AM29.
PRIDEiA2AM29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078090; ENSMUSP00000077232; ENSMUSG00000028496.
GeneIDi70122.
KEGGimmu:70122.
UCSCiuc008tmp.1. mouse.

Organism-specific databases

CTDi4300.
MGIiMGI:1917372. Mllt3.

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00440000039936.
HOGENOMiHOG000033834.
HOVERGENiHBG004191.
InParanoidiA2AM29.
KOiK15187.
OMAiPNRSVHT.
OrthoDBiEOG091G06LN.
PhylomeDBiA2AM29.
TreeFamiTF314586.

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-112387. Elongation arrest and recovery.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-75955. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

ChiTaRSiMllt3. mouse.
PROiA2AM29.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028496.
ExpressionAtlasiA2AM29. baseline and differential.
GenevisibleiA2AM29. MM.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAF9_MOUSE
AccessioniPrimary (citable) accession number: A2AM29
Secondary accession number(s): Q8VDR6, Q99MK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.