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A2AGL3

- RYR3_MOUSE

UniProt

A2AGL3 - RYR3_MOUSE

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Protein

Ryanodine receptor 3

Gene

Ryr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei3876 – 38761Important for activation by Ca(2+)By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ryanodine-sensitive calcium-release channel activity Source: UniProtKB

GO - Biological processi

  1. calcium ion transmembrane transport Source: UniProtKB
  2. cellular calcium ion homeostasis Source: MGI
  3. cellular response to ATP Source: UniProtKB
  4. cellular response to caffeine Source: UniProtKB
  5. cellular response to calcium ion Source: UniProtKB
  6. cellular response to magnesium ion Source: UniProtKB
  7. protein homotetramerization Source: UniProtKB
  8. striated muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_196640. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Ryanodine receptor 3
Short name:
RYR-3
Short name:
RyR3
Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor
Gene namesi
Name:Ryr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:99684. Ryr3.

Subcellular locationi

Sarcoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Microsome membrane By similarity; Multi-pass membrane protein By similarity
Note: The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. junctional membrane complex Source: MGI
  3. sarcoplasmic reticulum membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

No apparent phenotype. Mice are born at the expected Mendelian rate and are fertile. They appear normal, except for increased locomotor activity and decreased social contact duration in social interaction tests.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48634863Ryanodine receptor 3PRO_0000415648Add
BLAST

Proteomic databases

MaxQBiA2AGL3.
PaxDbiA2AGL3.
PRIDEiA2AGL3.

Expressioni

Tissue specificityi

Detected in hippocampus, cerebellum, striatum, frontal brain cortex and parietal brain cortex. Detected in skeletal muscle, diaphragm muscle and myometrium (at protein level). Detected in egg cells. Detected in heart, diaphragm, stomach, spleen, ovary, testis germ cells, brain and cerebellum. Detected in cerebral artery smooth muscle cells.6 Publications

Gene expression databases

BgeeiA2AGL3.
ExpressionAtlasiA2AGL3. baseline and differential.
GenevestigatoriA2AGL3.

Interactioni

Subunit structurei

Homotetramer. Isoform 2 can form tetramers with isoform 1. Heterotetramer with RYR2. Interacts with FKBP1A. Interacts with CALM (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliA2AGL3.
SMRiA2AGL3. Positions 13-532, 2596-2798, 3462-3488.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 41794179CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini4767 – 486397CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei4716 – 472510Pore-formingBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4180 – 420021HelicalSequence AnalysisAdd
BLAST
Transmembranei4403 – 442321HelicalSequence AnalysisAdd
BLAST
Transmembranei4478 – 449821HelicalSequence AnalysisAdd
BLAST
Transmembranei4603 – 462321HelicalSequence AnalysisAdd
BLAST
Transmembranei4626 – 464621HelicalSequence AnalysisAdd
BLAST
Transmembranei4665 – 468521HelicalSequence AnalysisAdd
BLAST
Transmembranei4746 – 476621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 15556MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini162 – 20746MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini215 – 26955MIR 3PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 33359MIR 4PROSITE-ProRule annotationAdd
BLAST
Domaini343 – 40058MIR 5PROSITE-ProRule annotationAdd
BLAST
Domaini585 – 796212B30.2/SPRY 1PROSITE-ProRule annotationAdd
BLAST
Repeati840 – 9531141Add
BLAST
Repeati954 – 10681152Add
BLAST
Domaini1012 – 1208197B30.2/SPRY 2PROSITE-ProRule annotationAdd
BLAST
Domaini1254 – 1466213B30.2/SPRY 3PROSITE-ProRule annotationAdd
BLAST
Repeati2587 – 27051193Add
BLAST
Repeati2706 – 28181134Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni840 – 281819794 X approximate repeatsAdd
BLAST
Regioni2320 – 233314Interaction with FKBP1ABy similarityAdd
BLAST
Regioni3462 – 349130Interaction with CALMBy similarityAdd
BLAST

Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

Sequence similaritiesi

Contains 3 B30.2/SPRY domains.PROSITE-ProRule annotation
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247670.
GeneTreeiENSGT00760000119152.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
InParanoidiA2AGL3.
OrthoDBiEOG71K622.
PhylomeDBiA2AGL3.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2AGL3-1) [UniParc]FASTAAdd to Basket

Also known as: RYR3L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL
60 70 80 90 100
EPTSEAKYIP PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH
110 120 130 140 150
RTLLYGHAIL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR EHATGEACWW
160 170 180 190 200
TIHPASKQRS EGEKVRIGDD LILVSVSSER YLHLSISNGS IQVDASFMQT
210 220 230 240 250
LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD QNDSQHRRVF
260 270 280 290 300
YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
310 320 330 340 350
QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD
360 370 380 390 400
SVCFVQHVAS GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC
410 420 430 440 450
QQEESQAARI IRNTTALFSQ FVSGNNRTTA PVALPTEEVL QTLQDLIAYF
460 470 480 490 500
QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNIYNSVAH
510 520 530 540 550
FAGIVREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN NLDWLISKLD
560 570 580 590 600
RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
610 620 630 640 650
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV
660 670 680 690 700
AEGSPQYKKW YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW
710 720 730 740 750
GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS INQHLLKSDD VVSCCLDLGV
760 770 780 790 800
PSISFRINGQ PVQGMFENFN TDGLFFPVMS FSAGVKVRFL MGGRHGEFKF
810 820 830 840 850
LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT TQFLSQASFI
860 870 880 890 900
PCPIDTSQVV LPLHLEKIRD RLAENIHELW GMNKIELGWT YGKVRDDNKR
910 920 930 940 950
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK
960 970 980 990 1000
VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK
1010 1020 1030 1040 1050
QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA VRTFVGYGYN
1060 1070 1080 1090 1100
IEPSDQELAD PTVEKVSIDK IRFFRVERSY AVKSGKWYFE FEVVTGGDMR
1110 1120 1130 1140 1150
VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR TWQPGDVVGC
1160 1170 1180 1190 1200
MINLDDASMV FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
1210 1220 1230 1240 1250
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR LPTFVNVPKD
1260 1270 1280 1290 1300
HPHIEVVRID GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF
1310 1320 1330 1340 1350
SHSPCLDSEA FQKRKQMQEI LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP
1360 1370 1380 1390 1400
DYHLYSEKFD LNKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDIVASSQ
1410 1420 1430 1440 1450
RSSRSNVDLE IGCLLDLAMG MLSFSANGKE LGTCYQVEPN TKVFPAVFLQ
1460 1470 1480 1490 1500
PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPTPQCPPRL DVQTIQPVLW
1510 1520 1530 1540 1550
SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE
1560 1570 1580 1590 1600
QEDLMQFHYH TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG
1610 1620 1630 1640 1650
LLRSGFYDLL ISIHLANAKE RKLMMKNEYI IPITSATRNI RLYPDESKRH
1660 1670 1680 1690 1700
GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ KQSPEIPLQI LKTKALSMLT
1710 1720 1730 1740 1750
EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD DDVRQILLLI
1760 1770 1780 1790 1800
DPSVFGEHSG ETEEGVEKEV THAEEKAVEA GEKACKEAPV KGLLQTRLPE
1810 1820 1830 1840 1850
SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA
1860 1870 1880 1890 1900
LNMSAALTAR KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE
1910 1920 1930 1940 1950
DLLVHCGVPL EEEEEEEEDT SWTGKLCALV YKIKGPPKPE KEQPTEEEKP
1960 1970 1980 1990 2000
YPTTLKELVS QTMIRWAQEN QIQDAELVRM MFNLLRRQYD SIGELLQALR
2010 2020 2030 2040 2050
KTYTISQASV NDTINLLAAL GQIRSLLSVR MGREEELLMI NGLGDIMNNK
2060 2070 2080 2090 2100
VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC
2110 2120 2130 2140 2150
RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA
2160 2170 2180 2190 2200
LGLEEPDLEK VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF
2210 2220 2230 2240 2250
AVFVNSESVE ENASVVVKLL IRRPECFGPA LRGEGGNGLL AAMQGAIKIS
2260 2270 2280 2290 2300
ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG NAIMSFYSAL IDLLGRCAPE
2310 2320 2330 2340 2350
MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL NKDGSVSEPD
2360 2370 2380 2390 2400
MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV
2410 2420 2430 2440 2450
SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI DSTLQTIYRL
2460 2470 2480 2490 2500
SKGRSLTKAQ RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM
2510 2520 2530 2540 2550
PLKLLTNHYE QCWKYYCLPS GWGSYGLAVE EELHLTEKLF WGIFDSLSHK
2560 2570 2580 2590 2600
KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI TATLEKQVSV DADGNFDPKP
2610 2620 2630 2640 2650
INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSHSGWKYGI SLDENVKTHP
2660 2670 2680 2690 2700
LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE
2710 2720 2730 2740 2750
KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK
2760 2770 2780 2790 2800
LELESKGGGS HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM
2810 2820 2830 2840 2850
KDLELDASSM EKRFAYKFLK KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH
2860 2870 2880 2890 2900
DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP LKPLSSSGYA SHKEKEMVAS
2910 2920 2930 2940 2950
LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM KSGSELVKAG
2960 2970 2980 2990 3000
LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT
3010 3020 3030 3040 3050
SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI YVERQRPALG
3060 3070 3080 3090 3100
ECLASLAAAI PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP
3110 3120 3130 3140 3150
DIPQLEGLMK EINDLAESGA RYTEMPHVIE VILPMLCNYL SYWWERGPEN
3160 3170 3180 3190 3200
LPPSTGPCCT KVTSEHLSLI LGNILKIINN NLGIDEASWM KRIAVYAQPI
3210 3220 3230 3240 3250
ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKTDGKG DTQEAELLIL
3260 3270 3280 3290 3300
DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDPDSDQLF RMVAEVFILW
3310 3320 3330 3340 3350
CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKSGGQD QERKKTKRRG
3360 3370 3380 3390 3400
DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SCRDTDEEVK
3410 3420 3430 3440 3450
EHLRNNLHLQ EKSDDPAVKW QLNLYKDVLR NDEPSNPEKT VERVQSISAA
3460 3470 3480 3490 3500
LFHLEQVEQP LRSKKAVWHK LLSKQRKRAV VACFRMAPLY NLPRHRSINL
3510 3520 3530 3540 3550
FLHGYQRFWI ETEAHFFEEK LVQDLAKSPR VEDEEEEETE RQPDPLHQII
3560 3570 3580 3590 3600
LHFSRNALTE RSKLEDDPLY TSYSSMMAKS CQSGEDEEEE EDKEKTFEEK
3610 3620 3630 3640 3650
EMEKQKTLYQ QARLHERGAA EMVLQMISAS KGEMSPMVVE TLKLGIAILN
3660 3670 3680 3690 3700
GGNAGVQQKM LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA FERQNKAEGL
3710 3720 3730 3740 3750
GMVTEEGTLI VRERGEKVLQ NDEFTQDLFR FLQLLCEGHN SDFQNFLRTQ
3760 3770 3780 3790 3800
MGNTTTVNII ISTVDYLLRL QESISDFYWY YSGKDIIDES GQHNFSKALA
3810 3820 3830 3840 3850
VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF ANMQMKLSQD
3860 3870 3880 3890 3900
SSQIELLKEL LDLLQDMVVM LLSLLEGNVV NGTIGKQMVD TLVESSTNVE
3910 3920 3930 3940 3950
MILKFFDMFL KLKDLTSSDT FKEYDPDGKG IISRKEFQKA MEGLKQYTQS
3960 3970 3980 3990 4000
EIDFLLSCTE ADENDMFNYV DFVERFHEPA KDIGFNVAVL LTNLSEHMPN
4010 4020 4030 4040 4050
DSRLKSLLDP AESVLNYFEP YLGRIEIMGG AKKIERVYFE ISESSRTQWE
4060 4070 4080 4090 4100
KPQVKESKRQ FIFDVVNEGG EQEKMELFVN FCEDTIFEMQ LASQISESDS
4110 4120 4130 4140 4150
TDRPEEEEEE DEDSAYSIET EGEEEEKSFE SASAFTMACV SVKRNVTKFL
4160 4170 4180 4190 4200
KRATLKNLRK QYRNVKKMSA KELVKVFFSF FWMLFVGLFQ LLFTIFGGIF
4210 4220 4230 4240 4250
QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDV IETDRAEVTE
4260 4270 4280 4290 4300
PGVTTELVHF VKGEAGDTDI MSDLFGIHSK KEGGLKQGPE VGLGDLSEII
4310 4320 4330 4340 4350
GKDEPPTLES TVRKKRKAQA AEMKAVHEAE GKAESEKADM EDREKEDKIK
4360 4370 4380 4390 4400
EEGQTDYLWA DVTVKKTRRR GQKAEKPEAF MANFFKGLEI YQTKLLHYLA
4410 4420 4430 4440 4450
RNFYNLRFLA LFVAFAINFI LLFYKVTEEP LEEETEDVAN LWNSFNDDDE
4460 4470 4480 4490 4500
EEAMVFFVLQ ESTGYMAPTL RALAIVHTII SLVCVVGYYC LKVPLVVFKR
4510 4520 4530 4540 4550
EKEIARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK
4560 4570 4580 4590 4600
VINKYGDLYG AERIAELLGL DKNALDFSPV EEAKAEAASL VSWLSSIDMK
4610 4620 4630 4640 4650
YHIWKLGVVF TDNSFLYLAW YTTMSVLGHY NNFFFAAHLL DIAMGFKTLR
4660 4670 4680 4690 4700
TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDDDEPDM
4710 4720 4730 4740 4750
KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI VFDITFFFFV
4760 4770 4780 4790 4800
IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG
4810 4820 4830 4840 4850
FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA
4860
GDCFRKQYED QLG
Length:4,863
Mass (Da):551,328
Last modified:February 5, 2008 - v1
Checksum:iD2B086935E99D40B
GO
Isoform 2 (identifier: A2AGL3-2) [UniParc]FASTAAdd to Basket

Also known as: RYR3S

The sequence of this isoform differs from the canonical sequence as follows:
     4397-4425: Missing.

Note: Lacks a predicted transmembrane segment and is not expected to form functional calcium channels.

Show »
Length:4,834
Mass (Da):547,747
Checksum:iED773D40A48B773A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4169 – 41691S → I in AAF21940. 1 PublicationCurated
Sequence conflicti4214 – 42141E → Q in AAF21940. 1 PublicationCurated
Sequence conflicti4427 – 44271T → A in AAF21940. 1 PublicationCurated
Sequence conflicti4450 – 44501E → V in BAE21181. (PubMed:16141072)Curated
Sequence conflicti4457 – 44571F → L in CAA58786. (PubMed:7876312)Curated
Sequence conflicti4469 – 44691T → N in CAA58786. (PubMed:7876312)Curated
Sequence conflicti4602 – 46021H → N in AAA64957. (PubMed:7635066)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4397 – 442529Missing in isoform 2. 1 PublicationVSP_042304Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL929348 Genomic DNA. No translation available.
AL672250
, AL691423, AL732316, BX649564 Genomic DNA. Translation: CAM15357.1.
AL691423
, AL672250, AL732316, BX649564 Genomic DNA. Translation: CAM17843.1.
AL732316
, AL672250, AL691423, BX649564 Genomic DNA. Translation: CAM22353.1.
BX649564
, AL672250, AL691423, AL732316 Genomic DNA. Translation: CAM23489.1.
D84237 mRNA. Translation: BAA12286.1.
AF111166 mRNA. Translation: AAF21940.1.
AK132464 mRNA. Translation: BAE21181.1.
X83934 mRNA. Translation: CAA58786.1.
U23756 mRNA. Translation: AAA64957.1.
D38218 mRNA. Translation: BAA07393.1.
PIRiI48743.
S56107.
UniGeneiMm.436657.

Genome annotation databases

EnsembliENSMUST00000080673; ENSMUSP00000079503; ENSMUSG00000057378. [A2AGL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL929348 Genomic DNA. No translation available.
AL672250
, AL691423 , AL732316 , BX649564 Genomic DNA. Translation: CAM15357.1 .
AL691423
, AL672250 , AL732316 , BX649564 Genomic DNA. Translation: CAM17843.1 .
AL732316
, AL672250 , AL691423 , BX649564 Genomic DNA. Translation: CAM22353.1 .
BX649564
, AL672250 , AL691423 , AL732316 Genomic DNA. Translation: CAM23489.1 .
D84237 mRNA. Translation: BAA12286.1 .
AF111166 mRNA. Translation: AAF21940.1 .
AK132464 mRNA. Translation: BAE21181.1 .
X83934 mRNA. Translation: CAA58786.1 .
U23756 mRNA. Translation: AAA64957.1 .
D38218 mRNA. Translation: BAA07393.1 .
PIRi I48743.
S56107.
UniGenei Mm.436657.

3D structure databases

ProteinModelPortali A2AGL3.
SMRi A2AGL3. Positions 13-532, 2596-2798, 3462-3488.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2365.

Proteomic databases

MaxQBi A2AGL3.
PaxDbi A2AGL3.
PRIDEi A2AGL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080673 ; ENSMUSP00000079503 ; ENSMUSG00000057378 . [A2AGL3-1 ]

Organism-specific databases

MGIi MGI:99684. Ryr3.

Phylogenomic databases

eggNOGi NOG247670.
GeneTreei ENSGT00760000119152.
HOGENOMi HOG000231428.
HOVERGENi HBG006699.
InParanoidi A2AGL3.
OrthoDBi EOG71K622.
PhylomeDBi A2AGL3.

Enzyme and pathway databases

Reactomei REACT_196640. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi RYR3. mouse.
PROi A2AGL3.
SOURCEi Search...

Gene expression databases

Bgeei A2AGL3.
ExpressionAtlasi A2AGL3. baseline and differential.
Genevestigatori A2AGL3.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view ]
PRINTSi PR00795. RYANODINER.
SMARTi SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Generation and characterization of mutant mice lacking ryanodine receptor type 3."
    Takeshima H., Ikemoto T., Nishi M., Nishiyama N., Shimuta M., Sugitani Y., Kuno J., Saito I., Saito H., Endo M., Iino M., Noda T.
    J. Biol. Chem. 271:19649-19652(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-67, FUNCTION, DISRUPTION PHENOTYPE.
    Tissue: Brain.
  3. "Calcium-induced calcium release dependent on ryanodine receptor type 3 (RyR3) modulates both neuronal excitability and transmitter release."
    Chameau P., Van de Vrede Y., Lucas-Meunier E., Fossier P., Denizot J.-P., Shimahara T., Tauc L., Baux G.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4088-4541 (ISOFORM 1).
    Strain: Swiss.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4220-4863 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Skin.
  5. "The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues."
    Giannini G., Conti A., Mammarella S., Scrobogna M., Sorrentino V.
    J. Cell Biol. 128:893-904(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4405-4692 (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  6. "Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs."
    Ayabe T., Kopf G.S., Schultz R.M.
    Development 121:2233-2244(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4598-4841, SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Egg.
  7. "Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor."
    Takeshima H., Yamazawa T., Ikemoto T., Takekura H., Nishi M., Noda T., Iino M.
    EMBO J. 14:2999-3006(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4741-4863, FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  8. "Functional properties of the ryanodine receptor type 3 (RyR3) Ca2+ release channel."
    Sonnleitner A., Conti A., Bertocchini F., Schindler H., Sorrentino V.
    EMBO J. 17:2790-2798(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells."
    Lohn M., Jessner W., Furstenau M., Wellner M., Sorrentino V., Haller H., Luft F.C., Gollasch M.
    Circ. Res. 89:1051-1057(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle."
    Yang D., Pan Z., Takeshima H., Wu C., Nagaraj R.Y., Ma J., Cheng H.
    J. Biol. Chem. 276:40210-40214(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometrium."
    Dabertrand F., Fritz N., Mironneau J., Macrez N., Morel J.L.
    Am. J. Physiol. 293:C848-C854(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CHARACTERIZATION OF ISOFORM 2, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  12. "Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests."
    Matsuo N., Tanda K., Nakanishi K., Yamasaki N., Toyama K., Takao K., Takeshima H., Miyakawa T.
    Front. Behav. Neurosci. 3:3-3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  13. "Ryanodine receptor studies using genetically engineered mice."
    Kushnir A., Betzenhauser M.J., Marks A.R.
    FEBS Lett. 584:1956-1965(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRYR3_MOUSE
AccessioniPrimary (citable) accession number: A2AGL3
Secondary accession number(s): P70184
, P70185, Q3V1H0, Q4JFC4, Q60836, Q62175, Q62198, Q9QY91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3