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Protein

Diacylglycerol kinase

Gene

Dgkz

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DgkzImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1278339 Dgkz

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiA2AHJ7
PeptideAtlasiA2AHJ7
PRIDEiA2AHJ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000040479
ExpressionAtlasiA2AHJ7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA2AHJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 443DAGKcInterPro annotationAdd BLAST135
Domaini812 – 928ANK_REP_REGIONInterPro annotationAdd BLAST117
Repeati840 – 863ANKPROSITE-ProRule annotationAdd BLAST24
Repeati875 – 907ANKPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000231472
HOVERGENiHBG067303

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00029 C1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit

Sequencei

Sequence statusi: Complete.

A2AHJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGPGGGGP SGDRAASGRA AAEEVVRRRC RRPEEAEVFQ PWPEGSRNVA
60 70 80 90 100
AGPLVEERFS QMHLRKQVSY RKAITKSGLQ HLAPPPPTPG APCGESEEQI
110 120 130 140 150
QSTVDWSESA VYGEHIWFET NVSGDFCYVG EQHCVAKMLP KSAPRKKCAA
160 170 180 190 200
CKIVVHTQCI KQLEKINFRC KPSFRESGSR NVREPTFVRH HWVHRRRQDG
210 220 230 240 250
KCRHCGKGFQ QKFTFHSKEI VAISCSWCKQ AYHSKVSCFM MQQIEEPCSL
260 270 280 290 300
GVHAAVVIPP TWILRARRPQ NTLKASKKKK RASFKRRSSK KGPEEGRWRP
310 320 330 340 350
FIIRPTPSPL MKPLLVFVNP KSGGNQGAKI IQSFLWYLNP RQVFDLSQGG
360 370 380 390 400
PREALEMYRK VHNLRILACG GDGTVGWILS TLDQLRLKPP PPVAILPLGT
410 420 430 440 450
GNDLARTLNW GGGYTDEPVS KILSHVEEGN VVQLDRWDLR AEPNPEAGPE
460 470 480 490 500
ERDDGATDRL PLDVFNNYFS LGFDAHVTLE FHESREANPE KFNSRFRNKM
510 520 530 540 550
FYAGTAFSDF LMGSSKDLAK HIRVVCDGMD LTPKIQDLKP QCIVFLNIPR
560 570 580 590 600
YCAGTMPWGH PGEHHDFEPQ RHDDGYLEVI GFTMTSLAAL QVGGHGERLT
610 620 630 640 650
QCREVLLTTA KAIPVQVDGE PCKLSASRIR IALRNQATMV QKAKRRSTAP
660 670 680 690 700
LHSDQQPVPE QLRIQVSRVS MHDYEALHYD KEQLKEASVP LGTVVVPGDS
710 720 730 740 750
DLELCRAHIE RLQREPDGAG AKSPMCHQLS SKWCFLDATT ASRFYRIDRA
760 770 780 790 800
QEHLNYVTEI AQDEIYILDP ELLGASARPD LPTPTSPLPA SPCSPTPGSM
810 820 830 840 850
QGDTALPQGE ELIEAAKRND CCKLQELHRA GGDLMHRDQK SRTLLHHAVS
860 870 880 890 900
TGSKEVVRYL LDHAPPEILD AVEENGETCL HQAAALGQRT ICHYIVEAGA
910 920 930 940
SLMKTDLQGD TPRQRAEKAQ DTELAAYLEN RQHYQMIQRE DQETAV
Length:946
Mass (Da):105,900
Last modified:February 20, 2007 - v1
Checksum:i20128118DB8F61F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731772 Genomic DNA No translation available.
AL732484 Genomic DNA No translation available.
RefSeqiXP_006498604.1, XM_006498541.2
UniGeneiMm.314923

Genome annotation databases

EnsembliENSMUST00000099709; ENSMUSP00000106937; ENSMUSG00000040479
GeneIDi104418

Similar proteinsi

Entry informationi

Entry nameiA2AHJ7_MOUSE
AccessioniPrimary (citable) accession number: A2AHJ7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health