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Protein

Diacylglycerol kinase

Gene

Dgkz

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DgkzImported
ORF Names:mCG_130421Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1278339 Dgkz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiA2AHK0

Expressioni

Gene expression databases

BgeeiENSMUSG00000040479

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini486 – 620DAGKcInterPro annotationAdd BLAST135
Domaini989 – 1105ANK_REP_REGIONInterPro annotationAdd BLAST117
Repeati1017 – 1040ANKPROSITE-ProRule annotationAdd BLAST24
Repeati1052 – 1084ANKPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000231472
HOVERGENiHBG067303
OMAiAGGDLMH
OrthoDBiEOG091G13Z8
TreeFamiTF312817

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00029 C1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit

Sequencei

Sequence statusi: Complete.

A2AHK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METFFRKHFQ RKARGPGERQ RRSSGVGLPT GKARRRSPAG QASSSLAQRR
60 70 80 90 100
RSSAQLQGCF PSCGVGTRGA SRRRSSTAPP TCNPRFMVDV VPTLQPVTVG
110 120 130 140 150
AQLLGAPLLL AGLTSMKEEE EEEGVQEGNE TAEATSDARP GTRTTPFSHQ
160 170 180 190 200
GTWPLLPMPR CLRRASSHLL PADVECGHTL WGLHGHYRRL SQRWPSGQHP
210 220 230 240 250
GLGGRSPRAS GAAACPMIPA RVRPLSRRRQ VALRRKSAGP QPWSTLLMKA
260 270 280 290 300
ITKSGLQHLA PPPPTPGAPC GESEEQIQST VDWSESAVYG EHIWFETNVS
310 320 330 340 350
GDFCYVGEQH CVAKMLPKSA PRKKCAACKI VVHTQCIKQL EKINFRCKPS
360 370 380 390 400
FRESGSRNVR EPTFVRHHWV HRRRQDGKCR HCGKGFQQKF TFHSKEIVAI
410 420 430 440 450
SCSWCKQAYH SKVSCFMMQQ IEEPCSLGVH AAVVIPPTWI LRARRPQNTL
460 470 480 490 500
KASKKKKRAS FKRRSSKKGP EEGRWRPFII RPTPSPLMKP LLVFVNPKSG
510 520 530 540 550
GNQGAKIIQS FLWYLNPRQV FDLSQGGPRE ALEMYRKVHN LRILACGGDG
560 570 580 590 600
TVGWILSTLD QLRLKPPPPV AILPLGTGND LARTLNWGGG YTDEPVSKIL
610 620 630 640 650
SHVEEGNVVQ LDRWDLRAEP NPEAGPEERD DGATDRLPLD VFNNYFSLGF
660 670 680 690 700
DAHVTLEFHE SREANPEKFN SRFRNKMFYA GTAFSDFLMG SSKDLAKHIR
710 720 730 740 750
VVCDGMDLTP KIQDLKPQCI VFLNIPRYCA GTMPWGHPGE HHDFEPQRHD
760 770 780 790 800
DGYLEVIGFT MTSLAALQVG GHGERLTQCR EVLLTTAKAI PVQVDGEPCK
810 820 830 840 850
LSASRIRIAL RNQATMVQKA KRRSTAPLHS DQQPVPEQLR IQVSRVSMHD
860 870 880 890 900
YEALHYDKEQ LKEASVPLGT VVVPGDSDLE LCRAHIERLQ REPDGAGAKS
910 920 930 940 950
PMCHQLSSKW CFLDATTASR FYRIDRAQEH LNYVTEIAQD EIYILDPELL
960 970 980 990 1000
GASARPDLPT PTSPLPASPC SPTPGSMQGD TALPQGEELI EAAKRNDCCK
1010 1020 1030 1040 1050
LQELHRAGGD LMHRDQKSRT LLHHAVSTGS KEVVRYLLDH APPEILDAVE
1060 1070 1080 1090 1100
ENGETCLHQA AALGQRTICH YIVEAGASLM KTDLQGDTPR QRAEKAQDTE
1110 1120
LAAYLENRQH YQMIQREDQE TAV
Length:1,123
Mass (Da):125,128
Last modified:February 20, 2007 - v1
Checksum:i84474F7A77CA9330
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731772 Genomic DNA No translation available.
AL732484 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL27585.1
RefSeqiNP_001160069.1, NM_001166597.1
UniGeneiMm.314923

Genome annotation databases

EnsembliENSMUST00000111303; ENSMUSP00000106934; ENSMUSG00000040479
GeneIDi104418
UCSCiuc008kxb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiA2AHK0_MOUSE
AccessioniPrimary (citable) accession number: A2AHK0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health