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A2AHJ4

- BRWD3_MOUSE

UniProt

A2AHJ4 - BRWD3_MOUSE

Protein

Bromodomain and WD repeat-containing protein 3

Gene

Brwd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape By similarity.By similarity

    GO - Biological processi

    1. cytoskeleton organization Source: UniProtKB
    2. regulation of cell shape Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bromodomain and WD repeat-containing protein 3
    Gene namesi
    Name:Brwd3
    Synonyms:Gm596
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:3029414. Brwd3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17991799Bromodomain and WD repeat-containing protein 3PRO_0000283090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1574 – 15741PhosphoserineBy similarity
    Modified residuei1576 – 15761PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA2AHJ4.
    PRIDEiA2AHJ4.

    PTM databases

    PhosphoSiteiA2AHJ4.

    Expressioni

    Gene expression databases

    ArrayExpressiA2AHJ4.
    BgeeiA2AHJ4.
    CleanExiMM_BRWD3.
    GenevestigatoriA2AHJ4.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AHJ4.
    SMRiA2AHJ4. Positions 127-557, 1012-1103, 1160-1239, 1302-1436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati86 – 12742WD 1Add
    BLAST
    Repeati178 – 21942WD 2Add
    BLAST
    Repeati221 – 25939WD 3Add
    BLAST
    Repeati262 – 30544WD 4Add
    BLAST
    Repeati316 – 35540WD 5Add
    BLAST
    Repeati360 – 40142WD 6Add
    BLAST
    Repeati421 – 46040WD 7Add
    BLAST
    Repeati463 – 50341WD 8Add
    BLAST
    Repeati511 – 55040WD 9Add
    BLAST
    Domaini1156 – 122671Bromo 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1315 – 140995Bromo 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi764 – 7674Poly-Lys
    Compositional biasi806 – 85752Ser-richAdd
    BLAST
    Compositional biasi903 – 9064Poly-Lys
    Compositional biasi1451 – 14599Poly-Ser
    Compositional biasi1599 – 162628Ser-richAdd
    BLAST
    Compositional biasi1666 – 171651Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 bromo domains.PROSITE-ProRule annotation
    Contains 9 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00720000108687.
    HOGENOMiHOG000203884.
    HOVERGENiHBG108248.
    InParanoidiA2AHJ4.
    KOiK11798.
    OMAiIEWQSES.
    OrthoDBiEOG7N37BR.
    TreeFamiTF324197.

    Family and domain databases

    Gene3Di1.20.920.10. 2 hits.
    2.130.10.10. 3 hits.
    InterProiIPR001487. Bromodomain.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00439. Bromodomain. 2 hits.
    PF00400. WD40. 5 hits.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 2 hits.
    SM00320. WD40. 8 hits.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS50014. BROMODOMAIN_2. 2 hits.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2AHJ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG     50
    KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV 100
    GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR 150
    QLTGCSRFSH VFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD 200
    DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC 250
    LRTCAPVAVL QGHSASITSI QFCPSTKGTT RYLTSTGADG TICFWQWHVK 300
    TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE 350
    IPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS 400
    IVLDMATKMS GNNLTSAEDK VTKLKVTMVA WDRYDTTVIT AVNNFLLKVW 450
    NSVTGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK 500
    IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK 550
    IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK 600
    FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQEESILDGI 650
    IRELQREQDL RLINEGDVPH FPINRSYSVN GALSSPNMDI PSSPNIGLRR 700
    SGQIEGVRQM HNNAPRSQMA TERDLMAWSR RVVVNELNSG VSRVQEECRN 750
    AKGDLEVSLY TVEKKKKPSY PIQRNDYQPS CGRSLRRTQR KRQHTYLTRS 800
    NIEHNSQASS QTSGVQEDSD SSSEEDETVG TSDASVEDPV VEWQSESSSS 850
    DSSSEYSDWI ADAGINLQPP KRQTRQATQK IYSSSEDENL KLEDRQKKPK 900
    QTKKKKGGLV SMAGEPNEEW LAPQWILDTI PRRSPFVPQM GDELIYFRQG 950
    HEAYVRAVRK SKIYSVNLQK QPWNKMDLRE QEFVKIVGIK YEIGPPTLCC 1000
    LKLAFLDPIS GKMTGESFSI KYHDMPDVID FLVLHQFYNE AKERNWQIGD 1050
    RFRSIIDDAW WFGTVESQQP FQPEYPDSSF QCYSVHWDNN EREKMSPWDM 1100
    EPIPDGTAFP DEVGAGIPVS QEELTALLYK PQEGEWGAHS RDEECERVIQ 1150
    GINNLLSLDF ASPFAVPVDL SAYPLYCTVV AYPTDLNTIK QRLENRFYRR 1200
    ISALMWEVRY IEHNARTFNE PDSPIVKAAK IVTDVLLRFI GDQSCSDILD 1250
    TYNKIKAEDP DSSDLEEDSE MVDLDSDGPG TSSGRRAKCR GRRQSLKCNP 1300
    DAWKKQCEEL LSLIYEREDS EPFRQPADPQ SYPVQQQQEG ESSQSVPPDR 1350
    QDPSLSEDYQ DGIDTPMDFS TVKETLESGN YDSPLEFYKD VRQIFSNSKA 1400
    YTSNKKSRIY SMTLRLSALF ENHIKNIISD YKSAIQSQKR RRPRYRKRLR 1450
    SSSSSLSSSR APSPKGKQKQ MKLQPKNDQN TSVAYARTSS PFSSPVSDAA 1500
    EGVSLYLLDD EGDGPFSPSS FSGYSRSGNS HDPGKAKSFR NRVLPAKQDH 1550
    SLDGPLTNVD GREPRTGAKR KLLSASEEDE SMGGEEKEMK ETKEQVHLSS 1600
    SESGELGSSL SSESTSGSDS DSESTSRTDQ DYVDGDHDYS KFIQTRPKRK 1650
    LRKQHTNGKR NWKTRGTGGR GRWGRWGRWS RGGRGRGGRG RGGRGRGGGG 1700
    GRGRGRGRGG RGASRGSSRA KRARVADDEF DTMFSGRFSR LPRIKTRNQG 1750
    RRTVLYNDDS DNDNFVSTED PLNLGTSRSG RVRKMTEKAR VSHLMGWNY 1799
    Length:1,799
    Mass (Da):202,942
    Last modified:February 20, 2007 - v1
    Checksum:i57E01C1ECBDD2D31
    GO
    Isoform 2 (identifier: A2AHJ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-283: FCPSTKGTTRYL → VRIMISSLPG
         284-1799: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:281
    Mass (Da):31,091
    Checksum:i2743DB889746285D
    GO
    Isoform 3 (identifier: A2AHJ4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         144-181: VNITSARQLT...MHKRILGHLS → GFFFVALTVL...VCHMTSYITF
         182-1799: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:181
    Mass (Da):20,156
    Checksum:iBB5B42040090F1B2
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei144 – 18138VNITS…LGHLS → GFFFVALTVLELYVDQAGLC LSSAGIKVVCHMTSYITF in isoform 3. 1 PublicationVSP_024308Add
    BLAST
    Alternative sequencei182 – 17991618Missing in isoform 3. 1 PublicationVSP_024309Add
    BLAST
    Alternative sequencei272 – 28312FCPST…TTRYL → VRIMISSLPG in isoform 2. 1 PublicationVSP_024310Add
    BLAST
    Alternative sequencei284 – 17991516Missing in isoform 2. 1 PublicationVSP_024311Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050539 mRNA. Translation: BAC34314.1.
    AK139563 mRNA. Translation: BAE24064.1.
    AK163354 mRNA. Translation: BAE37315.1.
    BX000698, AL731764 Genomic DNA. Translation: CAM25065.1.
    AL731764, BX000698 Genomic DNA. Translation: CAM26827.1.
    AL731764 Genomic DNA. Translation: CAM26828.1.
    BC082562 mRNA. Translation: AAH82562.1.
    CCDSiCCDS41100.1. [A2AHJ4-1]
    RefSeqiNP_001074946.1. NM_001081477.1. [A2AHJ4-1]
    UniGeneiMm.100112.
    Mm.426127.

    Genome annotation databases

    EnsembliENSMUST00000101283; ENSMUSP00000098841; ENSMUSG00000063663. [A2AHJ4-3]
    ENSMUST00000150434; ENSMUSP00000123588; ENSMUSG00000063663. [A2AHJ4-1]
    GeneIDi382236.
    KEGGimmu:382236.
    UCSCiuc009ucm.1. mouse. [A2AHJ4-1]
    uc009ucn.1. mouse. [A2AHJ4-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050539 mRNA. Translation: BAC34314.1 .
    AK139563 mRNA. Translation: BAE24064.1 .
    AK163354 mRNA. Translation: BAE37315.1 .
    BX000698 , AL731764 Genomic DNA. Translation: CAM25065.1 .
    AL731764 , BX000698 Genomic DNA. Translation: CAM26827.1 .
    AL731764 Genomic DNA. Translation: CAM26828.1 .
    BC082562 mRNA. Translation: AAH82562.1 .
    CCDSi CCDS41100.1. [A2AHJ4-1 ]
    RefSeqi NP_001074946.1. NM_001081477.1. [A2AHJ4-1 ]
    UniGenei Mm.100112.
    Mm.426127.

    3D structure databases

    ProteinModelPortali A2AHJ4.
    SMRi A2AHJ4. Positions 127-557, 1012-1103, 1160-1239, 1302-1436.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A2AHJ4.

    Proteomic databases

    PaxDbi A2AHJ4.
    PRIDEi A2AHJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101283 ; ENSMUSP00000098841 ; ENSMUSG00000063663 . [A2AHJ4-3 ]
    ENSMUST00000150434 ; ENSMUSP00000123588 ; ENSMUSG00000063663 . [A2AHJ4-1 ]
    GeneIDi 382236.
    KEGGi mmu:382236.
    UCSCi uc009ucm.1. mouse. [A2AHJ4-1 ]
    uc009ucn.1. mouse. [A2AHJ4-2 ]

    Organism-specific databases

    CTDi 254065.
    MGIi MGI:3029414. Brwd3.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00720000108687.
    HOGENOMi HOG000203884.
    HOVERGENi HBG108248.
    InParanoidi A2AHJ4.
    KOi K11798.
    OMAi IEWQSES.
    OrthoDBi EOG7N37BR.
    TreeFami TF324197.

    Miscellaneous databases

    ChiTaRSi BRWD3. mouse.
    NextBioi 403145.
    PROi A2AHJ4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AHJ4.
    Bgeei A2AHJ4.
    CleanExi MM_BRWD3.
    Genevestigatori A2AHJ4.

    Family and domain databases

    Gene3Di 1.20.920.10. 2 hits.
    2.130.10.10. 3 hits.
    InterProi IPR001487. Bromodomain.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 2 hits.
    PF00400. WD40. 5 hits.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 2 hits.
    SM00320. WD40. 8 hits.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS50014. BROMODOMAIN_2. 2 hits.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1595-1799 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Egg and Pancreas.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1390-1799 (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Eye.

    Entry informationi

    Entry nameiBRWD3_MOUSE
    AccessioniPrimary (citable) accession number: A2AHJ4
    Secondary accession number(s): Q3TQR7
    , Q3UTB6, Q640P3, Q8C7D5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3