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A2AJ26

- A2AJ26_MOUSE

UniProt

A2AJ26 - A2AJ26_MOUSE

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Protein
Submitted name:

ATP-binding cassette sub-family A member 2

Gene

Abca2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATPase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cholesterol homeostasis Source: Ensembl
  2. regulation of intracellular cholesterol transport Source: Ensembl
  3. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. response to steroid hormone Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family A member 2Imported
Submitted name:
ATP-binding cassette, sub-family A (ABC1), member 2Imported
Gene namesi
Name:Abca2Imported
ORF Names:mCG_18727Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:99606. Abca2.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: Ensembl
  2. lysosome Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
KOiK05642.
OMAiGYPAFIF.
OrthoDBiEOG78D7J6.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AJ26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS
60 70 80 90 100
VKEAFYTAAP LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLH
110 120 130 140 150
RVVEEGNLFD PVRPSLGSEL EALRQRLEAL SSGPGTWESH SARPAVSSFS
160 170 180 190 200
LDSVARDQRE LWRFLMQNLS LPNSTAQALL AARVDPSEVY RLLFGPLPDL
210 220 230 240 250
DGKLGFLRKQ EPWSRLGSNP LLQMEELLLA PALLEQLTCA PGSGELGRIL
260 270 280 290 300
TMPEGHQVDL QGYRDAVCSG QATARAQRFS DLAAELRNQL DTAKIAQQLG
310 320 330 340 350
FDVPNGSDPQ PQAPSPQSLP ALLGDLLDAQ KLLQDVDVLS ALALLLPQGA
360 370 380 390 400
CAGQASAPQA SSLNGLANST GIGANSGSNT TVEEGTQSPV SPASPDTLQG
410 420 430 440 450
QCSAFVQLWA GLQPILCGNN RTIEPEALRR GNMSSLGFTS KEQRNLGLLV
460 470 480 490 500
HLMTSNPKIL YAPVGSEADR VILKANETFA FVGNVTHYAQ VWLNISTEIR
510 520 530 540 550
SFLEQGRLQQ HLQWLQQYVA DLQLHPEAMN LSLEELPPAL RQDFSLPNGT
560 570 580 590 600
ALLQQLDTID NAACGWIQFM SKVSVDIFKG FPDEESIVNY TLNQAYQDNV
610 620 630 640 650
TVFASVIFQT RKDGSLPPHV HYKIRQNSSF TEKTNEIRRA YWRPGPNTGG
660 670 680 690 700
RFYFLYGFVW IQDMMERAII NTFVGHDVVE PGNYVQMFPY PCYTRDDFLF
710 720 730 740 750
VIEHMMPLCM VISWVYSVAM TIQHIVAEKE HRLKEVMKTM GLNNAVHWVA
760 770 780 790 800
WFITGFVQLS ISVTALTAIL KYGQVLMHSH VLIIWLFLAV YAVATIMFCF
810 820 830 840 850
LVSVLYSKAK LASACGGIIY FLSYVPYMYV AIREEVAHDK ITAFEKCIAS
860 870 880 890 900
LMSTTAFGLG SKYFALYEVA GVGIQWHTFS QSPVEGDDFN LLLAVTMLMV
910 920 930 940 950
DTVVYGVLTW YIEAVHPGMY GLPRPWYFPL QKSYWLGSGR TEAWEWSWPW
960 970 980 990 1000
AHTPRLSVME EDQACAMESR HFEETRGMEE EPTHLPLVVC VDKLTKVYKN
1010 1020 1030 1040 1050
DKKMALNKLS LNLYENQVVS FLGHNGAGKT TTMSILTGLF PPTSGSATIY
1060 1070 1080 1090 1100
GHDIRTEMDE IRKNLGMCPQ HNVLFDRLTV EEHLWFYSRL KSMAQEEIRK
1110 1120 1130 1140 1150
ETDKMIEDLE LSNKRHSLVQ TLSGGMKRKL SVAIAFVGGS RAIILDEPTA
1160 1170 1180 1190 1200
GVDPYARRAI WDLILKYKPG RTILLSTHHM DEADLLGDRI AIISHGKLKC
1210 1220 1230 1240 1250
CGSPLFLKGA YGDGYRLTLV KQPAEPGTSQ EPGLASSPSG CPRLSSCSEP
1260 1270 1280 1290 1300
QVSQFIRKHV ASSLLVSDTS TELSYILPSE AVKKGAFERL FQQLEHSLDA
1310 1320 1330 1340 1350
LHLSSFGLMD TTLEEVFLKV SEEDQSLENS EADVKESRKD VLPGAEGLTA
1360 1370 1380 1390 1400
VGGQAGNLAR CSELAQSQAS LQSASSVGSA RGEEGTGYSD GYGDYRPLFD
1410 1420 1430 1440 1450
NLQDPDNVSL QEAEMEALAQ VGQGSRKLEG WWLKMRQFHG LLVKRFHCAR
1460 1470 1480 1490 1500
RNSKALCSQI LLPAFFVCVA MTVALSVPEI GDLPPLVLSP SQYHNYTQPR
1510 1520 1530 1540 1550
GNFIPYANEE RQEYRLRLSP DASPQQLVST FRLPSGVGAT CVLKSPANGS
1560 1570 1580 1590 1600
LGPMLNLSSG ESRLLAARFF DSMCLESFTQ GLPLSNFVPP PPSPAPSDSP
1610 1620 1630 1640 1650
VSPDEDSLQA WNMSLPPTAG PETWTSAPSL PRLVHEPVRC TCSAQGTGFS
1660 1670 1680 1690 1700
CPSSVGGHPP QMRVVTGDIL TDITGHNVSE YLLFTSDRFR LHRYGAITFG
1710 1720 1730 1740 1750
NVQKSIPASF GARVPPMVRK IAVRRVAQVL YNNKGYHSMP TYLNSLNNAI
1760 1770 1780 1790 1800
LRANLPKSKG NPAAYGITVT NHPMNKTSAS LSLDYLLQGT DVVIAIFIIV
1810 1820 1830 1840 1850
AMSFVPASFV VFLVAEKSTK AKHLQFVSGC NPVIYWLANY VWDMLNYLVP
1860 1870 1880 1890 1900
ATCCVIILFV FDLPAYTSPT NFPAVLSLFL LYGWSITPIM YPASFWFEVP
1910 1920 1930 1940 1950
SSAYVFLIVI NLFIGITATV ATFLLQLFEH DKDLKVVNSY LKSCFLIFPN
1960 1970 1980 1990 2000
YNLGHGLMEM AYNEYINEYY AKIGQFDKMK SPFEWDIVTR GLVAMTVEGF
2010 2020 2030 2040 2050
VGFFLTIMCQ YNFLRQPQRL PVSTKPVEDD VDVASERQRV LRGDADNDMV
2060 2070 2080 2090 2100
KIENLTKVYK SRKIGRILAV DRLCLGVRPG ECFGLLGVNG AGKTSTFKML
2110 2120 2130 2140 2150
TGDESTTGGE AFVNGHSVLK DLLQVQQSLG YCPQFDALFD ELTAREHLQL
2160 2170 2180 2190 2200
YTRLRGIPWK DEAQVVKWAL EKLELTKYAD KPAGTYSGGN KRKLSTAIAL
2210 2220 2230 2240 2250
IGYPAFIFLD EPTTGMDPKA RRFLWNLILD LIKTGRSVVL TSHSMEECEA
2260 2270 2280 2290 2300
LCTRLAIMVN GRLRCLGSIQ HLKNRFGDGY MITVRTKSSQ NVKDVVRFFN
2310 2320 2330 2340 2350
RNFPEAMLKE RHHTKVQYQL KSEHISLAQV FSKMEQVVGV LGIEDYSVSQ
2360 2370 2380 2390 2400
TTLDNVFVNF AKKQSDNVEQ QEAEPSSLPS PLGLLSLLRP RPAPTELRAL
2410 2420 2430
VADEPEDLDT EDEGLISFEE ERAQLSFNTD TLC
Length:2,433
Mass (Da):270,525
Last modified:February 20, 2007 - v1
Checksum:iD5E92BDFA06C0AF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732557 Genomic DNA. No translation available.
CH466542 Genomic DNA. Translation: EDL08245.1.
RefSeqiNP_031405.2. NM_007379.2.
UniGeneiMm.2210.

Genome annotation databases

EnsembliENSMUST00000102919; ENSMUSP00000099983; ENSMUSG00000026944.
GeneIDi11305.
KEGGimmu:11305.
UCSCiuc008isc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732557 Genomic DNA. No translation available.
CH466542 Genomic DNA. Translation: EDL08245.1 .
RefSeqi NP_031405.2. NM_007379.2.
UniGenei Mm.2210.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102919 ; ENSMUSP00000099983 ; ENSMUSG00000026944 .
GeneIDi 11305.
KEGGi mmu:11305.
UCSCi uc008isc.1. mouse.

Organism-specific databases

CTDi 20.
MGIi MGI:99606. Abca2.

Phylogenomic databases

GeneTreei ENSGT00760000118965.
HOGENOMi HOG000231547.
HOVERGENi HBG050436.
KOi K05642.
OMAi GYPAFIF.
OrthoDBi EOG78D7J6.
TreeFami TF105191.

Miscellaneous databases

ChiTaRSi ABCA2. mouse.
NextBioi 278594.
SOURCEi Search...

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AJ26_MOUSE
AccessioniPrimary (citable) accession number: A2AJ26
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3