A2AJK6 (CHD7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromodomain-helicase-DNA-binding protein 7
Short name=CHD-7
EC=3.6.4.12

Alternative name(s):
ATP-dependent helicase CHD7

Gene names

Name:

Chd7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2986 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable transcription regulator.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	May interact with CTCF. Interacts with CHD8 By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain, olfactory pit, and mandibular component of the first branchial arch. Ref.4
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. Contains 2 chromo domains. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence BAE42701.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAE42701.1 differs from that shown. Reason: Frameshift at position 17.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Chromatin regulator Helicase Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell differentiation Inferred from electronic annotation. Source: Compara adult heart development Inferred from mutant phenotype PubMed 16207732. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 16207732. Source: MGI artery morphogenesis Inferred from genetic interaction PubMed 19855134. Source: MGI blood circulation Inferred from mutant phenotype PubMed 16207732. Source: MGI camera-type eye development Inferred from mutant phenotype PubMed 16207732. Source: MGI central nervous system development Inferred from electronic annotation. Source: Compara chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW cognition Inferred from electronic annotation. Source: Compara cranial nerve development Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from mutant phenotype PubMed 16207732. Source: MGI face development Inferred from electronic annotation. Source: Compara female genitalia development Inferred from mutant phenotype PubMed 16207732. Source: MGI heart morphogenesis Inferred from mutant phenotype PubMed 16207732. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 16207732. Source: MGI nose development Inferred from mutant phenotype PubMed 16207732. Source: MGI palate development Inferred from mutant phenotype PubMed 16207732. Source: MGI positive regulation of multicellular organism growth Inferred from mutant phenotype PubMed 16207732. Source: MGI regulation of growth hormone secretion Inferred from electronic annotation. Source: Compara regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW retina development in camera-type eye Inferred from electronic annotation. Source: Compara semicircular canal morphogenesis Inferred from genetic interaction PubMed 19855134. Source: MGI sensory perception of sound Inferred from mutant phenotype PubMed 10932191. Source: MGI skeletal system development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Sox2	Q60I23	6	EBI-6122905,EBI-6120118

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2AJK6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2AJK6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     549-558: HSPSEPFLEK → VRGADACPVA
     559-2986: Missing.

Note: May be due to an intron retention.

Isoform 3 (identifier: A2AJK6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2526-2551: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2986	2986	Chromodomain-helicase-DNA-binding protein 7		PRO_0000289964
Regions
	Domain	790 – 857	68	Chromo 1
	Domain	872 – 937	66	Chromo 2
	Domain	970 – 1144	175	Helicase ATP-binding
	Domain	1284 – 1454	171	Helicase C-terminal
	Nucleotide binding	983 – 990	8	ATP By similarity
	Coiled coil	2390 – 2420	31	Potential
	Motif	1095 – 1098	4	DEAH box
	Compositional bias	115 – 120	6	Poly-Gly
	Compositional bias	150 – 250	101	Gln-rich
	Compositional bias	377 – 561	185	Pro-rich
	Compositional bias	590 – 708	119	Lys-rich
	Compositional bias	1929 – 1935	7	Poly-Arg
	Compositional bias	2154 – 2247	94	Glu-rich
	Compositional bias	2387 – 2394	8	Poly-Arg
	Compositional bias	2715 – 2725	11	Poly-Ala
Amino acid modifications
	Modified residue	630	1	Phosphoserine By similarity
	Modified residue	715	1	Phosphoserine By similarity
	Modified residue	1567	1	Phosphoserine By similarity
	Modified residue	1571	1	Phosphoserine By similarity
	Modified residue	1864	1	Phosphoserine By similarity
	Modified residue	2220	1	Phosphoserine By similarity
	Modified residue	2222	1	Phosphoserine By similarity
	Modified residue	2226	1	Phosphoserine By similarity
	Modified residue	2240	1	Phosphoserine By similarity
	Modified residue	2261	1	Phosphoserine By similarity
	Modified residue	2264	1	Phosphoserine By similarity
	Modified residue	2345	1	Phosphoserine By similarity
	Modified residue	2384	1	Phosphoserine By similarity
	Modified residue	2461	1	Phosphothreonine By similarity
	Modified residue	2524	1	Phosphoserine By similarity
	Modified residue	2540	1	Phosphothreonine By similarity
	Modified residue	2548	1	Phosphoserine By similarity
	Modified residue	2608	1	Phosphoserine By similarity
	Modified residue	2945	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	549 – 558	10	HSPSEPFLEK → VRGADACPVA in isoform 2.		VSP_026040
	Alternative sequence	559 – 2986	2428	Missing in isoform 2.		VSP_026041
	Alternative sequence	2526 – 2551	26	Missing in isoform 3.		VSP_026042
Experimental info
	Sequence conflict	102	1	S → T in BAE42783. Ref.1
	Sequence conflict	130	1	N → D in BAE42783. Ref.1
	Sequence conflict	279	1	V → I in BAE42213. Ref.1
	Sequence conflict	2343	1	V → M in AAH34239. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 3CDDC3914E6640EB	FASTA	2,986	334,061
	10 20 30 40 50 60 MADPGMMSLF GEDGSLFSEG LEGLGECGYP ENPVNPMGQQ MPIDQGFPSL QPSLHHPSPN 70 80 90 100 110 120 QNQTKLTHFD HYSQYEQKMH LMDQPNRMMG SAPGNGLASP HSQYHTPPVP QVPHGGGGGG 130 140 150 160 170 180 QMGVYPGIQN ERHGQSFVDG GSMWGPRAVQ VPDQIRAPYQ QQQPQPAPSG PPAQGHPQHM 190 200 210 220 230 240 QQMGSYLARG DFSMQQHGQP QQRMGQFSQG QEGLSQGSPF IATSGPGHLS HMPQQSPSMA 250 260 270 280 290 300 PSLRHPVQQQ FHHHPAALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRN QTVPSPTVNN 310 320 330 340 350 360 SGQYSRYPYS NLNQGLVNST GMNQNLGLTN STPMNQSVPR YPNAVGFPSN SGQGLVHQQP 370 380 390 400 410 420 IHSSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA GTPPPQVRPG SAGMPMEVGS 430 440 450 460 470 480 YPNMPHPQPS HQPPGAMGIG QRNMGPRNMQ QPRSFMGMSS APRELTGHMR PNGCPGVGLA 490 500 510 520 530 540 DPQAIQERLI PGQQHPGQQP SFQQLPTCPP LQPHPGLHQS SPPHPHHQPW AQLHPSPQNT 550 560 570 580 590 600 PQKVPVHQHS PSEPFLEKPV PDMTQVSAQN AQLVKSDDYL PSIEQQPQQK KKKKKNNHIA 610 620 630 640 650 660 AGDSSKGFGK DDFPGGVENQ ELRRNSLDVS QEEKKKKKRP KVKKDPKESK EPKEKKEPKT 670 680 690 700 710 720 PKAPKIPKEP KEKKAKTVTP KPKSSKKSSN KKPDSEASAL KKKVNKGKTE GSENSDLDKT 730 740 750 760 770 780 PPPSPAPEED EDPGVQKRRS SRQVKRKRYT EDLEFKISDE EADDADAAGR DSPSNTSQSE 790 800 810 820 830 840 QQESVDAEGP VVEKIMSSRL VKKQKESGEE VEVEEFYVKY KNFSYLHCQW ASVEDLEKDK 850 860 870 880 890 900 RIQQKIKRFK SKQGQSKFLS EIEDDLFNPD YVEVDRIMDF ARSTDDRGEP VIHYLVKWCS 910 920 930 940 950 960 LPYEDSTWEL KQDIDQTKIE EFEKLMSREP ETERVERPPA DDWKKSESSR EYKNNNKLRE 970 980 990 1000 1010 1020 YQLEGVNWLL FNWYNMRNCI LADEMGLGKT IQSITFLYEI YLKGIHGPFL VIAPLSTIPN 1030 1040 1050 1060 1070 1080 WEREFRTWTE LNVVVYHGSQ ASRRTIQLYE MYFKDPQGRV IKGSYKFHAI ITTFEMILTD 1090 1100 1110 1120 1130 1140 CPELRNIPWR CVVIDEAHRL KNRNCKLLEG LKMMDLEHKV LLTGTPLQNT VEELFSLLHF 1150 1160 1170 1180 1190 1200 LEPSRFPSET TFMQEFGDLK TEEQVQKLQA ILKPMMLRRL KEDVEKNLAP KEETIIEVEL 1210 1220 1230 1240 1250 1260 TNIQKKYYRA ILEKNFTFLS KGGGQANVPN LLNTMMELRK CCNHPYLING AEEKILEEFK 1270 1280 1290 1300 1310 1320 ETHNAESPDF QLQAMIQAAG KLVLIDKLLP KLKAGGHRVL IFSQMVRCLD ILEDYLIQRR 1330 1340 1350 1360 1370 1380 YPYERIDGRV RGNLRQAAID RFSKPDSDRF VFLLCTRAGG LGINLTAADT CIIFDSDWNP 1390 1400 1410 1420 1430 1440 QNDLQAQARC HRIGQSKSVK IYRLITRNSY EREMFDKASL KLGLDKAVLQ SMSGRENATN 1450 1460 1470 1480 1490 1500 GVQQLSKKEI EDLLRKGAYG ALMDEEDEGS KFCEEDIDQI LLRRTHTITI ESEGKGSTFA 1510 1520 1530 1540 1550 1560 KASFVASGNR TDISLDDPNF WQKWAKKAEL DIDALNGRNN LVIDTPRVRK QTRLYSAVKE 1570 1580 1590 1600 1610 1620 DELMEFSDLE SDSEEKPCAK PRRPQDKSQG YARSECFRVE KNLLVYGWGR WTDILSHGRY 1630 1640 1650 1660 1670 1680 KRQLTEQDVE TICRAILVYC LNHYRGDENI KSFIWDLITP TADGQTRALL NHSGLSAPVP 1690 1700 1710 1720 1730 1740 RGRKGKKVKA QSTQPVVHDA HWLASCNPDA LFQEDSYKKH LKHHCNKVLL RVRMLYYLRQ 1750 1760 1770 1780 1790 1800 EVIGDQAEKI LEGADSSEAD VWIPEPFHAE VPTDWWDREA DKSLLIGVFK HGYEKYNSMR 1810 1820 1830 1840 1850 1860 ADPALCFLER VGMPDAKAIA AEQRGTDMLA DGGDGGEFDR EDEDPEYKPT RAPFKDEIDE 1870 1880 1890 1900 1910 1920 FANSPAEDKE ESMEVHSSGK HSESNAELGQ LYWPNTSTLT TRLRRLITAY QRSYKRQQMR 1930 1940 1950 1960 1970 1980 QEALMKTDRR RRRPREEVRA LEAEREAIIS EKRQKWTRRE EADFYRVVST FGVIFDPVKQ 1990 2000 2010 2020 2030 2040 QFDWNQFRAF ARLDKKSDES LGKYFSCFVA MCRRVCRMPA KPEDEPPDLA SLIEPITEER 2050 2060 2070 2080 2090 2100 ASRTLYRIEL LRKIREQVLH HPQLSDRLKL CQPSLDLPEW WECGRHDRDL LVGAAKHGVS 2110 2120 2130 2140 2150 2160 RTDYHILNDP ELSFLDAHKS FAQNRGASTV PPLNTLAMGF GQTPPVISSA HVHEEKAMEQ 2170 2180 2190 2200 2210 2220 AEGKAEECEH SPAKERSDGK EEEEEAGGAK DGKQECEVEA SSVKGELKGV EGSADPGSKS 2230 2240 2250 2260 2270 2280 VSEKGSEEDE EEKLEDDDKS EESSQPEAGA VSRGKTFDEE SNASLSTARD ETRDGFYMED 2290 2300 2310 2320 2330 2340 GDASVAQLLH ERTFAFSFWP KDRVMINRLD NICEAVLKGK WPVNRRQMFD FQGLVPGYPP 2350 2360 2370 2380 2390 2400 SAVDSPLQKR SFAELSMVSQ ASISASEDIT TSPQLSKDDA LNLSVPRQRR RRRRKVEIEA 2410 2420 2430 2440 2450 2460 ERAAKRRNLM EMVAQLRESQ VVSENGQEKV VDLSKASREA TSSTSNFSSL TSKFILPNVS 2470 2480 2490 2500 2510 2520 TPVSDAFKSQ MELLQAGLSR TPTRHMLNGS LVDGEPPMKR RRGRRKNVEG LDLLFMSHKR 2530 2540 2550 2560 2570 2580 TPLSAEDAEV TKAFEEDIET PPIRNIPSPG QLDPDTRIPV INLEDGTRLV GEDAPKNKDL 2590 2600 2610 2620 2630 2640 VDWLKLHPTY TVDMPSYVPK NTDVLFSSFQ KPKQKRHRCR NPNKLDINTL TGEERVPVVN 2650 2660 2670 2680 2690 2700 KRNGKKMGGA MAPPMKDLPR WLEENPEFAV APDWTDIVKQ SGFVPESMFD RLLTGPVVRG 2710 2720 2730 2740 2750 2760 EGASRRGRRP KSEIARAAAA AAAVASTSGI NPLLVNSLFA GMDLTSLQNL QNLQSLQLAG 2770 2780 2790 2800 2810 2820 LMGFPPGLAT AATAGGDAKS PAAVLPLMLP GMAGLPNVFG LGGLLNNPLS AATGNTTTAS 2830 2840 2850 2860 2870 2880 SQGEPEDGTS KAEEKGNDNE DENRDSEKST DTVSAADSAN GSVGAATAPA ALPSNPLAFN 2890 2900 2910 2920 2930 2940 PFLLSTMAPG LFYPSMFLPP GLGGLTLPGF PALAGLQNAV GTSEEKAADK AEGGPCKDGE 2950 2960 2970 2980 TLEGSDAEEN LDKTVESSIL EDEVAQGEEL DSLEGGDEIE NTGNDE
	Isoform 2 [UniParc]. Checksum: 6F6238F7991C66FD	FASTA	558	60,067
	10 20 30 40 50 60 MADPGMMSLF GEDGSLFSEG LEGLGECGYP ENPVNPMGQQ MPIDQGFPSL QPSLHHPSPN 70 80 90 100 110 120 QNQTKLTHFD HYSQYEQKMH LMDQPNRMMG SAPGNGLASP HSQYHTPPVP QVPHGGGGGG 130 140 150 160 170 180 QMGVYPGIQN ERHGQSFVDG GSMWGPRAVQ VPDQIRAPYQ QQQPQPAPSG PPAQGHPQHM 190 200 210 220 230 240 QQMGSYLARG DFSMQQHGQP QQRMGQFSQG QEGLSQGSPF IATSGPGHLS HMPQQSPSMA 250 260 270 280 290 300 PSLRHPVQQQ FHHHPAALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRN QTVPSPTVNN 310 320 330 340 350 360 SGQYSRYPYS NLNQGLVNST GMNQNLGLTN STPMNQSVPR YPNAVGFPSN SGQGLVHQQP 370 380 390 400 410 420 IHSSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA GTPPPQVRPG SAGMPMEVGS 430 440 450 460 470 480 YPNMPHPQPS HQPPGAMGIG QRNMGPRNMQ QPRSFMGMSS APRELTGHMR PNGCPGVGLA 490 500 510 520 530 540 DPQAIQERLI PGQQHPGQQP SFQQLPTCPP LQPHPGLHQS SPPHPHHQPW AQLHPSPQNT 550 PQKVPVHQVR GADACPVA
	Isoform 3 [UniParc]. Checksum: 0DE3895F5C467414	FASTA	2,960	331,195
	10 20 30 40 50 60 MADPGMMSLF GEDGSLFSEG LEGLGECGYP ENPVNPMGQQ MPIDQGFPSL QPSLHHPSPN 70 80 90 100 110 120 QNQTKLTHFD HYSQYEQKMH LMDQPNRMMG SAPGNGLASP HSQYHTPPVP QVPHGGGGGG 130 140 150 160 170 180 QMGVYPGIQN ERHGQSFVDG GSMWGPRAVQ VPDQIRAPYQ QQQPQPAPSG PPAQGHPQHM 190 200 210 220 230 240 QQMGSYLARG DFSMQQHGQP QQRMGQFSQG QEGLSQGSPF IATSGPGHLS HMPQQSPSMA 250 260 270 280 290 300 PSLRHPVQQQ FHHHPAALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRN QTVPSPTVNN 310 320 330 340 350 360 SGQYSRYPYS NLNQGLVNST GMNQNLGLTN STPMNQSVPR YPNAVGFPSN SGQGLVHQQP 370 380 390 400 410 420 IHSSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA GTPPPQVRPG SAGMPMEVGS 430 440 450 460 470 480 YPNMPHPQPS HQPPGAMGIG QRNMGPRNMQ QPRSFMGMSS APRELTGHMR PNGCPGVGLA 490 500 510 520 530 540 DPQAIQERLI PGQQHPGQQP SFQQLPTCPP LQPHPGLHQS SPPHPHHQPW AQLHPSPQNT 550 560 570 580 590 600 PQKVPVHQHS PSEPFLEKPV PDMTQVSAQN AQLVKSDDYL PSIEQQPQQK KKKKKNNHIA 610 620 630 640 650 660 AGDSSKGFGK DDFPGGVENQ ELRRNSLDVS QEEKKKKKRP KVKKDPKESK EPKEKKEPKT 670 680 690 700 710 720 PKAPKIPKEP KEKKAKTVTP KPKSSKKSSN KKPDSEASAL KKKVNKGKTE GSENSDLDKT 730 740 750 760 770 780 PPPSPAPEED EDPGVQKRRS SRQVKRKRYT EDLEFKISDE EADDADAAGR DSPSNTSQSE 790 800 810 820 830 840 QQESVDAEGP VVEKIMSSRL VKKQKESGEE VEVEEFYVKY KNFSYLHCQW ASVEDLEKDK 850 860 870 880 890 900 RIQQKIKRFK SKQGQSKFLS EIEDDLFNPD YVEVDRIMDF ARSTDDRGEP VIHYLVKWCS 910 920 930 940 950 960 LPYEDSTWEL KQDIDQTKIE EFEKLMSREP ETERVERPPA DDWKKSESSR EYKNNNKLRE 970 980 990 1000 1010 1020 YQLEGVNWLL FNWYNMRNCI LADEMGLGKT IQSITFLYEI YLKGIHGPFL VIAPLSTIPN 1030 1040 1050 1060 1070 1080 WEREFRTWTE LNVVVYHGSQ ASRRTIQLYE MYFKDPQGRV IKGSYKFHAI ITTFEMILTD 1090 1100 1110 1120 1130 1140 CPELRNIPWR CVVIDEAHRL KNRNCKLLEG LKMMDLEHKV LLTGTPLQNT VEELFSLLHF 1150 1160 1170 1180 1190 1200 LEPSRFPSET TFMQEFGDLK TEEQVQKLQA ILKPMMLRRL KEDVEKNLAP KEETIIEVEL 1210 1220 1230 1240 1250 1260 TNIQKKYYRA ILEKNFTFLS KGGGQANVPN LLNTMMELRK CCNHPYLING AEEKILEEFK 1270 1280 1290 1300 1310 1320 ETHNAESPDF QLQAMIQAAG KLVLIDKLLP KLKAGGHRVL IFSQMVRCLD ILEDYLIQRR 1330 1340 1350 1360 1370 1380 YPYERIDGRV RGNLRQAAID RFSKPDSDRF VFLLCTRAGG LGINLTAADT CIIFDSDWNP 1390 1400 1410 1420 1430 1440 QNDLQAQARC HRIGQSKSVK IYRLITRNSY EREMFDKASL KLGLDKAVLQ SMSGRENATN 1450 1460 1470 1480 1490 1500 GVQQLSKKEI EDLLRKGAYG ALMDEEDEGS KFCEEDIDQI LLRRTHTITI ESEGKGSTFA 1510 1520 1530 1540 1550 1560 KASFVASGNR TDISLDDPNF WQKWAKKAEL DIDALNGRNN LVIDTPRVRK QTRLYSAVKE 1570 1580 1590 1600 1610 1620 DELMEFSDLE SDSEEKPCAK PRRPQDKSQG YARSECFRVE KNLLVYGWGR WTDILSHGRY 1630 1640 1650 1660 1670 1680 KRQLTEQDVE TICRAILVYC LNHYRGDENI KSFIWDLITP TADGQTRALL NHSGLSAPVP 1690 1700 1710 1720 1730 1740 RGRKGKKVKA QSTQPVVHDA HWLASCNPDA LFQEDSYKKH LKHHCNKVLL RVRMLYYLRQ 1750 1760 1770 1780 1790 1800 EVIGDQAEKI LEGADSSEAD VWIPEPFHAE VPTDWWDREA DKSLLIGVFK HGYEKYNSMR 1810 1820 1830 1840 1850 1860 ADPALCFLER VGMPDAKAIA AEQRGTDMLA DGGDGGEFDR EDEDPEYKPT RAPFKDEIDE 1870 1880 1890 1900 1910 1920 FANSPAEDKE ESMEVHSSGK HSESNAELGQ LYWPNTSTLT TRLRRLITAY QRSYKRQQMR 1930 1940 1950 1960 1970 1980 QEALMKTDRR RRRPREEVRA LEAEREAIIS EKRQKWTRRE EADFYRVVST FGVIFDPVKQ 1990 2000 2010 2020 2030 2040 QFDWNQFRAF ARLDKKSDES LGKYFSCFVA MCRRVCRMPA KPEDEPPDLA SLIEPITEER 2050 2060 2070 2080 2090 2100 ASRTLYRIEL LRKIREQVLH HPQLSDRLKL CQPSLDLPEW WECGRHDRDL LVGAAKHGVS 2110 2120 2130 2140 2150 2160 RTDYHILNDP ELSFLDAHKS FAQNRGASTV PPLNTLAMGF GQTPPVISSA HVHEEKAMEQ 2170 2180 2190 2200 2210 2220 AEGKAEECEH SPAKERSDGK EEEEEAGGAK DGKQECEVEA SSVKGELKGV EGSADPGSKS 2230 2240 2250 2260 2270 2280 VSEKGSEEDE EEKLEDDDKS EESSQPEAGA VSRGKTFDEE SNASLSTARD ETRDGFYMED 2290 2300 2310 2320 2330 2340 GDASVAQLLH ERTFAFSFWP KDRVMINRLD NICEAVLKGK WPVNRRQMFD FQGLVPGYPP 2350 2360 2370 2380 2390 2400 SAVDSPLQKR SFAELSMVSQ ASISASEDIT TSPQLSKDDA LNLSVPRQRR RRRRKVEIEA 2410 2420 2430 2440 2450 2460 ERAAKRRNLM EMVAQLRESQ VVSENGQEKV VDLSKASREA TSSTSNFSSL TSKFILPNVS 2470 2480 2490 2500 2510 2520 TPVSDAFKSQ MELLQAGLSR TPTRHMLNGS LVDGEPPMKR RRGRRKNVEG LDLLFMSHKR 2530 2540 2550 2560 2570 2580 TPLSALDPDT RIPVINLEDG TRLVGEDAPK NKDLVDWLKL HPTYTVDMPS YVPKNTDVLF 2590 2600 2610 2620 2630 2640 SSFQKPKQKR HRCRNPNKLD INTLTGEERV PVVNKRNGKK MGGAMAPPMK DLPRWLEENP 2650 2660 2670 2680 2690 2700 EFAVAPDWTD IVKQSGFVPE SMFDRLLTGP VVRGEGASRR GRRPKSEIAR AAAAAAAVAS 2710 2720 2730 2740 2750 2760 TSGINPLLVN SLFAGMDLTS LQNLQNLQSL QLAGLMGFPP GLATAATAGG DAKSPAAVLP 2770 2780 2790 2800 2810 2820 LMLPGMAGLP NVFGLGGLLN NPLSAATGNT TTASSQGEPE DGTSKAEEKG NDNEDENRDS 2830 2840 2850 2860 2870 2880 EKSTDTVSAA DSANGSVGAA TAPAALPSNP LAFNPFLLST MAPGLFYPSM FLPPGLGGLT 2890 2900 2910 2920 2930 2940 LPGFPALAGL QNAVGTSEEK AADKAEGGPC KDGETLEGSD AEENLDKTVE SSILEDEVAQ 2950 2960 GEELDSLEGG DEIENTGNDE

References

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[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-590 (ISOFORM 1). Strain: C57BL/6J and NOD. Tissue: Cerebellum.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2282-2986 (ISOFORM 3). Strain: Czech II. Tissue: Mammary tumor.
[4]	"Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotype-phenotype correlation." Lalani S.R., Safiullah A.M., Fernbach S.D., Harutyunyan K.G., Thaller C., Peterson L.E., McPherson J.D., Gibbs R.A., White L.D., Hefner M., Davenport S.L.H., Graham J.M., Bacino C.A., Glass N.L., Towbin J.A., Craigen W.J., Neish S.R., Lin A.E., Belmont J.W. Am. J. Hum. Genet. 78:303-314(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK042727 mRNA. Translation: BAC31343.1. AK171051 mRNA. Translation: BAE42213.1. AK171857 mRNA. Translation: BAE42701.1. Sequence problems. AK172025 mRNA. Translation: BAE42783.1. AL732627, AL805903 Genomic DNA. Translation: CAM16768.1. AL732627, AL805903 Genomic DNA. Translation: CAM16769.1. AL805903, AL732627 Genomic DNA. Translation: CAM25203.1. AL805903, AL732627 Genomic DNA. Translation: CAM25204.1. BC034239 mRNA. Translation: AAH34239.2.
IPI	IPI00345676. IPI00666779. IPI00849588.
RefSeq	NP_001074886.1. NM_001081417.1.
UniGene	Mm.138792.
3D structure databases
ProteinModelPortal	A2AJK6.
SMR	A2AJK6. Positions 815-1454, 2552-2611, 2620-2704.
ModBase	Search...
Protein-protein interaction databases
IntAct	A2AJK6. 12 interactions.
PTM databases
PhosphoSite	A2AJK6.
Proteomic databases
PaxDb	A2AJK6.
PRIDE	A2AJK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039267; ENSMUSP00000043903; ENSMUSG00000041235. ENSMUST00000051558; ENSMUSP00000059079; ENSMUSG00000041235. ENSMUST00000127476; ENSMUSP00000118711; ENSMUSG00000041235.
GeneID	320790.
KEGG	mmu:320790.
UCSC	uc008rxy.1. mouse. uc008rya.1. mouse.
Organism-specific databases
CTD	55636.
MGI	MGI:2444748. Chd7.
Phylogenomic databases
eggNOG	COG0553.
GeneTree	ENSGT00560000077077.
HOGENOM	HOG000246942.
HOVERGEN	HBG081150.
InParanoid	A2AJK6.
KO	K14437.
OMA	TFGVIFD.
OrthoDB	EOG4MCWZD.
Gene expression databases
ArrayExpress	A2AJK6.
Bgee	A2AJK6.
CleanEx	MM_CHD7.
Genevestigator	A2AJK6.
Family and domain databases
InterPro	IPR006576. BRK_domain. IPR023780. Chromo_domain. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR001005. SANT/Myb. IPR000330. SNF2_N. [Graphical view]
Pfam	PF07533. BRK. 2 hits. PF00385. Chromo. 2 hits. PF00271. Helicase_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00592. BRK. 2 hits. SM00298. CHROMO. 2 hits. SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00717. SANT. 1 hit. [Graphical view]
SUPFAM	SSF54160. Chromodomain-like. 1 hit.
PROSITE	PS00598. CHROMO_1. False negative. PS50013. CHROMO_2. 2 hits. PS00690. DEAH_ATP_HELICASE. False negative. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	397435.
SOURCE	Search...

Entry information

Entry name

CHD7_MOUSE

Accession

Primary (citable) accession number: A2AJK6
Secondary accession number(s): Q3TA86 , Q3TAG7, Q3TBU4, Q8C986, Q8K244

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program