A2AKX3 (SETX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable helicase senataxin
EC=3.6.4.-

Alternative name(s):
Amyotrophic lateral sclerosis 4 protein homolog
SEN1 homolog

Gene names

Name:	Setx
Synonyms:	Als4, Kiaa0625

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2646 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable helicase, which may be involved in RNA maturation By similarity. Involved in DNA double-strand breaks damage response generated by oxidative stress By similarity.
Subcellular location	Nucleus › nucleoplasm. Nucleus › nucleolus. Cytoplasm. Note: Most abundant in the nucleus By similarity. Detected in granules By similarity. Colocalized in cycling cells with FBL in the nucleolus By similarity. May be detected in the nucleolus only in cycling cells. Ref.6
Tissue specificity	Expressed in cerebellum, hippocampus, olfactory bulb, Bergmann glial fibers, stellate cells and Purkinje cells. Expressed in the epithelial cells of the lens but not in mature lens fiber cells. Expressed in the retina (highly expressed in inner and outer segments of photoreceptors and outer plexiform layer cells but weakly expressed in the inner plexiform and ganglion cell layers). Expressed in the kidney. Ref.6
Sequence similarities	Belongs to the DNA2/NAM7 helicase family.
Sequence caution	The sequence BAC32054.1 differs from that shown. Reason: Frameshift at position 699. The sequence BAC97987.1 differs from that shown. Reason: The sequence differs from that shown because it is derived from pre-RNA.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	circadian rhythm Inferred from mutant phenotype PubMed 22767893. Source: MGI double-strand break repair Inferred from sequence or structural similarity. Source: UniProtKB termination of RNA polymerase II transcription Inferred from mutant phenotype PubMed 22767893. Source: MGI
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW helicase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2AKX3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2AKX3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-381: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2646	2646	Probable helicase senataxin		PRO_0000307777
Regions
	Nucleotide binding	1939 – 1946	8	ATP Potential
	Region	2632 – 2646	15	Necessary for nuclear localization By similarity
	Motif	2046 – 2063	18	Bipartite nuclear localization signal By similarity
Amino acid modifications
	Modified residue	1002	1	Phosphoserine By similarity
	Modified residue	1004	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 381	381	Missing in isoform 2.		VSP_028827
Experimental info
	Sequence conflict	644	1	S → C in BAC32054. Ref.2
	Sequence conflict	1048	1	Q → R in BAC33309. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 3036F84EFED4A098	FASTA	2,646	297,589
	10 20 30 40 50 60 MSTCCWCTPG GSSTIDVLKR YASSTGSSEF QTADEDLCYC LECVAEYHRA RDEVPFLHEV 70 80 90 100 110 120 LWELETLRLV SHFEKSMKAE AEDDDDLYIV DNNGEEQLFD CSGQDFENKL RVPLFEILKY 130 140 150 160 170 180 PYLLLHERVN ELCVEALCRM EQNNCSFQVF DKYPGIYLFL VHPNEMVRRW AILTARNLGK 190 200 210 220 230 240 VDRDDYYDLQ EVLTCLFKVI ELGLLESPDI YTSSVLEKGK LILLPAHMYD TTNYKNYWLG 250 260 270 280 290 300 ICMLLTILEE QAMDSLLLGS DKQNDFMQSI LHTMEKQSDD DSMDPFWPAL HCFMVILDRL 310 320 330 340 350 360 GSKVWGQLID PIEAFQTIIN NESYNREIQN IRNSSIRTKL EPEPHFDDMV TCSQIVYNFN 370 380 390 400 410 420 PEKTKKDSGW RSAICPDYCP NMYEEMETLA NVLQSDIGQD MRVHNSTFLW FIPFVQSLMD 430 440 450 460 470 480 LKDLGVAYIV EVIHHLYSEV KDVLNQTDAV CDKVTEFFIL ILISVIELHR NKKCLHLLWV 490 500 510 520 530 540 SSQQWVEAVV KCAKLPTTAF VRSCEKSPGS TSRGAAIMSS LALHSVQSNS VQLACVQLIR 550 560 570 580 590 600 GLLKEGYQLG QQTLCKRFWD KLNLFLRGNL SLGWQLTGQE THELQMCLKQ IIRNIKFKMP 610 620 630 640 650 660 QYSTFGDSTS TFKTPPSFKE ESDKIDRKHK KNIYCLENCS PVSSKEPMKA DTHRVLMKVN 670 680 690 700 710 720 TTEEENFKQH YIDLNEEEQE PLPAELCLKQ KSEALFSESA QEQVKISAEK SGKESSSYAP 730 740 750 760 770 780 SNSTSRNGPE WGCDRGVIMS AHSLTDSSSD FMEQVSTSNE DVSLKDGSVG KTSKPSFKLQ 790 800 810 820 830 840 KDEICAKLSH VIKKQIRKST LVDNIIDLEE NTAISDLENC SGTDGGALKE DSIGHNVPSD 850 860 870 880 890 900 PVLDDKHEEQ KSQNSSLFKK EIKSEELDNS SSDDEDKLQI QEGRADDDLV SFTEVTDTLV 910 920 930 940 950 960 KAPCEGHVKM VVESRDKEMR ESTALTSNLV EGQVPHDSSK PLVAGRQIDL CNITLISQTT 970 980 990 1000 1010 1020 VIQFPSGLSK QNSFQLQKGD KRCLTANQNS AATCRGQVIV ISDSDEEEDE DEDERSSSEE 1030 1040 1050 1060 1070 1080 NIKQSKACIG KDCSEHRSLA VNASVEKQLV KEEERYPVEF EDSESQVFEF ESSSEVFSVW 1090 1100 1110 1120 1130 1140 QDHKIDSKNS LQGEQKSYVT HVADSTNNNL GCGDSVSEEV VRNKAEGVKE HAGPHSSVSA 1150 1160 1170 1180 1190 1200 EEFCKTGVKK PKRKRYDKVT AEDPQRPSSS VGTDQLPDRR DLTESDLKSA DMGMATPSSS 1210 1220 1230 1240 1250 1260 VERDSTILQK STKSRTHSKP VRKVPASKAT KKTHSDTRRG QSKSSCYISC RTSPAIVPPK 1270 1280 1290 1300 1310 1320 KLRQCPEPTS TVEKLGLKKA PRKAFELSQR SLECIVQLRD HGKTVGVVDA PKKAKLISPQ 1330 1340 1350 1360 1370 1380 TLSIKNNKKL LTSQDLQFQR LMRSRSHKKR DFDYKNTDTV RVSRIVQGSD VLEADSDEPD 1390 1400 1410 1420 1430 1440 DHRVSEPLAI SNEKQLAKCM LSKTEVAEAS SDPWVTGITC LVNQCESRVL SGGVPTDVVM 1450 1460 1470 1480 1490 1500 VSASEDPVDG GAVTVQVGEV ASVKAAEPAS SSDTDDDDNL FLTQHDPQDM DLCSQLENKT 1510 1520 1530 1540 1550 1560 IIVAHKKDTV QREDSLSRPQ LESLSITKCK YKDCVETTKN QGEYCPRHSE AKAADDGLFR 1570 1580 1590 1600 1610 1620 KPGLPLSVAR PLRPTTTKIF SSSSASRTAN LSKSLESTTL QQSALKNKSS GAQPNLKVTP 1630 1640 1650 1660 1670 1680 PSSMGSQKPV AEVKSLCNIF HFQTPSSSSK QSCKLTFSEN RPTSAASPVN ILLPSQSIFD 1690 1700 1710 1720 1730 1740 TFIKEVLKWK YQMFLNFDKC GAPTSLCQSI SRPVPVRFQD CAEYFNVFLP LIILNAFETV 1750 1760 1770 1780 1790 1800 AQEWLSSPNK ENFYQLQLRK FPADYKKYWE FLIYLNESEL AKQLHPKEND LVFLAPEKSY 1810 1820 1830 1840 1850 1860 MDRHGMQDCS HYYCGYVHKF RRTSVMRSGK AECSLCIQTQ DTLPASVKNL TRCIVISSLV 1870 1880 1890 1900 1910 1920 TTQRKLKAMS LLSSRNQLAR AVLNPNPMDF CTKDLLTTTS ERIVAYLKDF NEDQKKAIET 1930 1940 1950 1960 1970 1980 AYAMVKHSPS VAKICLIHGP PGTGKSKTIV GLLYRLLTEN QRKGHSDENF NAKIKQNRVL 1990 2000 2010 2020 2030 2040 VCAPSNAAVD ELMKKIILEF KEKCKDKKNP LGNCGDINLV RLGPEKSINT EVLKFSLDSQ 2050 2060 2070 2080 2090 2100 VNHRMKKDLP SHIQEMLRRK EILDAQLDEL SRQRALCRGG REMQRQELDE HIAIVSKERQ 2110 2120 2130 2140 2150 2160 ELASKIKEVQ GRPQRAQNTI ILESHVICCT LSTSGGLLLE SAFRGQGGVP FSCVIVDEAG 2170 2180 2190 2200 2210 2220 QSCEVETLSP LIHRCNKLIL VGDPKQLPPT VISMKAQEYG YDQSMMARFC KLLEENVEQN 2230 2240 2250 2260 2270 2280 MIGRLPVLQL TIQYRMHPDI CLFPSNYVYN KNLKTNRLTE SIRCSSEWPF QPYLVFDVGD 2290 2300 2310 2320 2330 2340 GSERRDNDSY INVQEIKLVM EIIKLIKEKR KDISFRNIGI ITHYKAQKTM IQKDLEKEFD 2350 2360 2370 2380 2390 2400 KKGPAEVDTV DAFQGRQKDC IIVTCVRASA VQGSIGFLAS LQRLNVTITR AKYSLFILGH 2410 2420 2430 2440 2450 2460 LRTLMENQHW YELIQDAQKR GAIIKTSDPN YRHDAMKILK LKPVLQRSLT HPPATAPEAP 2470 2480 2490 2500 2510 2520 RPQGGLPSNR LDSGLATTSF AASLYHTPSD TVTSKGPERP LLQDRLRDPR LLRRLDAEAK 2530 2540 2550 2560 2570 2580 GTFLKDPQPV SPQLPGVVHL LGEPGFPVVF QDLGFVVPPS TAIVAPLGSH RSPMQAEPPP 2590 2600 2610 2620 2630 2640 AHPAAAASTS KRKYSDPDAG LSHKREPRAF SGEQGRHGSV THHVLRSTDW DRRRLDDSSA KRRQFL
	Isoform 2 [UniParc]. Checksum: AA0DCF08E90FAEED	FASTA	2,265	253,320
	10 20 30 40 50 60 MYEEMETLAN VLQSDIGQDM RVHNSTFLWF IPFVQSLMDL KDLGVAYIVE VIHHLYSEVK 70 80 90 100 110 120 DVLNQTDAVC DKVTEFFILI LISVIELHRN KKCLHLLWVS SQQWVEAVVK CAKLPTTAFV 130 140 150 160 170 180 RSCEKSPGST SRGAAIMSSL ALHSVQSNSV QLACVQLIRG LLKEGYQLGQ QTLCKRFWDK 190 200 210 220 230 240 LNLFLRGNLS LGWQLTGQET HELQMCLKQI IRNIKFKMPQ YSTFGDSTST FKTPPSFKEE 250 260 270 280 290 300 SDKIDRKHKK NIYCLENCSP VSSKEPMKAD THRVLMKVNT TEEENFKQHY IDLNEEEQEP 310 320 330 340 350 360 LPAELCLKQK SEALFSESAQ EQVKISAEKS GKESSSYAPS NSTSRNGPEW GCDRGVIMSA 370 380 390 400 410 420 HSLTDSSSDF MEQVSTSNED VSLKDGSVGK TSKPSFKLQK DEICAKLSHV IKKQIRKSTL 430 440 450 460 470 480 VDNIIDLEEN TAISDLENCS GTDGGALKED SIGHNVPSDP VLDDKHEEQK SQNSSLFKKE 490 500 510 520 530 540 IKSEELDNSS SDDEDKLQIQ EGRADDDLVS FTEVTDTLVK APCEGHVKMV VESRDKEMRE 550 560 570 580 590 600 STALTSNLVE GQVPHDSSKP LVAGRQIDLC NITLISQTTV IQFPSGLSKQ NSFQLQKGDK 610 620 630 640 650 660 RCLTANQNSA ATCRGQVIVI SDSDEEEDED EDERSSSEEN IKQSKACIGK DCSEHRSLAV 670 680 690 700 710 720 NASVEKQLVK EEERYPVEFE DSESQVFEFE SSSEVFSVWQ DHKIDSKNSL QGEQKSYVTH 730 740 750 760 770 780 VADSTNNNLG CGDSVSEEVV RNKAEGVKEH AGPHSSVSAE EFCKTGVKKP KRKRYDKVTA 790 800 810 820 830 840 EDPQRPSSSV GTDQLPDRRD LTESDLKSAD MGMATPSSSV ERDSTILQKS TKSRTHSKPV 850 860 870 880 890 900 RKVPASKATK KTHSDTRRGQ SKSSCYISCR TSPAIVPPKK LRQCPEPTST VEKLGLKKAP 910 920 930 940 950 960 RKAFELSQRS LECIVQLRDH GKTVGVVDAP KKAKLISPQT LSIKNNKKLL TSQDLQFQRL 970 980 990 1000 1010 1020 MRSRSHKKRD FDYKNTDTVR VSRIVQGSDV LEADSDEPDD HRVSEPLAIS NEKQLAKCML 1030 1040 1050 1060 1070 1080 SKTEVAEASS DPWVTGITCL VNQCESRVLS GGVPTDVVMV SASEDPVDGG AVTVQVGEVA 1090 1100 1110 1120 1130 1140 SVKAAEPASS SDTDDDDNLF LTQHDPQDMD LCSQLENKTI IVAHKKDTVQ REDSLSRPQL 1150 1160 1170 1180 1190 1200 ESLSITKCKY KDCVETTKNQ GEYCPRHSEA KAADDGLFRK PGLPLSVARP LRPTTTKIFS 1210 1220 1230 1240 1250 1260 SSSASRTANL SKSLESTTLQ QSALKNKSSG AQPNLKVTPP SSMGSQKPVA EVKSLCNIFH 1270 1280 1290 1300 1310 1320 FQTPSSSSKQ SCKLTFSENR PTSAASPVNI LLPSQSIFDT FIKEVLKWKY QMFLNFDKCG 1330 1340 1350 1360 1370 1380 APTSLCQSIS RPVPVRFQDC AEYFNVFLPL IILNAFETVA QEWLSSPNKE NFYQLQLRKF 1390 1400 1410 1420 1430 1440 PADYKKYWEF LIYLNESELA KQLHPKENDL VFLAPEKSYM DRHGMQDCSH YYCGYVHKFR 1450 1460 1470 1480 1490 1500 RTSVMRSGKA ECSLCIQTQD TLPASVKNLT RCIVISSLVT TQRKLKAMSL LSSRNQLARA 1510 1520 1530 1540 1550 1560 VLNPNPMDFC TKDLLTTTSE RIVAYLKDFN EDQKKAIETA YAMVKHSPSV AKICLIHGPP 1570 1580 1590 1600 1610 1620 GTGKSKTIVG LLYRLLTENQ RKGHSDENFN AKIKQNRVLV CAPSNAAVDE LMKKIILEFK 1630 1640 1650 1660 1670 1680 EKCKDKKNPL GNCGDINLVR LGPEKSINTE VLKFSLDSQV NHRMKKDLPS HIQEMLRRKE 1690 1700 1710 1720 1730 1740 ILDAQLDELS RQRALCRGGR EMQRQELDEH IAIVSKERQE LASKIKEVQG RPQRAQNTII 1750 1760 1770 1780 1790 1800 LESHVICCTL STSGGLLLES AFRGQGGVPF SCVIVDEAGQ SCEVETLSPL IHRCNKLILV 1810 1820 1830 1840 1850 1860 GDPKQLPPTV ISMKAQEYGY DQSMMARFCK LLEENVEQNM IGRLPVLQLT IQYRMHPDIC 1870 1880 1890 1900 1910 1920 LFPSNYVYNK NLKTNRLTES IRCSSEWPFQ PYLVFDVGDG SERRDNDSYI NVQEIKLVME 1930 1940 1950 1960 1970 1980 IIKLIKEKRK DISFRNIGII THYKAQKTMI QKDLEKEFDK KGPAEVDTVD AFQGRQKDCI 1990 2000 2010 2020 2030 2040 IVTCVRASAV QGSIGFLASL QRLNVTITRA KYSLFILGHL RTLMENQHWY ELIQDAQKRG 2050 2060 2070 2080 2090 2100 AIIKTSDPNY RHDAMKILKL KPVLQRSLTH PPATAPEAPR PQGGLPSNRL DSGLATTSFA 2110 2120 2130 2140 2150 2160 ASLYHTPSDT VTSKGPERPL LQDRLRDPRL LRRLDAEAKG TFLKDPQPVS PQLPGVVHLL 2170 2180 2190 2200 2210 2220 GEPGFPVVFQ DLGFVVPPST AIVAPLGSHR SPMQAEPPPA HPAAAASTSK RKYSDPDAGL 2230 2240 2250 2260 SHKREPRAFS GEQGRHGSVT HHVLRSTDWD RRRLDDSSAK RRQFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1050 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-858 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2464-2646. Strain: C57BL/6J. Tissue: Head, Retina and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1745-2646 (ISOFORM 1). Strain: 129 and C57BL/6. Tissue: Brain and Mammary tumor.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1915-2646 (ISOFORM 1). Tissue: Embryonic tail.
[5]	"Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2." Moreira M.-C., Klur S., Watanabe M., Nemeth A.H., Le Ber I., Moniz J.-C., Tranchant C., Aubourg P., Tazir M., Schoels L., Pandolfo M., Schulz J.B., Pouget J., Calvas P., Shizuka-Ikeda M., Shoji M., Tanaka M., Izatt L. , Shaw C.E., M'Zahem A., Dunne E., Bomont P., Benhassine T., Bouslam N., Stevanin G., Brice A., Guimaraes J., Mendonca P., Barbot C., Coutinho P., Sequeiros J., Duerr A., Warter J.-M., Koenig M. Nat. Genet. 36:225-227(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORM 1). Strain: C57BL/6J.
[6]	"Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease." Chen Y.-Z., Hashemi S.H., Anderson S.K., Huang Y., Moreira M.-C., Lynch D.R., Glass I.A., Chance P.F., Bennett C.L. Neurobiol. Dis. 23:97-108(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL772379, AL845267 Genomic DNA. Translation: CAM16246.1. AL845267, AL772379 Genomic DNA. Translation: CAM23971.1. AL845267 Genomic DNA. Translation: CAM23973.2. AK044730 mRNA. Translation: BAC32054.1. Frameshift. AK048354 mRNA. Translation: BAC33309.2. AK077911 mRNA. Translation: BAC37058.1. BC046382 mRNA. Translation: AAH46382.1. BC058109 mRNA. Translation: AAH58109.2. BC079604 mRNA. Translation: AAH79604.2. AK129177 Transcribed RNA. Translation: BAC97987.1. Sequence problems. BK001523 mRNA. Translation: DAA01946.1.
IPI	IPI00421108. IPI00626271.
RefSeq	NP_932150.2. NM_198033.2.
UniGene	Mm.41867.
3D structure databases
ProteinModelPortal	A2AKX3.
SMR	A2AKX3. Positions 1907-2437.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-56995N.
IntAct	A2AKX3. 3 interactions.
PTM databases
PhosphoSite	A2AKX3.
Proteomic databases
PaxDb	A2AKX3.
PRIDE	A2AKX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000061578; ENSMUSP00000051492; ENSMUSG00000043535. ENSMUST00000129544; ENSMUSP00000119521; ENSMUSG00000043535.
GeneID	269254.
KEGG	mmu:269254.
UCSC	uc008izm.1. mouse.
Organism-specific databases
CTD	23064.
MGI	MGI:2443480. Setx.
Rouge	Search...
Phylogenomic databases
eggNOG	COG1112.
GeneTree	ENSGT00580000081652.
HOVERGEN	HBG108476.
InParanoid	A2AKX3.
KO	K10706.
OrthoDB	EOG4XWFWX.
Gene expression databases
ArrayExpress	A2AKX3.
Bgee	A2AKX3.
CleanEx	MM_SETX.
Genevestigator	A2AKX3.
Family and domain databases
InterPro	IPR026121. Senataxin. [Graphical view]
PANTHER	PTHR10887:SF15. PTHR10887:SF15. 1 hit.
ProtoNet	Search...
Other
NextBio	392760.
SOURCE	Search...

Entry information

Entry name

SETX_MOUSE

Accession

Primary (citable) accession number: A2AKX3
Secondary accession number(s): A2AKX4 , A2AR33, Q6IMG6, Q6PED8, Q6ZQ81, Q80V90, Q8C5P1, Q8C859, Q8C8P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program