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A2AGL3

- RYR3_MOUSE

UniProt

A2AGL3 - RYR3_MOUSE

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Protein
Ryanodine receptor 3
Gene
Ryr3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei3876 – 38761Important for activation by Ca(2+) By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ryanodine-sensitive calcium-release channel activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. calcium ion transmembrane transport Source: UniProtKB
  2. cellular calcium ion homeostasis Source: MGI
  3. cellular response to ATP Source: UniProtKB
  4. cellular response to caffeine Source: UniProtKB
  5. cellular response to calcium ion Source: UniProtKB
  6. cellular response to magnesium ion Source: UniProtKB
  7. protein homotetramerization Source: UniProtKB
  8. striated muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_196640. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Ryanodine receptor 3
Short name:
RYR-3
Short name:
RyR3
Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor
Gene namesi
Name:Ryr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:99684. Ryr3.

Subcellular locationi

Sarcoplasmic reticulum membrane; Multi-pass membrane protein Inferred. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein By similarity
Note: The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 41794179Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei4180 – 420021Helical; Reviewed prediction
Add
BLAST
Transmembranei4403 – 442321Helical; Reviewed prediction
Add
BLAST
Transmembranei4478 – 449821Helical; Reviewed prediction
Add
BLAST
Transmembranei4603 – 462321Helical; Reviewed prediction
Add
BLAST
Transmembranei4626 – 464621Helical; Reviewed prediction
Add
BLAST
Transmembranei4665 – 468521Helical; Reviewed prediction
Add
BLAST
Intramembranei4716 – 472510Pore-forming; By similarity
Transmembranei4746 – 476621Helical; Reviewed prediction
Add
BLAST
Topological domaini4767 – 486397Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. junctional membrane complex Source: MGI
  3. sarcoplasmic reticulum membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

No apparent phenotype. Mice are born at the expected Mendelian rate and are fertile. They appear normal, except for increased locomotor activity and decreased social contact duration in social interaction tests.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48634863Ryanodine receptor 3
PRO_0000415648Add
BLAST

Proteomic databases

PaxDbiA2AGL3.
PRIDEiA2AGL3.

Expressioni

Tissue specificityi

Detected in hippocampus, cerebellum, striatum, frontal brain cortex and parietal brain cortex. Detected in skeletal muscle, diaphragm muscle and myometrium (at protein level). Detected in egg cells. Detected in heart, diaphragm, stomach, spleen, ovary, testis germ cells, brain and cerebellum. Detected in cerebral artery smooth muscle cells.6 Publications

Gene expression databases

ArrayExpressiA2AGL3.
BgeeiA2AGL3.
GenevestigatoriA2AGL3.

Interactioni

Subunit structurei

Homotetramer. Isoform 2 can form tetramers with isoform 1. Heterotetramer with RYR2. Interacts with FKBP1A. Interacts with CALM By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA2AGL3.
SMRiA2AGL3. Positions 13-532, 2596-2798, 3462-3488.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 15556MIR 1
Add
BLAST
Domaini162 – 20746MIR 2
Add
BLAST
Domaini215 – 26955MIR 3
Add
BLAST
Domaini275 – 33359MIR 4
Add
BLAST
Domaini343 – 40058MIR 5
Add
BLAST
Domaini585 – 796212B30.2/SPRY 1
Add
BLAST
Repeati840 – 9531141
Add
BLAST
Repeati954 – 10681152
Add
BLAST
Domaini1012 – 1208197B30.2/SPRY 2
Add
BLAST
Domaini1254 – 1466213B30.2/SPRY 3
Add
BLAST
Repeati2587 – 27051193
Add
BLAST
Repeati2706 – 28181134
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni840 – 281819794 X approximate repeats
Add
BLAST
Regioni2320 – 233314Interaction with FKBP1A By similarity
Add
BLAST
Regioni3462 – 349130Interaction with CALM By similarity
Add
BLAST

Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm Inferred.

Sequence similaritiesi

Contains 3 B30.2/SPRY domains.
Contains 5 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247670.
GeneTreeiENSGT00690000101961.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
OrthoDBiEOG71K622.
PhylomeDBiA2AGL3.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2AGL3-1) [UniParc]FASTAAdd to Basket

Also known as: RYR3L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEAGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL     50
EPTSEAKYIP PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH 100
RTLLYGHAIL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR EHATGEACWW 150
TIHPASKQRS EGEKVRIGDD LILVSVSSER YLHLSISNGS IQVDASFMQT 200
LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD QNDSQHRRVF 250
YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 300
QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD 350
SVCFVQHVAS GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC 400
QQEESQAARI IRNTTALFSQ FVSGNNRTTA PVALPTEEVL QTLQDLIAYF 450
QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNIYNSVAH 500
FAGIVREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN NLDWLISKLD 550
RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV 600
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV 650
AEGSPQYKKW YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW 700
GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS INQHLLKSDD VVSCCLDLGV 750
PSISFRINGQ PVQGMFENFN TDGLFFPVMS FSAGVKVRFL MGGRHGEFKF 800
LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT TQFLSQASFI 850
PCPIDTSQVV LPLHLEKIRD RLAENIHELW GMNKIELGWT YGKVRDDNKR 900
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK 950
VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK 1000
QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA VRTFVGYGYN 1050
IEPSDQELAD PTVEKVSIDK IRFFRVERSY AVKSGKWYFE FEVVTGGDMR 1100
VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR TWQPGDVVGC 1150
MINLDDASMV FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR 1200
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR LPTFVNVPKD 1250
HPHIEVVRID GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF 1300
SHSPCLDSEA FQKRKQMQEI LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP 1350
DYHLYSEKFD LNKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDIVASSQ 1400
RSSRSNVDLE IGCLLDLAMG MLSFSANGKE LGTCYQVEPN TKVFPAVFLQ 1450
PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPTPQCPPRL DVQTIQPVLW 1500
SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE 1550
QEDLMQFHYH TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG 1600
LLRSGFYDLL ISIHLANAKE RKLMMKNEYI IPITSATRNI RLYPDESKRH 1650
GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ KQSPEIPLQI LKTKALSMLT 1700
EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD DDVRQILLLI 1750
DPSVFGEHSG ETEEGVEKEV THAEEKAVEA GEKACKEAPV KGLLQTRLPE 1800
SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA 1850
LNMSAALTAR KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE 1900
DLLVHCGVPL EEEEEEEEDT SWTGKLCALV YKIKGPPKPE KEQPTEEEKP 1950
YPTTLKELVS QTMIRWAQEN QIQDAELVRM MFNLLRRQYD SIGELLQALR 2000
KTYTISQASV NDTINLLAAL GQIRSLLSVR MGREEELLMI NGLGDIMNNK 2050
VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC 2100
RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA 2150
LGLEEPDLEK VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF 2200
AVFVNSESVE ENASVVVKLL IRRPECFGPA LRGEGGNGLL AAMQGAIKIS 2250
ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG NAIMSFYSAL IDLLGRCAPE 2300
MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL NKDGSVSEPD 2350
MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV 2400
SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI DSTLQTIYRL 2450
SKGRSLTKAQ RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM 2500
PLKLLTNHYE QCWKYYCLPS GWGSYGLAVE EELHLTEKLF WGIFDSLSHK 2550
KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI TATLEKQVSV DADGNFDPKP 2600
INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSHSGWKYGI SLDENVKTHP 2650
LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE 2700
KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK 2750
LELESKGGGS HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM 2800
KDLELDASSM EKRFAYKFLK KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH 2850
DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP LKPLSSSGYA SHKEKEMVAS 2900
LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM KSGSELVKAG 2950
LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT 3000
SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI YVERQRPALG 3050
ECLASLAAAI PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP 3100
DIPQLEGLMK EINDLAESGA RYTEMPHVIE VILPMLCNYL SYWWERGPEN 3150
LPPSTGPCCT KVTSEHLSLI LGNILKIINN NLGIDEASWM KRIAVYAQPI 3200
ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKTDGKG DTQEAELLIL 3250
DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDPDSDQLF RMVAEVFILW 3300
CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKSGGQD QERKKTKRRG 3350
DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SCRDTDEEVK 3400
EHLRNNLHLQ EKSDDPAVKW QLNLYKDVLR NDEPSNPEKT VERVQSISAA 3450
LFHLEQVEQP LRSKKAVWHK LLSKQRKRAV VACFRMAPLY NLPRHRSINL 3500
FLHGYQRFWI ETEAHFFEEK LVQDLAKSPR VEDEEEEETE RQPDPLHQII 3550
LHFSRNALTE RSKLEDDPLY TSYSSMMAKS CQSGEDEEEE EDKEKTFEEK 3600
EMEKQKTLYQ QARLHERGAA EMVLQMISAS KGEMSPMVVE TLKLGIAILN 3650
GGNAGVQQKM LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA FERQNKAEGL 3700
GMVTEEGTLI VRERGEKVLQ NDEFTQDLFR FLQLLCEGHN SDFQNFLRTQ 3750
MGNTTTVNII ISTVDYLLRL QESISDFYWY YSGKDIIDES GQHNFSKALA 3800
VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF ANMQMKLSQD 3850
SSQIELLKEL LDLLQDMVVM LLSLLEGNVV NGTIGKQMVD TLVESSTNVE 3900
MILKFFDMFL KLKDLTSSDT FKEYDPDGKG IISRKEFQKA MEGLKQYTQS 3950
EIDFLLSCTE ADENDMFNYV DFVERFHEPA KDIGFNVAVL LTNLSEHMPN 4000
DSRLKSLLDP AESVLNYFEP YLGRIEIMGG AKKIERVYFE ISESSRTQWE 4050
KPQVKESKRQ FIFDVVNEGG EQEKMELFVN FCEDTIFEMQ LASQISESDS 4100
TDRPEEEEEE DEDSAYSIET EGEEEEKSFE SASAFTMACV SVKRNVTKFL 4150
KRATLKNLRK QYRNVKKMSA KELVKVFFSF FWMLFVGLFQ LLFTIFGGIF 4200
QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDV IETDRAEVTE 4250
PGVTTELVHF VKGEAGDTDI MSDLFGIHSK KEGGLKQGPE VGLGDLSEII 4300
GKDEPPTLES TVRKKRKAQA AEMKAVHEAE GKAESEKADM EDREKEDKIK 4350
EEGQTDYLWA DVTVKKTRRR GQKAEKPEAF MANFFKGLEI YQTKLLHYLA 4400
RNFYNLRFLA LFVAFAINFI LLFYKVTEEP LEEETEDVAN LWNSFNDDDE 4450
EEAMVFFVLQ ESTGYMAPTL RALAIVHTII SLVCVVGYYC LKVPLVVFKR 4500
EKEIARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK 4550
VINKYGDLYG AERIAELLGL DKNALDFSPV EEAKAEAASL VSWLSSIDMK 4600
YHIWKLGVVF TDNSFLYLAW YTTMSVLGHY NNFFFAAHLL DIAMGFKTLR 4650
TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDDDEPDM 4700
KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI VFDITFFFFV 4750
IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG 4800
FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA 4850
GDCFRKQYED QLG 4863
Length:4,863
Mass (Da):551,328
Last modified:February 5, 2008 - v1
Checksum:iD2B086935E99D40B
GO
Isoform 2 (identifier: A2AGL3-2) [UniParc]FASTAAdd to Basket

Also known as: RYR3S

The sequence of this isoform differs from the canonical sequence as follows:
     4397-4425: Missing.

Note: Lacks a predicted transmembrane segment and is not expected to form functional calcium channels.

Show »
Length:4,834
Mass (Da):547,747
Checksum:iED773D40A48B773A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4397 – 442529Missing in isoform 2.
VSP_042304Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4169 – 41691S → I in AAF21940. 1 Publication
Sequence conflicti4214 – 42141E → Q in AAF21940. 1 Publication
Sequence conflicti4427 – 44271T → A in AAF21940. 1 Publication
Sequence conflicti4450 – 44501E → V in BAE21181. 1 Publication
Sequence conflicti4457 – 44571F → L in CAA58786. 1 Publication
Sequence conflicti4469 – 44691T → N in CAA58786. 1 Publication
Sequence conflicti4602 – 46021H → N in AAA64957. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL929348 Genomic DNA. No translation available.
AL672250
, AL691423, AL732316, BX649564 Genomic DNA. Translation: CAM15357.1.
AL691423
, AL672250, AL732316, BX649564 Genomic DNA. Translation: CAM17843.1.
AL732316
, AL672250, AL691423, BX649564 Genomic DNA. Translation: CAM22353.1.
BX649564
, AL672250, AL691423, AL732316 Genomic DNA. Translation: CAM23489.1.
D84237 mRNA. Translation: BAA12286.1.
AF111166 mRNA. Translation: AAF21940.1.
AK132464 mRNA. Translation: BAE21181.1.
X83934 mRNA. Translation: CAA58786.1.
U23756 mRNA. Translation: AAA64957.1.
D38218 mRNA. Translation: BAA07393.1.
PIRiI48743.
S56107.
UniGeneiMm.436657.

Genome annotation databases

EnsembliENSMUST00000080673; ENSMUSP00000079503; ENSMUSG00000057378. [A2AGL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL929348 Genomic DNA. No translation available.
AL672250
, AL691423 , AL732316 , BX649564 Genomic DNA. Translation: CAM15357.1 .
AL691423
, AL672250 , AL732316 , BX649564 Genomic DNA. Translation: CAM17843.1 .
AL732316
, AL672250 , AL691423 , BX649564 Genomic DNA. Translation: CAM22353.1 .
BX649564
, AL672250 , AL691423 , AL732316 Genomic DNA. Translation: CAM23489.1 .
D84237 mRNA. Translation: BAA12286.1 .
AF111166 mRNA. Translation: AAF21940.1 .
AK132464 mRNA. Translation: BAE21181.1 .
X83934 mRNA. Translation: CAA58786.1 .
U23756 mRNA. Translation: AAA64957.1 .
D38218 mRNA. Translation: BAA07393.1 .
PIRi I48743.
S56107.
UniGenei Mm.436657.

3D structure databases

ProteinModelPortali A2AGL3.
SMRi A2AGL3. Positions 13-532, 2596-2798, 3462-3488.
ModBasei Search...

Chemistry

ChEMBLi CHEMBL2365.

Proteomic databases

PaxDbi A2AGL3.
PRIDEi A2AGL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080673 ; ENSMUSP00000079503 ; ENSMUSG00000057378 . [A2AGL3-1 ]

Organism-specific databases

MGIi MGI:99684. Ryr3.

Phylogenomic databases

eggNOGi NOG247670.
GeneTreei ENSGT00690000101961.
HOGENOMi HOG000231428.
HOVERGENi HBG006699.
OrthoDBi EOG71K622.
PhylomeDBi A2AGL3.

Enzyme and pathway databases

Reactomei REACT_196640. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi RYR3. mouse.
PROi A2AGL3.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2AGL3.
Bgeei A2AGL3.
Genevestigatori A2AGL3.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view ]
PRINTSi PR00795. RYANODINER.
SMARTi SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Generation and characterization of mutant mice lacking ryanodine receptor type 3."
    Takeshima H., Ikemoto T., Nishi M., Nishiyama N., Shimuta M., Sugitani Y., Kuno J., Saito I., Saito H., Endo M., Iino M., Noda T.
    J. Biol. Chem. 271:19649-19652(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-67, FUNCTION, DISRUPTION PHENOTYPE.
    Tissue: Brain.
  3. "Calcium-induced calcium release dependent on ryanodine receptor type 3 (RyR3) modulates both neuronal excitability and transmitter release."
    Chameau P., Van de Vrede Y., Lucas-Meunier E., Fossier P., Denizot J.-P., Shimahara T., Tauc L., Baux G.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4088-4541 (ISOFORM 1).
    Strain: Swiss.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4220-4863 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Skin.
  5. "The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues."
    Giannini G., Conti A., Mammarella S., Scrobogna M., Sorrentino V.
    J. Cell Biol. 128:893-904(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4405-4692 (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  6. "Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs."
    Ayabe T., Kopf G.S., Schultz R.M.
    Development 121:2233-2244(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4598-4841, SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Egg.
  7. "Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor."
    Takeshima H., Yamazawa T., Ikemoto T., Takekura H., Nishi M., Noda T., Iino M.
    EMBO J. 14:2999-3006(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4741-4863, FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  8. "Functional properties of the ryanodine receptor type 3 (RyR3) Ca2+ release channel."
    Sonnleitner A., Conti A., Bertocchini F., Schindler H., Sorrentino V.
    EMBO J. 17:2790-2798(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells."
    Lohn M., Jessner W., Furstenau M., Wellner M., Sorrentino V., Haller H., Luft F.C., Gollasch M.
    Circ. Res. 89:1051-1057(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle."
    Yang D., Pan Z., Takeshima H., Wu C., Nagaraj R.Y., Ma J., Cheng H.
    J. Biol. Chem. 276:40210-40214(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometrium."
    Dabertrand F., Fritz N., Mironneau J., Macrez N., Morel J.L.
    Am. J. Physiol. 293:C848-C854(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CHARACTERIZATION OF ISOFORM 2, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  12. "Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests."
    Matsuo N., Tanda K., Nakanishi K., Yamasaki N., Toyama K., Takao K., Takeshima H., Miyakawa T.
    Front. Behav. Neurosci. 3:3-3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  13. "Ryanodine receptor studies using genetically engineered mice."
    Kushnir A., Betzenhauser M.J., Marks A.R.
    FEBS Lett. 584:1956-1965(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRYR3_MOUSE
AccessioniPrimary (citable) accession number: A2AGL3
Secondary accession number(s): P70184
, P70185, Q3V1H0, Q4JFC4, Q60836, Q62175, Q62198, Q9QY91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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