SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2ALK8

- PTN3_MOUSE

UniProt

A2ALK8 - PTN3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tyrosine-protein phosphatase non-receptor type 3
Gene
Ptpn3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May act at junctions between the membrane and the cytoskeleton By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei811 – 8111Substrate By similarity
Active sitei842 – 8421Phosphocysteine intermediate By similarity
Binding sitei886 – 8861Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. negative regulation of membrane protein ectodomain proteolysis Source: Ensembl
  2. negative regulation of mitotic cell cycle Source: Ensembl
  3. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
Gene namesi
Name:Ptpn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:105307. Ptpn3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoplasmic side of plasma membrane Source: Ensembl
  3. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Tyrosine-protein phosphatase non-receptor type 3
PRO_0000320074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei359 – 3591Phosphoserine By similarity
Modified residuei367 – 3671Phosphoserine By similarity
Modified residuei376 – 3761Phosphothreonine By similarity
Modified residuei381 – 3811Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2ALK8.
PaxDbiA2ALK8.
PRIDEiA2ALK8.

PTM databases

PhosphoSiteiA2ALK8.

Expressioni

Gene expression databases

ArrayExpressiA2ALK8.
BgeeiA2ALK8.
CleanExiMM_PTPN3.
GenevestigatoriA2ALK8.

Interactioni

Protein-protein interaction databases

IntActiA2ALK8. 1 interaction.
MINTiMINT-8296855.

Structurei

3D structure databases

ProteinModelPortaliA2ALK8.
SMRiA2ALK8. Positions 31-309, 508-595, 605-904.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 312284FERM
Add
BLAST
Domaini510 – 58273PDZ
Add
BLAST
Domaini646 – 901256Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni842 – 8487Substrate binding By similarity

Sequence similaritiesi

Contains 1 FERM domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117342.
HOGENOMiHOG000007048.
HOVERGENiHBG008322.
InParanoidiA2ALK8.
KOiK18027.
OMAiHFGDYNS.
OrthoDBiEOG76HQ1B.
PhylomeDBiA2ALK8.
TreeFamiTF315900.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ALK8-1 [UniParc]FASTAAdd to Basket

« Hide

MTSRLRALGG RINNTRTSEL PKEKTRSEVI CSIRFLDGLV QTFKVNKQDL    50
GQSLLDMAYG HLGVTEKEYF GLQHGDDPVD SPRWLEASKP LRKQLKGGFP 100
CTLHFRVRYF IPDPNTLQQE QTRHLYFLQL KMDVCEGRLT CPLNSAVVLA 150
SYAVQSHFGD FNSSIHHPGY LADSQFIPDQ NDDFLSKVES LHEQHSGLKQ 200
SEAESCYINI ARTLDFYGVE LHGGRDLHNL DLMIGIASAG IAVYRKYICT 250
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 300
CVEHHSFFQA KKLLPQEKNV LSQYWTLGSR NPKKSVNNQY CKKVIGGMVW 350
NPVMRRSLSV ERLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA 400
NEMTYITETE DVFYTYKGPL SPKDSDSEVS QNHSPHRESL SENNPAQSCL 450
TQKSSSSVSP SSNAPGSCSP DGVDQRFLED YHKVTKGGFV EDASQYYCDK 500
SDDGDGYLVL IRITPDEEGR FGFNLKGGVD QKMPLVVSRI NPESPADTCM 550
PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRKAVR 600
SLAEIRSEDE LSQLFPEAMF PACPEGGDSL EGSMELLKKG LESGTVLIQF 650
EQLYRKKPGL AVSFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY 700
VNMEMPAANL VNKYIATQGP LPNTCAQFWQ VVWDQKLSLV VMLTTLTERG 750
RTKCHQYWPD PPDIMDHGIF HIQCQTEDCT IAYVSREMLV TNTETGEEHT 800
VTHLQYVAWP DHGVPDDSSD FLEFVKYVRS LRVDGEPALV HCSAGIGRTG 850
VLVTMETAMC LIERNLPVYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 900
VYEEGLVQRL DPS 913
Length:913
Mass (Da):103,896
Last modified:February 20, 2007 - v1
Checksum:i8D86101FA691142A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL805921 Genomic DNA. Translation: CAM19971.1.
CCDSiCCDS51181.1.
RefSeqiNP_035337.2. NM_011207.2.
XP_006538161.1. XM_006538098.1.
XP_006538162.1. XM_006538099.1.
XP_006538163.1. XM_006538100.1.
UniGeneiMm.246552.

Genome annotation databases

EnsembliENSMUST00000075637; ENSMUSP00000075063; ENSMUSG00000038764.
GeneIDi545622.
KEGGimmu:545622.
UCSCiuc008sya.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL805921 Genomic DNA. Translation: CAM19971.1 .
CCDSi CCDS51181.1.
RefSeqi NP_035337.2. NM_011207.2.
XP_006538161.1. XM_006538098.1.
XP_006538162.1. XM_006538099.1.
XP_006538163.1. XM_006538100.1.
UniGenei Mm.246552.

3D structure databases

ProteinModelPortali A2ALK8.
SMRi A2ALK8. Positions 31-309, 508-595, 605-904.
ModBasei Search...

Protein-protein interaction databases

IntActi A2ALK8. 1 interaction.
MINTi MINT-8296855.

PTM databases

PhosphoSitei A2ALK8.

Proteomic databases

MaxQBi A2ALK8.
PaxDbi A2ALK8.
PRIDEi A2ALK8.

Protocols and materials databases

DNASUi 545622.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075637 ; ENSMUSP00000075063 ; ENSMUSG00000038764 .
GeneIDi 545622.
KEGGi mmu:545622.
UCSCi uc008sya.2. mouse.

Organism-specific databases

CTDi 5774.
MGIi MGI:105307. Ptpn3.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117342.
HOGENOMi HOG000007048.
HOVERGENi HBG008322.
InParanoidi A2ALK8.
KOi K18027.
OMAi HFGDYNS.
OrthoDBi EOG76HQ1B.
PhylomeDBi A2ALK8.
TreeFami TF315900.

Miscellaneous databases

NextBioi 412806.
PROi A2ALK8.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2ALK8.
Bgeei A2ALK8.
CleanExi MM_PTPN3.
Genevestigatori A2ALK8.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPTN3_MOUSE
AccessioniPrimary (citable) accession number: A2ALK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi