A2AIV2 (VIR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein virilizer homolog

Gene names

Name:

Kiaa1429

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1811 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in mRNA splicing regulation By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the vir family.
Sequence caution	The sequence AAH28830.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2AIV2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2AIV2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1139: IEPHDISVA → PLHITCILS
     1140-1811: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 1811	1810	Protein virilizer homolog		PRO_0000308606
Regions
	Compositional bias	139 – 202	64	Pro-rich
	Compositional bias	208 – 314	107	Glu-rich
	Compositional bias	942 – 945	4	Poly-Pro
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	133	1	Phosphoserine By similarity
	Modified residue	138	1	Phosphoserine By similarity
	Modified residue	173	1	Phosphoserine Ref.5
	Modified residue	184	1	Phosphothreonine By similarity
	Modified residue	222	1	Phosphoserine By similarity
	Modified residue	913	1	Phosphotyrosine By similarity
	Modified residue	1578	1	Phosphoserine By similarity
	Modified residue	1707	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1131 – 1139	9	IEPHDISVA → PLHITCILS in isoform 2.		VSP_029022
	Alternative sequence	1140 – 1811	672	Missing in isoform 2.		VSP_029023
Experimental info
	Sequence conflict	97	1	S → Y in BAE41548. Ref.1
	Sequence conflict	373	1	K → E in BAC35017. Ref.1
	Sequence conflict	1520	1	A → T in AAH28830. Ref.4
	Sequence conflict	1582	1	S → T in AAH28830. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 5F505FADEC3211E3	FASTA	1,811	201,439
	10 20 30 40 50 60 MAVDSSMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH SGLPDNRAYG 70 80 90 100 110 120 ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF RPNSKVNTDG LVLRGWYNCL 130 140 150 160 170 180 TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ PQPTLKRNLK HADGEKEDQF NGSPPRPQPR 190 200 210 220 230 240 GPRTPPGPPP PDDDEDDPMS LPVSGDKEED VPHREDYFEP ISPDRNSVPQ EGQYSDEGEV 250 260 270 280 290 300 EEEPQEEGED DEDDVDVEEE EDEDEDDCHT VDSIPDDEEE DEEEEGEEDE EGEGDDGYEQ 310 320 330 340 350 360 ISSDEDGIAD LERETFKYPN FDVEYTPEDL ASVPPMTYDP YDRELAPLLY FSCPYKTTFE 370 380 390 400 410 420 IEISRMKDQG PDKENSGAVE ASVKLTELLD LYQEDRGAKW VTALEEIPSL IIKGLSYLQL 430 440 450 460 470 480 KNTEQDSLGQ LVDWTMQALN LQVAFRQPIA LNVRQLKAGT KLVTSLAECG APGVTELLQA 490 500 510 520 530 540 GVINVLFDLL FADHVSSSLK LNAFKALDSV ISMTEGMEAF LRSTQNEKSG YQRLLELILL 550 560 570 580 590 600 DQTVRVVTAG SAILQKCHFY EILSEIKRLG DHIAEKTSAV PNHSEPDQDT DAVLERANPD 610 620 630 640 650 660 YENEVEASMD MDLLESSIIS EGEIEKLTNL LEEVFHVMET APHTMTQPPV KSFPTIARIT 670 680 690 700 710 720 GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPITSAHQGV LQATKDVLKF LAQSQKGLLF 730 740 750 760 770 780 FMSEYEATNL LIRALCHLYD QDEEEGLQSD GADDAFALWL QDSTQTLQCI TELFSHFQRC 790 800 810 820 830 840 TASEETDHSD LLGTLHNLYL ITFNPVGRSA VGHVFSLDKN LQSLITLMEY YSKEALGDSK 850 860 870 880 890 900 SKKSVAYNYA CVLTLVVAQS SSGVQMLEQH AASLLKLCKA DENNAKLQEL GKWLEPLKNL 910 920 930 940 950 960 RFEINCIPNL IEYVKQNIDN LMTAEGVGLT TALRVLCNVA CPPPPVEGQQ KDLKWNLAVI 970 980 990 1000 1010 1020 QLFSAEGMDT FIRVLQKLNS ILTQPWRLHV NMGTTLHRVT TISMARCTLT LLKTMLTELL 1030 1040 1050 1060 1070 1080 RGGSFEFKDM RVPSALVTLH MLLCSIPLSG RLDSDEQKIQ NDIIDILLTF TQGVNEKLTI 1090 1100 1110 1120 1130 1140 SEETLANNTW SLMLKEVLSS ILKVPEGFFS GLILLSELLP LPLPMQTTQV IEPHDISVAL 1150 1160 1170 1180 1190 1200 NTRKLWSMHL HVQAKLLQEI VRSFSGTTCQ PIQHMLRRIC VQLCDLASPT ALLIMRTVLD 1210 1220 1230 1240 1250 1260 LIVEDLQSTS EDKEKQYTSQ TTRLLALLDA LASHKACKLA ILHLINGTIK GDERYAEIFQ 1270 1280 1290 1300 1310 1320 DLLALVRSPG DSVTRQQCVE YVTSILQSLC DQDIALILPS PSEGPASELE QLSNSLPSKE 1330 1340 1350 1360 1370 1380 LMTAICDCLL ATLANSESSY NCLLTCVRTM MFLAEHDYGL FHLKSSLRKN SSALHSLLKR 1390 1400 1410 1420 1430 1440 VVSTFSKDTG ELASASLDFM RQILNADAMG CCGDDSGLME VEGAHPPRTM SLNAAELKQL 1450 1460 1470 1480 1490 1500 LQSKEESPES LFLELEKLVL EHSKDDDSLE SLLDNVIGLK QMLESSGEPL PLSDQDVEPV 1510 1520 1530 1540 1550 1560 LSAPESLQNL FNNRTAYVLA DVMDDQLKSM WFTPFQAEEI DTDLDLVKVD LIELSEKCCS 1570 1580 1590 1600 1610 1620 DFDLHSELER SFLSEPSSPG RSKTTKGFKL GKHKHETFIT SSGKSEYIEP AKRAHVVPPP 1630 1640 1650 1660 1670 1680 RGRGRGGFGQ GIRPHDIFRQ RKQNTSRPPS MHVDDFVAAE SKEVVPQDGI PPPKRPLKVS 1690 1700 1710 1720 1730 1740 QKISSRGGFS GNRGGRGAFH SQNRFFTPPA SKGNYSRREG TRGSSWSAQN TPRGNYNESR 1750 1760 1770 1780 1790 1800 GGQSNFNRGP LPPLRPLSST GYRPSPRDRA SRGRGGLGPS WASTNSGSGG SRGKFVSGGS 1810 GRGRHVRSFT R
	Isoform 2 [UniParc]. Checksum: 90063C903B5C0D85	FASTA	1,139	127,461
	10 20 30 40 50 60 MAVDSSMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH SGLPDNRAYG 70 80 90 100 110 120 ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF RPNSKVNTDG LVLRGWYNCL 130 140 150 160 170 180 TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ PQPTLKRNLK HADGEKEDQF NGSPPRPQPR 190 200 210 220 230 240 GPRTPPGPPP PDDDEDDPMS LPVSGDKEED VPHREDYFEP ISPDRNSVPQ EGQYSDEGEV 250 260 270 280 290 300 EEEPQEEGED DEDDVDVEEE EDEDEDDCHT VDSIPDDEEE DEEEEGEEDE EGEGDDGYEQ 310 320 330 340 350 360 ISSDEDGIAD LERETFKYPN FDVEYTPEDL ASVPPMTYDP YDRELAPLLY FSCPYKTTFE 370 380 390 400 410 420 IEISRMKDQG PDKENSGAVE ASVKLTELLD LYQEDRGAKW VTALEEIPSL IIKGLSYLQL 430 440 450 460 470 480 KNTEQDSLGQ LVDWTMQALN LQVAFRQPIA LNVRQLKAGT KLVTSLAECG APGVTELLQA 490 500 510 520 530 540 GVINVLFDLL FADHVSSSLK LNAFKALDSV ISMTEGMEAF LRSTQNEKSG YQRLLELILL 550 560 570 580 590 600 DQTVRVVTAG SAILQKCHFY EILSEIKRLG DHIAEKTSAV PNHSEPDQDT DAVLERANPD 610 620 630 640 650 660 YENEVEASMD MDLLESSIIS EGEIEKLTNL LEEVFHVMET APHTMTQPPV KSFPTIARIT 670 680 690 700 710 720 GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPITSAHQGV LQATKDVLKF LAQSQKGLLF 730 740 750 760 770 780 FMSEYEATNL LIRALCHLYD QDEEEGLQSD GADDAFALWL QDSTQTLQCI TELFSHFQRC 790 800 810 820 830 840 TASEETDHSD LLGTLHNLYL ITFNPVGRSA VGHVFSLDKN LQSLITLMEY YSKEALGDSK 850 860 870 880 890 900 SKKSVAYNYA CVLTLVVAQS SSGVQMLEQH AASLLKLCKA DENNAKLQEL GKWLEPLKNL 910 920 930 940 950 960 RFEINCIPNL IEYVKQNIDN LMTAEGVGLT TALRVLCNVA CPPPPVEGQQ KDLKWNLAVI 970 980 990 1000 1010 1020 QLFSAEGMDT FIRVLQKLNS ILTQPWRLHV NMGTTLHRVT TISMARCTLT LLKTMLTELL 1030 1040 1050 1060 1070 1080 RGGSFEFKDM RVPSALVTLH MLLCSIPLSG RLDSDEQKIQ NDIIDILLTF TQGVNEKLTI 1090 1100 1110 1120 1130 SEETLANNTW SLMLKEVLSS ILKVPEGFFS GLILLSELLP LPLPMQTTQV PLHITCILS

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1210 AND 1737-1811 (ISOFORM 1). Strain: C57BL/6J and NOD. Tissue: Lung and Urinary bladder.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-1811 (ISOFORM 1). Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1421-1811 (ISOFORM 1). Strain: FVB/N. Tissue: Liver.
[5]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK012768 mRNA. Translation: BAB28456.1. AK052499 mRNA. Translation: BAC35017.2. AK155623 mRNA. Translation: BAE33351.1. AK162531 mRNA. Translation: BAE36958.1. AK170075 mRNA. Translation: BAE41548.1. AL732538, AL772170 Genomic DNA. Translation: CAM18405.1. AL732538, AL772170 Genomic DNA. Translation: CAM18406.1. AL772170, AL732538 Genomic DNA. Translation: CAM20819.1. AL772170, AL732538 Genomic DNA. Translation: CAM20820.1. AK122509 mRNA. Translation: BAC65791.1. BC028830 mRNA. Translation: AAH28830.1. Different initiation.
IPI	IPI00348445. IPI00869461.
UniGene	Mm.331487.
3D structure databases
ProteinModelPortal	A2AIV2.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000103943.
PTM databases
PhosphoSite	A2AIV2.
Proteomic databases
PaxDb	A2AIV2.
PRIDE	A2AIV2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000055372; ENSMUSP00000063188; ENSMUSG00000040720. ENSMUST00000059914; ENSMUSP00000058078; ENSMUSG00000040720.
UCSC	uc008rzo.1. mouse. uc008rzp.1. mouse.
Organism-specific databases
MGI	MGI:1913435. 1110037F02Rik.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG322397.
GeneTree	ENSGT00390000002833.
HOVERGEN	HBG094918.
OrthoDB	EOG4D52WT.
Gene expression databases
ArrayExpress	A2AIV2.
Bgee	A2AIV2.
CleanEx	MM_1110037F02RIK.
Genevestigator	A2AIV2.
Family and domain databases
InterPro	IPR026736. Virilizer. [Graphical view]
PANTHER	PTHR23185. PTHR23185. 1 hit.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

VIR_MOUSE

Accession

Primary (citable) accession number: A2AIV2
Secondary accession number(s): A2AIV1 , Q3TDQ3, Q3TRR9, Q3U1Z2, Q80TD6, Q8C758, Q8K151, Q9CSI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program