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Protein

Sodium bicarbonate transporter-like protein 11

Gene

Slc4a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.1 Publication

GO - Molecular functioni

  1. anion transmembrane transporter activity Source: GO_Central
  2. bicarbonate transmembrane transporter activity Source: MGI
  3. borate transmembrane transporter activity Source: MGI
  4. hydrogen ion channel activity Source: MGI
  5. inorganic anion exchanger activity Source: InterPro
  6. protein dimerization activity Source: UniProtKB
  7. sodium channel activity Source: MGI
  8. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. bicarbonate transport Source: MGI
  2. borate transmembrane transport Source: MGI
  3. borate transport Source: MGI
  4. cellular cation homeostasis Source: MGI
  5. fluid transport Source: UniProtKB
  6. ion homeostasis Source: UniProtKB
  7. proton transport Source: MGI
  8. regulation of intracellular pH Source: GO_Central
  9. sodium ion transmembrane transport Source: MGI
  10. sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium bicarbonate transporter-like protein 11
Alternative name(s):
Bicarbonate transporter-related protein 1
Sodium borate cotransporter 1
Short name:
NaBC1
Solute carrier family 4 member 11
Gene namesi
Name:Slc4a11
Synonyms:BTR1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2138987. Slc4a11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence AnalysisAdd
BLAST
Transmembranei543 – 56321HelicalSequence AnalysisAdd
BLAST
Transmembranei634 – 65421HelicalSequence AnalysisAdd
BLAST
Transmembranei671 – 69121HelicalSequence AnalysisAdd
BLAST
Transmembranei727 – 74721HelicalSequence AnalysisAdd
BLAST
Transmembranei749 – 76921HelicalSequence AnalysisAdd
BLAST
Transmembranei817 – 83721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show thickening of the stroma and Descement membrane concomitant with increased sodium chloride concentration in the stroma of the cornea. Show impaired urinary concentration, increased urinary volume, and increased urinary sodium loss in the kidney. Also show stress-induced morphological changes of fibrocytes of the inner ear resulting in deafness.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Sodium bicarbonate transporter-like protein 11PRO_0000352350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2AJN7.
PRIDEiA2AJN7.

PTM databases

PhosphoSiteiA2AJN7.

Expressioni

Tissue specificityi

Expressed in the endothelial cells of the cornea. In the inner ear, is located in fibrocytes underlying the stria vascularis. In the kidney, is expressed in the thin descending limb of Henle loop.1 Publication

Gene expression databases

BgeeiA2AJN7.
ExpressionAtlasiA2AJN7. baseline and differential.
GenevestigatoriA2AJN7.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2AJN7.
SMRiA2AJN7. Positions 322-369, 770-802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000016966.
HOVERGENiHBG079162.
InParanoidiA2AJN7.
KOiK13862.
OMAiRRFPVYP.
OrthoDBiEOG7M6D7V.
PhylomeDBiA2AJN7.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF00955. HCO3_cotransp. 1 hit.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.

Sequencei

Sequence statusi: Complete.

A2AJN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNEHCQDS GEYFSAGTQG YFKNNMEDNL EVREDSLGDE VFDTVNSSIV
60 70 80 90 100
SGESIRFFVN VNLEVQPSKS DLEAATGGCV LLHTSRKYLK LKNFEEEVRA
110 120 130 140 150
HRDLDGFLAQ ASIILNETAT SLDDVLRTML NRFALDPNHA EPDCDLDLLM
160 170 180 190 200
AKLFTDAGAP MESKVHLLSD TIQGVTATVR GVQYEQSWLC IICTMKTLQK
210 220 230 240 250
RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF
260 270 280 290 300
SDITFRQKLL KTRTEEEFKE ALVHQRQLLT MMMPRAAGHS MSSLHTHRHP
310 320 330 340 350
QPPKCKDFFP FGKGIWMDIM RRFPVYPMDF TDGIIGKSKS VGKYVTTTLF
360 370 380 390 400
LYFACLLPTI AFGSLNDENT NGAIDVQKTI AGQSIGGLLY ALFSGQPLVI
410 420 430 440 450
LLTTAPLAIY TQVIRVICDD YNLDFNAFYA WTGLWNSFFL ALYAFLNLSL
460 470 480 490 500
LMNLFKRSTE EIIALFISIT FVLDAVKGMV KIFGKYYYGH HYHTKRTSSL
510 520 530 540 550
VSLLGIGRSP NSSLHTALNA SLLASPVEMA TTSSPGSTHS GQATAVLSLL
560 570 580 590 600
IMLGTLWLGY TLYQFKKSPY LHPCVRETLS DCALPIAVLS FSLIGSYGFQ
610 620 630 640 650
EIEMSKFRYN PSESLFEVAQ IHSLSFKAIG SAMGLGFLLS LLFFIEQNLV
660 670 680 690 700
AALVNAPENR LVKGTAYHWD LLLLAIINTG LSLFGLPWIH AAYPHSPLHV
710 720 730 740 750
RALALVEERV ENGHIYETIV DVKETRLTAL GASVLVGLSL LLLPFPLQWI
760 770 780 790 800
PKPVLYGLFL YIALTSLDGN QLFSRVALLL KEQTSYPPTH YIRRVPQRKI
810 820 830 840 850
HYFTGLQILQ LLLLCAFGMS SLPYMKMVFP LIMIAMIPIR YNLLPRIIEA
860
KYLDVMDAEH RP
Length:862
Mass (Da):96,751
Last modified:February 20, 2007 - v1
Checksum:iD8118D841B1B8D6A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511A → T in AAI11885 (PubMed:15489334).Curated
Sequence conflicti850 – 8501A → S in AAI11885 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772162 Genomic DNA. Translation: CAM16451.1.
BC111884 mRNA. Translation: AAI11885.1.
AK141286 mRNA. Translation: BAE24637.1.
CCDSiCCDS38244.1.
RefSeqiNP_001074631.1. NM_001081162.1.
UniGeneiMm.441391.

Genome annotation databases

EnsembliENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796.
GeneIDi269356.
KEGGimmu:269356.
UCSCiuc008mjv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772162 Genomic DNA. Translation: CAM16451.1.
BC111884 mRNA. Translation: AAI11885.1.
AK141286 mRNA. Translation: BAE24637.1.
CCDSiCCDS38244.1.
RefSeqiNP_001074631.1. NM_001081162.1.
UniGeneiMm.441391.

3D structure databases

ProteinModelPortaliA2AJN7.
SMRiA2AJN7. Positions 322-369, 770-802.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA2AJN7.

Proteomic databases

PaxDbiA2AJN7.
PRIDEiA2AJN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099362; ENSMUSP00000096963; ENSMUSG00000074796.
GeneIDi269356.
KEGGimmu:269356.
UCSCiuc008mjv.1. mouse.

Organism-specific databases

CTDi83959.
MGIiMGI:2138987. Slc4a11.

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000016966.
HOVERGENiHBG079162.
InParanoidiA2AJN7.
KOiK13862.
OMAiRRFPVYP.
OrthoDBiEOG7M6D7V.
PhylomeDBiA2AJN7.
TreeFamiTF313630.

Miscellaneous databases

NextBioi392801.
PROiA2AJN7.
SOURCEiSearch...

Gene expression databases

BgeeiA2AJN7.
ExpressionAtlasiA2AJN7. baseline and differential.
GenevestigatoriA2AJN7.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF00955. HCO3_cotransp. 1 hit.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-862.
    Strain: C57BL/6J.
  4. "SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria."
    Groger N., Frohlich H., Maier H., Olbrich A., Kostin S., Braun T., Boettger T.
    J. Biol. Chem. 285:14467-14474(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS4A11_MOUSE
AccessioniPrimary (citable) accession number: A2AJN7
Secondary accession number(s): Q0VG86, Q3URQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: February 20, 2007
Last modified: March 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.