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A2AJK6 (CHD7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromodomain-helicase-DNA-binding protein 7

Short name=CHD-7
EC=3.6.4.12
Alternative name(s):
ATP-dependent helicase CHD7
Gene names
Name:Chd7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2986 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

May interact with CTCF. Interacts with CHD8 By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain, olfactory pit, and mandibular component of the first branchial arch. Ref.4

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Contains 2 chromo domains.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence caution

The sequence BAE42701.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAE42701.1 differs from that shown. Reason: Frameshift at position 17.

Ontologies

Keywords
   Biological processrRNA processing
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Molecular functionChromatin regulator
Helicase
Hydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell differentiation

Inferred from electronic annotation. Source: Ensembl

adult heart development

Inferred from mutant phenotype PubMed 16207732. Source: MGI

adult walking behavior

Inferred from mutant phenotype PubMed 16207732. Source: MGI

artery morphogenesis

Inferred from genetic interaction PubMed 19855134. Source: MGI

blood circulation

Inferred from mutant phenotype PubMed 16207732. Source: MGI

blood vessel development

Inferred from mutant phenotype PubMed 16207732. Source: MGI

camera-type eye development

Inferred from mutant phenotype PubMed 16207732. Source: MGI

chromatin modification

Inferred from electronic annotation. Source: UniProtKB-KW

cognition

Inferred from electronic annotation. Source: Ensembl

ear morphogenesis

Inferred from mutant phenotype PubMed 10932191. Source: MGI

embryonic hindlimb morphogenesis

Inferred from mutant phenotype PubMed 16207732. Source: MGI

epithelium development

Inferred from mutant phenotype PubMed 19279158. Source: MGI

face development

Inferred from electronic annotation. Source: Ensembl

female genitalia development

Inferred from mutant phenotype PubMed 16207732. Source: MGI

heart morphogenesis

Inferred from mutant phenotype PubMed 16207732. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 16207732. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 15353999. Source: MGI

locomotory behavior

Inferred from mutant phenotype PubMed 10932191. Source: MGI

nose development

Inferred from mutant phenotype PubMed 16207732. Source: MGI

olfactory behavior

Inferred from mutant phenotype PubMed 19279158. Source: MGI

olfactory bulb development

Inferred from mutant phenotype PubMed 19279158. Source: MGI

olfactory nerve development

Inferred from mutant phenotype PubMed 19279158. Source: MGI

palate development

Inferred from mutant phenotype PubMed 16207732. Source: MGI

positive regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 16207732. Source: MGI

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of growth hormone secretion

Inferred from electronic annotation. Source: Ensembl

regulation of neurogenesis

Inferred from mutant phenotype PubMed 19279158. Source: MGI

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

retina development in camera-type eye

Inferred from electronic annotation. Source: Ensembl

semicircular canal morphogenesis

Inferred from genetic interaction PubMed 19855134. Source: MGI

sensory perception of sound

Inferred from mutant phenotype PubMed 10932191. Source: MGI

skeletal system development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin binding

Inferred from electronic annotation. Source: InterPro

helicase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sox2Q60I236EBI-6122905,EBI-6120118

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2AJK6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2AJK6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     549-558: HSPSEPFLEK → VRGADACPVA
     559-2986: Missing.
Note: May be due to an intron retention.
Isoform 3 (identifier: A2AJK6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2526-2551: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 29862986Chromodomain-helicase-DNA-binding protein 7
PRO_0000289964

Regions

Domain790 – 85768Chromo 1
Domain872 – 93766Chromo 2
Domain970 – 1144175Helicase ATP-binding
Domain1284 – 1454171Helicase C-terminal
Nucleotide binding983 – 9908ATP By similarity
Coiled coil2390 – 242031 Potential
Motif1095 – 10984DEAH box
Compositional bias115 – 1206Poly-Gly
Compositional bias150 – 250101Gln-rich
Compositional bias377 – 561185Pro-rich
Compositional bias590 – 708119Lys-rich
Compositional bias1929 – 19357Poly-Arg
Compositional bias2154 – 224794Glu-rich
Compositional bias2387 – 23948Poly-Arg
Compositional bias2715 – 272511Poly-Ala

Amino acid modifications

Modified residue6301Phosphoserine By similarity
Modified residue7151Phosphoserine By similarity
Modified residue15671Phosphoserine By similarity
Modified residue15711Phosphoserine By similarity
Modified residue18641Phosphoserine By similarity
Modified residue22201Phosphoserine By similarity
Modified residue22221Phosphoserine By similarity
Modified residue22261Phosphoserine By similarity
Modified residue22401Phosphoserine By similarity
Modified residue22611Phosphoserine By similarity
Modified residue22641Phosphoserine By similarity
Modified residue23451Phosphoserine By similarity
Modified residue23841Phosphoserine By similarity
Modified residue24611Phosphothreonine By similarity
Modified residue25241Phosphoserine By similarity
Modified residue25401Phosphothreonine By similarity
Modified residue25481Phosphoserine By similarity
Modified residue26081Phosphoserine By similarity
Modified residue29451Phosphoserine By similarity

Natural variations

Alternative sequence549 – 55810HSPSEPFLEK → VRGADACPVA in isoform 2.
VSP_026040
Alternative sequence559 – 29862428Missing in isoform 2.
VSP_026041
Alternative sequence2526 – 255126Missing in isoform 3.
VSP_026042

Experimental info

Sequence conflict1021S → T in BAE42783. Ref.1
Sequence conflict1301N → D in BAE42783. Ref.1
Sequence conflict2791V → I in BAE42213. Ref.1
Sequence conflict23431V → M in AAH34239. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 3CDDC3914E6640EB

FASTA2,986334,061
        10         20         30         40         50         60 
MADPGMMSLF GEDGSLFSEG LEGLGECGYP ENPVNPMGQQ MPIDQGFPSL QPSLHHPSPN 

        70         80         90        100        110        120 
QNQTKLTHFD HYSQYEQKMH LMDQPNRMMG SAPGNGLASP HSQYHTPPVP QVPHGGGGGG 

       130        140        150        160        170        180 
QMGVYPGIQN ERHGQSFVDG GSMWGPRAVQ VPDQIRAPYQ QQQPQPAPSG PPAQGHPQHM 

       190        200        210        220        230        240 
QQMGSYLARG DFSMQQHGQP QQRMGQFSQG QEGLSQGSPF IATSGPGHLS HMPQQSPSMA 

       250        260        270        280        290        300 
PSLRHPVQQQ FHHHPAALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRN QTVPSPTVNN 

       310        320        330        340        350        360 
SGQYSRYPYS NLNQGLVNST GMNQNLGLTN STPMNQSVPR YPNAVGFPSN SGQGLVHQQP 

       370        380        390        400        410        420 
IHSSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA GTPPPQVRPG SAGMPMEVGS 

       430        440        450        460        470        480 
YPNMPHPQPS HQPPGAMGIG QRNMGPRNMQ QPRSFMGMSS APRELTGHMR PNGCPGVGLA 

       490        500        510        520        530        540 
DPQAIQERLI PGQQHPGQQP SFQQLPTCPP LQPHPGLHQS SPPHPHHQPW AQLHPSPQNT 

       550        560        570        580        590        600 
PQKVPVHQHS PSEPFLEKPV PDMTQVSAQN AQLVKSDDYL PSIEQQPQQK KKKKKNNHIA 

       610        620        630        640        650        660 
AGDSSKGFGK DDFPGGVENQ ELRRNSLDVS QEEKKKKKRP KVKKDPKESK EPKEKKEPKT 

       670        680        690        700        710        720 
PKAPKIPKEP KEKKAKTVTP KPKSSKKSSN KKPDSEASAL KKKVNKGKTE GSENSDLDKT 

       730        740        750        760        770        780 
PPPSPAPEED EDPGVQKRRS SRQVKRKRYT EDLEFKISDE EADDADAAGR DSPSNTSQSE 

       790        800        810        820        830        840 
QQESVDAEGP VVEKIMSSRL VKKQKESGEE VEVEEFYVKY KNFSYLHCQW ASVEDLEKDK 

       850        860        870        880        890        900 
RIQQKIKRFK SKQGQSKFLS EIEDDLFNPD YVEVDRIMDF ARSTDDRGEP VIHYLVKWCS 

       910        920        930        940        950        960 
LPYEDSTWEL KQDIDQTKIE EFEKLMSREP ETERVERPPA DDWKKSESSR EYKNNNKLRE 

       970        980        990       1000       1010       1020 
YQLEGVNWLL FNWYNMRNCI LADEMGLGKT IQSITFLYEI YLKGIHGPFL VIAPLSTIPN 

      1030       1040       1050       1060       1070       1080 
WEREFRTWTE LNVVVYHGSQ ASRRTIQLYE MYFKDPQGRV IKGSYKFHAI ITTFEMILTD 

      1090       1100       1110       1120       1130       1140 
CPELRNIPWR CVVIDEAHRL KNRNCKLLEG LKMMDLEHKV LLTGTPLQNT VEELFSLLHF 

      1150       1160       1170       1180       1190       1200 
LEPSRFPSET TFMQEFGDLK TEEQVQKLQA ILKPMMLRRL KEDVEKNLAP KEETIIEVEL 

      1210       1220       1230       1240       1250       1260 
TNIQKKYYRA ILEKNFTFLS KGGGQANVPN LLNTMMELRK CCNHPYLING AEEKILEEFK 

      1270       1280       1290       1300       1310       1320 
ETHNAESPDF QLQAMIQAAG KLVLIDKLLP KLKAGGHRVL IFSQMVRCLD ILEDYLIQRR 

      1330       1340       1350       1360       1370       1380 
YPYERIDGRV RGNLRQAAID RFSKPDSDRF VFLLCTRAGG LGINLTAADT CIIFDSDWNP 

      1390       1400       1410       1420       1430       1440 
QNDLQAQARC HRIGQSKSVK IYRLITRNSY EREMFDKASL KLGLDKAVLQ SMSGRENATN 

      1450       1460       1470       1480       1490       1500 
GVQQLSKKEI EDLLRKGAYG ALMDEEDEGS KFCEEDIDQI LLRRTHTITI ESEGKGSTFA 

      1510       1520       1530       1540       1550       1560 
KASFVASGNR TDISLDDPNF WQKWAKKAEL DIDALNGRNN LVIDTPRVRK QTRLYSAVKE 

      1570       1580       1590       1600       1610       1620 
DELMEFSDLE SDSEEKPCAK PRRPQDKSQG YARSECFRVE KNLLVYGWGR WTDILSHGRY 

      1630       1640       1650       1660       1670       1680 
KRQLTEQDVE TICRAILVYC LNHYRGDENI KSFIWDLITP TADGQTRALL NHSGLSAPVP 

      1690       1700       1710       1720       1730       1740 
RGRKGKKVKA QSTQPVVHDA HWLASCNPDA LFQEDSYKKH LKHHCNKVLL RVRMLYYLRQ 

      1750       1760       1770       1780       1790       1800 
EVIGDQAEKI LEGADSSEAD VWIPEPFHAE VPTDWWDREA DKSLLIGVFK HGYEKYNSMR 

      1810       1820       1830       1840       1850       1860 
ADPALCFLER VGMPDAKAIA AEQRGTDMLA DGGDGGEFDR EDEDPEYKPT RAPFKDEIDE 

      1870       1880       1890       1900       1910       1920 
FANSPAEDKE ESMEVHSSGK HSESNAELGQ LYWPNTSTLT TRLRRLITAY QRSYKRQQMR 

      1930       1940       1950       1960       1970       1980 
QEALMKTDRR RRRPREEVRA LEAEREAIIS EKRQKWTRRE EADFYRVVST FGVIFDPVKQ 

      1990       2000       2010       2020       2030       2040 
QFDWNQFRAF ARLDKKSDES LGKYFSCFVA MCRRVCRMPA KPEDEPPDLA SLIEPITEER 

      2050       2060       2070       2080       2090       2100 
ASRTLYRIEL LRKIREQVLH HPQLSDRLKL CQPSLDLPEW WECGRHDRDL LVGAAKHGVS 

      2110       2120       2130       2140       2150       2160 
RTDYHILNDP ELSFLDAHKS FAQNRGASTV PPLNTLAMGF GQTPPVISSA HVHEEKAMEQ 

      2170       2180       2190       2200       2210       2220 
AEGKAEECEH SPAKERSDGK EEEEEAGGAK DGKQECEVEA SSVKGELKGV EGSADPGSKS 

      2230       2240       2250       2260       2270       2280 
VSEKGSEEDE EEKLEDDDKS EESSQPEAGA VSRGKTFDEE SNASLSTARD ETRDGFYMED 

      2290       2300       2310       2320       2330       2340 
GDASVAQLLH ERTFAFSFWP KDRVMINRLD NICEAVLKGK WPVNRRQMFD FQGLVPGYPP 

      2350       2360       2370       2380       2390       2400 
SAVDSPLQKR SFAELSMVSQ ASISASEDIT TSPQLSKDDA LNLSVPRQRR RRRRKVEIEA 

      2410       2420       2430       2440       2450       2460 
ERAAKRRNLM EMVAQLRESQ VVSENGQEKV VDLSKASREA TSSTSNFSSL TSKFILPNVS 

      2470       2480       2490       2500       2510       2520 
TPVSDAFKSQ MELLQAGLSR TPTRHMLNGS LVDGEPPMKR RRGRRKNVEG LDLLFMSHKR 

      2530       2540       2550       2560       2570       2580 
TPLSAEDAEV TKAFEEDIET PPIRNIPSPG QLDPDTRIPV INLEDGTRLV GEDAPKNKDL 

      2590       2600       2610       2620       2630       2640 
VDWLKLHPTY TVDMPSYVPK NTDVLFSSFQ KPKQKRHRCR NPNKLDINTL TGEERVPVVN 

      2650       2660       2670       2680       2690       2700 
KRNGKKMGGA MAPPMKDLPR WLEENPEFAV APDWTDIVKQ SGFVPESMFD RLLTGPVVRG 

      2710       2720       2730       2740       2750       2760 
EGASRRGRRP KSEIARAAAA AAAVASTSGI NPLLVNSLFA GMDLTSLQNL QNLQSLQLAG 

      2770       2780       2790       2800       2810       2820 
LMGFPPGLAT AATAGGDAKS PAAVLPLMLP GMAGLPNVFG LGGLLNNPLS AATGNTTTAS 

      2830       2840       2850       2860       2870       2880 
SQGEPEDGTS KAEEKGNDNE DENRDSEKST DTVSAADSAN GSVGAATAPA ALPSNPLAFN 

      2890       2900       2910       2920       2930       2940 
PFLLSTMAPG LFYPSMFLPP GLGGLTLPGF PALAGLQNAV GTSEEKAADK AEGGPCKDGE 

      2950       2960       2970       2980 
TLEGSDAEEN LDKTVESSIL EDEVAQGEEL DSLEGGDEIE NTGNDE 

« Hide

Isoform 2 [UniParc].

Checksum: 6F6238F7991C66FD
Show »

FASTA55860,067
Isoform 3 [UniParc].

Checksum: 0DE3895F5C467414
Show »

FASTA2,960331,195

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-590 (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Cerebellum.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2282-2986 (ISOFORM 3).
Strain: Czech II.
Tissue: Mammary tumor.
[4]"Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotype-phenotype correlation."
Lalani S.R., Safiullah A.M., Fernbach S.D., Harutyunyan K.G., Thaller C., Peterson L.E., McPherson J.D., Gibbs R.A., White L.D., Hefner M., Davenport S.L.H., Graham J.M., Bacino C.A., Glass N.L., Towbin J.A., Craigen W.J., Neish S.R., Lin A.E., Belmont J.W.
Am. J. Hum. Genet. 78:303-314(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK042727 mRNA. Translation: BAC31343.1.
AK171051 mRNA. Translation: BAE42213.1.
AK171857 mRNA. Translation: BAE42701.1. Sequence problems.
AK172025 mRNA. Translation: BAE42783.1.
AL732627, AL805903 Genomic DNA. Translation: CAM16768.1.
AL732627, AL805903 Genomic DNA. Translation: CAM16769.1.
AL805903, AL732627 Genomic DNA. Translation: CAM25203.1.
AL805903, AL732627 Genomic DNA. Translation: CAM25204.1.
BC034239 mRNA. Translation: AAH34239.2.
RefSeqNP_001264078.1. NM_001277149.1.
XP_006538067.1. XM_006538004.1.
UniGeneMm.138792.

3D structure databases

ProteinModelPortalA2AJK6.
SMRA2AJK6. Positions 788-1502, 1774-1807, 2552-2611, 2620-2704.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid236292. 2 interactions.
IntActA2AJK6. 14 interactions.
MINTMINT-4117188.

PTM databases

PhosphoSiteA2AJK6.

Proteomic databases

PaxDbA2AJK6.
PRIDEA2AJK6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039267; ENSMUSP00000043903; ENSMUSG00000041235. [A2AJK6-1]
ENSMUST00000051558; ENSMUSP00000059079; ENSMUSG00000041235. [A2AJK6-1]
ENSMUST00000127476; ENSMUSP00000118711; ENSMUSG00000041235.
GeneID320790.
KEGGmmu:320790.
UCSCuc008rxy.1. mouse. [A2AJK6-2]
uc008rya.1. mouse. [A2AJK6-1]

Organism-specific databases

CTD55636.
MGIMGI:2444748. Chd7.

Phylogenomic databases

eggNOGCOG0553.
GeneTreeENSGT00560000077077.
HOGENOMHOG000246942.
HOVERGENHBG081150.
InParanoidA2AJK6.
KOK14437.
OMASYKRQQM.
PhylomeDBA2AJK6.
TreeFamTF313572.

Gene expression databases

ArrayExpressA2AJK6.
BgeeA2AJK6.
CleanExMM_CHD7.
GenevestigatorA2AJK6.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR006576. BRK_domain.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001005. SANT/Myb.
IPR000330. SNF2_N.
[Graphical view]
PfamPF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTSM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEPS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
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Other

NextBio397435.
PROA2AJK6.
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Entry information

Entry nameCHD7_MOUSE
AccessionPrimary (citable) accession number: A2AJK6
Secondary accession number(s): Q3TA86 expand/collapse secondary AC list , Q3TAG7, Q3TBU4, Q8C986, Q8K244
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot