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Protein

Diacylglycerol kinase

Gene

Dgkz

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DgkzImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1278339. Dgkz.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiA2AHJ7.
PaxDbiA2AHJ7.
PeptideAtlasiA2AHJ7.
PRIDEiA2AHJ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040479.
ExpressionAtlasiA2AHJ7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106934.

Structurei

3D structure databases

ProteinModelPortaliA2AHJ7.
SMRiA2AHJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 443DAGKcInterPro annotationAdd BLAST135
Domaini812 – 928ANK_REP_REGIONInterPro annotationAdd BLAST117

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation
Contains 1 DAGKc domain.UniRule annotation
Contains 2 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, RepeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0782. Eukaryota.
ENOG410XSCB. LUCA.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000231472.
HOVERGENiHBG067303.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AHJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGPGGGGP SGDRAASGRA AAEEVVRRRC RRPEEAEVFQ PWPEGSRNVA
60 70 80 90 100
AGPLVEERFS QMHLRKQVSY RKAITKSGLQ HLAPPPPTPG APCGESEEQI
110 120 130 140 150
QSTVDWSESA VYGEHIWFET NVSGDFCYVG EQHCVAKMLP KSAPRKKCAA
160 170 180 190 200
CKIVVHTQCI KQLEKINFRC KPSFRESGSR NVREPTFVRH HWVHRRRQDG
210 220 230 240 250
KCRHCGKGFQ QKFTFHSKEI VAISCSWCKQ AYHSKVSCFM MQQIEEPCSL
260 270 280 290 300
GVHAAVVIPP TWILRARRPQ NTLKASKKKK RASFKRRSSK KGPEEGRWRP
310 320 330 340 350
FIIRPTPSPL MKPLLVFVNP KSGGNQGAKI IQSFLWYLNP RQVFDLSQGG
360 370 380 390 400
PREALEMYRK VHNLRILACG GDGTVGWILS TLDQLRLKPP PPVAILPLGT
410 420 430 440 450
GNDLARTLNW GGGYTDEPVS KILSHVEEGN VVQLDRWDLR AEPNPEAGPE
460 470 480 490 500
ERDDGATDRL PLDVFNNYFS LGFDAHVTLE FHESREANPE KFNSRFRNKM
510 520 530 540 550
FYAGTAFSDF LMGSSKDLAK HIRVVCDGMD LTPKIQDLKP QCIVFLNIPR
560 570 580 590 600
YCAGTMPWGH PGEHHDFEPQ RHDDGYLEVI GFTMTSLAAL QVGGHGERLT
610 620 630 640 650
QCREVLLTTA KAIPVQVDGE PCKLSASRIR IALRNQATMV QKAKRRSTAP
660 670 680 690 700
LHSDQQPVPE QLRIQVSRVS MHDYEALHYD KEQLKEASVP LGTVVVPGDS
710 720 730 740 750
DLELCRAHIE RLQREPDGAG AKSPMCHQLS SKWCFLDATT ASRFYRIDRA
760 770 780 790 800
QEHLNYVTEI AQDEIYILDP ELLGASARPD LPTPTSPLPA SPCSPTPGSM
810 820 830 840 850
QGDTALPQGE ELIEAAKRND CCKLQELHRA GGDLMHRDQK SRTLLHHAVS
860 870 880 890 900
TGSKEVVRYL LDHAPPEILD AVEENGETCL HQAAALGQRT ICHYIVEAGA
910 920 930 940
SLMKTDLQGD TPRQRAEKAQ DTELAAYLEN RQHYQMIQRE DQETAV
Length:946
Mass (Da):105,900
Last modified:February 20, 2007 - v1
Checksum:i20128118DB8F61F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731772 Genomic DNA. No translation available.
AL732484 Genomic DNA. No translation available.
RefSeqiXP_006498604.1. XM_006498541.2.
UniGeneiMm.314923.

Genome annotation databases

EnsembliENSMUST00000099709; ENSMUSP00000106937; ENSMUSG00000040479.
GeneIDi104418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731772 Genomic DNA. No translation available.
AL732484 Genomic DNA. No translation available.
RefSeqiXP_006498604.1. XM_006498541.2.
UniGeneiMm.314923.

3D structure databases

ProteinModelPortaliA2AHJ7.
SMRiA2AHJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106934.

Proteomic databases

MaxQBiA2AHJ7.
PaxDbiA2AHJ7.
PeptideAtlasiA2AHJ7.
PRIDEiA2AHJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099709; ENSMUSP00000106937; ENSMUSG00000040479.
GeneIDi104418.

Organism-specific databases

CTDi8525.
MGIiMGI:1278339. Dgkz.

Phylogenomic databases

eggNOGiKOG0782. Eukaryota.
ENOG410XSCB. LUCA.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000231472.
HOVERGENiHBG067303.

Miscellaneous databases

ChiTaRSiDgkz. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040479.
ExpressionAtlasiA2AHJ7. baseline and differential.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2AHJ7_MOUSE
AccessioniPrimary (citable) accession number: A2AHJ7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.