A2AI21 (A2AI21_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glutamate receptor ionotropic NMDA1 (Zeta 1) EMBL CAM14691.1

Submitted name:
Uncharacterized protein Ensembl ENSMUSP00000109949

Gene names

Name:	Grin1 MGI 95819 Ensembl ENSMUSP00000109949
ORF Names:	RP23-132N23.20-007 EMBL CAM14691.1

Organism

Mus musculus (Mouse) EMBL CAM14691.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	959 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane SAAS SAAS001508 Membrane Postsynaptic cell membrane SAAS SAAS001508 Synapse
Domain	Transmembrane Transmembrane helix SAAS SAAS001508
Molecular function	Ionic channel Ligand-gated ion channel SAAS SAAS001508 Receptor SAAS SAAS001508 EMBL CAM14691.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adult locomotory behavior Inferred from mutant phenotype. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype. Source: MGI cerebral cortex development Inferred from mutant phenotype. Source: MGI conditioned taste aversion Inferred from mutant phenotype. Source: MGI ionotropic glutamate receptor signaling pathway Inferred from direct assay. Source: MGI long-term memory Inferred from mutant phenotype. Source: MGI male mating behavior Inferred from mutant phenotype. Source: MGI negative regulation of neuron apoptosis Inferred from mutant phenotype. Source: MGI olfactory learning Inferred from mutant phenotype. Source: MGI pons maturation Inferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI prepulse inhibition Inferred from mutant phenotype. Source: MGI regulation of axonogenesis Inferred from mutant phenotype. Source: MGI regulation of dendrite morphogenesis Inferred from mutant phenotype. Source: MGI regulation of excitatory postsynaptic membrane potential Inferred from mutant phenotype. Source: MGI regulation of long-term neuronal synaptic plasticity Inferred from mutant phenotype. Source: MGI regulation of respiratory gaseous exchange Inferred from mutant phenotype. Source: MGI regulation of synapse assembly Inferred from mutant phenotype. Source: MGI respiratory gaseous exchange Inferred from mutant phenotype. Source: MGI response to amphetamine Inferred from mutant phenotype. Source: MGI response to morphine Inferred from mutant phenotype. Source: MGI sensory perception of pain Inferred from mutant phenotype. Source: MGI social behavior Inferred from mutant phenotype. Source: MGI suckling behavior Inferred from mutant phenotype. Source: MGI synaptic transmission, glutamatergic Inferred from mutant phenotype. Source: MGI visual learning Inferred from mutant phenotype. Source: MGI
Cellular component	N-methyl-D-aspartate selective glutamate receptor complex Inferred from physical interaction. Source: MGI cell junction Inferred from electronic annotation. Source: UniProtKB-KW outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro postsynaptic density Inferred from direct assay. Source: MGI postsynaptic membrane Inferred from direct assay. Source: MGI synaptic vesicle Inferred from direct assay. Source: MGI synaptosome Inferred from direct assay. Source: MGI
Molecular function	N-methyl-D-aspartate selective glutamate receptor activity Inferred from direct assay. Source: MGI calcium channel activity Inferred from direct assay. Source: MGI calcium ion binding Inferred from direct assay. Source: MGI calmodulin binding Inferred from direct assay. Source: MGI extracellular-glutamate-gated ion channel activity Inferred from electronic annotation. Source: InterPro receptor binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2AI21 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 7E4806D130DD30DF	FASTA	959	108,017
	10 20 30 40 50 60 MSTMHLLTFA LLFSCSFARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL 70 80 90 100 110 120 NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG 130 140 150 160 170 180 LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYNW NHIILLVSDD HEGRAAQKRL 190 200 210 220 230 240 ETLLEERESK SKKRNYENLD QLSYDNKRGP KAEKVLQFDP GTKNVTALLM EARDLEARVI 250 260 270 280 290 300 ILSASEDDAA TVYRAAAMLN MTGSGYVWLV GEREISGNAL RYAPDGIIGL QLINGKNESA 310 320 330 340 350 360 HISDAVGVVA QAVHELLEKE NITDPPRGCV GNTNIWKTGP LFKRVLMSSK YADGVTGRVE 370 380 390 400 410 420 FNEDGDRKFA NYSIMNLQNR KLVQVGIYNG THVIPNDRKI IWPGGETEKP RGYQMSTRLK 430 440 450 460 470 480 IVTIHQEPFV YVKPTMSDGT CKEEFTVNGD PVKKVICTGP NDTSPGSPRH TVPQCCYGFC 490 500 510 520 530 540 VDLLIKLART MNFTYEVHLV ADGKFGTQER VNNSNKKEWN GMMGELLSGQ ADMIVAPLTI 550 560 570 580 590 600 NNERAQYIEF SKPFKYQGLT ILVKKEIPRS TLDSFMQPFQ STLWLLVGLS VHVVAVMLYL 610 620 630 640 650 660 LDRFSPFGRF KVNSEEEEED ALTLSSAMWF SWGVLLNSGI GEGAPRSFSA RILGMVWAGF 670 680 690 700 710 720 AMIIVASYTA NLAAFLVLDR PEERITGIND PRLRNPSDKF IYATVKQSSV DIYFRRQVEL 730 740 750 760 770 780 STMYRHMEKH NYESAAEAIQ AVRDNKLHAF IWDSAVLEFE ASQKCDLVTT GELFFRSGFG 790 800 810 820 830 840 IGMRKDSPWK QNVSLSILKS HENGFMEDLD KTWVRYQECD SRSNAPATLT FENMAGVFML 850 860 870 880 890 900 VAGGIVAGIF LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQDRKSGR AEPDPKKKAT 910 920 930 940 950 FRAITSTLAS SFKRRRSSKD TSTGGGRGAL QNQKDTVLPR RAIEREEGQL QLCSRHRES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Mouse Genome Sequencing Consortium Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6 Ensembl ENSMUSP00000109949.
[2]	Leongamornlert D. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ensembl Submitted (JUN-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000109949.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL732309 Genomic DNA. Translation: CAM14691.1.
IPI	IPI00751834.
UniGene	Mm.278672.
3D structure databases
ProteinModelPortal	A2AI21.
SMR	A2AI21. Positions 24-415, 418-821.
ModBase	Search...
Protein-protein interaction databases
IntAct	A2AI21. 1 interaction.
STRING	A2AI21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000114310; ENSMUSP00000109949; ENSMUSG00000026959.
Organism-specific databases
MGI	MGI:95819. Grin1.
Phylogenomic databases
GeneTree	ENSGT00590000083017.
HOGENOM	HBG713365.
HOVERGEN	HBG052638.
InParanoid	A2AI21.
OMA	VYVKPTL.
Gene expression databases
Bgee	A2AI21.
Genevestigator	A2AI21.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR018882. CaM-bd_C0_NMDA_rcpt_NR1. IPR019594. Glu_rcpt_Glu/Gly-bd. IPR001320. Iontro_glu_rcpt. IPR001508. NMDA_rcpt. IPR001638. SBP_bac_3. [Graphical view]
Pfam	PF01094. ANF_receptor. 1 hit. PF10562. CaM_bdg_C0. 1 hit. PF00060. Lig_chan. 1 hit. PF00497. SBP_bac_3. 1 hit. [Graphical view]
PRINTS	PR00177. NMDARECEPTOR.
SMART	SM00918. Lig_chan-Glu_bd. 1 hit. SM00079. PBPe. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

A2AI21_MOUSE

Accession

Primary (citable) accession number: A2AI21

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)