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A2AHJ4 (BRWD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bromodomain and WD repeat-containing protein 3
Gene names
Name:Brwd3
Synonyms:Gm596
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1799 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape By similarity.

Sequence similarities

Contains 2 bromo domains.

Contains 9 WD repeats.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A2AHJ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A2AHJ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     272-283: FCPSTKGTTRYL → VRIMISSLPG
     284-1799: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: A2AHJ4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     144-181: VNITSARQLT...MHKRILGHLS → GFFFVALTVL...VCHMTSYITF
     182-1799: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17991799Bromodomain and WD repeat-containing protein 3
PRO_0000283090

Regions

Repeat86 – 12742WD 1
Repeat178 – 21942WD 2
Repeat221 – 25939WD 3
Repeat262 – 30544WD 4
Repeat316 – 35540WD 5
Repeat360 – 40142WD 6
Repeat421 – 46040WD 7
Repeat463 – 50341WD 8
Repeat511 – 55040WD 9
Domain1156 – 122671Bromo 1
Domain1315 – 140995Bromo 2
Compositional bias764 – 7674Poly-Lys
Compositional bias806 – 85752Ser-rich
Compositional bias903 – 9064Poly-Lys
Compositional bias1451 – 14599Poly-Ser
Compositional bias1599 – 162628Ser-rich
Compositional bias1666 – 171651Gly-rich

Amino acid modifications

Modified residue15741Phosphoserine By similarity
Modified residue15761Phosphoserine By similarity

Natural variations

Alternative sequence144 – 18138VNITS…LGHLS → GFFFVALTVLELYVDQAGLC LSSAGIKVVCHMTSYITF in isoform 3.
VSP_024308
Alternative sequence182 – 17991618Missing in isoform 3.
VSP_024309
Alternative sequence272 – 28312FCPST…TTRYL → VRIMISSLPG in isoform 2.
VSP_024310
Alternative sequence284 – 17991516Missing in isoform 2.
VSP_024311

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 57E01C1ECBDD2D31

FASTA1,799202,942
        10         20         30         40         50         60 
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG KEHRRSFEDL 

        70         80         90        100        110        120 
VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV GRQSLLRDAK DCKSTLWNGS 

       130        140        150        160        170        180 
AFAALHRGRP PELPVNYVKP PNVVNITSAR QLTGCSRFSH VFPSSAYQHI KMHKRILGHL 

       190        200        210        220        230        240 
SSVYCVAFDR SGRRIFTGSD DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG 

       250        260        270        280        290        300 
SCDKVVRVWC LRTCAPVAVL QGHSASITSI QFCPSTKGTT RYLTSTGADG TICFWQWHVK 

       310        320        330        340        350        360 
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE IPEKIAELES 

       370        380        390        400        410        420 
HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS IVLDMATKMS GNNLTSAEDK 

       430        440        450        460        470        480 
VTKLKVTMVA WDRYDTTVIT AVNNFLLKVW NSVTGQLLHT LSGHDDEVFV LEAHPFDQRI 

       490        500        510        520        530        540 
ILSAGHDGNI FIWDLDRGTK IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF 

       550        560        570        580        590        600 
GFGCSKYYEK IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK 

       610        620        630        640        650        660 
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQEESILDGI IRELQREQDL 

       670        680        690        700        710        720 
RLINEGDVPH FPINRSYSVN GALSSPNMDI PSSPNIGLRR SGQIEGVRQM HNNAPRSQMA 

       730        740        750        760        770        780 
TERDLMAWSR RVVVNELNSG VSRVQEECRN AKGDLEVSLY TVEKKKKPSY PIQRNDYQPS 

       790        800        810        820        830        840 
CGRSLRRTQR KRQHTYLTRS NIEHNSQASS QTSGVQEDSD SSSEEDETVG TSDASVEDPV 

       850        860        870        880        890        900 
VEWQSESSSS DSSSEYSDWI ADAGINLQPP KRQTRQATQK IYSSSEDENL KLEDRQKKPK 

       910        920        930        940        950        960 
QTKKKKGGLV SMAGEPNEEW LAPQWILDTI PRRSPFVPQM GDELIYFRQG HEAYVRAVRK 

       970        980        990       1000       1010       1020 
SKIYSVNLQK QPWNKMDLRE QEFVKIVGIK YEIGPPTLCC LKLAFLDPIS GKMTGESFSI 

      1030       1040       1050       1060       1070       1080 
KYHDMPDVID FLVLHQFYNE AKERNWQIGD RFRSIIDDAW WFGTVESQQP FQPEYPDSSF 

      1090       1100       1110       1120       1130       1140 
QCYSVHWDNN EREKMSPWDM EPIPDGTAFP DEVGAGIPVS QEELTALLYK PQEGEWGAHS 

      1150       1160       1170       1180       1190       1200 
RDEECERVIQ GINNLLSLDF ASPFAVPVDL SAYPLYCTVV AYPTDLNTIK QRLENRFYRR 

      1210       1220       1230       1240       1250       1260 
ISALMWEVRY IEHNARTFNE PDSPIVKAAK IVTDVLLRFI GDQSCSDILD TYNKIKAEDP 

      1270       1280       1290       1300       1310       1320 
DSSDLEEDSE MVDLDSDGPG TSSGRRAKCR GRRQSLKCNP DAWKKQCEEL LSLIYEREDS 

      1330       1340       1350       1360       1370       1380 
EPFRQPADPQ SYPVQQQQEG ESSQSVPPDR QDPSLSEDYQ DGIDTPMDFS TVKETLESGN 

      1390       1400       1410       1420       1430       1440 
YDSPLEFYKD VRQIFSNSKA YTSNKKSRIY SMTLRLSALF ENHIKNIISD YKSAIQSQKR 

      1450       1460       1470       1480       1490       1500 
RRPRYRKRLR SSSSSLSSSR APSPKGKQKQ MKLQPKNDQN TSVAYARTSS PFSSPVSDAA 

      1510       1520       1530       1540       1550       1560 
EGVSLYLLDD EGDGPFSPSS FSGYSRSGNS HDPGKAKSFR NRVLPAKQDH SLDGPLTNVD 

      1570       1580       1590       1600       1610       1620 
GREPRTGAKR KLLSASEEDE SMGGEEKEMK ETKEQVHLSS SESGELGSSL SSESTSGSDS 

      1630       1640       1650       1660       1670       1680 
DSESTSRTDQ DYVDGDHDYS KFIQTRPKRK LRKQHTNGKR NWKTRGTGGR GRWGRWGRWS 

      1690       1700       1710       1720       1730       1740 
RGGRGRGGRG RGGRGRGGGG GRGRGRGRGG RGASRGSSRA KRARVADDEF DTMFSGRFSR 

      1750       1760       1770       1780       1790 
LPRIKTRNQG RRTVLYNDDS DNDNFVSTED PLNLGTSRSG RVRKMTEKAR VSHLMGWNY 

« Hide

Isoform 2 [UniParc].

Checksum: 2743DB889746285D
Show »

FASTA28131,091
Isoform 3 [UniParc].

Checksum: BB5B42040090F1B2
Show »

FASTA18120,156

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1595-1799 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Egg and Pancreas.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1390-1799 (ISOFORM 1).
Strain: C57BL/6.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK050539 mRNA. Translation: BAC34314.1.
AK139563 mRNA. Translation: BAE24064.1.
AK163354 mRNA. Translation: BAE37315.1.
BX000698, AL731764 Genomic DNA. Translation: CAM25065.1.
AL731764, BX000698 Genomic DNA. Translation: CAM26827.1.
AL731764 Genomic DNA. Translation: CAM26828.1.
BC082562 mRNA. Translation: AAH82562.1.
CCDSCCDS41100.1. [A2AHJ4-1]
RefSeqNP_001074946.1. NM_001081477.1. [A2AHJ4-1]
UniGeneMm.100112.
Mm.426127.

3D structure databases

ProteinModelPortalA2AHJ4.
SMRA2AHJ4. Positions 127-557, 1012-1103, 1160-1239, 1302-1436.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA2AHJ4.

Proteomic databases

PaxDbA2AHJ4.
PRIDEA2AHJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000101283; ENSMUSP00000098841; ENSMUSG00000063663. [A2AHJ4-3]
ENSMUST00000150434; ENSMUSP00000123588; ENSMUSG00000063663. [A2AHJ4-1]
GeneID382236.
KEGGmmu:382236.
UCSCuc009ucm.1. mouse. [A2AHJ4-1]
uc009ucn.1. mouse. [A2AHJ4-2]

Organism-specific databases

CTD254065.
MGIMGI:3029414. Brwd3.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00720000108687.
HOGENOMHOG000203884.
HOVERGENHBG108248.
InParanoidA2AHJ4.
KOK11798.
OMAIEWQSES.
OrthoDBEOG7N37BR.
TreeFamTF324197.

Gene expression databases

ArrayExpressA2AHJ4.
BgeeA2AHJ4.
CleanExMM_BRWD3.
GenevestigatorA2AHJ4.

Family and domain databases

Gene3D1.20.920.10. 2 hits.
2.130.10.10. 3 hits.
InterProIPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMSSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEPS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBRWD3. mouse.
NextBio403145.
PROA2AHJ4.
SOURCESearch...

Entry information

Entry nameBRWD3_MOUSE
AccessionPrimary (citable) accession number: A2AHJ4
Secondary accession number(s): Q3TQR7 expand/collapse secondary AC list , Q3UTB6, Q640P3, Q8C7D5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot