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A2ALK8

- PTN3_MOUSE

UniProt

A2ALK8 - PTN3_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 3

Gene

Ptpn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    May act at junctions between the membrane and the cytoskeleton.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei811 – 8111SubstrateBy similarity
    Active sitei842 – 8421Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei886 – 8861SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of membrane protein ectodomain proteolysis Source: Ensembl
    2. negative regulation of mitotic cell cycle Source: Ensembl
    3. peptidyl-tyrosine dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
    Gene namesi
    Name:Ptpn3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:105307. Ptpn3.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 913913Tyrosine-protein phosphatase non-receptor type 3PRO_0000320074Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei359 – 3591PhosphoserineBy similarity
    Modified residuei367 – 3671PhosphoserineBy similarity
    Modified residuei376 – 3761PhosphothreonineBy similarity
    Modified residuei381 – 3811PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiA2ALK8.
    PaxDbiA2ALK8.
    PRIDEiA2ALK8.

    PTM databases

    PhosphoSiteiA2ALK8.

    Expressioni

    Gene expression databases

    ArrayExpressiA2ALK8.
    BgeeiA2ALK8.
    CleanExiMM_PTPN3.
    GenevestigatoriA2ALK8.

    Interactioni

    Protein-protein interaction databases

    IntActiA2ALK8. 1 interaction.
    MINTiMINT-8296855.

    Structurei

    3D structure databases

    ProteinModelPortaliA2ALK8.
    SMRiA2ALK8. Positions 31-309, 508-595, 605-904.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 312284FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini510 – 58273PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini646 – 901256Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni842 – 8487Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117342.
    HOGENOMiHOG000007048.
    HOVERGENiHBG008322.
    InParanoidiA2ALK8.
    KOiK18027.
    OMAiHFGDYNS.
    OrthoDBiEOG76HQ1B.
    PhylomeDBiA2ALK8.
    TreeFamiTF315900.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2ALK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSRLRALGG RINNTRTSEL PKEKTRSEVI CSIRFLDGLV QTFKVNKQDL    50
    GQSLLDMAYG HLGVTEKEYF GLQHGDDPVD SPRWLEASKP LRKQLKGGFP 100
    CTLHFRVRYF IPDPNTLQQE QTRHLYFLQL KMDVCEGRLT CPLNSAVVLA 150
    SYAVQSHFGD FNSSIHHPGY LADSQFIPDQ NDDFLSKVES LHEQHSGLKQ 200
    SEAESCYINI ARTLDFYGVE LHGGRDLHNL DLMIGIASAG IAVYRKYICT 250
    SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS 300
    CVEHHSFFQA KKLLPQEKNV LSQYWTLGSR NPKKSVNNQY CKKVIGGMVW 350
    NPVMRRSLSV ERLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA 400
    NEMTYITETE DVFYTYKGPL SPKDSDSEVS QNHSPHRESL SENNPAQSCL 450
    TQKSSSSVSP SSNAPGSCSP DGVDQRFLED YHKVTKGGFV EDASQYYCDK 500
    SDDGDGYLVL IRITPDEEGR FGFNLKGGVD QKMPLVVSRI NPESPADTCM 550
    PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRKAVR 600
    SLAEIRSEDE LSQLFPEAMF PACPEGGDSL EGSMELLKKG LESGTVLIQF 650
    EQLYRKKPGL AVSFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY 700
    VNMEMPAANL VNKYIATQGP LPNTCAQFWQ VVWDQKLSLV VMLTTLTERG 750
    RTKCHQYWPD PPDIMDHGIF HIQCQTEDCT IAYVSREMLV TNTETGEEHT 800
    VTHLQYVAWP DHGVPDDSSD FLEFVKYVRS LRVDGEPALV HCSAGIGRTG 850
    VLVTMETAMC LIERNLPVYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR 900
    VYEEGLVQRL DPS 913
    Length:913
    Mass (Da):103,896
    Last modified:February 20, 2007 - v1
    Checksum:i8D86101FA691142A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL805921 Genomic DNA. Translation: CAM19971.1.
    CCDSiCCDS51181.1.
    RefSeqiNP_035337.2. NM_011207.2.
    XP_006538161.1. XM_006538098.1.
    XP_006538162.1. XM_006538099.1.
    XP_006538163.1. XM_006538100.1.
    UniGeneiMm.246552.

    Genome annotation databases

    EnsembliENSMUST00000075637; ENSMUSP00000075063; ENSMUSG00000038764.
    GeneIDi545622.
    KEGGimmu:545622.
    UCSCiuc008sya.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL805921 Genomic DNA. Translation: CAM19971.1 .
    CCDSi CCDS51181.1.
    RefSeqi NP_035337.2. NM_011207.2.
    XP_006538161.1. XM_006538098.1.
    XP_006538162.1. XM_006538099.1.
    XP_006538163.1. XM_006538100.1.
    UniGenei Mm.246552.

    3D structure databases

    ProteinModelPortali A2ALK8.
    SMRi A2ALK8. Positions 31-309, 508-595, 605-904.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A2ALK8. 1 interaction.
    MINTi MINT-8296855.

    PTM databases

    PhosphoSitei A2ALK8.

    Proteomic databases

    MaxQBi A2ALK8.
    PaxDbi A2ALK8.
    PRIDEi A2ALK8.

    Protocols and materials databases

    DNASUi 545622.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075637 ; ENSMUSP00000075063 ; ENSMUSG00000038764 .
    GeneIDi 545622.
    KEGGi mmu:545622.
    UCSCi uc008sya.2. mouse.

    Organism-specific databases

    CTDi 5774.
    MGIi MGI:105307. Ptpn3.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117342.
    HOGENOMi HOG000007048.
    HOVERGENi HBG008322.
    InParanoidi A2ALK8.
    KOi K18027.
    OMAi HFGDYNS.
    OrthoDBi EOG76HQ1B.
    PhylomeDBi A2ALK8.
    TreeFami TF315900.

    Miscellaneous databases

    NextBioi 412806.
    PROi A2ALK8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2ALK8.
    Bgeei A2ALK8.
    CleanExi MM_PTPN3.
    Genevestigatori A2ALK8.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiPTN3_MOUSE
    AccessioniPrimary (citable) accession number: A2ALK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3