Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FERM and PDZ domain-containing protein 1

Gene

Frmpd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 1
Gene namesi
Name:Frmpd1
Synonyms:Kiaa0967
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2446274 Frmpd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068061 – 1549FERM and PDZ domain-containing protein 1Add BLAST1549

Proteomic databases

PaxDbiA2AKB4
PeptideAtlasiA2AKB4
PRIDEiA2AKB4

PTM databases

iPTMnetiA2AKB4
PhosphoSitePlusiA2AKB4

Expressioni

Gene expression databases

BgeeiENSMUSG00000035615
CleanExiMM_FRMPD1
ExpressionAtlasiA2AKB4 baseline and differential
GenevisibleiA2AKB4 MM

Interactioni

Subunit structurei

Interacts with GPSM1 (By similarity). Interacts with GPSM2 (PubMed:23318951).By similarity1 Publication

Protein-protein interaction databases

IntActiA2AKB4, 1 interactor
STRINGi10090.ENSMUSP00000047232

Structurei

3D structure databases

ProteinModelPortaliA2AKB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 135PDZPROSITE-ProRule annotationAdd BLAST79
Domaini181 – 496FERMPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni924 – 931Important for interaction with GPSM2By similarity8

Phylogenomic databases

eggNOGiENOG410IPBG Eukaryota
ENOG410YCJX LUCA
GeneTreeiENSGT00530000063201
HOGENOMiHOG000112646
HOVERGENiHBG101205
InParanoidiA2AKB4
OMAiSHIWPEY
OrthoDBiEOG091G00W9
PhylomeDBiA2AKB4
TreeFamiTF316497

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

A2AKB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELDGSLSQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPPGNPAQA
60 70 80 90 100
LTPVRHTVTL DKDVLLQNYG FHISETLPLT VVAVTAGGSA HGKLFPGDQI
110 120 130 140 150
LQMNNELAED LSCERAADIL RETEDALSIT VVRCTSGVPK SSFLTEEKRA
160 170 180 190 200
RLKSNPVKVH FAEEVLVSGH SQGNSLLCMP NVLKVYLENG QTKAFKFEAN
210 220 230 240 250
TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE EELVQQVVER
260 270 280 290 300
EESQDSRCLF RVSFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM
310 320 330 340 350
KCNSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK
360 370 380 390 400
GKDIKKAISF HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGKV
410 420 430 440 450
FNATLMLQDR ESYIALLVGA KYGISQIINS KLNIISTLAE FANISRVELT
460 470 480 490 500
EESEKVSMVK VYLQDVKVLT LLLESSSAKD LACLIAGYYR LFVDPANSVF
510 520 530 540 550
HWSGNRRPTH RVSAEEGYES RACSDSEESS EVDCVLEPLS DRCLVKLSLC
560 570 580 590 600
RPFAREEQPP GDSPTPEATR RGPSTCGASS MTDSAESEAS DSANTESRGC
610 620 630 640 650
RTSGSSESMD ALEEDDLDAC SSSGTSFFHF GPPGFSKGLE TNSQEENSRV
660 670 680 690 700
ETSGFLCLLD LGQNANPQCQ KIDGPQGLAS EACSWGPELS MGRLDPRLYE
710 720 730 740 750
GSRTDYYNLC SSISPGSHLS DSGSESTASR QGAAPPQWCQ QGWMEAQSGS
760 770 780 790 800
MLESLGLPAL PPLAFEGGSS DEEYYDAADK LTPPDTLSGP RAADPSAMRL
810 820 830 840 850
QSQSRTRGSE ESLHPGPEGG EPSRQGGVKK YAKSLRKRRS FLQTDHTSQV
860 870 880 890 900
SFPLEASASQ ENTDDVCYYD REPYLTLTAP SPTVSSLQDM QGEPGLLETK
910 920 930 940 950
ALGLLASLRE TKSTNPASRI MEMEPETMET KSVIDSRVSS ISAIRLRIDP
960 970 980 990 1000
SNTENPVTTD GSSASIPHSP HHSNPGSSSP QAAQVRPFPI VSPDQDPGGT
1010 1020 1030 1040 1050
TPKELTAEPE DSTFPLSSDH PNPDNPGPHH VSQGDTSELG EVRSEIGSES
1060 1070 1080 1090 1100
FLINHVQEVI PQITGPLCPG DGPTSGECEV NSEETALAAD EVQGQLSLDS
1110 1120 1130 1140 1150
DREVMHRNGP SLFQKGSGKD LGDSKGDRLD NVPQALDVRA PAGEINSSLC
1160 1170 1180 1190 1200
SEPPATGTGQ TSSDSEGENR EAQEQELLTE LDLAPDFLLP SAFPPETIKA
1210 1220 1230 1240 1250
EQLDRVIGED SVPVSTSQQV CVHTVPSLPK LSPCQEEPRS ADSGHGSPAE
1260 1270 1280 1290 1300
SKGDDSPIIC LPPERSFLCF APESHPEGST SLSRVTSFSF AGINEVAPAE
1310 1320 1330 1340 1350
IGIEHCRCQF SYATCFRGLQ PETEEEDGDP QTHPAAPLTS PPSAGSQVTL
1360 1370 1380 1390 1400
PWRAARAYSC TTPLSRKSHI WPEFCSRALR QLKTTPTNAP EGFVQLTESL
1410 1420 1430 1440 1450
LELQDILEAS WGVGNKHPPD KCTLHFSESR SRLCMGSQKL LASCQHVIRM
1460 1470 1480 1490 1500
DQSPEEMQGA VRVTFQHLVQ LAGLCFQFTD CSRCSTRHRE VAGNLRDVVY
1510 1520 1530 1540
TYHQFVEAAK LTCERGYHDF SVKLLARQCT ALTAAVFCLT QKFRASTAL
Length:1,549
Mass (Da):169,208
Last modified:February 20, 2007 - v1
Checksum:i809B6E0EC046CE2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti501H → L in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti812S → G in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti819G → E in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti991V → L in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1000T → S in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1092V → VQ in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1160Q → R in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1163S → P in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1212V → A in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1241A → V in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1254Missing in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1309Q → H in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1319L → P in BAC65691 (PubMed:12693553).Curated1
Sequence conflicti1431S → N in BAC65691 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772285 Genomic DNA No translation available.
AK122409 mRNA Translation: BAC65691.1
BC031840 mRNA Translation: AAH31840.1
BC046469 mRNA Translation: AAH46469.1
BC051097 mRNA Translation: AAH51097.1
CCDSiCCDS38753.1
RefSeqiNP_001074641.1, NM_001081172.2
XP_006538238.1, XM_006538175.2
XP_006538239.1, XM_006538176.3
XP_006538240.1, XM_006538177.3
XP_006538241.1, XM_006538178.3
XP_011248387.1, XM_011250085.2
UniGeneiMm.24783

Genome annotation databases

EnsembliENSMUST00000044773; ENSMUSP00000047232; ENSMUSG00000035615
ENSMUST00000107804; ENSMUSP00000103434; ENSMUSG00000035615
GeneIDi666060
KEGGimmu:666060
UCSCiuc008ssi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFRPD1_MOUSE
AccessioniPrimary (citable) accession number: A2AKB4
Secondary accession number(s): Q80TN2, Q80XK5, Q8K0C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 20, 2007
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health