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Protein

Calmodulin-regulated spectrin-associated protein 1

Gene

Camsap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable microtubule-binding protein that plays a role in the regulation of cell morphology and cytoskeletal organization. Through interaction with spectrin may regulate neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 1
Gene namesi
Name:Camsap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3036242. Camsap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15811581Calmodulin-regulated spectrin-associated protein 1PRO_0000316829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161PhosphoserineBy similarity
Modified residuei370 – 3701PhosphoserineBy similarity
Modified residuei374 – 3741PhosphoserineBy similarity
Modified residuei415 – 4151PhosphoserineBy similarity
Modified residuei511 – 5111PhosphothreonineBy similarity
Modified residuei550 – 5501PhosphoserineCombined sources
Modified residuei553 – 5531PhosphoserineCombined sources
Modified residuei560 – 5601PhosphoserineBy similarity
Modified residuei572 – 5721PhosphoserineCombined sources
Modified residuei586 – 5861PhosphoserineBy similarity
Modified residuei626 – 6261PhosphoserineBy similarity
Modified residuei718 – 7181PhosphoserineBy similarity
Modified residuei724 – 7241PhosphoserineCombined sources
Modified residuei734 – 7341PhosphoserineBy similarity
Modified residuei736 – 7361PhosphoserineBy similarity
Modified residuei1069 – 10691PhosphoserineBy similarity
Modified residuei1133 – 11331PhosphoserineCombined sources
Modified residuei1378 – 13781PhosphoserineBy similarity
Modified residuei1407 – 14071PhosphoserineCombined sources
Modified residuei1516 – 15161PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AHC3.
MaxQBiA2AHC3.
PaxDbiA2AHC3.
PeptideAtlasiA2AHC3.
PRIDEiA2AHC3.

PTM databases

iPTMnetiA2AHC3.
PhosphoSiteiA2AHC3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026933.
ExpressionAtlasiA2AHC3. baseline and differential.
GenevisibleiA2AHC3. MM.

Interactioni

Subunit structurei

Interacts with spectrin via SPTBN1; the interaction is direct. Interacts with calmodulin; calcium-dependent it prevents interaction with spectrin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiA2AHC3. 1 interaction.
MINTiMINT-4115002.
STRINGi10090.ENSMUSP00000109804.

Structurei

3D structure databases

ProteinModelPortaliA2AHC3.
SMRiA2AHC3. Positions 1442-1570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 327146CHAdd
BLAST
Domaini1443 – 1576134CKKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni867 – 88822Sufficient for interaction with SPTBN1By similarityAdd
BLAST
Regioni899 – 91820Sufficient for interaction with calmodulinBy similarityAdd
BLAST

Domaini

The CKK domain binds microtubules.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation
Contains 1 CKK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3654. Eukaryota.
ENOG4111D0B. LUCA.
GeneTreeiENSGT00390000010026.
HOGENOMiHOG000059671.
HOVERGENiHBG107572.
InParanoidiA2AHC3.
KOiK17493.
PhylomeDBiA2AHC3.
TreeFamiTF315529.

Family and domain databases

InterProiIPR032940. CAMSAP.
IPR031372. CAMSAP_CC1.
IPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR014797. CKK_domain.
IPR011033. PRC_barrel-like.
[Graphical view]
PANTHERiPTHR21595. PTHR21595. 1 hit.
PfamiPF17095. CAMSAP_CC1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF08683. CAMSAP_CKK. 1 hit.
[Graphical view]
SMARTiSM01051. CAMSAP_CKK. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50346. SSF50346. 1 hit.
PROSITEiPS51508. CKK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AHC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDAGGRCAA EGWRRMEAPP EGADLVPLDR YDAARAKIAA NLQWICAKAY
60 70 80 90 100
GLDNIPEDLR DPFYIDQYEQ EHIKPPVIKL LLSSELYCRV CSLILKGDQV
110 120 130 140 150
ATLQGHQSVI QALSRKGIYV MESDDTPVTD ADLSQAPIKM SGHMAMVDAL
160 170 180 190 200
MMAYTVEMIS IEKVVASVKR FSTFSASKEL PYDLEDAMVF WINKVNLKMR
210 220 230 240 250
EITEKEVKLK QQPLESPAHQ KVRYRREHLS ARQSPYFPLL EDLMRDGSDG
260 270 280 290 300
AALLAVVHYY CPEQMKLDDI CLKEVPSMAD SLYNIRLLRE FSNEHLNKCF
310 320 330 340 350
YLTLEDMLYA PLVLKPNVMV FIAELFWWFE NVKPDFVQPR DIQELKDAKT
360 370 380 390 400
VLQQKSSRPP VPISNATKRS FLGSPAAMSP ADQPPSTQPL AEGSHRYHLH
410 420 430 440 450
SEEPECLGKG ASTFSPSHPL LPLRQKQQKV SQTEEIPDQR HRSNSLTRVD
460 470 480 490 500
GQPRGAIGAW PDKKNRPVSQ PTSFALHHAA SCDVDPSSGD SVSLARSISK
510 520 530 540 550
DSLASNIIHL TPQNQPHPSA GKSNGKSLLS NVNIEDEDEE LVAIIRTDVS
560 570 580 590 600
PPSPQMPRTS PQAPGLVASI RSPQRQADTL ESKPDSFYLE PLMPAVLRPA
610 620 630 640 650
KEKQITTKED ERGEGRPRTI MAKRPSEGSQ PMVRKKVSGG HGSRDLNRTF
660 670 680 690 700
TPIPCSEFAA SIDLAEVGPQ SAEATGEGQP LALGRFDTLP QGQAADGFFL
710 720 730 740 750
HVGRAEEDEG RWYVGSQSPS SHDSEPWTIL RQDSDSDVVD VEDTEQDFIG
760 770 780 790 800
EDHPVVIPRY AGEEESAKLQ EDMKVKEHED KDDASGRSSP CLSTTSQLSS
810 820 830 840 850
MSMASGSVKM TSFAERKLQR LNSCETKSST SSSQKTTPDA SESCPAPLTT
860 870 880 890 900
WRQKREQSPG RHSKDPASLL ASELVQLHMQ LEEKRRAIEA QKKKMEALSA
910 920 930 940 950
RQRLKLGKAA FLHVVKKGKA DGAPQPLRPE HFTKEFTQHN GEDLDDGTCK
960 970 980 990 1000
TEGFLVKEEQ RDLSDAQDVA FVQLHKPRDP AALHDGEKHR MISTALLEDS
1010 1020 1030 1040 1050
VGEVDVNECD LSIEKLNETI STLQQAILKI SQQQEQLLMK SPTVPTPGTK
1060 1070 1080 1090 1100
NNCQDQKIKA PVHFVEPLSP TGVPGHRKPP RLGQGRNSRS GRPAELKVPK
1110 1120 1130 1140 1150
DRQQGCSRSK TPTPSVETLP QSRSLPPSTH PRSPSDPGGE LPEKCLFDSY
1160 1170 1180 1190 1200
RLHDESNHRT FVLSSCKDAN IVSEQVNFKE GLDTSVKEAG LSSSTITGKE
1210 1220 1230 1240 1250
HTPVEEPLRS KASLIEVDLS DLKAPDEDGE VVGHESSVEL GGDSDQKPGV
1260 1270 1280 1290 1300
GFFFKDEQKA EDELAKKRAA FLLKQQRKAE EARARKQQLE AEVELKRDEA
1310 1320 1330 1340 1350
RRKAEEDRLR KEEEKARREL IKQEYLRRKQ QQALEEQGLG KPKSKPKKPR
1360 1370 1380 1390 1400
PKSVHREESY SDSGTKCSST HNLSQTHSGS SLSLASAATT EPESVYSGGT
1410 1420 1430 1440 1450
PSHRVESLEA LPILSRNPSR STDRDWETAS AASSLASVAE YTGPKLFKEP
1460 1470 1480 1490 1500
SSKSNKPIIH NAISHCCLAG KVNEPHKNSI LELEKCDANH YIILFRDAGC
1510 1520 1530 1540 1550
QFRALYCYQP DTEEIYKLTG TGPKSITKKM IDKLYKYSSD RKQFNLIPAK
1560 1570 1580
TMSVSVDALT IHNHLWQPKR PTVPKKTQTR K
Length:1,581
Mass (Da):175,887
Last modified:February 20, 2007 - v1
Checksum:i4293DE86DE3A2585
GO
Isoform 2 (identifier: A2AHC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-221: K → KPGLEHAVMHCMLEPVDFARV
     1058-1062: IKAPV → ASPRR
     1063-1581: Missing.

Show »
Length:1,082
Mass (Da):120,300
Checksum:i4B6E596D32FCB67F
GO

Sequence cautioni

The sequence AAH54553 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti901 – 9011R → L in BAC28983 (PubMed:15489334).Curated
Sequence conflicti1482 – 14821E → EE in BAC28983 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei221 – 2211K → KPGLEHAVMHCMLEPVDFAR V in isoform 2. 1 PublicationVSP_030802
Alternative sequencei1058 – 10625IKAPV → ASPRR in isoform 2. 1 PublicationVSP_030803
Alternative sequencei1063 – 1581519Missing in isoform 2. 1 PublicationVSP_030804Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731682 Genomic DNA. Translation: CAM14279.1.
BC054553 mRNA. Translation: AAH54553.1. Different initiation.
AK035221 mRNA. Translation: BAC28983.1.
RefSeqiNP_001263288.1. NM_001276359.1.
NP_001263289.1. NM_001276360.1.
NP_001263290.1. NM_001276361.1.
UniGeneiMm.36834.

Genome annotation databases

EnsembliENSMUST00000091268; ENSMUSP00000088812; ENSMUSG00000026933. [A2AHC3-1]
ENSMUST00000183461; ENSMUSP00000139028; ENSMUSG00000026933. [A2AHC3-1]
GeneIDi227634.
KEGGimmu:227634.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731682 Genomic DNA. Translation: CAM14279.1.
BC054553 mRNA. Translation: AAH54553.1. Different initiation.
AK035221 mRNA. Translation: BAC28983.1.
RefSeqiNP_001263288.1. NM_001276359.1.
NP_001263289.1. NM_001276360.1.
NP_001263290.1. NM_001276361.1.
UniGeneiMm.36834.

3D structure databases

ProteinModelPortaliA2AHC3.
SMRiA2AHC3. Positions 1442-1570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AHC3. 1 interaction.
MINTiMINT-4115002.
STRINGi10090.ENSMUSP00000109804.

PTM databases

iPTMnetiA2AHC3.
PhosphoSiteiA2AHC3.

Proteomic databases

EPDiA2AHC3.
MaxQBiA2AHC3.
PaxDbiA2AHC3.
PeptideAtlasiA2AHC3.
PRIDEiA2AHC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091268; ENSMUSP00000088812; ENSMUSG00000026933. [A2AHC3-1]
ENSMUST00000183461; ENSMUSP00000139028; ENSMUSG00000026933. [A2AHC3-1]
GeneIDi227634.
KEGGimmu:227634.

Organism-specific databases

CTDi157922.
MGIiMGI:3036242. Camsap1.

Phylogenomic databases

eggNOGiKOG3654. Eukaryota.
ENOG4111D0B. LUCA.
GeneTreeiENSGT00390000010026.
HOGENOMiHOG000059671.
HOVERGENiHBG107572.
InParanoidiA2AHC3.
KOiK17493.
PhylomeDBiA2AHC3.
TreeFamiTF315529.

Miscellaneous databases

ChiTaRSiCamsap1. mouse.
PROiA2AHC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026933.
ExpressionAtlasiA2AHC3. baseline and differential.
GenevisibleiA2AHC3. MM.

Family and domain databases

InterProiIPR032940. CAMSAP.
IPR031372. CAMSAP_CC1.
IPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR014797. CKK_domain.
IPR011033. PRC_barrel-like.
[Graphical view]
PANTHERiPTHR21595. PTHR21595. 1 hit.
PfamiPF17095. CAMSAP_CC1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF08683. CAMSAP_CKK. 1 hit.
[Graphical view]
SMARTiSM01051. CAMSAP_CKK. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50346. SSF50346. 1 hit.
PROSITEiPS51508. CKK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAMP1_MOUSE
AccessioniPrimary (citable) accession number: A2AHC3
Secondary accession number(s): Q7TQF8, Q8CBV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.