Unreviewed, UniProtKB/TrEMBL A2AIR8 (A2AIR8_MOUSE)

Names and origin

Protein names

Submitted name:
    Calcium channel, voltage-dependent, N type, alpha 1B subunit EMBL CAM22108.1

Gene names

Name:	Cacna1b MGI 88296
ORF Names:	RP23-264D16.5-002 EMBL CAM22108.1

Organism

Mus musculus (Mouse) EMBL CAM22108.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	2327 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity. RuleBase RU003808V0
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808V0

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from mutant phenotype. Source: MGI locomotory behavior Inferred from mutant phenotype. Source: MGI neurotransmitter secretion Inferred from mutant phenotype. Source: MGI regulation of blood pressure Inferred from mutant phenotype. Source: MGI regulation of heart contraction Inferred from mutant phenotype. Source: MGI
Cellular component	cell soma Inferred from direct assay. Source: MGI dendrite Inferred from direct assay. Source: MGI voltage-gated calcium channel complex Inferred from direct assay. Source: MGI
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: MGI voltage-gated calcium channel activity Inferred from mutant phenotype. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2AIR8-1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: AD42CDD38482895A	FASTA	2,327	261,481
	10 20 30 40 50 60 MVRFGDELGG RYGGTGGGER ARGGGAGGAG GPGQGGLPPG QRVLYKQSIA QRARTMALYN 70 80 90 100 110 120 PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM ILATIIANCI VLALEQHLPD 130 140 150 160 170 180 GDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA 190 200 210 220 230 240 TAGTDFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII 250 260 270 280 290 300 GLEFYMGKFH KACFPNSTDT EPVGDFPCGK DPPARQCDGD TECREYWPGP NFGITNFDNI 310 320 330 340 350 360 LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL VLGVLSGEFA 370 380 390 400 410 420 KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML AEEDKNAEEK SPLDVLKRAA 430 440 450 460 470 480 TKKSRNDLIH AEEGEDRFVD LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRMVK 490 500 510 520 530 540 AQSFYWVVLC VVALNTLCVA MVHYNQPQRL TTALYFAEFV FLGLFLTEMS LKMYGLGPRS 550 560 570 580 590 600 YFRSSFNCFD FGVIVGSIFE VVWAAIKPGT SFGISVLRAL RLLRIFKVTK YWNSLRNLVV 610 620 630 640 650 660 SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL 670 680 690 700 710 720 TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK 730 740 750 760 770 780 DEEEMEEAAN QKLALQKAKE VAEVSPMSAA NISIAARQQN SAKARSVWEQ RASQLRLQNL 790 800 810 820 830 840 RASCEALYSE MDPEERLRYA STRHVRPDMK THMDRPLVVE PGRDGLRGPV GSKSKPEGTE 850 860 870 880 890 900 ATESADLPRR HHRHRDRDKT SATAPAGGEQ DRTESTETGA REERARPRRS HSKETPGADT 910 920 930 940 950 960 QVRCERSRRH HRRGSPEEAT EREPRRHRAH RHAQDSSKEG TAPVLVPKGE RRARHRGPRT 970 980 990 1000 1010 1020 GPREAENNEE PTRRHRARHK VPPTLQPPER EAAEKESNAV EGDKETRNHQ PKEPHCDLEA 1030 1040 1050 1060 1070 1080 IAVTGVGPLH MLPSTCLQKV DEQPEDADNQ RNVTRMGSQP SDPSTTVHVP VTLTGPPGET 1090 1100 1110 1120 1130 1140 PVVPSGNMNL EGQAEGKKEA EADDVLRRGP RPIVPYSSMF CLSPTNLLRR FCHYIVTMRY 1150 1160 1170 1180 1190 1200 FEMVILVVIA LSSIALAAED PVRTDSFRNN ALKYMDYIFT GVFTFEMVIK MIDLGLLLHP 1210 1220 1230 1240 1250 1260 GAYFRDLWNI LDFIVVSGAL VAFAFSSFMG GSKGKDINTI KSLRVLRVLR PLKTIKRLPK 1270 1280 1290 1300 1310 1320 LKAVFDCVVN SLKNVLNILI VYMLFMFIFA VIAVQLFKGK FFYCTDESKE LERDCRGQYL 1330 1340 1350 1360 1370 1380 DYEKEEVEAQ PRQWKKYDFH YDNVLWALLT LFTVSTGEGW PMVLKHSVDA TYEEQGPSPG 1390 1400 1410 1420 1430 1440 FRMELSIFYV VYFVVFPFFF VNIFVALIII TFQEQGDKVM SECSLEKNER ACIDFAISAK 1450 1460 1470 1480 1490 1500 PLTRYMPQNK QSFQYKTWTF VVSPPFEYFI MAMIALNTVV LMMKFYDAPY EYELMLKCLN 1510 1520 1530 1540 1550 1560 IVFTSMFSME CILKIIAFGV LNYFRDAWNV FDFVTVLGSI TDILVTEIAN NFINLSFLRL 1570 1580 1590 1600 1610 1620 FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ VFGNIALDDD 1630 1640 1650 1660 1670 1680 TSINRHNNFR TFLQALMLLF RSATGEAWHE IMLSCLGNRA CDPHANASEC GSDFAYFYFV 1690 1700 1710 1720 1730 1740 SFIFLCSFLM LNLFVAVIMD NFEYLTRDSS ILGPHHLDEF IRVWAEYDPA ACGRISYNDM 1750 1760 1770 1780 1790 1800 FEMLKHMSPP LGLGKKCPAR VAYKRLVRMN MPISNEDMTV HFTSTLMALI RTALEIKLAP 1810 1820 1830 1840 1850 1860 AGTKQHQCDA ELRKEISSVW ANLPQKTLDL LVPPHKPDEM TVGKVYAALM IFDFYKQNKT 1870 1880 1890 1900 1910 1920 TRDQTHQAPG GLSQMGPVSL FHPLKATLEQ TQPAVLRGAR VFLRQKSATS LSNGGAIQTQ 1930 1940 1950 1960 1970 1980 ESGIKESLSW GTQRTQDALY EARAPLERGH SAEIPVGQSG TLAVDVQMQN MTLRGPDGEP 1990 2000 2010 2020 2030 2040 QPGLESQGRA ASMPRLAAET QPAPNASPMK RSISTLAPRP HGTQLCSTVL DRPPPSQASH 2050 2060 2070 2080 2090 2100 HHHHRCHRRR DKKQRSLEKG PSLSVDPEGA PSTAAGPGLP HGEGSTACRR DRKQERGRSQ 2110 2120 2130 2140 2150 2160 ERRQPSSSSS EKQRFYSCDR FGSREPPQLM PSLSSHPTSP TAALEPAPHP QGSGSVNGSP 2170 2180 2190 2200 2210 2220 LMSTSGASTP GRGGRRQLPQ TPLTPRPSIT YKTANSSPVH FAEGQSGLPA FSPGRLSRGL 2230 2240 2250 2260 2270 2280 SEHNALLQKE PLSQPLAPGS RIGSDPYLGQ RLDSEASAHT LPEDTLTFEE AVATNSGRSS 2290 2300 2310 2320 RTSYVSSLTS QSHPLRRVPN GYHCTLGLST GVRARHSYHH PDQDHWC

References

[1]	Leongamornlert D. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Griffiths C. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Howden P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL732546, AL732525, BX294112 Genomic DNA. Translation: CAM19045.1. AL732525, AL732546, BX294112 Genomic DNA. Translation: CAM22108.1. BX294112, AL732525, AL732546 Genomic DNA. Translation: CAM27787.1.
IPI	IPI00115062.
RefSeq	NP_001035993.1.
UniGene	Mm.4424
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2AIR8.
Proteomic databases
PRIDE	A2AIR8.
Genome annotation databases
Ensembl	ENSMUST00000041342; ENSMUSP00000037416; ENSMUSG00000004113; Mus musculus. [Genome view] ENSMUST00000070864; ENSMUSP00000063236; ENSMUSG00000004113; Mus musculus. [Genome view] ENSMUST00000093372; ENSMUSP00000091064; ENSMUSG00000004113; Mus musculus. [Genome view] ENSMUST00000100348; ENSMUSP00000097920; ENSMUSG00000004113; Mus musculus. [Genome view] ENSMUST00000102939; ENSMUSP00000100003; ENSMUSG00000004113; Mus musculus. [Genome view] ENSMUST00000114442; ENSMUSP00000110085; ENSMUSG00000004113; Mus musculus. [Genome view] ENSMUST00000114447; ENSMUSP00000110090; ENSMUSG00000004113; Mus musculus. [Genome view] ENSMUST00000114453; ENSMUSP00000110097; ENSMUSG00000004113; Mus musculus. [Genome view]
GeneID	12287.
KEGG	mmu:12287.
Organism-specific databases
CTD	12287.
MGI	MGI:88296. Cacna1b.
Phylogenomic databases
HOVERGEN	A2AIR8.
Gene expression databases
Bgee	A2AIR8.
Genevestigator	A2AIR8.
Family and domain databases
InterPro	IPR018249. EF_HAND_2. IPR005821. Ion_trans. IPR005447. VDCC_N_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF58. NVDCCAlpha1. 1 hit.
Pfam	PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01631. NVDCCALPHA1.
PROSITE	PS50222. EF_HAND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	280760.
SOURCE	Search...

Entry information

Entry name

A2AIR8_MOUSE

Accession

Primary (citable) accession number: A2AIR8

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)