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Protein

Taperin

Gene

Tprn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Taperin
Gene namesi
Name:Tprn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139535. Tprn.

Subcellular locationi

GO - Cellular componenti

  • stereocilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749TaperinPRO_0000330310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741PhosphoserineBy similarity
Modified residuei457 – 4571PhosphoserineCombined sources
Modified residuei501 – 5011PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AI08.
MaxQBiA2AI08.
PaxDbiA2AI08.
PRIDEiA2AI08.

PTM databases

iPTMnetiA2AI08.
PhosphoSiteiA2AI08.

Expressioni

Tissue specificityi

Expressed in the sensory epithelia of the organ of Corti and vestibular end organs and, to a lesser extent, in Reisner's membrane and the spiral ligament (at protein level). At postnatal day 2, expression is detected in cochlea, liver, brain, kidney, heart and lung.2 Publications

Gene expression databases

BgeeiA2AI08.
GenevisibleiA2AI08. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109975.

Structurei

3D structure databases

ProteinModelPortaliA2AI08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi106 – 321216Pro-richAdd
BLAST
Compositional biasi637 – 66529Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the taperin family.Curated

Phylogenomic databases

eggNOGiENOG410IHYC. Eukaryota.
ENOG410ZR6R. LUCA.
GeneTreeiENSGT00530000064035.
HOVERGENiHBG107679.
InParanoidiA2AI08.
OMAiRMPAWKR.
OrthoDBiEOG72G18V.
PhylomeDBiA2AI08.
TreeFamiTF333324.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
IPR033359. TPRN.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PTHR21685:SF1. PTHR21685:SF1. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AI08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLGRLDPG PRTVMPAWKR EILERRRAKL AALSGGQGSG AAPDGPNERL
60 70 80 90 100
VLAESLGPLS QNPFMRLESE RRRGTRPAQQ LLELYCRVPG VRTIRADNIL
110 120 130 140 150
IIESAPGFPP AVPPAAGIRA AEVVVYEAPQ PGRVSRLLEK FDSPAAPCRR
160 170 180 190 200
GSPERFRPAL PQLPVASASA ATRTPTNRSL APASPVRLSQ PAPPISPVPV
210 220 230 240 250
AQRAGQRSAC CEPAHPDGTA GPGARRSDFL QKTGSNSFTV HPRGLPRSAV
260 270 280 290 300
NRSLSNGPMT QESPTGPANG LSGSPPVPGK WKPKVESKEP SLHPPPSPGT
310 320 330 340 350
PSATSVGPPA FPAPSPASAT PSQRQWVSSA TSANDSFEIR PSSKPDMETI
360 370 380 390 400
PIGDLQARAL ANLRVNSRNS FVLIPKRKAP GNYPLAGRQF EEPKGEVGWA
410 420 430 440 450
SQSQGLGSQL VSTVDGAPAL EKSPLAAEMQ WAVRKGACPR PAISDTDKCV
460 470 480 490 500
RWQRPASPPP FLPATAEAEP AEGLGVPGLA KNGQEPVRPG LPVTFIDEVD
510 520 530 540 550
SEEEAFQEAK LPSSAVGVPS QYHLHPARPG HTSELLNRGS NTFTVVPKRK
560 570 580 590 600
PGTLQEPHLS QTNGQSQQGA EEQDAESLSG PHTTLENTLK KRYPTVHEIE
610 620 630 640 650
VIGGYLALQK SCLIKAGSSR KKMKISFNDK SLHTTFEYPS ESSLAQEEAE
660 670 680 690 700
EEEEEEGEED GEEEEVGPDS EKPFTVFLPR ATFVSSVGPE SSSGLSSYTP
710 720 730 740
KHSMAFSKWQ EQTLVQTPTD VELPPKEVML TPASQNDLSD FRSEPALYF
Length:749
Mass (Da):80,089
Last modified:February 20, 2007 - v1
Checksum:i02E3D12D60051082
GO

Sequence cautioni

The sequence AAH89508.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC38669.1 differs from that shown. Reason: Frameshift at position 241. Curated
The sequence BAC38669.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE38373.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE42670.1 differs from that shown. Reason: Frameshift at position 180. Curated
The sequence BAE42670.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti264 – 2641P → T in BAE38373 (PubMed:16141072).Curated
Sequence conflicti265 – 2651T → A in BAE42670 (PubMed:16141072).Curated
Sequence conflicti432 – 4321A → V in BAE42670 (PubMed:16141072).Curated
Sequence conflicti527 – 5271A → D in BAE42670 (PubMed:16141072).Curated
Sequence conflicti531 – 5322HT → DN in BAE42670 (PubMed:16141072).Curated
Sequence conflicti650 – 6501Missing in BAE42670 (PubMed:16141072).Curated
Sequence conflicti671 – 6711E → G in AAH89508 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082888 mRNA. Translation: BAC38669.1. Sequence problems.
AK165772 mRNA. Translation: BAE38373.1. Different initiation.
AK171799 mRNA. Translation: BAE42670.1. Sequence problems.
AL732309 Genomic DNA. Translation: CAM14678.1.
BC024573 mRNA. Translation: AAH24573.1.
BC055478 mRNA. Translation: AAH55478.1.
BC089508 mRNA. Translation: AAH89508.1. Different initiation.
CCDSiCCDS15759.2.
RefSeqiNP_780495.2. NM_175286.4.
UniGeneiMm.308539.

Genome annotation databases

EnsembliENSMUST00000114336; ENSMUSP00000109975; ENSMUSG00000048707.
GeneIDi97031.
KEGGimmu:97031.
UCSCiuc008ira.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082888 mRNA. Translation: BAC38669.1. Sequence problems.
AK165772 mRNA. Translation: BAE38373.1. Different initiation.
AK171799 mRNA. Translation: BAE42670.1. Sequence problems.
AL732309 Genomic DNA. Translation: CAM14678.1.
BC024573 mRNA. Translation: AAH24573.1.
BC055478 mRNA. Translation: AAH55478.1.
BC089508 mRNA. Translation: AAH89508.1. Different initiation.
CCDSiCCDS15759.2.
RefSeqiNP_780495.2. NM_175286.4.
UniGeneiMm.308539.

3D structure databases

ProteinModelPortaliA2AI08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109975.

PTM databases

iPTMnetiA2AI08.
PhosphoSiteiA2AI08.

Proteomic databases

EPDiA2AI08.
MaxQBiA2AI08.
PaxDbiA2AI08.
PRIDEiA2AI08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114336; ENSMUSP00000109975; ENSMUSG00000048707.
GeneIDi97031.
KEGGimmu:97031.
UCSCiuc008ira.2. mouse.

Organism-specific databases

CTDi286262.
MGIiMGI:2139535. Tprn.

Phylogenomic databases

eggNOGiENOG410IHYC. Eukaryota.
ENOG410ZR6R. LUCA.
GeneTreeiENSGT00530000064035.
HOVERGENiHBG107679.
InParanoidiA2AI08.
OMAiRMPAWKR.
OrthoDBiEOG72G18V.
PhylomeDBiA2AI08.
TreeFamiTF333324.

Miscellaneous databases

NextBioi352461.
PROiA2AI08.
SOURCEiSearch...

Gene expression databases

BgeeiA2AI08.
GenevisibleiA2AI08. MM.

Family and domain databases

InterProiIPR025903. Phostensin/Taperin_N_dom.
IPR025907. Phostensin/Taperin_PP1-bd_dom.
IPR026671. PPP1R18/Tprn.
IPR033359. TPRN.
[Graphical view]
PANTHERiPTHR21685. PTHR21685. 1 hit.
PTHR21685:SF1. PTHR21685:SF1. 1 hit.
PfamiPF13914. Phostensin. 1 hit.
PF13916. Phostensin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Diencephalon.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 135-749.
    Strain: FVB/N.
    Tissue: Brain and Kidney.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79."
    Rehman A.U., Morell R.J., Belyantseva I.A., Khan S.Y., Boger E.T., Shahzad M., Ahmed Z.M., Riazuddin S., Khan S.N., Riazuddin S., Friedman T.B.
    Am. J. Hum. Genet. 86:378-388(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. Cited for: TISSUE SPECIFICITY.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Spleen and Testis.

Entry informationi

Entry nameiTPRN_MOUSE
AccessioniPrimary (citable) accession number: A2AI08
Secondary accession number(s): Q3TAJ8
, Q3TMR8, Q5FWB3, Q7TNG3, Q8BNM5, Q8R1G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.