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Protein
Submitted name:

Glutamate receptor ionotropic, NMDA3A

Gene

Grin3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • calcium ion transport Source: MGI
  • dendrite development Source: MGI
  • ionotropic glutamate receptor signaling pathway Source: MGI
  • prepulse inhibition Source: MGI
  • response to ethanol Source: MGI
  • rhythmic process Source: MGI

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate receptor ionotropic, NMDA3AImported
Gene namesi
Name:Grin3aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1933206 Grin3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Transmembranei716 – 734HelicalSequence analysisAdd BLAST19
Transmembranei746 – 769HelicalSequence analysisAdd BLAST24
Transmembranei934 – 956HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500264269327 – 1115Sequence analysisAdd BLAST1089

Proteomic databases

MaxQBiA2AIR4
PaxDbiA2AIR4
PRIDEiA2AIR4

Expressioni

Gene expression databases

BgeeiENSMUSG00000039579
ExpressionAtlasiA2AIR4 baseline and differential
GenevisibleiA2AIR4 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075970

Structurei

3D structure databases

ProteinModelPortaliA2AIR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini557 – 622Lig_chan-Glu_bdInterPro annotationAdd BLAST66
Domaini565 – 910PBPeInterPro annotationAdd BLAST346

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1065 – 1099Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
KOiK05213
TreeFamiTF314731

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

A2AIR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV
60 70 80 90 100
GAVHLQPWTT APRAASRAQD GGRAGAQRDE PESGTWRPPA PSQGARWLGS
110 120 130 140 150
ALHGRGPPGS RKLGEGAGTE TLWPRDALLF AVENLNRVEG LLPYNLSLEV
160 170 180 190 200
VMAIEAGLGD LPLMPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP
210 220 230 240 250
QSQGEMMELD LVSSVLHIPV LSIVRHEFPR ESQNPLHLQL SLENSLSSDA
260 270 280 290 300
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTENNSKFH LESIINITAN
310 320 330 340 350
LSSTKDLLSF LQVQLENIRN STPTMVMFGC DMGSIRQIFE MSTQFGLSPP
360 370 380 390 400
DLHWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEYYVQ DAMELVARAV
410 420 430 440 450
ATATMIQPEL ALLPSTMNCM DVKTTNLTSG QYLSRFLANT TFRGLSGSIK
460 470 480 490 500
VKGSTIVSSE NNFFIWNLQY DPMGKPMWTR LGSWQGGRIV MDSGIWPEQA
510 520 530 540 550
QRHKTHFHHP NKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND
560 570 580 590 600
SSILDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEQLAED MNFDFDLYIV
610 620 630 640 650
GDGKYGAWKN GHWTGLVGDL LSGTANMAVT SFSINTARSQ VIDFTSPFFS
660 670 680 690 700
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAI FLTLYEWKSP
710 720 730 740 750
FGMTPKGRNR NKVFSFSSAL NVCYALLFGR TAAIKPPKCW TGRFLMNLWA
760 770 780 790 800
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES
810 820 830 840 850
SAEDYVRQSF PEMHEYMRRY NVPATPDGVQ YLKNDPEKLD AFIMDKALLD
860 870 880 890 900
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTSNISEL ISQYKSHGFM
910 920 930 940 950
DVLHDKWYKV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI
960 970 980 990 1000
GEHIVYRLLL PRIKNKSKLQ YWLHTSQRFH RALNTSFVEE KQPCSKTKRV
1010 1020 1030 1040 1050
EKRSNMGPQQ LMVWNTSNLS HDNQRKYIFN DEEGQNQLGT QTHQDIPLPP
1060 1070 1080 1090 1100
RRRELPASLT TNGKADSLNV ARNSVMQELS ELEKQIQVIR QELQLAVSRK
1110
TELEEYQRTN RTCES
Length:1,115
Mass (Da):125,105
Last modified:February 20, 2007 - v1
Checksum:iC10145036DF07774
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732521 Genomic DNA No translation available.
AL807392 Genomic DNA No translation available.
RefSeqiNP_001028523.1, NM_001033351.2
UniGeneiMm.440095

Genome annotation databases

EnsembliENSMUST00000076674; ENSMUSP00000075970; ENSMUSG00000039579
GeneIDi242443
KEGGimmu:242443
UCSCiuc008swe.3 mouse

Similar proteinsi

Entry informationi

Entry nameiA2AIR4_MOUSE
AccessioniPrimary (citable) accession number: A2AIR4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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