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A2ALK8 (PTN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 3

EC=3.1.3.48
Gene names
Name:Ptpn3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length913 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act at junctions between the membrane and the cytoskeleton By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 913913Tyrosine-protein phosphatase non-receptor type 3
PRO_0000320074

Regions

Domain29 – 312284FERM
Domain510 – 58273PDZ
Domain646 – 901256Tyrosine-protein phosphatase
Region842 – 8487Substrate binding By similarity

Sites

Active site8421Phosphocysteine intermediate By similarity
Binding site8111Substrate By similarity
Binding site8861Substrate By similarity

Amino acid modifications

Modified residue3591Phosphoserine By similarity
Modified residue3671Phosphoserine By similarity
Modified residue3761Phosphothreonine By similarity
Modified residue3811Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A2ALK8 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 8D86101FA691142A

FASTA913103,896
        10         20         30         40         50         60 
MTSRLRALGG RINNTRTSEL PKEKTRSEVI CSIRFLDGLV QTFKVNKQDL GQSLLDMAYG 

        70         80         90        100        110        120 
HLGVTEKEYF GLQHGDDPVD SPRWLEASKP LRKQLKGGFP CTLHFRVRYF IPDPNTLQQE 

       130        140        150        160        170        180 
QTRHLYFLQL KMDVCEGRLT CPLNSAVVLA SYAVQSHFGD FNSSIHHPGY LADSQFIPDQ 

       190        200        210        220        230        240 
NDDFLSKVES LHEQHSGLKQ SEAESCYINI ARTLDFYGVE LHGGRDLHNL DLMIGIASAG 

       250        260        270        280        290        300 
IAVYRKYICT SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 

       310        320        330        340        350        360 
CVEHHSFFQA KKLLPQEKNV LSQYWTLGSR NPKKSVNNQY CKKVIGGMVW NPVMRRSLSV 

       370        380        390        400        410        420 
ERLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA NEMTYITETE DVFYTYKGPL 

       430        440        450        460        470        480 
SPKDSDSEVS QNHSPHRESL SENNPAQSCL TQKSSSSVSP SSNAPGSCSP DGVDQRFLED 

       490        500        510        520        530        540 
YHKVTKGGFV EDASQYYCDK SDDGDGYLVL IRITPDEEGR FGFNLKGGVD QKMPLVVSRI 

       550        560        570        580        590        600 
NPESPADTCM PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRKAVR 

       610        620        630        640        650        660 
SLAEIRSEDE LSQLFPEAMF PACPEGGDSL EGSMELLKKG LESGTVLIQF EQLYRKKPGL 

       670        680        690        700        710        720 
AVSFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY VNMEMPAANL VNKYIATQGP 

       730        740        750        760        770        780 
LPNTCAQFWQ VVWDQKLSLV VMLTTLTERG RTKCHQYWPD PPDIMDHGIF HIQCQTEDCT 

       790        800        810        820        830        840 
IAYVSREMLV TNTETGEEHT VTHLQYVAWP DHGVPDDSSD FLEFVKYVRS LRVDGEPALV 

       850        860        870        880        890        900 
HCSAGIGRTG VLVTMETAMC LIERNLPVYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 

       910 
VYEEGLVQRL DPS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL805921 Genomic DNA. Translation: CAM19971.1.
RefSeqNP_035337.2. NM_011207.2.
XP_006538161.1. XM_006538098.1.
XP_006538162.1. XM_006538099.1.
XP_006538163.1. XM_006538100.1.
UniGeneMm.246552.

3D structure databases

ProteinModelPortalA2ALK8.
SMRA2ALK8. Positions 28-330, 508-595, 607-904.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActA2ALK8. 1 interaction.
MINTMINT-8296855.

PTM databases

PhosphoSiteA2ALK8.

Proteomic databases

PaxDbA2ALK8.
PRIDEA2ALK8.

Protocols and materials databases

DNASU545622.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075637; ENSMUSP00000075063; ENSMUSG00000038764.
GeneID545622.
KEGGmmu:545622.
UCSCuc008sya.2. mouse.

Organism-specific databases

CTD5774.
MGIMGI:105307. Ptpn3.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117342.
HOGENOMHOG000007048.
HOVERGENHBG008322.
InParanoidA2ALK8.
KOK18027.
OMAHFGDYNS.
OrthoDBEOG76HQ1B.
PhylomeDBA2ALK8.
TreeFamTF315900.

Gene expression databases

ArrayExpressA2ALK8.
BgeeA2ALK8.
CleanExMM_PTPN3.
GenevestigatorA2ALK8.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio412806.
PROA2ALK8.
SOURCESearch...

Entry information

Entry namePTN3_MOUSE
AccessionPrimary (citable) accession number: A2ALK8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot