Unreviewed, UniProtKB/TrEMBL A2AIS0 (A2AIS0_MOUSE)

Names and origin

Protein names

Submitted name:
    Calcium channel, voltage-dependent, N type, alpha 1B subunit EMBL CAM22110.1

Gene names

Name:	Cacna1b MGI 88296
ORF Names:	RP23-264D16.5-001 EMBL CAM22110.1

Organism

Mus musculus (Mouse) EMBL CAM22110.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	2288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2AIS0-1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 2847EB88FE600366	FASTA	2,288	257,072
	10 20 30 40 50 60 MVRFGDELGG RYGGTGGGER ARGGGAGGAG GPGQGGLPPG QRVLYKQSIA QRARTMALYN 70 80 90 100 110 120 PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM ILATIIANCI VLALEQHLPD 130 140 150 160 170 180 GDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA 190 200 210 220 230 240 TAGTDFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII 250 260 270 280 290 300 GLEFYMGKFH KACFPNSTDT EPVGDFPCGK DPPARQCDGD TECREYWPGP NFGITNFDNI 310 320 330 340 350 360 LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL VLGVLSGEFA 370 380 390 400 410 420 KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML AEEDKNAEEK SPLDVLKRAA 430 440 450 460 470 480 TKKSRNDLIH AEEGEDRFVD LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRMVK 490 500 510 520 530 540 AQSFYWVVLC VVALNTLCVA MVHYNQPQRL TTALYFAEFV FLGLFLTEMS LKMYGLGPRS 550 560 570 580 590 600 YFRSSFNCFD FGVIVGSIFE VVWAAIKPGT SFGISVLRAL RLLRIFKVTK YWNSLRNLVV 610 620 630 640 650 660 SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL 670 680 690 700 710 720 TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK 730 740 750 760 770 780 DEEEMEEAAN QKLALQKAKE VAEVSPMSAA NISIAAQQNS AKARSVWEQR ASQLRLQNLR 790 800 810 820 830 840 ASCEALYSEM DPEERLRYAS TRHVRPDMKT HMDRPLVVEP GRDGLRGPVG SKSKPEGTEA 850 860 870 880 890 900 TESADLPRRH HRHRDRDKTS ATAPAGGEQD RTESTETGAR EERARPRRSH SKETPGADTQ 910 920 930 940 950 960 VRCERSRRHH RRGSPEEATE REPRRHRAHR HAQDSSKEGT APVLVPKGER RARHRGPRTG 970 980 990 1000 1010 1020 PREAENNEEP TRRHRARHKV PPTLQPPERE AAEKESNAVE GDKETRNHQP KEPHCDLEAI 1030 1040 1050 1060 1070 1080 AVTGVGPLHM LPSTCLQKVD EQPEDADNQR NVTRMGSQPS DPSTTVHVPV TLTGPPGETP 1090 1100 1110 1120 1130 1140 VVPSGNMNLE GQAEGKKEAE ADDVLRRGPR PIVPYSSMFC LSPTNLLRRF CHYIVTMRYF 1150 1160 1170 1180 1190 1200 EMVILVVIAL SSIALAAEDP VRTDSFRNNA LKYMDYIFTG VFTFEMVIKM IDLGLLLHPG 1210 1220 1230 1240 1250 1260 AYFRDLWNIL DFIVVSGALV AFAFSGSKGK DINTIKSLRV LRVLRPLKTI KRLPKLKAVF 1270 1280 1290 1300 1310 1320 DCVVNSLKNV LNILIVYMLF MFIFAVIAVQ LFKGKFFYCT DESKELERDC RGQYLDYEKE 1330 1340 1350 1360 1370 1380 EVEAQPRQWK KYDFHYDNVL WALLTLFTVS TGEGWPMVLK HSVDATYEEQ GPSPGFRMEL 1390 1400 1410 1420 1430 1440 SIFYVVYFVV FPFFFVNIFV ALIIITFQEQ GDKVMSECSL EKNERACIDF AISAKPLTRY 1450 1460 1470 1480 1490 1500 MPQNKQSFQY KTWTFVVSPP FEYFIMAMIA LNTVVLMMKF YDAPYEYELM LKCLNIVFTS 1510 1520 1530 1540 1550 1560 MFSMECILKI IAFGVLNYFR DAWNVFDFVT VLGSITDILV TEIAETNNFI NLSFLRLFRA 1570 1580 1590 1600 1610 1620 ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIAMLFFI YAIIGMQVFG NIALDDDTSI 1630 1640 1650 1660 1670 1680 NRHNNFRTFL QALMLLFRSA TGEAWHEIML SCLGNRACDP HANASECGSD FAYFYFVSFI 1690 1700 1710 1720 1730 1740 FLCSFLMLNL FVAVIMDNFE YLTRDSSILG PHHLDEFIRV WAEYDPAACG RISYNDMFEM 1750 1760 1770 1780 1790 1800 LKHMSPPLGL GKKCPARVAY KRLVRMNMPI SNEDMTVHFT STLMALIRTA LEIKLAPADE 1810 1820 1830 1840 1850 1860 MTVGKVYAAL MIFDFYKQNK TTRDQTHQAP GGLSQMGPVS LFHPLKATLE QTQPAVLRGA 1870 1880 1890 1900 1910 1920 RVFLRQKSAT SLSNGGAIQT QESGIKESLS WGTQRTQDAL YEARAPLERG HSAEIPVGQS 1930 1940 1950 1960 1970 1980 GTLAVDVQMQ NMTLRGPDGE PQPGLESQGR AASMPRLAAE TQPAPNASPM KRSISTLAPR 1990 2000 2010 2020 2030 2040 PHGTQLCSTV LDRPPPSQAS HHHHHRCHRR RDKKQRSLEK GPSLSVDPEG APSTAAGPGL 2050 2060 2070 2080 2090 2100 PHGEGSTACR RDRKQERGRS QERRQPSSSS SEKQRFYSCD RFGSREPPQL MPSLSSHPTS 2110 2120 2130 2140 2150 2160 PTAALEPAPH PQGSGSVNGS PLMSTSGAST PGRGGRRQLP QTPLTPRPSI TYKTANSSPV 2170 2180 2190 2200 2210 2220 HFAEGQSGLP AFSPGRLSRG LSEHNALLQK EPLSQPLAPG SRIGSDPYLG QRLDSEASAH 2230 2240 2250 2260 2270 2280 TLPEDTLTFE EAVATNSGRS SRTSYVSSLT SQSHPLRRVP NGYHCTLGLS TGVRARHSYH HPDQDHWC

References

[1]	Leongamornlert D. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Griffiths C. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Howden P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL732546, AL732525, BX294112 Genomic DNA. Translation: CAM19043.1. AL732525, AL732546, BX294112 Genomic DNA. Translation: CAM22110.1. BX294112, AL732525, AL732546 Genomic DNA. Translation: CAM27786.1.
IPI	IPI00625414.
RefSeq	NP_031605.2.
UniGene	Mm.4424
3D structure databases
SMR	A2AIS0. Positions 1136-1215.
ModBase	Search...
Protein-protein interaction databases
STRING	A2AIS0.
Proteomic databases
PRIDE	A2AIS0.
Genome annotation databases
Ensembl	ENSMUST00000070864; ENSMUSP00000063236; ENSMUSG00000004113; Mus musculus. [Genome view]
GeneID	12287.
Organism-specific databases
CTD	12287.
MGI	MGI:88296. Cacna1b.
Phylogenomic databases
HOVERGEN	A2AIS0.
Gene expression databases
Bgee	A2AIS0.
Genevestigator	A2AIS0.
Family and domain databases
InterPro	IPR018249. EF_HAND_2. IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005447. VDCC_N_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF58. NVDCCAlpha1. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01631. NVDCCALPHA1.
PROSITE	PS50222. EF_HAND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	280760.
SOURCE	Search...

Entry information

Entry name

A2AIS0_MOUSE

Accession

Primary (citable) accession number: A2AIS0

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)