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A2AJK6

- CHD7_MOUSE

UniProt

A2AJK6 - CHD7_MOUSE

Protein

Chromodomain-helicase-DNA-binding protein 7

Gene

Chd7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi983 – 9908ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. chromatin binding Source: InterPro
    3. DNA binding Source: UniProtKB-KW
    4. helicase activity Source: UniProtKB-KW
    5. protein binding Source: IntAct

    GO - Biological processi

    1. adult heart development Source: MGI
    2. adult walking behavior Source: MGI
    3. artery morphogenesis Source: MGI
    4. blood circulation Source: MGI
    5. blood vessel development Source: MGI
    6. camera-type eye development Source: MGI
    7. chromatin modification Source: UniProtKB-KW
    8. cognition Source: Ensembl
    9. ear morphogenesis Source: MGI
    10. embryonic hindlimb morphogenesis Source: MGI
    11. epithelium development Source: MGI
    12. face development Source: Ensembl
    13. female genitalia development Source: MGI
    14. heart morphogenesis Source: MGI
    15. inner ear morphogenesis Source: MGI
    16. in utero embryonic development Source: MGI
    17. locomotory behavior Source: MGI
    18. nose development Source: MGI
    19. olfactory behavior Source: MGI
    20. olfactory bulb development Source: MGI
    21. olfactory nerve development Source: MGI
    22. palate development Source: MGI
    23. positive regulation of multicellular organism growth Source: MGI
    24. regulation of growth hormone secretion Source: Ensembl
    25. regulation of neurogenesis Source: MGI
    26. regulation of transcription, DNA-templated Source: UniProtKB-KW
    27. retina development in camera-type eye Source: Ensembl
    28. rRNA processing Source: UniProtKB-KW
    29. semicircular canal morphogenesis Source: MGI
    30. sensory perception of sound Source: MGI
    31. skeletal system development Source: Ensembl
    32. T cell differentiation Source: Ensembl
    33. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Helicase, Hydrolase

    Keywords - Biological processi

    rRNA processing, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 7 (EC:3.6.4.12)
    Short name:
    CHD-7
    Alternative name(s):
    ATP-dependent helicase CHD7
    Gene namesi
    Name:Chd7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2444748. Chd7.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 29862986Chromodomain-helicase-DNA-binding protein 7PRO_0000289964Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei630 – 6301PhosphoserineBy similarity
    Modified residuei715 – 7151PhosphoserineBy similarity
    Modified residuei1567 – 15671PhosphoserineBy similarity
    Modified residuei1571 – 15711PhosphoserineBy similarity
    Modified residuei1864 – 18641PhosphoserineBy similarity
    Modified residuei2220 – 22201PhosphoserineBy similarity
    Modified residuei2222 – 22221PhosphoserineBy similarity
    Modified residuei2226 – 22261PhosphoserineBy similarity
    Modified residuei2240 – 22401PhosphoserineBy similarity
    Modified residuei2261 – 22611PhosphoserineBy similarity
    Modified residuei2264 – 22641PhosphoserineBy similarity
    Modified residuei2345 – 23451PhosphoserineBy similarity
    Modified residuei2384 – 23841PhosphoserineBy similarity
    Modified residuei2461 – 24611PhosphothreonineBy similarity
    Modified residuei2524 – 25241PhosphoserineBy similarity
    Modified residuei2540 – 25401PhosphothreonineBy similarity
    Modified residuei2548 – 25481PhosphoserineBy similarity
    Modified residuei2608 – 26081PhosphoserineBy similarity
    Modified residuei2945 – 29451PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA2AJK6.
    PRIDEiA2AJK6.

    PTM databases

    PhosphoSiteiA2AJK6.

    Expressioni

    Tissue specificityi

    Expressed in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain, olfactory pit, and mandibular component of the first branchial arch.1 Publication

    Gene expression databases

    ArrayExpressiA2AJK6.
    BgeeiA2AJK6.
    CleanExiMM_CHD7.
    GenevestigatoriA2AJK6.

    Interactioni

    Subunit structurei

    May interact with CTCF. Interacts with CHD8 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Sox2Q60I236EBI-6122905,EBI-6120118

    Protein-protein interaction databases

    BioGridi236292. 3 interactions.
    IntActiA2AJK6. 14 interactions.
    MINTiMINT-4117188.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AJK6.
    SMRiA2AJK6. Positions 815-1454, 2552-2611, 2620-2704.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini790 – 85768Chromo 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini872 – 93766Chromo 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini970 – 1144175Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1284 – 1454171Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili2390 – 242031Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1095 – 10984DEAH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi115 – 1206Poly-Gly
    Compositional biasi150 – 250101Gln-richAdd
    BLAST
    Compositional biasi377 – 561185Pro-richAdd
    BLAST
    Compositional biasi590 – 708119Lys-richAdd
    BLAST
    Compositional biasi1929 – 19357Poly-Arg
    Compositional biasi2154 – 224794Glu-richAdd
    BLAST
    Compositional biasi2387 – 23948Poly-Arg
    Compositional biasi2715 – 272511Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated
    Contains 2 chromo domains.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0553.
    GeneTreeiENSGT00560000077077.
    HOGENOMiHOG000246942.
    HOVERGENiHBG081150.
    InParanoidiA2AJK6.
    KOiK14437.
    OMAiSYKRQQM.
    PhylomeDBiA2AJK6.
    TreeFamiTF313572.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR006576. BRK_domain.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001005. SANT/Myb.
    IPR000330. SNF2_N.
    [Graphical view]
    PfamiPF07533. BRK. 2 hits.
    PF00385. Chromo. 2 hits.
    PF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    SMARTiSM00592. BRK. 2 hits.
    SM00298. CHROMO. 2 hits.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00717. SANT. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF54160. SSF54160. 2 hits.
    PROSITEiPS50013. CHROMO_2. 2 hits.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2AJK6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADPGMMSLF GEDGSLFSEG LEGLGECGYP ENPVNPMGQQ MPIDQGFPSL     50
    QPSLHHPSPN QNQTKLTHFD HYSQYEQKMH LMDQPNRMMG SAPGNGLASP 100
    HSQYHTPPVP QVPHGGGGGG QMGVYPGIQN ERHGQSFVDG GSMWGPRAVQ 150
    VPDQIRAPYQ QQQPQPAPSG PPAQGHPQHM QQMGSYLARG DFSMQQHGQP 200
    QQRMGQFSQG QEGLSQGSPF IATSGPGHLS HMPQQSPSMA PSLRHPVQQQ 250
    FHHHPAALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRN QTVPSPTVNN 300
    SGQYSRYPYS NLNQGLVNST GMNQNLGLTN STPMNQSVPR YPNAVGFPSN 350
    SGQGLVHQQP IHSSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA 400
    GTPPPQVRPG SAGMPMEVGS YPNMPHPQPS HQPPGAMGIG QRNMGPRNMQ 450
    QPRSFMGMSS APRELTGHMR PNGCPGVGLA DPQAIQERLI PGQQHPGQQP 500
    SFQQLPTCPP LQPHPGLHQS SPPHPHHQPW AQLHPSPQNT PQKVPVHQHS 550
    PSEPFLEKPV PDMTQVSAQN AQLVKSDDYL PSIEQQPQQK KKKKKNNHIA 600
    AGDSSKGFGK DDFPGGVENQ ELRRNSLDVS QEEKKKKKRP KVKKDPKESK 650
    EPKEKKEPKT PKAPKIPKEP KEKKAKTVTP KPKSSKKSSN KKPDSEASAL 700
    KKKVNKGKTE GSENSDLDKT PPPSPAPEED EDPGVQKRRS SRQVKRKRYT 750
    EDLEFKISDE EADDADAAGR DSPSNTSQSE QQESVDAEGP VVEKIMSSRL 800
    VKKQKESGEE VEVEEFYVKY KNFSYLHCQW ASVEDLEKDK RIQQKIKRFK 850
    SKQGQSKFLS EIEDDLFNPD YVEVDRIMDF ARSTDDRGEP VIHYLVKWCS 900
    LPYEDSTWEL KQDIDQTKIE EFEKLMSREP ETERVERPPA DDWKKSESSR 950
    EYKNNNKLRE YQLEGVNWLL FNWYNMRNCI LADEMGLGKT IQSITFLYEI 1000
    YLKGIHGPFL VIAPLSTIPN WEREFRTWTE LNVVVYHGSQ ASRRTIQLYE 1050
    MYFKDPQGRV IKGSYKFHAI ITTFEMILTD CPELRNIPWR CVVIDEAHRL 1100
    KNRNCKLLEG LKMMDLEHKV LLTGTPLQNT VEELFSLLHF LEPSRFPSET 1150
    TFMQEFGDLK TEEQVQKLQA ILKPMMLRRL KEDVEKNLAP KEETIIEVEL 1200
    TNIQKKYYRA ILEKNFTFLS KGGGQANVPN LLNTMMELRK CCNHPYLING 1250
    AEEKILEEFK ETHNAESPDF QLQAMIQAAG KLVLIDKLLP KLKAGGHRVL 1300
    IFSQMVRCLD ILEDYLIQRR YPYERIDGRV RGNLRQAAID RFSKPDSDRF 1350
    VFLLCTRAGG LGINLTAADT CIIFDSDWNP QNDLQAQARC HRIGQSKSVK 1400
    IYRLITRNSY EREMFDKASL KLGLDKAVLQ SMSGRENATN GVQQLSKKEI 1450
    EDLLRKGAYG ALMDEEDEGS KFCEEDIDQI LLRRTHTITI ESEGKGSTFA 1500
    KASFVASGNR TDISLDDPNF WQKWAKKAEL DIDALNGRNN LVIDTPRVRK 1550
    QTRLYSAVKE DELMEFSDLE SDSEEKPCAK PRRPQDKSQG YARSECFRVE 1600
    KNLLVYGWGR WTDILSHGRY KRQLTEQDVE TICRAILVYC LNHYRGDENI 1650
    KSFIWDLITP TADGQTRALL NHSGLSAPVP RGRKGKKVKA QSTQPVVHDA 1700
    HWLASCNPDA LFQEDSYKKH LKHHCNKVLL RVRMLYYLRQ EVIGDQAEKI 1750
    LEGADSSEAD VWIPEPFHAE VPTDWWDREA DKSLLIGVFK HGYEKYNSMR 1800
    ADPALCFLER VGMPDAKAIA AEQRGTDMLA DGGDGGEFDR EDEDPEYKPT 1850
    RAPFKDEIDE FANSPAEDKE ESMEVHSSGK HSESNAELGQ LYWPNTSTLT 1900
    TRLRRLITAY QRSYKRQQMR QEALMKTDRR RRRPREEVRA LEAEREAIIS 1950
    EKRQKWTRRE EADFYRVVST FGVIFDPVKQ QFDWNQFRAF ARLDKKSDES 2000
    LGKYFSCFVA MCRRVCRMPA KPEDEPPDLA SLIEPITEER ASRTLYRIEL 2050
    LRKIREQVLH HPQLSDRLKL CQPSLDLPEW WECGRHDRDL LVGAAKHGVS 2100
    RTDYHILNDP ELSFLDAHKS FAQNRGASTV PPLNTLAMGF GQTPPVISSA 2150
    HVHEEKAMEQ AEGKAEECEH SPAKERSDGK EEEEEAGGAK DGKQECEVEA 2200
    SSVKGELKGV EGSADPGSKS VSEKGSEEDE EEKLEDDDKS EESSQPEAGA 2250
    VSRGKTFDEE SNASLSTARD ETRDGFYMED GDASVAQLLH ERTFAFSFWP 2300
    KDRVMINRLD NICEAVLKGK WPVNRRQMFD FQGLVPGYPP SAVDSPLQKR 2350
    SFAELSMVSQ ASISASEDIT TSPQLSKDDA LNLSVPRQRR RRRRKVEIEA 2400
    ERAAKRRNLM EMVAQLRESQ VVSENGQEKV VDLSKASREA TSSTSNFSSL 2450
    TSKFILPNVS TPVSDAFKSQ MELLQAGLSR TPTRHMLNGS LVDGEPPMKR 2500
    RRGRRKNVEG LDLLFMSHKR TPLSAEDAEV TKAFEEDIET PPIRNIPSPG 2550
    QLDPDTRIPV INLEDGTRLV GEDAPKNKDL VDWLKLHPTY TVDMPSYVPK 2600
    NTDVLFSSFQ KPKQKRHRCR NPNKLDINTL TGEERVPVVN KRNGKKMGGA 2650
    MAPPMKDLPR WLEENPEFAV APDWTDIVKQ SGFVPESMFD RLLTGPVVRG 2700
    EGASRRGRRP KSEIARAAAA AAAVASTSGI NPLLVNSLFA GMDLTSLQNL 2750
    QNLQSLQLAG LMGFPPGLAT AATAGGDAKS PAAVLPLMLP GMAGLPNVFG 2800
    LGGLLNNPLS AATGNTTTAS SQGEPEDGTS KAEEKGNDNE DENRDSEKST 2850
    DTVSAADSAN GSVGAATAPA ALPSNPLAFN PFLLSTMAPG LFYPSMFLPP 2900
    GLGGLTLPGF PALAGLQNAV GTSEEKAADK AEGGPCKDGE TLEGSDAEEN 2950
    LDKTVESSIL EDEVAQGEEL DSLEGGDEIE NTGNDE 2986
    Length:2,986
    Mass (Da):334,061
    Last modified:February 20, 2007 - v1
    Checksum:i3CDDC3914E6640EB
    GO
    Isoform 2 (identifier: A2AJK6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         549-558: HSPSEPFLEK → VRGADACPVA
         559-2986: Missing.

    Note: May be due to an intron retention.

    Show »
    Length:558
    Mass (Da):60,067
    Checksum:i6F6238F7991C66FD
    GO
    Isoform 3 (identifier: A2AJK6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2526-2551: Missing.

    Show »
    Length:2,960
    Mass (Da):331,195
    Checksum:i0DE3895F5C467414
    GO

    Sequence cautioni

    The sequence BAE42701.1 differs from that shown. Reason: Frameshift at position 17.
    The sequence BAE42701.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021S → T in BAE42783. (PubMed:16141072)Curated
    Sequence conflicti130 – 1301N → D in BAE42783. (PubMed:16141072)Curated
    Sequence conflicti279 – 2791V → I in BAE42213. (PubMed:16141072)Curated
    Sequence conflicti2343 – 23431V → M in AAH34239. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei549 – 55810HSPSEPFLEK → VRGADACPVA in isoform 2. 1 PublicationVSP_026040
    Alternative sequencei559 – 29862428Missing in isoform 2. 1 PublicationVSP_026041Add
    BLAST
    Alternative sequencei2526 – 255126Missing in isoform 3. 1 PublicationVSP_026042Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042727 mRNA. Translation: BAC31343.1.
    AK171051 mRNA. Translation: BAE42213.1.
    AK171857 mRNA. Translation: BAE42701.1. Sequence problems.
    AK172025 mRNA. Translation: BAE42783.1.
    AL732627, AL805903 Genomic DNA. Translation: CAM16768.1.
    AL732627, AL805903 Genomic DNA. Translation: CAM16769.1.
    AL805903, AL732627 Genomic DNA. Translation: CAM25203.1.
    AL805903, AL732627 Genomic DNA. Translation: CAM25204.1.
    BC034239 mRNA. Translation: AAH34239.2.
    CCDSiCCDS38689.1. [A2AJK6-1]
    RefSeqiNP_001264078.1. NM_001277149.1. [A2AJK6-1]
    XP_006538067.1. XM_006538004.1. [A2AJK6-1]
    UniGeneiMm.138792.

    Genome annotation databases

    EnsembliENSMUST00000039267; ENSMUSP00000043903; ENSMUSG00000041235. [A2AJK6-1]
    ENSMUST00000051558; ENSMUSP00000059079; ENSMUSG00000041235. [A2AJK6-1]
    ENSMUST00000127476; ENSMUSP00000118711; ENSMUSG00000041235.
    GeneIDi320790.
    KEGGimmu:320790.
    UCSCiuc008rxy.1. mouse. [A2AJK6-2]
    uc008rya.1. mouse. [A2AJK6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042727 mRNA. Translation: BAC31343.1 .
    AK171051 mRNA. Translation: BAE42213.1 .
    AK171857 mRNA. Translation: BAE42701.1 . Sequence problems.
    AK172025 mRNA. Translation: BAE42783.1 .
    AL732627 , AL805903 Genomic DNA. Translation: CAM16768.1 .
    AL732627 , AL805903 Genomic DNA. Translation: CAM16769.1 .
    AL805903 , AL732627 Genomic DNA. Translation: CAM25203.1 .
    AL805903 , AL732627 Genomic DNA. Translation: CAM25204.1 .
    BC034239 mRNA. Translation: AAH34239.2 .
    CCDSi CCDS38689.1. [A2AJK6-1 ]
    RefSeqi NP_001264078.1. NM_001277149.1. [A2AJK6-1 ]
    XP_006538067.1. XM_006538004.1. [A2AJK6-1 ]
    UniGenei Mm.138792.

    3D structure databases

    ProteinModelPortali A2AJK6.
    SMRi A2AJK6. Positions 815-1454, 2552-2611, 2620-2704.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 236292. 3 interactions.
    IntActi A2AJK6. 14 interactions.
    MINTi MINT-4117188.

    PTM databases

    PhosphoSitei A2AJK6.

    Proteomic databases

    PaxDbi A2AJK6.
    PRIDEi A2AJK6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039267 ; ENSMUSP00000043903 ; ENSMUSG00000041235 . [A2AJK6-1 ]
    ENSMUST00000051558 ; ENSMUSP00000059079 ; ENSMUSG00000041235 . [A2AJK6-1 ]
    ENSMUST00000127476 ; ENSMUSP00000118711 ; ENSMUSG00000041235 .
    GeneIDi 320790.
    KEGGi mmu:320790.
    UCSCi uc008rxy.1. mouse. [A2AJK6-2 ]
    uc008rya.1. mouse. [A2AJK6-1 ]

    Organism-specific databases

    CTDi 55636.
    MGIi MGI:2444748. Chd7.

    Phylogenomic databases

    eggNOGi COG0553.
    GeneTreei ENSGT00560000077077.
    HOGENOMi HOG000246942.
    HOVERGENi HBG081150.
    InParanoidi A2AJK6.
    KOi K14437.
    OMAi SYKRQQM.
    PhylomeDBi A2AJK6.
    TreeFami TF313572.

    Miscellaneous databases

    NextBioi 397435.
    PROi A2AJK6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AJK6.
    Bgeei A2AJK6.
    CleanExi MM_CHD7.
    Genevestigatori A2AJK6.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR006576. BRK_domain.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001005. SANT/Myb.
    IPR000330. SNF2_N.
    [Graphical view ]
    Pfami PF07533. BRK. 2 hits.
    PF00385. Chromo. 2 hits.
    PF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    SMARTi SM00592. BRK. 2 hits.
    SM00298. CHROMO. 2 hits.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00717. SANT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF54160. SSF54160. 2 hits.
    PROSITEi PS50013. CHROMO_2. 2 hits.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-590 (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Cerebellum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2282-2986 (ISOFORM 3).
      Strain: Czech II.
      Tissue: Mammary tumor.
    4. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCHD7_MOUSE
    AccessioniPrimary (citable) accession number: A2AJK6
    Secondary accession number(s): Q3TA86
    , Q3TAG7, Q3TBU4, Q8C986, Q8K244
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3