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A2AJN7 (S4A11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium bicarbonate transporter-like protein 11
Alternative name(s):
Bicarbonate transporter-related protein 1
Sodium borate cotransporter 1
Short name=NaBC1
Solute carrier family 4 member 11
Gene names
Name:Slc4a11
Synonyms:BTR1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter. Ref.4

Subunit structure

Homodimer By similarity.

Subcellular location

Cell membrane. Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop. Ref.4

Post-translational modification

Glycosylated By similarity.

Disruption phenotype

Mice show thickening of the stroma and Descement membrane concomitant with increased sodium chloride concentration in the stroma of the cornea. Show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. Also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness. Ref.4

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 862862Sodium bicarbonate transporter-like protein 11
PRO_0000352350

Regions

Transmembrane345 – 36521Helical; Potential
Transmembrane385 – 40521Helical; Potential
Transmembrane428 – 44821Helical; Potential
Transmembrane462 – 48221Helical; Potential
Transmembrane543 – 56321Helical; Potential
Transmembrane634 – 65421Helical; Potential
Transmembrane671 – 69121Helical; Potential
Transmembrane727 – 74721Helical; Potential
Transmembrane749 – 76921Helical; Potential
Transmembrane817 – 83721Helical; Potential

Amino acid modifications

Glycosylation5111N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1511A → T in AAI11885. Ref.2
Sequence conflict8501A → S in AAI11885. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A2AJN7 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: D8118D841B1B8D6A

FASTA86296,751
        10         20         30         40         50         60 
MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV SGESIRFFVN 

        70         80         90        100        110        120 
VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA HRDLDGFLAQ ASIILNETAT 

       130        140        150        160        170        180 
SLDDVLRTML NRFALDPNHA EPDCDLDLLM AKLFTDAGAP MESKVHLLSD TIQGVTATVR 

       190        200        210        220        230        240 
GVQYEQSWLC IICTMKTLQK RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM 

       250        260        270        280        290        300 
EVARTFATMF SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP 

       310        320        330        340        350        360 
QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF LYFACLLPTI 

       370        380        390        400        410        420 
AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI LLTTAPLAIY TQVIRVICDD 

       430        440        450        460        470        480 
YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL LMNLFKRSTE EIIALFISIT FVLDAVKGMV 

       490        500        510        520        530        540 
KIFGKYYYGH HYHTKRTSSL VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS 

       550        560        570        580        590        600 
GQATAVLSLL IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ 

       610        620        630        640        650        660 
EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV AALVNAPENR 

       670        680        690        700        710        720 
LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV RALALVEERV ENGHIYETIV 

       730        740        750        760        770        780 
DVKETRLTAL GASVLVGLSL LLLPFPLQWI PKPVLYGLFL YIALTSLDGN QLFSRVALLL 

       790        800        810        820        830        840 
KEQTSYPPTH YIRRVPQRKI HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR 

       850        860 
YNLLPRIIEA KYLDVMDAEH RP 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-862.
Strain: C57BL/6J.
[4]"SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria."
Groger N., Frohlich H., Maier H., Olbrich A., Kostin S., Braun T., Boettger T.
J. Biol. Chem. 285:14467-14474(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL772162 Genomic DNA. Translation: CAM16451.1.
BC111884 mRNA. Translation: AAI11885.1.
AK141286 mRNA. Translation: BAE24637.1.
RefSeqNP_001074631.1. NM_001081162.1.
UniGeneMm.441391.

3D structure databases

ProteinModelPortalA2AJN7.
SMRA2AJN7. Positions 322-369, 770-802.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA2AJN7.

Proteomic databases

PaxDbA2AJN7.
PRIDEA2AJN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796.
GeneID269356.
KEGGmmu:269356.
UCSCuc008mjv.1. mouse.

Organism-specific databases

CTD83959.
MGIMGI:2138987. Slc4a11.

Phylogenomic databases

eggNOGNOG268067.
GeneTreeENSGT00560000076933.
HOGENOMHOG000016966.
HOVERGENHBG079162.
InParanoidA2AJN7.
KOK13862.
OMASDITFRQ.
OrthoDBEOG7M6D7V.
PhylomeDBA2AJN7.
TreeFamTF313630.

Gene expression databases

BgeeA2AJN7.
GenevestigatorA2AJN7.

Family and domain databases

Gene3D3.40.930.10. 1 hit.
InterProIPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PfamPF00955. HCO3_cotransp. 1 hit.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
PRINTSPR01231. HCO3TRNSPORT.
SUPFAMSSF55804. SSF55804. 1 hit.
ProtoNetSearch...

Other

NextBio392801.
PROA2AJN7.
SOURCESearch...

Entry information

Entry nameS4A11_MOUSE
AccessionPrimary (citable) accession number: A2AJN7
Secondary accession number(s): Q0VG86, Q3URQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot