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Protein

Uncharacterized protein CXorf23

Gene

CXorf23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein CXorf23
Gene namesi
Name:CXorf23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27413. CXorf23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885371.

Polymorphism and mutation databases

BioMutaiCXorf23.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Uncharacterized protein CXorf23PRO_0000287434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei78 – 781PhosphoserineCombined sources
Modified residuei80 – 801PhosphoserineCombined sources
Modified residuei187 – 1871PhosphoserineBy similarity
Modified residuei402 – 4021PhosphoserineCombined sources
Modified residuei578 – 5781PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AJT9.
MaxQBiA2AJT9.
PaxDbiA2AJT9.
PeptideAtlasiA2AJT9.
PRIDEiA2AJT9.

PTM databases

iPTMnetiA2AJT9.
PhosphoSiteiA2AJT9.

Expressioni

Gene expression databases

BgeeiA2AJT9.
CleanExiHS_CXorf23.
ExpressionAtlasiA2AJT9. baseline and differential.
GenevisibleiA2AJT9. HS.

Organism-specific databases

HPAiHPA027215.

Interactioni

Protein-protein interaction databases

BioGridi129173. 2 interactions.
IntActiA2AJT9. 2 interactions.
STRINGi9606.ENSP00000369009.

Structurei

3D structure databases

ProteinModelPortaliA2AJT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHH3. Eukaryota.
ENOG4112BI7. LUCA.
GeneTreeiENSGT00530000063211.
HOGENOMiHOG000112098.
HOVERGENiHBG101041.
InParanoidiA2AJT9.
OMAiYEHRSPS.
OrthoDBiEOG7RZ5P9.
PhylomeDBiA2AJT9.
TreeFamiTF335939.

Family and domain databases

InterProiIPR029199. THRAP3_BCLAF1.
[Graphical view]
PfamiPF15440. THRAP3_BCLAF1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AJT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARSRSRSPR WKHRSLSPVP RNAEHYKQRH SHGHYGCEYR KDPKRPVAWR
60 70 80 90 100
MDSEKHGQSK PRIPSRGNIY YQSYEHRSPS PNIRNSLENV YMYKPHRGYS
110 120 130 140 150
PGRGDSNRRA QYMPKYSEGI PYKEHERNSY PQKVQGGHSP DDHRVRGSGK
160 170 180 190 200
GGKPPQRSIA DSFRFEGKWH EDELRHQRIQ EEKYSQSTRR GSEDFETRSS
210 220 230 240 250
FQKRYPEDRD FRKYGHTSKR PKDVERYESR EPARNPKWKP EHSLPPYQED
260 270 280 290 300
TDQWNLGPQT YRHAEREHPE TSSATKVSYD YRHKRPKLLD GDQDFSDGRT
310 320 330 340 350
QKYCKEEDRK YSFQKGPLNR ELDCFNTGRG RETQDGQVKE PFKPSKKDSI
360 370 380 390 400
ACTYSNKNDV DLRSSNDKWK EKIKKEGDCR KESNSSSNQL DKSQKLPDVK
410 420 430 440 450
PSPINLRKKS LTVKVDVKKT VDTFRVASSY STERQMSHDL VAVGRKSENF
460 470 480 490 500
HPVFEHLDST QNTENKPTGE FAQEIITIIH QVKANYFPSP GITLHERFST
510 520 530 540 550
MQDIHKADVN EIPLNSDPEI HRRIDMSLAE LQSKQAVIYE SEQTLIKIID
560 570 580 590 600
PNDLRHDIER RRKERLQNED EHIFHIASAA ERDDQNSSFS KVKNVHTDGF
610 620 630 640 650
QKPTHFIKSN FRKCIEKPYM NYTTQRKDII THKPFEVEGN HRNTRVRPFK
660 670 680 690 700
SNFRGGRCQP NYKSGLVQKS LYIQAKYQRL RFTGPRGFIT HKFRERLMRK
710
KKEYTDVATG I
Length:711
Mass (Da):83,871
Last modified:February 20, 2007 - v1
Checksum:iED389DC27B6C2D1B
GO
Isoform 2 (identifier: A2AJT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-620: Missing.

Show »
Length:682
Mass (Da):80,395
Checksum:iC1373DE270D5966D
GO
Isoform 3 (identifier: A2AJT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-711: VKNVHTDGFQ...KEYTDVATGI → GLALSPRLECGVTITAYCSLYLQDSSYLPPQPPE

Note: No experimental confirmation available.Curated
Show »
Length:625
Mass (Da):73,187
Checksum:i435AB65759C38A26
GO

Sequence cautioni

The sequence BAC04399.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC87094.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH71712.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: A2AJT9-3)
Sequence conflicti617 – 6171S → G in BAC04399 (PubMed:14702039).Curated
Sequence conflicti622 – 6221Q → R in BAC04399 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei592 – 711120VKNVH…VATGI → GLALSPRLECGVTITAYCSL YLQDSSYLPPQPPE in isoform 3. 1 PublicationVSP_025458Add
BLAST
Alternative sequencei592 – 62029Missing in isoform 2. 1 PublicationVSP_025459Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772197 Genomic DNA. Translation: CAH71712.2. Sequence problems.
AL772197 Genomic DNA. Translation: CAH71713.1.
AL772197 Genomic DNA. Translation: CAM15087.1.
AK094661 mRNA. Translation: BAC04399.1. Different initiation.
AK127709 mRNA. Translation: BAC87094.1. Different initiation.
BC126172 mRNA. Translation: AAI26173.1.
CCDSiCCDS14194.2. [A2AJT9-2]
RefSeqiNP_938020.2. NM_198279.3. [A2AJT9-2]
XP_005274530.1. XM_005274473.2. [A2AJT9-1]
XP_011543777.1. XM_011545475.1. [A2AJT9-1]
XP_011543778.1. XM_011545476.1. [A2AJT9-1]
XP_011543779.1. XM_011545477.1. [A2AJT9-2]
UniGeneiHs.28896.
Hs.661616.

Genome annotation databases

EnsembliENST00000379682; ENSP00000369004; ENSG00000173681. [A2AJT9-1]
ENST00000379687; ENSP00000369009; ENSG00000173681. [A2AJT9-2]
GeneIDi256643.
KEGGihsa:256643.
UCSCiuc004czp.4. human. [A2AJT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772197 Genomic DNA. Translation: CAH71712.2. Sequence problems.
AL772197 Genomic DNA. Translation: CAH71713.1.
AL772197 Genomic DNA. Translation: CAM15087.1.
AK094661 mRNA. Translation: BAC04399.1. Different initiation.
AK127709 mRNA. Translation: BAC87094.1. Different initiation.
BC126172 mRNA. Translation: AAI26173.1.
CCDSiCCDS14194.2. [A2AJT9-2]
RefSeqiNP_938020.2. NM_198279.3. [A2AJT9-2]
XP_005274530.1. XM_005274473.2. [A2AJT9-1]
XP_011543777.1. XM_011545475.1. [A2AJT9-1]
XP_011543778.1. XM_011545476.1. [A2AJT9-1]
XP_011543779.1. XM_011545477.1. [A2AJT9-2]
UniGeneiHs.28896.
Hs.661616.

3D structure databases

ProteinModelPortaliA2AJT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129173. 2 interactions.
IntActiA2AJT9. 2 interactions.
STRINGi9606.ENSP00000369009.

PTM databases

iPTMnetiA2AJT9.
PhosphoSiteiA2AJT9.

Polymorphism and mutation databases

BioMutaiCXorf23.

Proteomic databases

EPDiA2AJT9.
MaxQBiA2AJT9.
PaxDbiA2AJT9.
PeptideAtlasiA2AJT9.
PRIDEiA2AJT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379682; ENSP00000369004; ENSG00000173681. [A2AJT9-1]
ENST00000379687; ENSP00000369009; ENSG00000173681. [A2AJT9-2]
GeneIDi256643.
KEGGihsa:256643.
UCSCiuc004czp.4. human. [A2AJT9-1]

Organism-specific databases

CTDi256643.
GeneCardsiCXorf23.
H-InvDBHIX0023033.
HGNCiHGNC:27413. CXorf23.
HPAiHPA027215.
neXtProtiNX_A2AJT9.
PharmGKBiPA134885371.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHH3. Eukaryota.
ENOG4112BI7. LUCA.
GeneTreeiENSGT00530000063211.
HOGENOMiHOG000112098.
HOVERGENiHBG101041.
InParanoidiA2AJT9.
OMAiYEHRSPS.
OrthoDBiEOG7RZ5P9.
PhylomeDBiA2AJT9.
TreeFamiTF335939.

Miscellaneous databases

GenomeRNAii256643.
PROiA2AJT9.

Gene expression databases

BgeeiA2AJT9.
CleanExiHS_CXorf23.
ExpressionAtlasiA2AJT9. baseline and differential.
GenevisibleiA2AJT9. HS.

Family and domain databases

InterProiIPR029199. THRAP3_BCLAF1.
[Graphical view]
PfamiPF15440. THRAP3_BCLAF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-711 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 393-711 (ISOFORM 3).
    Tissue: Amygdala and Teratocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 290-711 (ISOFORM 2).
    Tissue: Colon.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78 AND SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiCX023_HUMAN
AccessioniPrimary (citable) accession number: A2AJT9
Secondary accession number(s): A1A4E8
, Q5VSM7, Q5VSN1, Q6ZS60, Q8N1W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.