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A2AHJ4

- BRWD3_MOUSE

UniProt

A2AHJ4 - BRWD3_MOUSE

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Protein
Bromodomain and WD repeat-containing protein 3
Gene
Brwd3, Gm596
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape By similarity.

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. regulation of cell shape Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 3
Gene namesi
Name:Brwd3
Synonyms:Gm596
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:3029414. Brwd3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17991799Bromodomain and WD repeat-containing protein 3
PRO_0000283090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1574 – 15741Phosphoserine By similarity
Modified residuei1576 – 15761Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA2AHJ4.
PRIDEiA2AHJ4.

PTM databases

PhosphoSiteiA2AHJ4.

Expressioni

Gene expression databases

ArrayExpressiA2AHJ4.
BgeeiA2AHJ4.
CleanExiMM_BRWD3.
GenevestigatoriA2AHJ4.

Structurei

3D structure databases

ProteinModelPortaliA2AHJ4.
SMRiA2AHJ4. Positions 127-557, 1012-1103, 1160-1239, 1302-1436.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati86 – 12742WD 1
Add
BLAST
Repeati178 – 21942WD 2
Add
BLAST
Repeati221 – 25939WD 3
Add
BLAST
Repeati262 – 30544WD 4
Add
BLAST
Repeati316 – 35540WD 5
Add
BLAST
Repeati360 – 40142WD 6
Add
BLAST
Repeati421 – 46040WD 7
Add
BLAST
Repeati463 – 50341WD 8
Add
BLAST
Repeati511 – 55040WD 9
Add
BLAST
Domaini1156 – 122671Bromo 1
Add
BLAST
Domaini1315 – 140995Bromo 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi764 – 7674Poly-Lys
Compositional biasi806 – 85752Ser-rich
Add
BLAST
Compositional biasi903 – 9064Poly-Lys
Compositional biasi1451 – 14599Poly-Ser
Compositional biasi1599 – 162628Ser-rich
Add
BLAST
Compositional biasi1666 – 171651Gly-rich
Add
BLAST

Sequence similaritiesi

Contains 2 bromo domains.
Contains 9 WD repeats.

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00720000108687.
HOGENOMiHOG000203884.
HOVERGENiHBG108248.
InParanoidiA2AHJ4.
KOiK11798.
OMAiIEWQSES.
OrthoDBiEOG7N37BR.
TreeFamiTF324197.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2AHJ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG     50
KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV 100
GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR 150
QLTGCSRFSH VFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD 200
DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC 250
LRTCAPVAVL QGHSASITSI QFCPSTKGTT RYLTSTGADG TICFWQWHVK 300
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE 350
IPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS 400
IVLDMATKMS GNNLTSAEDK VTKLKVTMVA WDRYDTTVIT AVNNFLLKVW 450
NSVTGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK 500
IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK 550
IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK 600
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQEESILDGI 650
IRELQREQDL RLINEGDVPH FPINRSYSVN GALSSPNMDI PSSPNIGLRR 700
SGQIEGVRQM HNNAPRSQMA TERDLMAWSR RVVVNELNSG VSRVQEECRN 750
AKGDLEVSLY TVEKKKKPSY PIQRNDYQPS CGRSLRRTQR KRQHTYLTRS 800
NIEHNSQASS QTSGVQEDSD SSSEEDETVG TSDASVEDPV VEWQSESSSS 850
DSSSEYSDWI ADAGINLQPP KRQTRQATQK IYSSSEDENL KLEDRQKKPK 900
QTKKKKGGLV SMAGEPNEEW LAPQWILDTI PRRSPFVPQM GDELIYFRQG 950
HEAYVRAVRK SKIYSVNLQK QPWNKMDLRE QEFVKIVGIK YEIGPPTLCC 1000
LKLAFLDPIS GKMTGESFSI KYHDMPDVID FLVLHQFYNE AKERNWQIGD 1050
RFRSIIDDAW WFGTVESQQP FQPEYPDSSF QCYSVHWDNN EREKMSPWDM 1100
EPIPDGTAFP DEVGAGIPVS QEELTALLYK PQEGEWGAHS RDEECERVIQ 1150
GINNLLSLDF ASPFAVPVDL SAYPLYCTVV AYPTDLNTIK QRLENRFYRR 1200
ISALMWEVRY IEHNARTFNE PDSPIVKAAK IVTDVLLRFI GDQSCSDILD 1250
TYNKIKAEDP DSSDLEEDSE MVDLDSDGPG TSSGRRAKCR GRRQSLKCNP 1300
DAWKKQCEEL LSLIYEREDS EPFRQPADPQ SYPVQQQQEG ESSQSVPPDR 1350
QDPSLSEDYQ DGIDTPMDFS TVKETLESGN YDSPLEFYKD VRQIFSNSKA 1400
YTSNKKSRIY SMTLRLSALF ENHIKNIISD YKSAIQSQKR RRPRYRKRLR 1450
SSSSSLSSSR APSPKGKQKQ MKLQPKNDQN TSVAYARTSS PFSSPVSDAA 1500
EGVSLYLLDD EGDGPFSPSS FSGYSRSGNS HDPGKAKSFR NRVLPAKQDH 1550
SLDGPLTNVD GREPRTGAKR KLLSASEEDE SMGGEEKEMK ETKEQVHLSS 1600
SESGELGSSL SSESTSGSDS DSESTSRTDQ DYVDGDHDYS KFIQTRPKRK 1650
LRKQHTNGKR NWKTRGTGGR GRWGRWGRWS RGGRGRGGRG RGGRGRGGGG 1700
GRGRGRGRGG RGASRGSSRA KRARVADDEF DTMFSGRFSR LPRIKTRNQG 1750
RRTVLYNDDS DNDNFVSTED PLNLGTSRSG RVRKMTEKAR VSHLMGWNY 1799
Length:1,799
Mass (Da):202,942
Last modified:February 20, 2007 - v1
Checksum:i57E01C1ECBDD2D31
GO
Isoform 2 (identifier: A2AHJ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-283: FCPSTKGTTRYL → VRIMISSLPG
     284-1799: Missing.

Note: No experimental confirmation available.

Show »
Length:281
Mass (Da):31,091
Checksum:i2743DB889746285D
GO
Isoform 3 (identifier: A2AHJ4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-181: VNITSARQLT...MHKRILGHLS → GFFFVALTVL...VCHMTSYITF
     182-1799: Missing.

Note: No experimental confirmation available.

Show »
Length:181
Mass (Da):20,156
Checksum:iBB5B42040090F1B2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 18138VNITS…LGHLS → GFFFVALTVLELYVDQAGLC LSSAGIKVVCHMTSYITF in isoform 3.
VSP_024308Add
BLAST
Alternative sequencei182 – 17991618Missing in isoform 3.
VSP_024309Add
BLAST
Alternative sequencei272 – 28312FCPST…TTRYL → VRIMISSLPG in isoform 2.
VSP_024310Add
BLAST
Alternative sequencei284 – 17991516Missing in isoform 2.
VSP_024311Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050539 mRNA. Translation: BAC34314.1.
AK139563 mRNA. Translation: BAE24064.1.
AK163354 mRNA. Translation: BAE37315.1.
BX000698, AL731764 Genomic DNA. Translation: CAM25065.1.
AL731764, BX000698 Genomic DNA. Translation: CAM26827.1.
AL731764 Genomic DNA. Translation: CAM26828.1.
BC082562 mRNA. Translation: AAH82562.1.
CCDSiCCDS41100.1. [A2AHJ4-1]
RefSeqiNP_001074946.1. NM_001081477.1. [A2AHJ4-1]
UniGeneiMm.100112.
Mm.426127.

Genome annotation databases

EnsembliENSMUST00000101283; ENSMUSP00000098841; ENSMUSG00000063663. [A2AHJ4-3]
ENSMUST00000150434; ENSMUSP00000123588; ENSMUSG00000063663. [A2AHJ4-1]
GeneIDi382236.
KEGGimmu:382236.
UCSCiuc009ucm.1. mouse. [A2AHJ4-1]
uc009ucn.1. mouse. [A2AHJ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050539 mRNA. Translation: BAC34314.1 .
AK139563 mRNA. Translation: BAE24064.1 .
AK163354 mRNA. Translation: BAE37315.1 .
BX000698 , AL731764 Genomic DNA. Translation: CAM25065.1 .
AL731764 , BX000698 Genomic DNA. Translation: CAM26827.1 .
AL731764 Genomic DNA. Translation: CAM26828.1 .
BC082562 mRNA. Translation: AAH82562.1 .
CCDSi CCDS41100.1. [A2AHJ4-1 ]
RefSeqi NP_001074946.1. NM_001081477.1. [A2AHJ4-1 ]
UniGenei Mm.100112.
Mm.426127.

3D structure databases

ProteinModelPortali A2AHJ4.
SMRi A2AHJ4. Positions 127-557, 1012-1103, 1160-1239, 1302-1436.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A2AHJ4.

Proteomic databases

PaxDbi A2AHJ4.
PRIDEi A2AHJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101283 ; ENSMUSP00000098841 ; ENSMUSG00000063663 . [A2AHJ4-3 ]
ENSMUST00000150434 ; ENSMUSP00000123588 ; ENSMUSG00000063663 . [A2AHJ4-1 ]
GeneIDi 382236.
KEGGi mmu:382236.
UCSCi uc009ucm.1. mouse. [A2AHJ4-1 ]
uc009ucn.1. mouse. [A2AHJ4-2 ]

Organism-specific databases

CTDi 254065.
MGIi MGI:3029414. Brwd3.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00720000108687.
HOGENOMi HOG000203884.
HOVERGENi HBG108248.
InParanoidi A2AHJ4.
KOi K11798.
OMAi IEWQSES.
OrthoDBi EOG7N37BR.
TreeFami TF324197.

Miscellaneous databases

ChiTaRSi BRWD3. mouse.
NextBioi 403145.
PROi A2AHJ4.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2AHJ4.
Bgeei A2AHJ4.
CleanExi MM_BRWD3.
Genevestigatori A2AHJ4.

Family and domain databases

Gene3Di 1.20.920.10. 2 hits.
2.130.10.10. 3 hits.
InterProi IPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1595-1799 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Egg and Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1390-1799 (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiBRWD3_MOUSE
AccessioniPrimary (citable) accession number: A2AHJ4
Secondary accession number(s): Q3TQR7
, Q3UTB6, Q640P3, Q8C7D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi