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A2AJ26

- A2AJ26_MOUSE

UniProt

A2AJ26 - A2AJ26_MOUSE

Protein
Submitted name:

ATP-binding cassette sub-family A member 2

Gene

Abca2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cholesterol homeostasis Source: Ensembl
    2. regulation of intracellular cholesterol transport Source: Ensembl
    3. regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. response to steroid hormone Source: Ensembl

    Keywords - Ligandi

    ATP-bindingUniRule annotationImported, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP-binding cassette sub-family A member 2Imported
    Submitted name:
    ATP-binding cassette, sub-family A (ABC1), member 2Imported
    Gene namesi
    Name:Abca2Imported
    ORF Names:mCG_18727Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:99606. Abca2.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: Ensembl
    2. lysosome Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00720000108414.
    HOGENOMiHOG000231547.
    HOVERGENiHBG050436.
    InParanoidiA2AJ26.
    KOiK05642.
    OMAiGYPAFIF.
    OrthoDBiEOG78D7J6.
    TreeFamiTF105191.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2AJ26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS     50
    VKEAFYTAAP LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLH 100
    RVVEEGNLFD PVRPSLGSEL EALRQRLEAL SSGPGTWESH SARPAVSSFS 150
    LDSVARDQRE LWRFLMQNLS LPNSTAQALL AARVDPSEVY RLLFGPLPDL 200
    DGKLGFLRKQ EPWSRLGSNP LLQMEELLLA PALLEQLTCA PGSGELGRIL 250
    TMPEGHQVDL QGYRDAVCSG QATARAQRFS DLAAELRNQL DTAKIAQQLG 300
    FDVPNGSDPQ PQAPSPQSLP ALLGDLLDAQ KLLQDVDVLS ALALLLPQGA 350
    CAGQASAPQA SSLNGLANST GIGANSGSNT TVEEGTQSPV SPASPDTLQG 400
    QCSAFVQLWA GLQPILCGNN RTIEPEALRR GNMSSLGFTS KEQRNLGLLV 450
    HLMTSNPKIL YAPVGSEADR VILKANETFA FVGNVTHYAQ VWLNISTEIR 500
    SFLEQGRLQQ HLQWLQQYVA DLQLHPEAMN LSLEELPPAL RQDFSLPNGT 550
    ALLQQLDTID NAACGWIQFM SKVSVDIFKG FPDEESIVNY TLNQAYQDNV 600
    TVFASVIFQT RKDGSLPPHV HYKIRQNSSF TEKTNEIRRA YWRPGPNTGG 650
    RFYFLYGFVW IQDMMERAII NTFVGHDVVE PGNYVQMFPY PCYTRDDFLF 700
    VIEHMMPLCM VISWVYSVAM TIQHIVAEKE HRLKEVMKTM GLNNAVHWVA 750
    WFITGFVQLS ISVTALTAIL KYGQVLMHSH VLIIWLFLAV YAVATIMFCF 800
    LVSVLYSKAK LASACGGIIY FLSYVPYMYV AIREEVAHDK ITAFEKCIAS 850
    LMSTTAFGLG SKYFALYEVA GVGIQWHTFS QSPVEGDDFN LLLAVTMLMV 900
    DTVVYGVLTW YIEAVHPGMY GLPRPWYFPL QKSYWLGSGR TEAWEWSWPW 950
    AHTPRLSVME EDQACAMESR HFEETRGMEE EPTHLPLVVC VDKLTKVYKN 1000
    DKKMALNKLS LNLYENQVVS FLGHNGAGKT TTMSILTGLF PPTSGSATIY 1050
    GHDIRTEMDE IRKNLGMCPQ HNVLFDRLTV EEHLWFYSRL KSMAQEEIRK 1100
    ETDKMIEDLE LSNKRHSLVQ TLSGGMKRKL SVAIAFVGGS RAIILDEPTA 1150
    GVDPYARRAI WDLILKYKPG RTILLSTHHM DEADLLGDRI AIISHGKLKC 1200
    CGSPLFLKGA YGDGYRLTLV KQPAEPGTSQ EPGLASSPSG CPRLSSCSEP 1250
    QVSQFIRKHV ASSLLVSDTS TELSYILPSE AVKKGAFERL FQQLEHSLDA 1300
    LHLSSFGLMD TTLEEVFLKV SEEDQSLENS EADVKESRKD VLPGAEGLTA 1350
    VGGQAGNLAR CSELAQSQAS LQSASSVGSA RGEEGTGYSD GYGDYRPLFD 1400
    NLQDPDNVSL QEAEMEALAQ VGQGSRKLEG WWLKMRQFHG LLVKRFHCAR 1450
    RNSKALCSQI LLPAFFVCVA MTVALSVPEI GDLPPLVLSP SQYHNYTQPR 1500
    GNFIPYANEE RQEYRLRLSP DASPQQLVST FRLPSGVGAT CVLKSPANGS 1550
    LGPMLNLSSG ESRLLAARFF DSMCLESFTQ GLPLSNFVPP PPSPAPSDSP 1600
    VSPDEDSLQA WNMSLPPTAG PETWTSAPSL PRLVHEPVRC TCSAQGTGFS 1650
    CPSSVGGHPP QMRVVTGDIL TDITGHNVSE YLLFTSDRFR LHRYGAITFG 1700
    NVQKSIPASF GARVPPMVRK IAVRRVAQVL YNNKGYHSMP TYLNSLNNAI 1750
    LRANLPKSKG NPAAYGITVT NHPMNKTSAS LSLDYLLQGT DVVIAIFIIV 1800
    AMSFVPASFV VFLVAEKSTK AKHLQFVSGC NPVIYWLANY VWDMLNYLVP 1850
    ATCCVIILFV FDLPAYTSPT NFPAVLSLFL LYGWSITPIM YPASFWFEVP 1900
    SSAYVFLIVI NLFIGITATV ATFLLQLFEH DKDLKVVNSY LKSCFLIFPN 1950
    YNLGHGLMEM AYNEYINEYY AKIGQFDKMK SPFEWDIVTR GLVAMTVEGF 2000
    VGFFLTIMCQ YNFLRQPQRL PVSTKPVEDD VDVASERQRV LRGDADNDMV 2050
    KIENLTKVYK SRKIGRILAV DRLCLGVRPG ECFGLLGVNG AGKTSTFKML 2100
    TGDESTTGGE AFVNGHSVLK DLLQVQQSLG YCPQFDALFD ELTAREHLQL 2150
    YTRLRGIPWK DEAQVVKWAL EKLELTKYAD KPAGTYSGGN KRKLSTAIAL 2200
    IGYPAFIFLD EPTTGMDPKA RRFLWNLILD LIKTGRSVVL TSHSMEECEA 2250
    LCTRLAIMVN GRLRCLGSIQ HLKNRFGDGY MITVRTKSSQ NVKDVVRFFN 2300
    RNFPEAMLKE RHHTKVQYQL KSEHISLAQV FSKMEQVVGV LGIEDYSVSQ 2350
    TTLDNVFVNF AKKQSDNVEQ QEAEPSSLPS PLGLLSLLRP RPAPTELRAL 2400
    VADEPEDLDT EDEGLISFEE ERAQLSFNTD TLC 2433
    Length:2,433
    Mass (Da):270,525
    Last modified:February 20, 2007 - v1
    Checksum:iD5E92BDFA06C0AF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL732557 Genomic DNA. No translation available.
    CH466542 Genomic DNA. Translation: EDL08245.1.
    RefSeqiNP_031405.2. NM_007379.2.
    UniGeneiMm.2210.

    Genome annotation databases

    EnsembliENSMUST00000102919; ENSMUSP00000099983; ENSMUSG00000026944.
    GeneIDi11305.
    KEGGimmu:11305.
    UCSCiuc008isc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL732557 Genomic DNA. No translation available.
    CH466542 Genomic DNA. Translation: EDL08245.1 .
    RefSeqi NP_031405.2. NM_007379.2.
    UniGenei Mm.2210.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102919 ; ENSMUSP00000099983 ; ENSMUSG00000026944 .
    GeneIDi 11305.
    KEGGi mmu:11305.
    UCSCi uc008isc.1. mouse.

    Organism-specific databases

    CTDi 20.
    MGIi MGI:99606. Abca2.

    Phylogenomic databases

    GeneTreei ENSGT00720000108414.
    HOGENOMi HOG000231547.
    HOVERGENi HBG050436.
    InParanoidi A2AJ26.
    KOi K05642.
    OMAi GYPAFIF.
    OrthoDBi EOG78D7J6.
    TreeFami TF105191.

    Miscellaneous databases

    ChiTaRSi ABCA2. mouse.
    NextBioi 278594.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2AJ26_MOUSE
    AccessioniPrimary (citable) accession number: A2AJ26
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3