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Protein

1-aminocyclopropane-1-carboxylate synthase-like protein 1

Gene

Accs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate synthase-like protein 1
Short name:
ACC synthase-like protein 1
Gene namesi
Name:Accs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919717. Accs.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5025021-aminocyclopropane-1-carboxylate synthase-like protein 1PRO_0000318072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei324 – 3241N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

EPDiA2AIG8.
MaxQBiA2AIG8.
PaxDbiA2AIG8.
PRIDEiA2AIG8.

PTM databases

PhosphoSiteiA2AIG8.

Expressioni

Gene expression databases

BgeeiA2AIG8.
ExpressionAtlasiA2AIG8. baseline and differential.
GenevisibleiA2AIG8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036268.

Structurei

3D structure databases

ProteinModelPortaliA2AIG8.
SMRiA2AIG8. Positions 81-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0256. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiA2AIG8.
OMAiQVAEDPP.
OrthoDBiEOG7Q8CN0.
PhylomeDBiA2AIG8.
TreeFamiTF354218.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AIG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFCLPQQEST APTTCTGSAS TQDMDSGYGD GLQGECLRKP DQTQPKLYGV
60 70 80 90 100
GDPTATFSSD SSCLSSRGRV IKWFWDSAEE GYRTYHMDEY DEDKNPSGII
110 120 130 140 150
NLGTSENKLC FDLLSWRLTQ GDMLHVEPSL LQYPDWRGHL FLREEVAKFL
160 170 180 190 200
SFYCKSPAPL KPENVVVLNG CASLFSALAT VLCEAGEALL IPTPYYGAIT
210 220 230 240 250
QHIYLYGNVR LAYVYLDSKV TGLNTRPFQL TVEKLEMVLQ GVSSEGVKVK
260 270 280 290 300
GLILINPQNP LGDVYSPEEL QDFLRFAMRH KLHVIMDEVY MLSVFEESLG
310 320 330 340 350
YRSVLSLERL PDPQRTHVMW ATSKDFGMSG LRFGVLYTEN QHVATAVASL
360 370 380 390 400
CRYHGLSGLV QHQMAQLLRD HDWISQVYLP ENHARLKAAH TYVSEELRAL
410 420 430 440 450
GIPFVSRGAG FFIWVDLRKY LCKGTFEEEA LLWRQFLDNK VLLSSGKTFE
460 470 480 490 500
CKEPGWFRVV FSDKENRLRL GMQRMRQVLE GQSQVVEDAS PCHAQEPQSQ

PR
Length:502
Mass (Da):56,879
Last modified:February 20, 2007 - v1
Checksum:i9399891308FC91A0
GO
Isoform 21 Publication (identifier: A2AIG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:479
Mass (Da):54,492
Checksum:i85C5DAF048E3AE14
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2. 1 PublicationVSP_052669Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732472 Genomic DNA. Translation: CAM23884.1.
AL732472 Genomic DNA. Translation: CAM23885.1.
BC039569 mRNA. Translation: AAH39569.1.
CCDSiCCDS16457.1. [A2AIG8-2]
CCDS71105.1. [A2AIG8-1]
RefSeqiNP_001277711.1. NM_001290782.1. [A2AIG8-1]
NP_899043.1. NM_183220.3. [A2AIG8-2]
XP_006499823.1. XM_006499760.2. [A2AIG8-1]
XP_006499824.1. XM_006499761.2. [A2AIG8-1]
XP_006499825.1. XM_006499762.2. [A2AIG8-1]
XP_006499826.1. XM_006499763.2. [A2AIG8-2]
XP_006499827.1. XM_006499764.2. [A2AIG8-2]
XP_006499828.1. XM_006499765.2. [A2AIG8-2]
XP_006499829.1. XM_006499766.2. [A2AIG8-2]
UniGeneiMm.486910.

Genome annotation databases

EnsembliENSMUST00000041593; ENSMUSP00000036268; ENSMUSG00000040272. [A2AIG8-2]
ENSMUST00000068513; ENSMUSP00000065389; ENSMUSG00000040272. [A2AIG8-2]
ENSMUST00000111246; ENSMUSP00000106877; ENSMUSG00000040272. [A2AIG8-1]
GeneIDi329470.
KEGGimmu:329470.
UCSCiuc008lgj.2. mouse. [A2AIG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732472 Genomic DNA. Translation: CAM23884.1.
AL732472 Genomic DNA. Translation: CAM23885.1.
BC039569 mRNA. Translation: AAH39569.1.
CCDSiCCDS16457.1. [A2AIG8-2]
CCDS71105.1. [A2AIG8-1]
RefSeqiNP_001277711.1. NM_001290782.1. [A2AIG8-1]
NP_899043.1. NM_183220.3. [A2AIG8-2]
XP_006499823.1. XM_006499760.2. [A2AIG8-1]
XP_006499824.1. XM_006499761.2. [A2AIG8-1]
XP_006499825.1. XM_006499762.2. [A2AIG8-1]
XP_006499826.1. XM_006499763.2. [A2AIG8-2]
XP_006499827.1. XM_006499764.2. [A2AIG8-2]
XP_006499828.1. XM_006499765.2. [A2AIG8-2]
XP_006499829.1. XM_006499766.2. [A2AIG8-2]
UniGeneiMm.486910.

3D structure databases

ProteinModelPortaliA2AIG8.
SMRiA2AIG8. Positions 81-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036268.

PTM databases

PhosphoSiteiA2AIG8.

Proteomic databases

EPDiA2AIG8.
MaxQBiA2AIG8.
PaxDbiA2AIG8.
PRIDEiA2AIG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041593; ENSMUSP00000036268; ENSMUSG00000040272. [A2AIG8-2]
ENSMUST00000068513; ENSMUSP00000065389; ENSMUSG00000040272. [A2AIG8-2]
ENSMUST00000111246; ENSMUSP00000106877; ENSMUSG00000040272. [A2AIG8-1]
GeneIDi329470.
KEGGimmu:329470.
UCSCiuc008lgj.2. mouse. [A2AIG8-1]

Organism-specific databases

CTDi84680.
MGIiMGI:1919717. Accs.

Phylogenomic databases

eggNOGiKOG0256. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiA2AIG8.
OMAiQVAEDPP.
OrthoDBiEOG7Q8CN0.
PhylomeDBiA2AIG8.
TreeFamiTF354218.

Miscellaneous databases

NextBioi398767.
PROiA2AIG8.
SOURCEiSearch...

Gene expression databases

BgeeiA2AIG8.
ExpressionAtlasiA2AIG8. baseline and differential.
GenevisibleiA2AIG8. MM.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6JImported.
    Tissue: Mammary glandImported.

Entry informationi

Entry namei1A1L1_MOUSE
AccessioniPrimary (citable) accession number: A2AIG8
Secondary accession number(s): Q8CHS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: March 16, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.