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A2AJN7

- S4A11_MOUSE

UniProt

A2AJN7 - S4A11_MOUSE

Protein

Sodium bicarbonate transporter-like protein 11

Gene

Slc4a11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.1 Publication

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro
    2. protein dimerization activity Source: UniProtKB
    3. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. fluid transport Source: UniProtKB
    2. ion homeostasis Source: UniProtKB

    Keywords - Biological processi

    Anion exchange, Ion transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium bicarbonate transporter-like protein 11
    Alternative name(s):
    Bicarbonate transporter-related protein 1
    Sodium borate cotransporter 1
    Short name:
    NaBC1
    Solute carrier family 4 member 11
    Gene namesi
    Name:Slc4a11
    Synonyms:BTR1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2138987. Slc4a11.

    Subcellular locationi

    Cell membrane. Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice show thickening of the stroma and Descement membrane concomitant with increased sodium chloride concentration in the stroma of the cornea. Show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. Also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Sodium bicarbonate transporter-like protein 11PRO_0000352350Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiA2AJN7.
    PRIDEiA2AJN7.

    PTM databases

    PhosphoSiteiA2AJN7.

    Expressioni

    Tissue specificityi

    Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop.1 Publication

    Gene expression databases

    BgeeiA2AJN7.
    GenevestigatoriA2AJN7.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA2AJN7.
    SMRiA2AJN7. Positions 322-369, 770-802.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei543 – 56321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei634 – 65421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei671 – 69121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei727 – 74721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei749 – 76921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei817 – 83721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    GeneTreeiENSGT00560000076933.
    HOGENOMiHOG000016966.
    HOVERGENiHBG079162.
    InParanoidiA2AJN7.
    KOiK13862.
    OMAiNSFYAWT.
    OrthoDBiEOG7M6D7V.
    PhylomeDBiA2AJN7.
    TreeFamiTF313630.

    Family and domain databases

    Gene3Di3.40.930.10. 1 hit.
    InterProiIPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    IPR002178. PTS_EIIA_type-2_dom.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF00955. HCO3_cotransp. 1 hit.
    PF00359. PTS_EIIA_2. 1 hit.
    [Graphical view]
    PRINTSiPR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2AJN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV    50
    SGESIRFFVN VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA 100
    HRDLDGFLAQ ASIILNETAT SLDDVLRTML NRFALDPNHA EPDCDLDLLM 150
    AKLFTDAGAP MESKVHLLSD TIQGVTATVR GVQYEQSWLC IICTMKTLQK 200
    RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF 250
    SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP 300
    QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF 350
    LYFACLLPTI AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI 400
    LLTTAPLAIY TQVIRVICDD YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL 450
    LMNLFKRSTE EIIALFISIT FVLDAVKGMV KIFGKYYYGH HYHTKRTSSL 500
    VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS GQATAVLSLL 550
    IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ 600
    EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV 650
    AALVNAPENR LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV 700
    RALALVEERV ENGHIYETIV DVKETRLTAL GASVLVGLSL LLLPFPLQWI 750
    PKPVLYGLFL YIALTSLDGN QLFSRVALLL KEQTSYPPTH YIRRVPQRKI 800
    HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR YNLLPRIIEA 850
    KYLDVMDAEH RP 862
    Length:862
    Mass (Da):96,751
    Last modified:February 20, 2007 - v1
    Checksum:iD8118D841B1B8D6A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511A → T in AAI11885. (PubMed:15489334)Curated
    Sequence conflicti850 – 8501A → S in AAI11885. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772162 Genomic DNA. Translation: CAM16451.1.
    BC111884 mRNA. Translation: AAI11885.1.
    AK141286 mRNA. Translation: BAE24637.1.
    CCDSiCCDS38244.1.
    RefSeqiNP_001074631.1. NM_001081162.1.
    UniGeneiMm.441391.

    Genome annotation databases

    EnsembliENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796.
    GeneIDi269356.
    KEGGimmu:269356.
    UCSCiuc008mjv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772162 Genomic DNA. Translation: CAM16451.1 .
    BC111884 mRNA. Translation: AAI11885.1 .
    AK141286 mRNA. Translation: BAE24637.1 .
    CCDSi CCDS38244.1.
    RefSeqi NP_001074631.1. NM_001081162.1.
    UniGenei Mm.441391.

    3D structure databases

    ProteinModelPortali A2AJN7.
    SMRi A2AJN7. Positions 322-369, 770-802.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A2AJN7.

    Proteomic databases

    PaxDbi A2AJN7.
    PRIDEi A2AJN7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099362 ; ENSMUSP00000096963 ; ENSMUSG00000074796 .
    GeneIDi 269356.
    KEGGi mmu:269356.
    UCSCi uc008mjv.1. mouse.

    Organism-specific databases

    CTDi 83959.
    MGIi MGI:2138987. Slc4a11.

    Phylogenomic databases

    eggNOGi NOG268067.
    GeneTreei ENSGT00560000076933.
    HOGENOMi HOG000016966.
    HOVERGENi HBG079162.
    InParanoidi A2AJN7.
    KOi K13862.
    OMAi NSFYAWT.
    OrthoDBi EOG7M6D7V.
    PhylomeDBi A2AJN7.
    TreeFami TF313630.

    Miscellaneous databases

    NextBioi 392801.
    PROi A2AJN7.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2AJN7.
    Genevestigatori A2AJN7.

    Family and domain databases

    Gene3Di 3.40.930.10. 1 hit.
    InterProi IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    IPR002178. PTS_EIIA_type-2_dom.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF00955. HCO3_cotransp. 1 hit.
    PF00359. PTS_EIIA_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-862.
      Strain: C57BL/6J.
    4. "SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria."
      Groger N., Frohlich H., Maier H., Olbrich A., Kostin S., Braun T., Boettger T.
      J. Biol. Chem. 285:14467-14474(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS4A11_MOUSE
    AccessioniPrimary (citable) accession number: A2AJN7
    Secondary accession number(s): Q0VG86, Q3URQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3