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Protein

Serologically defined colon cancer antigen 3 homolog

Gene

Sdccag3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (PubMed:16332174). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Serologically defined colon cancer antigen 3 homolog
Gene namesi
Name:Sdccag3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915362. Sdccag3.

Subcellular locationi

  • Midbody By similarity
  • Early endosome By similarity
  • Recycling endosome By similarity
  • Cytoplasm 1 Publication

  • Note: During cytokinesis colocalized with PTPN13 at the midbody. Colocalizes in a FAM21-dependent manner with the retromer CSC complex at endosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Serologically defined colon cancer antigen 3 homologPRO_0000324286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei148 – 1481PhosphoserineBy similarity
Modified residuei241 – 2411PhosphoserineCombined sources
Modified residuei245 – 2451PhosphoserineCombined sources
Isoform 3 (identifier: A2AIW0-3)
Modified residuei18 – 181PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AIW0.
PaxDbiA2AIW0.
PRIDEiA2AIW0.

PTM databases

iPTMnetiA2AIW0.
PhosphoSiteiA2AIW0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026927.
CleanExiMM_SDCCAG3.
ExpressionAtlasiA2AIW0. baseline and differential.
GenevisibleiA2AIW0. MM.

Interactioni

Subunit structurei

Interacts with PTPN13, GIT1, VPS35 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109737.

Structurei

3D structure databases

ProteinModelPortaliA2AIW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 19623Required for interaction with PTPN13By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili262 – 28928Sequence analysisAdd
BLAST
Coiled coili315 – 37056Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SDCCAG3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHIY. Eukaryota.
ENOG4111TAC. LUCA.
GeneTreeiENSGT00390000000560.
HOVERGENiHBG058095.
InParanoidiA2AIW0.
OMAiYERRSCL.
OrthoDBiEOG091G0JQ8.
PhylomeDBiA2AIW0.
TreeFamiTF335840.

Family and domain databases

InterProiIPR026757. SDCCAG3.
[Graphical view]
PANTHERiPTHR31259. PTHR31259. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AIW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGYARRQGA PPLSRTRSLV VPDAPAFYER RSCLPQLDCE RPHGGDLHPH
60 70 80 90 100
LFGFRPTFMC YVPSPVLASV GDTGFGYGKG KCTNQGPSGA PETRFGGDKL
110 120 130 140 150
EDLEEANPFS FKEFLKTKNL SLSKEDTTTS RIYPKEASRH PLGLEHSSPA
160 170 180 190 200
SQLMGYGLES QQPFFEDPTR ASNLEEDEDD GWNITYLPSA VDQTHSSRDT
210 220 230 240 250
QDSPPCDTYL SFFSNSSELA CPESLPPWTL SDTDSRISPA SPAGSPNADF
260 270 280 290 300
AAHEESLGDR HLRTLQISYE ALKDENSKLR RKLNEVQSFS ETQTEMVRTL
310 320 330 340 350
ERKLEAKMIK EESDFHDLES VVQQVEQNLE LMTKRAVKAE NHVLKLKQEI
360 370 380 390 400
NLLQAQLSNL RRENEALRSG QGASLSVVKQ NTDVALQNLH LVMNSAHASI
410 420 430
KQLVSGADTL NLVAEILKSI DRISEVKDEV DS
Length:432
Mass (Da):48,025
Last modified:February 20, 2007 - v1
Checksum:i7BFEF3179D254C9A
GO
Isoform 2 (identifier: A2AIW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-73: Missing.

Show »
Length:382
Mass (Da):42,454
Checksum:iA9B95BB1044C70F3
GO
Isoform 3 (identifier: A2AIW0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-96: Missing.

Show »
Length:359
Mass (Da):40,156
Checksum:iFEA1DE9F347F758B
GO
Isoform 4 (identifier: A2AIW0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:374
Mass (Da):41,478
Checksum:iD78995E5AC6CDAF9
GO
Isoform 5 (identifier: A2AIW0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-432: LKDENSKLRR...ISEVKDEVDS → VSEGSVAPNT...AWAQCHGQGS

Show »
Length:307
Mass (Da):33,478
Checksum:i7596D829E85452AA
GO
Isoform 6 (identifier: A2AIW0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-73: Missing.
     136-143: EASRHPLG → VHLGSCQW
     144-432: Missing.

Note: No experimental confirmation available.
Show »
Length:93
Mass (Da):10,227
Checksum:iEE86241CEAC52386
GO

Sequence cautioni

The sequence BAB30158 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB32357 differs from that shown. Reason: Frameshift at position 263. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731N → D in BAE37459 (PubMed:16141072).Curated
Sequence conflicti183 – 1831N → Y in BAB29602 (PubMed:16141072).Curated
Sequence conflicti233 – 2331T → P in BAB32357 (PubMed:16141072).Curated
Sequence conflicti375 – 3751L → V in BAB30158 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 4. 1 PublicationVSP_032178Add
BLAST
Alternative sequencei24 – 9673Missing in isoform 3. 2 PublicationsVSP_032179Add
BLAST
Alternative sequencei24 – 7350Missing in isoform 2 and isoform 6. 2 PublicationsVSP_032180Add
BLAST
Alternative sequencei136 – 1438EASRHPLG → VHLGSCQW in isoform 6. 1 PublicationVSP_032181
Alternative sequencei144 – 432289Missing in isoform 6. 1 PublicationVSP_032182Add
BLAST
Alternative sequencei272 – 432161LKDEN…DEVDS → VSEGSVAPNTAELCCGEELQ SSTSWVAWAQCHGQGS in isoform 5. 1 PublicationVSP_032183Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082787 mRNA. Translation: BAC38620.1.
AK016227 mRNA. Translation: BAB30158.1. Different initiation.
AK021273 mRNA. Translation: BAB32357.1. Frameshift.
AK014885 mRNA. Translation: BAB29602.1.
AK163690 mRNA. Translation: BAE37459.1.
AL732541 Genomic DNA. Translation: CAM20315.1.
AL732541 Genomic DNA. Translation: CAM20316.1.
AL732541 Genomic DNA. Translation: CAM20317.1.
BC031199 mRNA. Translation: AAH31199.1.
BC061037 mRNA. Translation: AAH61037.1.
CCDSiCCDS15803.2. [A2AIW0-1]
CCDS50540.1. [A2AIW0-3]
CCDS50541.1. [A2AIW0-2]
RefSeqiNP_001078876.1. NM_001085407.1. [A2AIW0-2]
NP_001078877.1. NM_001085408.1. [A2AIW0-3]
NP_080839.2. NM_026563.3. [A2AIW0-1]
UniGeneiMm.253771.

Genome annotation databases

EnsembliENSMUST00000028293; ENSMUSP00000028293; ENSMUSG00000026927. [A2AIW0-2]
ENSMUST00000077983; ENSMUSP00000077133; ENSMUSG00000026927. [A2AIW0-3]
ENSMUST00000114102; ENSMUSP00000109737; ENSMUSG00000026927. [A2AIW0-1]
GeneIDi68112.
KEGGimmu:68112.
UCSCiuc008iuy.1. mouse. [A2AIW0-1]
uc008iuz.1. mouse. [A2AIW0-2]
uc008iva.1. mouse. [A2AIW0-3]
uc008ivb.1. mouse. [A2AIW0-5]
uc008ivc.1. mouse. [A2AIW0-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082787 mRNA. Translation: BAC38620.1.
AK016227 mRNA. Translation: BAB30158.1. Different initiation.
AK021273 mRNA. Translation: BAB32357.1. Frameshift.
AK014885 mRNA. Translation: BAB29602.1.
AK163690 mRNA. Translation: BAE37459.1.
AL732541 Genomic DNA. Translation: CAM20315.1.
AL732541 Genomic DNA. Translation: CAM20316.1.
AL732541 Genomic DNA. Translation: CAM20317.1.
BC031199 mRNA. Translation: AAH31199.1.
BC061037 mRNA. Translation: AAH61037.1.
CCDSiCCDS15803.2. [A2AIW0-1]
CCDS50540.1. [A2AIW0-3]
CCDS50541.1. [A2AIW0-2]
RefSeqiNP_001078876.1. NM_001085407.1. [A2AIW0-2]
NP_001078877.1. NM_001085408.1. [A2AIW0-3]
NP_080839.2. NM_026563.3. [A2AIW0-1]
UniGeneiMm.253771.

3D structure databases

ProteinModelPortaliA2AIW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109737.

PTM databases

iPTMnetiA2AIW0.
PhosphoSiteiA2AIW0.

Proteomic databases

MaxQBiA2AIW0.
PaxDbiA2AIW0.
PRIDEiA2AIW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028293; ENSMUSP00000028293; ENSMUSG00000026927. [A2AIW0-2]
ENSMUST00000077983; ENSMUSP00000077133; ENSMUSG00000026927. [A2AIW0-3]
ENSMUST00000114102; ENSMUSP00000109737; ENSMUSG00000026927. [A2AIW0-1]
GeneIDi68112.
KEGGimmu:68112.
UCSCiuc008iuy.1. mouse. [A2AIW0-1]
uc008iuz.1. mouse. [A2AIW0-2]
uc008iva.1. mouse. [A2AIW0-3]
uc008ivb.1. mouse. [A2AIW0-5]
uc008ivc.1. mouse. [A2AIW0-6]

Organism-specific databases

CTDi10807.
MGIiMGI:1915362. Sdccag3.

Phylogenomic databases

eggNOGiENOG410IHIY. Eukaryota.
ENOG4111TAC. LUCA.
GeneTreeiENSGT00390000000560.
HOVERGENiHBG058095.
InParanoidiA2AIW0.
OMAiYERRSCL.
OrthoDBiEOG091G0JQ8.
PhylomeDBiA2AIW0.
TreeFamiTF335840.

Miscellaneous databases

ChiTaRSiSdccag3. mouse.
PROiA2AIW0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026927.
CleanExiMM_SDCCAG3.
ExpressionAtlasiA2AIW0. baseline and differential.
GenevisibleiA2AIW0. MM.

Family and domain databases

InterProiIPR026757. SDCCAG3.
[Graphical view]
PANTHERiPTHR31259. PTHR31259. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSDCG3_MOUSE
AccessioniPrimary (citable) accession number: A2AIW0
Secondary accession number(s): A2AIW1
, Q3TQC5, Q6P8W2, Q8BIV5, Q8K0I8, Q9D1V2, Q9D4S1, Q9D5W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.