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Protein

Tyrosine-protein phosphatase non-receptor type 3

Gene

Ptpn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

May act at junctions between the membrane and the cytoskeleton.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei811 – 8111SubstrateBy similarity
Active sitei842 – 8421Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei886 – 8861SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
Gene namesi
Name:Ptpn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:105307. Ptpn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Tyrosine-protein phosphatase non-receptor type 3PRO_0000320074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei359 – 3591PhosphoserineBy similarity
Modified residuei367 – 3671PhosphoserineBy similarity
Modified residuei376 – 3761PhosphothreonineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei425 – 4251PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2ALK8.
PaxDbiA2ALK8.
PRIDEiA2ALK8.

PTM databases

PhosphoSiteiA2ALK8.

Expressioni

Gene expression databases

BgeeiA2ALK8.
CleanExiMM_PTPN3.
ExpressionAtlasiA2ALK8. baseline and differential.
GenevisibleiA2ALK8. MM.

Interactioni

Protein-protein interaction databases

IntActiA2ALK8. 1 interaction.
MINTiMINT-8296855.
STRINGi10090.ENSMUSP00000075063.

Structurei

3D structure databases

ProteinModelPortaliA2ALK8.
SMRiA2ALK8. Positions 31-309, 508-595, 605-904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 312284FERMPROSITE-ProRule annotationAdd
BLAST
Domaini510 – 58273PDZPROSITE-ProRule annotationAdd
BLAST
Domaini646 – 901256Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni842 – 8487Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000007048.
HOVERGENiHBG008322.
InParanoidiA2ALK8.
KOiK18027.
OMAiHFGDYNS.
OrthoDBiEOG76HQ1B.
PhylomeDBiA2ALK8.
TreeFamiTF315900.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ALK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRLRALGG RINNTRTSEL PKEKTRSEVI CSIRFLDGLV QTFKVNKQDL
60 70 80 90 100
GQSLLDMAYG HLGVTEKEYF GLQHGDDPVD SPRWLEASKP LRKQLKGGFP
110 120 130 140 150
CTLHFRVRYF IPDPNTLQQE QTRHLYFLQL KMDVCEGRLT CPLNSAVVLA
160 170 180 190 200
SYAVQSHFGD FNSSIHHPGY LADSQFIPDQ NDDFLSKVES LHEQHSGLKQ
210 220 230 240 250
SEAESCYINI ARTLDFYGVE LHGGRDLHNL DLMIGIASAG IAVYRKYICT
260 270 280 290 300
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS
310 320 330 340 350
CVEHHSFFQA KKLLPQEKNV LSQYWTLGSR NPKKSVNNQY CKKVIGGMVW
360 370 380 390 400
NPVMRRSLSV ERLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA
410 420 430 440 450
NEMTYITETE DVFYTYKGPL SPKDSDSEVS QNHSPHRESL SENNPAQSCL
460 470 480 490 500
TQKSSSSVSP SSNAPGSCSP DGVDQRFLED YHKVTKGGFV EDASQYYCDK
510 520 530 540 550
SDDGDGYLVL IRITPDEEGR FGFNLKGGVD QKMPLVVSRI NPESPADTCM
560 570 580 590 600
PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRKAVR
610 620 630 640 650
SLAEIRSEDE LSQLFPEAMF PACPEGGDSL EGSMELLKKG LESGTVLIQF
660 670 680 690 700
EQLYRKKPGL AVSFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY
710 720 730 740 750
VNMEMPAANL VNKYIATQGP LPNTCAQFWQ VVWDQKLSLV VMLTTLTERG
760 770 780 790 800
RTKCHQYWPD PPDIMDHGIF HIQCQTEDCT IAYVSREMLV TNTETGEEHT
810 820 830 840 850
VTHLQYVAWP DHGVPDDSSD FLEFVKYVRS LRVDGEPALV HCSAGIGRTG
860 870 880 890 900
VLVTMETAMC LIERNLPVYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR
910
VYEEGLVQRL DPS
Length:913
Mass (Da):103,896
Last modified:February 20, 2007 - v1
Checksum:i8D86101FA691142A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805921 Genomic DNA. Translation: CAM19971.1.
CCDSiCCDS51181.1.
RefSeqiNP_035337.2. NM_011207.2.
XP_006538161.1. XM_006538098.1.
XP_006538162.1. XM_006538099.2.
XP_006538163.1. XM_006538100.2.
UniGeneiMm.246552.

Genome annotation databases

EnsembliENSMUST00000075637; ENSMUSP00000075063; ENSMUSG00000038764.
GeneIDi545622.
KEGGimmu:545622.
UCSCiuc008sya.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805921 Genomic DNA. Translation: CAM19971.1.
CCDSiCCDS51181.1.
RefSeqiNP_035337.2. NM_011207.2.
XP_006538161.1. XM_006538098.1.
XP_006538162.1. XM_006538099.2.
XP_006538163.1. XM_006538100.2.
UniGeneiMm.246552.

3D structure databases

ProteinModelPortaliA2ALK8.
SMRiA2ALK8. Positions 31-309, 508-595, 605-904.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2ALK8. 1 interaction.
MINTiMINT-8296855.
STRINGi10090.ENSMUSP00000075063.

PTM databases

PhosphoSiteiA2ALK8.

Proteomic databases

MaxQBiA2ALK8.
PaxDbiA2ALK8.
PRIDEiA2ALK8.

Protocols and materials databases

DNASUi545622.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075637; ENSMUSP00000075063; ENSMUSG00000038764.
GeneIDi545622.
KEGGimmu:545622.
UCSCiuc008sya.2. mouse.

Organism-specific databases

CTDi5774.
MGIiMGI:105307. Ptpn3.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000007048.
HOVERGENiHBG008322.
InParanoidiA2ALK8.
KOiK18027.
OMAiHFGDYNS.
OrthoDBiEOG76HQ1B.
PhylomeDBiA2ALK8.
TreeFamiTF315900.

Miscellaneous databases

NextBioi412806.
PROiA2ALK8.
SOURCEiSearch...

Gene expression databases

BgeeiA2ALK8.
CleanExiMM_PTPN3.
ExpressionAtlasiA2ALK8. baseline and differential.
GenevisibleiA2ALK8. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPTN3_MOUSE
AccessioniPrimary (citable) accession number: A2ALK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.