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Protein

MAP7 domain-containing protein 1

Gene

Map7d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAP7 domain-containing protein 1
Gene namesi
Name:Map7d1
Synonyms:Kiaa1187, Mtap7d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2384297. Map7d1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846MAP7 domain-containing protein 1PRO_0000306808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphothreonineBy similarity
Modified residuei53 – 531PhosphothreonineCombined sources
Modified residuei95 – 951PhosphoserineBy similarity
Modified residuei99 – 991PhosphothreonineBy similarity
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei118 – 1181PhosphoserineBy similarity
Modified residuei120 – 1201PhosphothreonineBy similarity
Modified residuei125 – 1251PhosphoserineBy similarity
Modified residuei127 – 1271PhosphoserineBy similarity
Modified residuei256 – 2561PhosphoserineBy similarity
Modified residuei275 – 2751PhosphoserineBy similarity
Modified residuei315 – 3151PhosphoserineCombined sources
Modified residuei368 – 3681PhosphoserineBy similarity
Modified residuei401 – 4011PhosphoserineBy similarity
Cross-linki441 – 441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei444 – 4441PhosphoserineBy similarity
Modified residuei448 – 4481PhosphoserineBy similarity
Modified residuei454 – 4541PhosphoserineBy similarity
Modified residuei460 – 4601PhosphoserineBy similarity
Modified residuei479 – 4791PhosphoserineCombined sources
Modified residuei496 – 4961PhosphoserineCombined sources
Modified residuei544 – 5441PhosphoserineCombined sources
Modified residuei548 – 5481PhosphoserineCombined sources
Modified residuei552 – 5521PhosphoserineCombined sources
Modified residuei554 – 5541PhosphothreonineCombined sources
Modified residuei818 – 8181PhosphothreonineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiA2AJI0.
MaxQBiA2AJI0.
PaxDbiA2AJI0.
PeptideAtlasiA2AJI0.
PRIDEiA2AJI0.

PTM databases

iPTMnetiA2AJI0.
PhosphoSiteiA2AJI0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028849.
ExpressionAtlasiA2AJI0. baseline and differential.
GenevisibleiA2AJI0. MM.

Interactioni

Protein-protein interaction databases

BioGridi232845. 2 interactions.
IntActiA2AJI0. 2 interactions.
MINTiMINT-4116390.
STRINGi10090.ENSMUSP00000054338.

Structurei

3D structure databases

ProteinModelPortaliA2AJI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 22495Sequence analysisAdd
BLAST
Coiled coili414 – 44330Sequence analysisAdd
BLAST
Coiled coili599 – 740142Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 129125Pro-richAdd
BLAST
Compositional biasi467 – 595129Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the MAP7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH56. Eukaryota.
ENOG410XTH2. LUCA.
GeneTreeiENSGT00660000095160.
HOGENOMiHOG000231569.
HOVERGENiHBG071099.
InParanoidiA2AJI0.
KOiK16806.
OMAiAPQEPQW.
OrthoDBiEOG091G07NV.
PhylomeDBiA2AJI0.
TreeFamiTF332273.

Family and domain databases

InterProiIPR008604. MAP7_fam.
[Graphical view]
PANTHERiPTHR15073. PTHR15073. 2 hits.
PfamiPF05672. MAP7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AJI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGPRVEPG PGAPAAVLAR IPQEPRPSPE GDPSPPPPPT PMSALVPDTP
60 70 80 90 100
PDTPPALKTA TNPKQLPLEP GNPTGQISPQ PAPPQEECPS SEAKSRGPTP
110 120 130 140 150
TATGPREAKP SRRSSQPSPT TVPASDSPPA KQDVKKAGER HKLAKERREE
160 170 180 190 200
RAKYLAAKKA VWLEKEEKAK ALREKQLQER RRRLEEQRLK AEQRRAALEE
210 220 230 240 250
RQRQKLEKNK ERYEAAIQRS VKKTWAEIRQ QRWSWAGALH HSSPGRKTSG
260 270 280 290 300
SRCSVSAVNL PKHVDSIINK RLSKSSATLW NSPSRNRSLQ LSAWESSIVD
310 320 330 340 350
RLMTPTLSFL ARSRSAVTLP RNGRDQGRGS GPGRRPTRAR AGASLAPGPH
360 370 380 390 400
PDRTHPSAAV PVCPRSASAS PLTPCSAPRS AHRCTPSGER PERRKPGAGG
410 420 430 440 450
SPALARRRLE ATPVQKKEKK DKERENEKEK SALARERNLK KRQSLPASIR
460 470 480 490 500
PRLSTGSELS PKSKARPSSP STTWHRPASP CPSPGPGHAL PPKPPSPRGT
510 520 530 540 550
TASPKGRVRR KEEAKESPSP SGPEDKNHRK SRAAEEKEPA APASPAPSPV
560 570 580 590 600
PSPTPAQPQK EQSSTQIPAE TAVPAVPAAP TAPPTAAPSV TPSKPMAGTT
610 620 630 640 650
DREEATRLLA EKRRQAREQR EREEQERKLQ AERDKRMREE QLAREAEARA
660 670 680 690 700
EREAEARRRE EQEAREKAQA EQEEQERLQK QKEEAEARSR EEAERQRQER
710 720 730 740 750
EKHFQKEEQE RQERRKRLEE IMKRTRKSEA AETKKQDAKE TAANNSGPDP
760 770 780 790 800
VKAVETRPSG LQKDSMQKEE LAPQEPQWSL PSKEMPGSLV NGLQPLPAHQ
810 820 830 840
ENGFSPKGTA GDKSLGRTAE GLLPFAEAEA FLKKAVVQPP QVTEVL
Length:846
Mass (Da):93,276
Last modified:February 20, 2007 - v1
Checksum:i3B4EEDAFEAC93C56
GO
Isoform 2 (identifier: A2AJI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-285: Missing.

Note: No experimental confirmation available.
Show »
Length:809
Mass (Da):89,310
Checksum:i955156C88A06DEE8
GO

Sequence cautioni

The sequence AAH16081 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH19977 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC65744 differs from that shown.The sequence differs from that shown because it is derived from pre-RNA.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1253PAS → SAY in AAH23677 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei249 – 28537Missing in isoform 2. 1 PublicationVSP_028489Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732624 Genomic DNA. Translation: CAM13850.1.
BC016081 mRNA. Translation: AAH16081.1. Different initiation.
BC019977 mRNA. Translation: AAH19977.1. Different initiation.
BC023677 mRNA. Translation: AAH23677.1.
AK122462 Transcribed RNA. Translation: BAC65744.3. Sequence problems.
CCDSiCCDS18646.1. [A2AJI0-1]
RefSeqiNP_659190.3. NM_144941.3. [A2AJI0-1]
XP_006503175.1. XM_006503112.2. [A2AJI0-2]
UniGeneiMm.266716.

Genome annotation databases

EnsembliENSMUST00000061143; ENSMUSP00000054338; ENSMUSG00000028849. [A2AJI0-1]
GeneIDi245877.
KEGGimmu:245877.
UCSCiuc008usy.1. mouse. [A2AJI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732624 Genomic DNA. Translation: CAM13850.1.
BC016081 mRNA. Translation: AAH16081.1. Different initiation.
BC019977 mRNA. Translation: AAH19977.1. Different initiation.
BC023677 mRNA. Translation: AAH23677.1.
AK122462 Transcribed RNA. Translation: BAC65744.3. Sequence problems.
CCDSiCCDS18646.1. [A2AJI0-1]
RefSeqiNP_659190.3. NM_144941.3. [A2AJI0-1]
XP_006503175.1. XM_006503112.2. [A2AJI0-2]
UniGeneiMm.266716.

3D structure databases

ProteinModelPortaliA2AJI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232845. 2 interactions.
IntActiA2AJI0. 2 interactions.
MINTiMINT-4116390.
STRINGi10090.ENSMUSP00000054338.

PTM databases

iPTMnetiA2AJI0.
PhosphoSiteiA2AJI0.

Proteomic databases

EPDiA2AJI0.
MaxQBiA2AJI0.
PaxDbiA2AJI0.
PeptideAtlasiA2AJI0.
PRIDEiA2AJI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061143; ENSMUSP00000054338; ENSMUSG00000028849. [A2AJI0-1]
GeneIDi245877.
KEGGimmu:245877.
UCSCiuc008usy.1. mouse. [A2AJI0-1]

Organism-specific databases

CTDi55700.
MGIiMGI:2384297. Map7d1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IH56. Eukaryota.
ENOG410XTH2. LUCA.
GeneTreeiENSGT00660000095160.
HOGENOMiHOG000231569.
HOVERGENiHBG071099.
InParanoidiA2AJI0.
KOiK16806.
OMAiAPQEPQW.
OrthoDBiEOG091G07NV.
PhylomeDBiA2AJI0.
TreeFamiTF332273.

Miscellaneous databases

PROiA2AJI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028849.
ExpressionAtlasiA2AJI0. baseline and differential.
GenevisibleiA2AJI0. MM.

Family and domain databases

InterProiIPR008604. MAP7_fam.
[Graphical view]
PANTHERiPTHR15073. PTHR15073. 2 hits.
PfamiPF05672. MAP7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMA7D1_MOUSE
AccessioniPrimary (citable) accession number: A2AJI0
Secondary accession number(s): Q80TI3
, Q8CIL3, Q8VCG2, Q91YQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.