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A2AJ26

- A2AJ26_MOUSE

UniProt

A2AJ26 - A2AJ26_MOUSE

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Protein
Submitted name: ATP-binding cassette sub-family A member 2
Gene
Abca2, mCG_18727
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: Ensembl

GO - Biological processi

  1. cholesterol homeostasis Source: Ensembl
  2. regulation of intracellular cholesterol transport Source: Ensembl
  3. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. response to steroid hormone Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family A member 2Imported
Submitted name:
ATP-binding cassette, sub-family A (ABC1), member 2Imported
Gene namesi
Name:Abca2Imported
ORF Names:mCG_18727Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:99606. Abca2.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: Ensembl
  2. lysosome Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00720000108414.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiA2AJ26.
KOiK05642.
OMAiGYPAFIF.
OrthoDBiEOG78D7J6.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AJ26-1 [UniParc]FASTAAdd to Basket

« Hide

MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS     50
VKEAFYTAAP LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLH 100
RVVEEGNLFD PVRPSLGSEL EALRQRLEAL SSGPGTWESH SARPAVSSFS 150
LDSVARDQRE LWRFLMQNLS LPNSTAQALL AARVDPSEVY RLLFGPLPDL 200
DGKLGFLRKQ EPWSRLGSNP LLQMEELLLA PALLEQLTCA PGSGELGRIL 250
TMPEGHQVDL QGYRDAVCSG QATARAQRFS DLAAELRNQL DTAKIAQQLG 300
FDVPNGSDPQ PQAPSPQSLP ALLGDLLDAQ KLLQDVDVLS ALALLLPQGA 350
CAGQASAPQA SSLNGLANST GIGANSGSNT TVEEGTQSPV SPASPDTLQG 400
QCSAFVQLWA GLQPILCGNN RTIEPEALRR GNMSSLGFTS KEQRNLGLLV 450
HLMTSNPKIL YAPVGSEADR VILKANETFA FVGNVTHYAQ VWLNISTEIR 500
SFLEQGRLQQ HLQWLQQYVA DLQLHPEAMN LSLEELPPAL RQDFSLPNGT 550
ALLQQLDTID NAACGWIQFM SKVSVDIFKG FPDEESIVNY TLNQAYQDNV 600
TVFASVIFQT RKDGSLPPHV HYKIRQNSSF TEKTNEIRRA YWRPGPNTGG 650
RFYFLYGFVW IQDMMERAII NTFVGHDVVE PGNYVQMFPY PCYTRDDFLF 700
VIEHMMPLCM VISWVYSVAM TIQHIVAEKE HRLKEVMKTM GLNNAVHWVA 750
WFITGFVQLS ISVTALTAIL KYGQVLMHSH VLIIWLFLAV YAVATIMFCF 800
LVSVLYSKAK LASACGGIIY FLSYVPYMYV AIREEVAHDK ITAFEKCIAS 850
LMSTTAFGLG SKYFALYEVA GVGIQWHTFS QSPVEGDDFN LLLAVTMLMV 900
DTVVYGVLTW YIEAVHPGMY GLPRPWYFPL QKSYWLGSGR TEAWEWSWPW 950
AHTPRLSVME EDQACAMESR HFEETRGMEE EPTHLPLVVC VDKLTKVYKN 1000
DKKMALNKLS LNLYENQVVS FLGHNGAGKT TTMSILTGLF PPTSGSATIY 1050
GHDIRTEMDE IRKNLGMCPQ HNVLFDRLTV EEHLWFYSRL KSMAQEEIRK 1100
ETDKMIEDLE LSNKRHSLVQ TLSGGMKRKL SVAIAFVGGS RAIILDEPTA 1150
GVDPYARRAI WDLILKYKPG RTILLSTHHM DEADLLGDRI AIISHGKLKC 1200
CGSPLFLKGA YGDGYRLTLV KQPAEPGTSQ EPGLASSPSG CPRLSSCSEP 1250
QVSQFIRKHV ASSLLVSDTS TELSYILPSE AVKKGAFERL FQQLEHSLDA 1300
LHLSSFGLMD TTLEEVFLKV SEEDQSLENS EADVKESRKD VLPGAEGLTA 1350
VGGQAGNLAR CSELAQSQAS LQSASSVGSA RGEEGTGYSD GYGDYRPLFD 1400
NLQDPDNVSL QEAEMEALAQ VGQGSRKLEG WWLKMRQFHG LLVKRFHCAR 1450
RNSKALCSQI LLPAFFVCVA MTVALSVPEI GDLPPLVLSP SQYHNYTQPR 1500
GNFIPYANEE RQEYRLRLSP DASPQQLVST FRLPSGVGAT CVLKSPANGS 1550
LGPMLNLSSG ESRLLAARFF DSMCLESFTQ GLPLSNFVPP PPSPAPSDSP 1600
VSPDEDSLQA WNMSLPPTAG PETWTSAPSL PRLVHEPVRC TCSAQGTGFS 1650
CPSSVGGHPP QMRVVTGDIL TDITGHNVSE YLLFTSDRFR LHRYGAITFG 1700
NVQKSIPASF GARVPPMVRK IAVRRVAQVL YNNKGYHSMP TYLNSLNNAI 1750
LRANLPKSKG NPAAYGITVT NHPMNKTSAS LSLDYLLQGT DVVIAIFIIV 1800
AMSFVPASFV VFLVAEKSTK AKHLQFVSGC NPVIYWLANY VWDMLNYLVP 1850
ATCCVIILFV FDLPAYTSPT NFPAVLSLFL LYGWSITPIM YPASFWFEVP 1900
SSAYVFLIVI NLFIGITATV ATFLLQLFEH DKDLKVVNSY LKSCFLIFPN 1950
YNLGHGLMEM AYNEYINEYY AKIGQFDKMK SPFEWDIVTR GLVAMTVEGF 2000
VGFFLTIMCQ YNFLRQPQRL PVSTKPVEDD VDVASERQRV LRGDADNDMV 2050
KIENLTKVYK SRKIGRILAV DRLCLGVRPG ECFGLLGVNG AGKTSTFKML 2100
TGDESTTGGE AFVNGHSVLK DLLQVQQSLG YCPQFDALFD ELTAREHLQL 2150
YTRLRGIPWK DEAQVVKWAL EKLELTKYAD KPAGTYSGGN KRKLSTAIAL 2200
IGYPAFIFLD EPTTGMDPKA RRFLWNLILD LIKTGRSVVL TSHSMEECEA 2250
LCTRLAIMVN GRLRCLGSIQ HLKNRFGDGY MITVRTKSSQ NVKDVVRFFN 2300
RNFPEAMLKE RHHTKVQYQL KSEHISLAQV FSKMEQVVGV LGIEDYSVSQ 2350
TTLDNVFVNF AKKQSDNVEQ QEAEPSSLPS PLGLLSLLRP RPAPTELRAL 2400
VADEPEDLDT EDEGLISFEE ERAQLSFNTD TLC 2433
Length:2,433
Mass (Da):270,525
Last modified:February 20, 2007 - v1
Checksum:iD5E92BDFA06C0AF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732557 Genomic DNA. No translation available.
CH466542 Genomic DNA. Translation: EDL08245.1.
RefSeqiNP_031405.2. NM_007379.2.
UniGeneiMm.2210.

Genome annotation databases

EnsembliENSMUST00000102919; ENSMUSP00000099983; ENSMUSG00000026944.
GeneIDi11305.
KEGGimmu:11305.
UCSCiuc008isc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732557 Genomic DNA. No translation available.
CH466542 Genomic DNA. Translation: EDL08245.1 .
RefSeqi NP_031405.2. NM_007379.2.
UniGenei Mm.2210.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102919 ; ENSMUSP00000099983 ; ENSMUSG00000026944 .
GeneIDi 11305.
KEGGi mmu:11305.
UCSCi uc008isc.1. mouse.

Organism-specific databases

CTDi 20.
MGIi MGI:99606. Abca2.

Phylogenomic databases

GeneTreei ENSGT00720000108414.
HOGENOMi HOG000231547.
HOVERGENi HBG050436.
InParanoidi A2AJ26.
KOi K05642.
OMAi GYPAFIF.
OrthoDBi EOG78D7J6.
TreeFami TF105191.

Miscellaneous databases

ChiTaRSi ABCA2. mouse.
NextBioi 278594.
SOURCEi Search...

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AJ26_MOUSE
AccessioniPrimary (citable) accession number: A2AJ26
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi