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Protein

UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter

Gene

Slc35d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development.1 Publication

GO - Molecular functioni

  • pyrimidine nucleotide-sugar transmembrane transporter activity Source: MGI

GO - Biological processi

  • chondroitin sulfate biosynthetic process Source: MGI
  • embryonic skeletal system development Source: MGI
  • pyrimidine nucleotide-sugar transport Source: MGI

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-173599. Formation of the active cofactor, UDP-glucuronate.
R-MMU-727802. Transport of nucleotide sugars.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporterImported
Short name:
UDP-GlcA/UDP-GalNAc transporterCurated
Alternative name(s):
Solute carrier family 35 member D11 Publication
Gene namesi
Name:Slc35d11 PublicationImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140361. Slc35d1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Transmembranei281 – 303HelicalSequence analysisAdd BLAST23
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Neonatal lethality. Skeletal development is severely impaired leading to reduced snout and body length, and extremely short limbs. The proliferating zone of epiphyseal cartilage is disorganized with densely packed round chondrocytes and little extracellular matrix, in contrast to the regular columnar organization of chondrocytes in wild type cartilage. Chondroitin sulfate content of cartilage is significantly reduced, associated with reduced proteoglycan aggregates in the extracellular matrix.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004409901 – 355UDP-glucuronic acid/UDP-N-acetylgalactosamine transporterAdd BLAST355

Proteomic databases

MaxQBiA2AKQ0.
PeptideAtlasiA2AKQ0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028521.
ExpressionAtlasiA2AKQ0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122124.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
GeneTreeiENSGT00390000014204.
HOGENOMiHOG000038339.
HOVERGENiHBG054071.
InParanoidiA2AKQ0.
KOiK15281.
OMAiKFSRPVQ.
OrthoDBiEOG091G0KCU.
PhylomeDBiA2AKQ0.
TreeFamiTF313307.

Family and domain databases

InterProiView protein in InterPro
IPR004853. Sugar_P_trans_dom.
PfamiView protein in Pfam
PF03151. TPT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AKQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEVHRRQHA PVKGEAPAKS STHRDEEELG MAPAETLTVF LKLLAAGFYG
60 70 80 90 100
VSSFLIVVVN KSVLTNYRFP SSLCVGLGQM VATVAVLWVG KTLRVVKFPD
110 120 130 140 150
FDRNVPRKTF PLPLLYFGNQ ITGLFSTKKL NLPMFTVLRR FSILFTMFAE
160 170 180 190 200
GALLKKTFSW GIKMTVFAMI IGAFVAASSD LAFDLEGYVF ILINDVLTAA
210 220 230 240 250
NGAYVKQKLD SKELGKYGLL YYNALFMILP TLAIAYFTGD AQKAMEFEGW
260 270 280 290 300
ADTLFLLQFT LSCVMGFILM YATVLCTQYN SALTTTIVGC IKNILITYIG
310 320 330 340 350
MVFGGDYIFT WTNFIGLNIS IAGSLVYSYI TFTEEQLSKQ SEASNKLDTK

GKGAV
Length:355
Mass (Da):39,272
Last modified:July 5, 2017 - v2
Checksum:i917C3E01F9F7BDBD
GO
Isoform 2 (identifier: A2AKQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-292: Missing.

Show »
Length:306
Mass (Da):33,830
Checksum:i47A2D62481E58632
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116Y → N in BAC33758 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059020244 – 292Missing in isoform 2. CuratedAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772338 Genomic DNA. No translation available.
AK049180 mRNA. Translation: BAC33591.1.
AK049462 mRNA. Translation: BAC33758.1.
AK169775 mRNA. Translation: BAE41358.1.
AK220330 mRNA. Translation: BAD90239.1.
RefSeqiNP_808400.1. NM_177732.4.
UniGeneiMm.281800.

Genome annotation databases

EnsembliENSMUST00000036195; ENSMUSP00000037617; ENSMUSG00000028521.
GeneIDi242585.
KEGGimmu:242585.
UCSCiuc008txl.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiS35D1_MOUSE
AccessioniPrimary (citable) accession number: A2AKQ0
Secondary accession number(s): Q3TE90
, Q5DU40, Q8BKX2, Q8BX24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: July 5, 2017
Last modified: July 5, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families