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Protein

FERM and PDZ domain-containing protein 1

Gene

Frmpd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 1
Gene namesi
Name:Frmpd1
Synonyms:Kiaa0967
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2446274. Frmpd1.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

  • Note: Found both in the cytoplasm and associated with the cell membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15491549FERM and PDZ domain-containing protein 1PRO_0000306806Add
BLAST

Proteomic databases

MaxQBiA2AKB4.
PaxDbiA2AKB4.
PRIDEiA2AKB4.

PTM databases

iPTMnetiA2AKB4.
PhosphoSiteiA2AKB4.

Expressioni

Gene expression databases

BgeeiA2AKB4.
CleanExiMM_FRMPD1.
ExpressionAtlasiA2AKB4. baseline and differential.
GenevisibleiA2AKB4. MM.

Interactioni

Subunit structurei

Interacts with GPSM1 (By similarity). Interacts with GPSM2 (PubMed:23318951).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047232.

Structurei

3D structure databases

ProteinModelPortaliA2AKB4.
SMRiA2AKB4. Positions 54-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 13579PDZPROSITE-ProRule annotationAdd
BLAST
Domaini181 – 496316FERMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni924 – 9318Important for interaction with GPSM2By similarity

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPBG. Eukaryota.
ENOG410YCJX. LUCA.
GeneTreeiENSGT00530000063201.
HOGENOMiHOG000112646.
HOVERGENiHBG101205.
InParanoidiA2AKB4.
OMAiSHIWPEY.
OrthoDBiEOG7W419W.
PhylomeDBiA2AKB4.
TreeFamiTF316497.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AKB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELDGSLSQ TRKAHRIEQM VARWLRRSRD SSARAKVAAA DGPPGNPAQA
60 70 80 90 100
LTPVRHTVTL DKDVLLQNYG FHISETLPLT VVAVTAGGSA HGKLFPGDQI
110 120 130 140 150
LQMNNELAED LSCERAADIL RETEDALSIT VVRCTSGVPK SSFLTEEKRA
160 170 180 190 200
RLKSNPVKVH FAEEVLVSGH SQGNSLLCMP NVLKVYLENG QTKAFKFEAN
210 220 230 240 250
TTVKDIILTV KEKLSIRSIE YFALALEEQY SISRLHLLHE EELVQQVVER
260 270 280 290 300
EESQDSRCLF RVSFVPKDPL DLLKEDPVAF EYLYLQSCSD VLQERFAVEM
310 320 330 340 350
KCNSALRLAA LHIQERIYAC AQPQKISLKY IEKDWGIENF ISPTLLRNMK
360 370 380 390 400
GKDIKKAISF HMKRNQNLLE PRQKQLISAA QLRLNYLQIL GELKTYGGKV
410 420 430 440 450
FNATLMLQDR ESYIALLVGA KYGISQIINS KLNIISTLAE FANISRVELT
460 470 480 490 500
EESEKVSMVK VYLQDVKVLT LLLESSSAKD LACLIAGYYR LFVDPANSVF
510 520 530 540 550
HWSGNRRPTH RVSAEEGYES RACSDSEESS EVDCVLEPLS DRCLVKLSLC
560 570 580 590 600
RPFAREEQPP GDSPTPEATR RGPSTCGASS MTDSAESEAS DSANTESRGC
610 620 630 640 650
RTSGSSESMD ALEEDDLDAC SSSGTSFFHF GPPGFSKGLE TNSQEENSRV
660 670 680 690 700
ETSGFLCLLD LGQNANPQCQ KIDGPQGLAS EACSWGPELS MGRLDPRLYE
710 720 730 740 750
GSRTDYYNLC SSISPGSHLS DSGSESTASR QGAAPPQWCQ QGWMEAQSGS
760 770 780 790 800
MLESLGLPAL PPLAFEGGSS DEEYYDAADK LTPPDTLSGP RAADPSAMRL
810 820 830 840 850
QSQSRTRGSE ESLHPGPEGG EPSRQGGVKK YAKSLRKRRS FLQTDHTSQV
860 870 880 890 900
SFPLEASASQ ENTDDVCYYD REPYLTLTAP SPTVSSLQDM QGEPGLLETK
910 920 930 940 950
ALGLLASLRE TKSTNPASRI MEMEPETMET KSVIDSRVSS ISAIRLRIDP
960 970 980 990 1000
SNTENPVTTD GSSASIPHSP HHSNPGSSSP QAAQVRPFPI VSPDQDPGGT
1010 1020 1030 1040 1050
TPKELTAEPE DSTFPLSSDH PNPDNPGPHH VSQGDTSELG EVRSEIGSES
1060 1070 1080 1090 1100
FLINHVQEVI PQITGPLCPG DGPTSGECEV NSEETALAAD EVQGQLSLDS
1110 1120 1130 1140 1150
DREVMHRNGP SLFQKGSGKD LGDSKGDRLD NVPQALDVRA PAGEINSSLC
1160 1170 1180 1190 1200
SEPPATGTGQ TSSDSEGENR EAQEQELLTE LDLAPDFLLP SAFPPETIKA
1210 1220 1230 1240 1250
EQLDRVIGED SVPVSTSQQV CVHTVPSLPK LSPCQEEPRS ADSGHGSPAE
1260 1270 1280 1290 1300
SKGDDSPIIC LPPERSFLCF APESHPEGST SLSRVTSFSF AGINEVAPAE
1310 1320 1330 1340 1350
IGIEHCRCQF SYATCFRGLQ PETEEEDGDP QTHPAAPLTS PPSAGSQVTL
1360 1370 1380 1390 1400
PWRAARAYSC TTPLSRKSHI WPEFCSRALR QLKTTPTNAP EGFVQLTESL
1410 1420 1430 1440 1450
LELQDILEAS WGVGNKHPPD KCTLHFSESR SRLCMGSQKL LASCQHVIRM
1460 1470 1480 1490 1500
DQSPEEMQGA VRVTFQHLVQ LAGLCFQFTD CSRCSTRHRE VAGNLRDVVY
1510 1520 1530 1540
TYHQFVEAAK LTCERGYHDF SVKLLARQCT ALTAAVFCLT QKFRASTAL
Length:1,549
Mass (Da):169,208
Last modified:February 20, 2007 - v1
Checksum:i809B6E0EC046CE2D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti501 – 5011H → L in BAC65691 (PubMed:12693553).Curated
Sequence conflicti812 – 8121S → G in BAC65691 (PubMed:12693553).Curated
Sequence conflicti819 – 8191G → E in BAC65691 (PubMed:12693553).Curated
Sequence conflicti991 – 9911V → L in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1000 – 10001T → S in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1092 – 10921V → VQ in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1160 – 11601Q → R in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1163 – 11631S → P in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1212 – 12121V → A in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1241 – 12411A → V in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1254 – 12541Missing in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1309 – 13091Q → H in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1319 – 13191L → P in BAC65691 (PubMed:12693553).Curated
Sequence conflicti1431 – 14311S → N in BAC65691 (PubMed:12693553).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772285 Genomic DNA. Translation: CAM26861.1.
AK122409 mRNA. Translation: BAC65691.1.
BC031840 mRNA. Translation: AAH31840.1.
BC046469 mRNA. Translation: AAH46469.1.
BC051097 mRNA. Translation: AAH51097.1.
CCDSiCCDS38753.1.
RefSeqiNP_001074641.1. NM_001081172.2.
XP_006538238.1. XM_006538175.1.
XP_006538239.1. XM_006538176.2.
XP_006538240.1. XM_006538177.2.
XP_006538241.1. XM_006538178.2.
XP_011248387.1. XM_011250085.1.
UniGeneiMm.24783.

Genome annotation databases

EnsembliENSMUST00000044773; ENSMUSP00000047232; ENSMUSG00000035615.
ENSMUST00000107804; ENSMUSP00000103434; ENSMUSG00000035615.
GeneIDi666060.
KEGGimmu:666060.
UCSCiuc008ssi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772285 Genomic DNA. Translation: CAM26861.1.
AK122409 mRNA. Translation: BAC65691.1.
BC031840 mRNA. Translation: AAH31840.1.
BC046469 mRNA. Translation: AAH46469.1.
BC051097 mRNA. Translation: AAH51097.1.
CCDSiCCDS38753.1.
RefSeqiNP_001074641.1. NM_001081172.2.
XP_006538238.1. XM_006538175.1.
XP_006538239.1. XM_006538176.2.
XP_006538240.1. XM_006538177.2.
XP_006538241.1. XM_006538178.2.
XP_011248387.1. XM_011250085.1.
UniGeneiMm.24783.

3D structure databases

ProteinModelPortaliA2AKB4.
SMRiA2AKB4. Positions 54-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047232.

PTM databases

iPTMnetiA2AKB4.
PhosphoSiteiA2AKB4.

Proteomic databases

MaxQBiA2AKB4.
PaxDbiA2AKB4.
PRIDEiA2AKB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044773; ENSMUSP00000047232; ENSMUSG00000035615.
ENSMUST00000107804; ENSMUSP00000103434; ENSMUSG00000035615.
GeneIDi666060.
KEGGimmu:666060.
UCSCiuc008ssi.1. mouse.

Organism-specific databases

CTDi22844.
MGIiMGI:2446274. Frmpd1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IPBG. Eukaryota.
ENOG410YCJX. LUCA.
GeneTreeiENSGT00530000063201.
HOGENOMiHOG000112646.
HOVERGENiHBG101205.
InParanoidiA2AKB4.
OMAiSHIWPEY.
OrthoDBiEOG7W419W.
PhylomeDBiA2AKB4.
TreeFamiTF316497.

Miscellaneous databases

NextBioi428985.
PROiA2AKB4.
SOURCEiSearch...

Gene expression databases

BgeeiA2AKB4.
CleanExiMM_FRMPD1.
ExpressionAtlasiA2AKB4. baseline and differential.
GenevisibleiA2AKB4. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-1549.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 363-1549.
    Tissue: Eye.
  4. "Structural and biochemical characterization of the interaction between LGN and Frmpd1."
    Pan Z., Shang Y., Jia M., Zhang L., Xia C., Zhang M., Wang W., Wen W.
    J. Mol. Biol. 425:1039-1049(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPSM2.

Entry informationi

Entry nameiFRPD1_MOUSE
AccessioniPrimary (citable) accession number: A2AKB4
Secondary accession number(s): Q80TN2, Q80XK5, Q8K0C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 20, 2007
Last modified: February 17, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.