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A2AJK6

- CHD7_MOUSE

UniProt

A2AJK6 - CHD7_MOUSE

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Protein

Chromodomain-helicase-DNA-binding protein 7

Gene

Chd7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi983 – 9908ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. chromatin binding Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. adult heart development Source: MGI
  2. adult walking behavior Source: MGI
  3. artery morphogenesis Source: MGI
  4. blood circulation Source: MGI
  5. blood vessel development Source: MGI
  6. camera-type eye development Source: MGI
  7. chromatin modification Source: UniProtKB-KW
  8. cognition Source: Ensembl
  9. ear morphogenesis Source: MGI
  10. embryonic hindlimb morphogenesis Source: MGI
  11. epithelium development Source: MGI
  12. face development Source: Ensembl
  13. female genitalia development Source: MGI
  14. heart morphogenesis Source: MGI
  15. inner ear morphogenesis Source: MGI
  16. in utero embryonic development Source: MGI
  17. locomotory behavior Source: MGI
  18. nose development Source: MGI
  19. olfactory behavior Source: MGI
  20. olfactory bulb development Source: MGI
  21. olfactory nerve development Source: MGI
  22. palate development Source: MGI
  23. positive regulation of multicellular organism growth Source: MGI
  24. regulation of growth hormone secretion Source: Ensembl
  25. regulation of neurogenesis Source: MGI
  26. regulation of transcription, DNA-templated Source: UniProtKB-KW
  27. retina development in camera-type eye Source: Ensembl
  28. rRNA processing Source: UniProtKB-KW
  29. semicircular canal morphogenesis Source: MGI
  30. sensory perception of sound Source: MGI
  31. skeletal system development Source: Ensembl
  32. T cell differentiation Source: Ensembl
  33. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

rRNA processing, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 7 (EC:3.6.4.12)
Short name:
CHD-7
Alternative name(s):
ATP-dependent helicase CHD7
Gene namesi
Name:Chd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2444748. Chd7.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29862986Chromodomain-helicase-DNA-binding protein 7PRO_0000289964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei630 – 6301PhosphoserineBy similarity
Modified residuei715 – 7151PhosphoserineBy similarity
Modified residuei1567 – 15671PhosphoserineBy similarity
Modified residuei1571 – 15711PhosphoserineBy similarity
Modified residuei1864 – 18641PhosphoserineBy similarity
Modified residuei2220 – 22201PhosphoserineBy similarity
Modified residuei2222 – 22221PhosphoserineBy similarity
Modified residuei2226 – 22261PhosphoserineBy similarity
Modified residuei2240 – 22401PhosphoserineBy similarity
Modified residuei2261 – 22611PhosphoserineBy similarity
Modified residuei2264 – 22641PhosphoserineBy similarity
Modified residuei2345 – 23451PhosphoserineBy similarity
Modified residuei2384 – 23841PhosphoserineBy similarity
Modified residuei2461 – 24611PhosphothreonineBy similarity
Modified residuei2524 – 25241PhosphoserineBy similarity
Modified residuei2540 – 25401PhosphothreonineBy similarity
Modified residuei2548 – 25481PhosphoserineBy similarity
Modified residuei2608 – 26081PhosphoserineBy similarity
Modified residuei2945 – 29451PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AJK6.
PaxDbiA2AJK6.
PRIDEiA2AJK6.

PTM databases

PhosphoSiteiA2AJK6.

Expressioni

Tissue specificityi

Expressed in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain, olfactory pit, and mandibular component of the first branchial arch.1 Publication

Gene expression databases

BgeeiA2AJK6.
CleanExiMM_CHD7.
ExpressionAtlasiA2AJK6. baseline and differential.
GenevestigatoriA2AJK6.

Interactioni

Subunit structurei

May interact with CTCF. Interacts with CHD8 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Sox2Q60I236EBI-6122905,EBI-6120118

Protein-protein interaction databases

BioGridi236292. 3 interactions.
IntActiA2AJK6. 14 interactions.
MINTiMINT-4117188.

Structurei

3D structure databases

ProteinModelPortaliA2AJK6.
SMRiA2AJK6. Positions 815-1454, 2552-2611, 2620-2704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini790 – 85768Chromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini872 – 93766Chromo 2PROSITE-ProRule annotationAdd
BLAST
Domaini970 – 1144175Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1284 – 1454171Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2390 – 242031Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1095 – 10984DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi115 – 1206Poly-Gly
Compositional biasi150 – 250101Gln-richAdd
BLAST
Compositional biasi377 – 561185Pro-richAdd
BLAST
Compositional biasi590 – 708119Lys-richAdd
BLAST
Compositional biasi1929 – 19357Poly-Arg
Compositional biasi2154 – 224794Glu-richAdd
BLAST
Compositional biasi2387 – 23948Poly-Arg
Compositional biasi2715 – 272511Poly-AlaAdd
BLAST

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 2 chromo domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000246942.
HOVERGENiHBG081150.
InParanoidiA2AJK6.
KOiK14437.
OMAiSYKRQQM.
PhylomeDBiA2AJK6.
TreeFamiTF313572.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001005. SANT/Myb.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2AJK6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADPGMMSLF GEDGSLFSEG LEGLGECGYP ENPVNPMGQQ MPIDQGFPSL
60 70 80 90 100
QPSLHHPSPN QNQTKLTHFD HYSQYEQKMH LMDQPNRMMG SAPGNGLASP
110 120 130 140 150
HSQYHTPPVP QVPHGGGGGG QMGVYPGIQN ERHGQSFVDG GSMWGPRAVQ
160 170 180 190 200
VPDQIRAPYQ QQQPQPAPSG PPAQGHPQHM QQMGSYLARG DFSMQQHGQP
210 220 230 240 250
QQRMGQFSQG QEGLSQGSPF IATSGPGHLS HMPQQSPSMA PSLRHPVQQQ
260 270 280 290 300
FHHHPAALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRN QTVPSPTVNN
310 320 330 340 350
SGQYSRYPYS NLNQGLVNST GMNQNLGLTN STPMNQSVPR YPNAVGFPSN
360 370 380 390 400
SGQGLVHQQP IHSSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA
410 420 430 440 450
GTPPPQVRPG SAGMPMEVGS YPNMPHPQPS HQPPGAMGIG QRNMGPRNMQ
460 470 480 490 500
QPRSFMGMSS APRELTGHMR PNGCPGVGLA DPQAIQERLI PGQQHPGQQP
510 520 530 540 550
SFQQLPTCPP LQPHPGLHQS SPPHPHHQPW AQLHPSPQNT PQKVPVHQHS
560 570 580 590 600
PSEPFLEKPV PDMTQVSAQN AQLVKSDDYL PSIEQQPQQK KKKKKNNHIA
610 620 630 640 650
AGDSSKGFGK DDFPGGVENQ ELRRNSLDVS QEEKKKKKRP KVKKDPKESK
660 670 680 690 700
EPKEKKEPKT PKAPKIPKEP KEKKAKTVTP KPKSSKKSSN KKPDSEASAL
710 720 730 740 750
KKKVNKGKTE GSENSDLDKT PPPSPAPEED EDPGVQKRRS SRQVKRKRYT
760 770 780 790 800
EDLEFKISDE EADDADAAGR DSPSNTSQSE QQESVDAEGP VVEKIMSSRL
810 820 830 840 850
VKKQKESGEE VEVEEFYVKY KNFSYLHCQW ASVEDLEKDK RIQQKIKRFK
860 870 880 890 900
SKQGQSKFLS EIEDDLFNPD YVEVDRIMDF ARSTDDRGEP VIHYLVKWCS
910 920 930 940 950
LPYEDSTWEL KQDIDQTKIE EFEKLMSREP ETERVERPPA DDWKKSESSR
960 970 980 990 1000
EYKNNNKLRE YQLEGVNWLL FNWYNMRNCI LADEMGLGKT IQSITFLYEI
1010 1020 1030 1040 1050
YLKGIHGPFL VIAPLSTIPN WEREFRTWTE LNVVVYHGSQ ASRRTIQLYE
1060 1070 1080 1090 1100
MYFKDPQGRV IKGSYKFHAI ITTFEMILTD CPELRNIPWR CVVIDEAHRL
1110 1120 1130 1140 1150
KNRNCKLLEG LKMMDLEHKV LLTGTPLQNT VEELFSLLHF LEPSRFPSET
1160 1170 1180 1190 1200
TFMQEFGDLK TEEQVQKLQA ILKPMMLRRL KEDVEKNLAP KEETIIEVEL
1210 1220 1230 1240 1250
TNIQKKYYRA ILEKNFTFLS KGGGQANVPN LLNTMMELRK CCNHPYLING
1260 1270 1280 1290 1300
AEEKILEEFK ETHNAESPDF QLQAMIQAAG KLVLIDKLLP KLKAGGHRVL
1310 1320 1330 1340 1350
IFSQMVRCLD ILEDYLIQRR YPYERIDGRV RGNLRQAAID RFSKPDSDRF
1360 1370 1380 1390 1400
VFLLCTRAGG LGINLTAADT CIIFDSDWNP QNDLQAQARC HRIGQSKSVK
1410 1420 1430 1440 1450
IYRLITRNSY EREMFDKASL KLGLDKAVLQ SMSGRENATN GVQQLSKKEI
1460 1470 1480 1490 1500
EDLLRKGAYG ALMDEEDEGS KFCEEDIDQI LLRRTHTITI ESEGKGSTFA
1510 1520 1530 1540 1550
KASFVASGNR TDISLDDPNF WQKWAKKAEL DIDALNGRNN LVIDTPRVRK
1560 1570 1580 1590 1600
QTRLYSAVKE DELMEFSDLE SDSEEKPCAK PRRPQDKSQG YARSECFRVE
1610 1620 1630 1640 1650
KNLLVYGWGR WTDILSHGRY KRQLTEQDVE TICRAILVYC LNHYRGDENI
1660 1670 1680 1690 1700
KSFIWDLITP TADGQTRALL NHSGLSAPVP RGRKGKKVKA QSTQPVVHDA
1710 1720 1730 1740 1750
HWLASCNPDA LFQEDSYKKH LKHHCNKVLL RVRMLYYLRQ EVIGDQAEKI
1760 1770 1780 1790 1800
LEGADSSEAD VWIPEPFHAE VPTDWWDREA DKSLLIGVFK HGYEKYNSMR
1810 1820 1830 1840 1850
ADPALCFLER VGMPDAKAIA AEQRGTDMLA DGGDGGEFDR EDEDPEYKPT
1860 1870 1880 1890 1900
RAPFKDEIDE FANSPAEDKE ESMEVHSSGK HSESNAELGQ LYWPNTSTLT
1910 1920 1930 1940 1950
TRLRRLITAY QRSYKRQQMR QEALMKTDRR RRRPREEVRA LEAEREAIIS
1960 1970 1980 1990 2000
EKRQKWTRRE EADFYRVVST FGVIFDPVKQ QFDWNQFRAF ARLDKKSDES
2010 2020 2030 2040 2050
LGKYFSCFVA MCRRVCRMPA KPEDEPPDLA SLIEPITEER ASRTLYRIEL
2060 2070 2080 2090 2100
LRKIREQVLH HPQLSDRLKL CQPSLDLPEW WECGRHDRDL LVGAAKHGVS
2110 2120 2130 2140 2150
RTDYHILNDP ELSFLDAHKS FAQNRGASTV PPLNTLAMGF GQTPPVISSA
2160 2170 2180 2190 2200
HVHEEKAMEQ AEGKAEECEH SPAKERSDGK EEEEEAGGAK DGKQECEVEA
2210 2220 2230 2240 2250
SSVKGELKGV EGSADPGSKS VSEKGSEEDE EEKLEDDDKS EESSQPEAGA
2260 2270 2280 2290 2300
VSRGKTFDEE SNASLSTARD ETRDGFYMED GDASVAQLLH ERTFAFSFWP
2310 2320 2330 2340 2350
KDRVMINRLD NICEAVLKGK WPVNRRQMFD FQGLVPGYPP SAVDSPLQKR
2360 2370 2380 2390 2400
SFAELSMVSQ ASISASEDIT TSPQLSKDDA LNLSVPRQRR RRRRKVEIEA
2410 2420 2430 2440 2450
ERAAKRRNLM EMVAQLRESQ VVSENGQEKV VDLSKASREA TSSTSNFSSL
2460 2470 2480 2490 2500
TSKFILPNVS TPVSDAFKSQ MELLQAGLSR TPTRHMLNGS LVDGEPPMKR
2510 2520 2530 2540 2550
RRGRRKNVEG LDLLFMSHKR TPLSAEDAEV TKAFEEDIET PPIRNIPSPG
2560 2570 2580 2590 2600
QLDPDTRIPV INLEDGTRLV GEDAPKNKDL VDWLKLHPTY TVDMPSYVPK
2610 2620 2630 2640 2650
NTDVLFSSFQ KPKQKRHRCR NPNKLDINTL TGEERVPVVN KRNGKKMGGA
2660 2670 2680 2690 2700
MAPPMKDLPR WLEENPEFAV APDWTDIVKQ SGFVPESMFD RLLTGPVVRG
2710 2720 2730 2740 2750
EGASRRGRRP KSEIARAAAA AAAVASTSGI NPLLVNSLFA GMDLTSLQNL
2760 2770 2780 2790 2800
QNLQSLQLAG LMGFPPGLAT AATAGGDAKS PAAVLPLMLP GMAGLPNVFG
2810 2820 2830 2840 2850
LGGLLNNPLS AATGNTTTAS SQGEPEDGTS KAEEKGNDNE DENRDSEKST
2860 2870 2880 2890 2900
DTVSAADSAN GSVGAATAPA ALPSNPLAFN PFLLSTMAPG LFYPSMFLPP
2910 2920 2930 2940 2950
GLGGLTLPGF PALAGLQNAV GTSEEKAADK AEGGPCKDGE TLEGSDAEEN
2960 2970 2980
LDKTVESSIL EDEVAQGEEL DSLEGGDEIE NTGNDE
Length:2,986
Mass (Da):334,061
Last modified:February 20, 2007 - v1
Checksum:i3CDDC3914E6640EB
GO
Isoform 2 (identifier: A2AJK6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-558: HSPSEPFLEK → VRGADACPVA
     559-2986: Missing.

Note: May be due to an intron retention.

Show »
Length:558
Mass (Da):60,067
Checksum:i6F6238F7991C66FD
GO
Isoform 3 (identifier: A2AJK6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2526-2551: Missing.

Show »
Length:2,960
Mass (Da):331,195
Checksum:i0DE3895F5C467414
GO

Sequence cautioni

The sequence BAE42701.1 differs from that shown. Reason: Frameshift at position 17.
The sequence BAE42701.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021S → T in BAE42783. (PubMed:16141072)Curated
Sequence conflicti130 – 1301N → D in BAE42783. (PubMed:16141072)Curated
Sequence conflicti279 – 2791V → I in BAE42213. (PubMed:16141072)Curated
Sequence conflicti2343 – 23431V → M in AAH34239. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei549 – 55810HSPSEPFLEK → VRGADACPVA in isoform 2. 1 PublicationVSP_026040
Alternative sequencei559 – 29862428Missing in isoform 2. 1 PublicationVSP_026041Add
BLAST
Alternative sequencei2526 – 255126Missing in isoform 3. 1 PublicationVSP_026042Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042727 mRNA. Translation: BAC31343.1.
AK171051 mRNA. Translation: BAE42213.1.
AK171857 mRNA. Translation: BAE42701.1. Sequence problems.
AK172025 mRNA. Translation: BAE42783.1.
AL732627, AL805903 Genomic DNA. Translation: CAM16768.1.
AL732627, AL805903 Genomic DNA. Translation: CAM16769.1.
AL805903, AL732627 Genomic DNA. Translation: CAM25203.1.
AL805903, AL732627 Genomic DNA. Translation: CAM25204.1.
BC034239 mRNA. Translation: AAH34239.2.
CCDSiCCDS38689.1. [A2AJK6-1]
RefSeqiNP_001264078.1. NM_001277149.1. [A2AJK6-1]
XP_006538067.1. XM_006538004.1. [A2AJK6-1]
UniGeneiMm.138792.

Genome annotation databases

EnsembliENSMUST00000039267; ENSMUSP00000043903; ENSMUSG00000041235. [A2AJK6-1]
ENSMUST00000051558; ENSMUSP00000059079; ENSMUSG00000041235. [A2AJK6-1]
ENSMUST00000127476; ENSMUSP00000118711; ENSMUSG00000041235.
GeneIDi320790.
KEGGimmu:320790.
UCSCiuc008rxy.1. mouse. [A2AJK6-2]
uc008rya.1. mouse. [A2AJK6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042727 mRNA. Translation: BAC31343.1 .
AK171051 mRNA. Translation: BAE42213.1 .
AK171857 mRNA. Translation: BAE42701.1 . Sequence problems.
AK172025 mRNA. Translation: BAE42783.1 .
AL732627 , AL805903 Genomic DNA. Translation: CAM16768.1 .
AL732627 , AL805903 Genomic DNA. Translation: CAM16769.1 .
AL805903 , AL732627 Genomic DNA. Translation: CAM25203.1 .
AL805903 , AL732627 Genomic DNA. Translation: CAM25204.1 .
BC034239 mRNA. Translation: AAH34239.2 .
CCDSi CCDS38689.1. [A2AJK6-1 ]
RefSeqi NP_001264078.1. NM_001277149.1. [A2AJK6-1 ]
XP_006538067.1. XM_006538004.1. [A2AJK6-1 ]
UniGenei Mm.138792.

3D structure databases

ProteinModelPortali A2AJK6.
SMRi A2AJK6. Positions 815-1454, 2552-2611, 2620-2704.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 236292. 3 interactions.
IntActi A2AJK6. 14 interactions.
MINTi MINT-4117188.

PTM databases

PhosphoSitei A2AJK6.

Proteomic databases

MaxQBi A2AJK6.
PaxDbi A2AJK6.
PRIDEi A2AJK6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039267 ; ENSMUSP00000043903 ; ENSMUSG00000041235 . [A2AJK6-1 ]
ENSMUST00000051558 ; ENSMUSP00000059079 ; ENSMUSG00000041235 . [A2AJK6-1 ]
ENSMUST00000127476 ; ENSMUSP00000118711 ; ENSMUSG00000041235 .
GeneIDi 320790.
KEGGi mmu:320790.
UCSCi uc008rxy.1. mouse. [A2AJK6-2 ]
uc008rya.1. mouse. [A2AJK6-1 ]

Organism-specific databases

CTDi 55636.
MGIi MGI:2444748. Chd7.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00760000119067.
HOGENOMi HOG000246942.
HOVERGENi HBG081150.
InParanoidi A2AJK6.
KOi K14437.
OMAi SYKRQQM.
PhylomeDBi A2AJK6.
TreeFami TF313572.

Miscellaneous databases

NextBioi 397435.
PROi A2AJK6.
SOURCEi Search...

Gene expression databases

Bgeei A2AJK6.
CleanExi MM_CHD7.
ExpressionAtlasi A2AJK6. baseline and differential.
Genevestigatori A2AJK6.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006576. BRK_domain.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001005. SANT/Myb.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEi PS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-590 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2282-2986 (ISOFORM 3).
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCHD7_MOUSE
AccessioniPrimary (citable) accession number: A2AJK6
Secondary accession number(s): Q3TA86
, Q3TAG7, Q3TBU4, Q8C986, Q8K244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3