A2AGL3 (RYR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ryanodine receptor 3
Short name=RYR-3
Short name=RyR3

Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor

Gene names

Name:

Ryr3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	4863 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity. Ref.2 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11
Subunit structure	Homotetramer. Isoform 2 can form tetramers with isoform 1. Heterotetramer with RYR2. Interacts with FKBP1A. Interacts with CALM By similarity. Ref.6
Subcellular location	Sarcoplasmic reticulum membrane; Multi-pass membrane protein Probable. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein By similarity. Note: The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic By similarity. Ref.8
Tissue specificity	Detected in hippocampus, cerebellum, striatum, frontal brain cortex and parietal brain cortex. Detected in skeletal muscle, diaphragm muscle and myometrium (at protein level). Detected in egg cells. Detected in heart, diaphragm, stomach, spleen, ovary, testis germ cells, brain and cerebellum. Detected in cerebral artery smooth muscle cells. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.11
Domain	The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm Probable.
Disruption phenotype	No apparent phenotype. Mice are born at the expected Mendelian rate and are fertile. They appear normal, except for increased locomotor activity and decreased social contact duration in social interaction tests. Ref.2 Ref.12
Miscellaneous	Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red.
Sequence similarities	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily. [View classification] Contains 3 B30.2/SPRY domains. Contains 5 MIR domains.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Endoplasmic reticulum Membrane Microsome Sarcoplasmic reticulum
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium Calmodulin-binding
Molecular function	Calcium channel Ion channel Ligand-gated ion channel Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 9384575. Source: MGI cellular response to ATP Inferred from sequence or structural similarity. Source: UniProtKB cellular response to caffeine Inferred from sequence or structural similarity. Source: UniProtKB cellular response to calcium ion Inferred from sequence or structural similarity. Source: UniProtKB cellular response to magnesium ion Inferred from sequence or structural similarity. Source: UniProtKB protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB striated muscle contraction Inferred from mutant phenotype PubMed 9384575. Source: MGI
Cellular_component	integral to membrane Inferred from sequence or structural similarity. Source: UniProtKB junctional membrane complex Inferred from direct assay PubMed 10444070. Source: MGI sarcoplasmic reticulum membrane Inferred from direct assay PubMed 14592808. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro ryanodine-sensitive calcium-release channel activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2AGL3-1)

Also known as: RYR3L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2AGL3-2)

Also known as: RYR3S;

The sequence of this isoform differs from the canonical sequence as follows:
     4397-4425: Missing.

Note: Lacks a predicted transmembrane segment and is not expected to form functional calcium channels.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4863	4863	Ryanodine receptor 3		PRO_0000415648
Regions
	Topological domain	1 – 4179	4179	Cytoplasmic Potential
	Transmembrane	4180 – 4200	21	Helical; Potential
	Transmembrane	4403 – 4423	21	Helical; Potential
	Transmembrane	4478 – 4498	21	Helical; Potential
	Transmembrane	4603 – 4623	21	Helical; Potential
	Transmembrane	4626 – 4646	21	Helical; Potential
	Transmembrane	4665 – 4685	21	Helical; Potential
	Intramembrane	4716 – 4725	10	Pore-forming; By similarity
	Transmembrane	4746 – 4766	21	Helical; Potential
	Topological domain	4767 – 4863	97	Cytoplasmic Potential
	Domain	100 – 155	56	MIR 1
	Domain	162 – 207	46	MIR 2
	Domain	215 – 269	55	MIR 3
	Domain	275 – 333	59	MIR 4
	Domain	343 – 400	58	MIR 5
	Domain	585 – 796	212	B30.2/SPRY 1
	Repeat	840 – 953	114	1
	Repeat	954 – 1068	115	2
	Domain	1012 – 1208	197	B30.2/SPRY 2
	Domain	1254 – 1466	213	B30.2/SPRY 3
	Repeat	2587 – 2705	119	3
	Repeat	2706 – 2818	113	4
	Region	840 – 2818	1979	4 X approximate repeats
	Region	2320 – 2333	14	Interaction with FKBP1A By similarity
	Region	3462 – 3491	30	Interaction with CALM By similarity
Sites
	Site	3876	1	Important for activation by Ca(2+) By similarity
Natural variations
	Alternative sequence	4397 – 4425	29	Missing in isoform 2.		VSP_042304
Experimental info
	Sequence conflict	4169	1	S → I in AAF21940. Ref.3
	Sequence conflict	4214	1	E → Q in AAF21940. Ref.3
	Sequence conflict	4427	1	T → A in AAF21940. Ref.3
	Sequence conflict	4450	1	E → V in BAE21181. Ref.4
	Sequence conflict	4457	1	F → L in CAA58786. Ref.5
	Sequence conflict	4469	1	T → N in CAA58786. Ref.5
	Sequence conflict	4602	1	H → N in AAA64957. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RYR3L) [UniParc]. Last modified February 5, 2008. Version 1. Checksum: D2B086935E99D40B	FASTA	4,863	551,328
	10 20 30 40 50 60 MAEAGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP 70 80 90 100 110 120 PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL 130 140 150 160 170 180 TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER 190 200 210 220 230 240 YLHLSISNGS IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD 250 260 270 280 290 300 QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 310 320 330 340 350 360 QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD SVCFVQHVAS 370 380 390 400 410 420 GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QQEESQAARI IRNTTALFSQ 430 440 450 460 470 480 FVSGNNRTTA PVALPTEEVL QTLQDLIAYF QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG 490 500 510 520 530 540 MLALVLNCID RLNIYNSVAH FAGIVREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN 550 560 570 580 590 600 NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV 610 620 630 640 650 660 LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSPQYKKW 670 680 690 700 710 720 YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW 730 740 750 760 770 780 SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS 790 800 810 820 830 840 FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT 850 860 870 880 890 900 TQFLSQASFI PCPIDTSQVV LPLHLEKIRD RLAENIHELW GMNKIELGWT YGKVRDDNKR 910 920 930 940 950 960 QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS 970 980 990 1000 1010 1020 NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV 1030 1040 1050 1060 1070 1080 PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD PTVEKVSIDK IRFFRVERSY 1090 1100 1110 1120 1130 1140 AVKSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR 1150 1160 1170 1180 1190 1200 TWQPGDVVGC MINLDDASMV FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR 1210 1220 1230 1240 1250 1260 MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR LPTFVNVPKD HPHIEVVRID 1270 1280 1290 1300 1310 1320 GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI 1330 1340 1350 1360 1370 1380 LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE 1390 1400 1410 1420 1430 1440 SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLLDLAMG MLSFSANGKE LGTCYQVEPN 1450 1460 1470 1480 1490 1500 TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPTPQCPPRL DVQTIQPVLW 1510 1520 1530 1540 1550 1560 SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMQFHYH 1570 1580 1590 1600 1610 1620 TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLANAKE 1630 1640 1650 1660 1670 1680 RKLMMKNEYI IPITSATRNI RLYPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ 1690 1700 1710 1720 1730 1740 KQSPEIPLQI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD 1750 1760 1770 1780 1790 1800 DDVRQILLLI DPSVFGEHSG ETEEGVEKEV THAEEKAVEA GEKACKEAPV KGLLQTRLPE 1810 1820 1830 1840 1850 1860 SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA LNMSAALTAR 1870 1880 1890 1900 1910 1920 KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE DLLVHCGVPL EEEEEEEEDT 1930 1940 1950 1960 1970 1980 SWTGKLCALV YKIKGPPKPE KEQPTEEEKP YPTTLKELVS QTMIRWAQEN QIQDAELVRM 1990 2000 2010 2020 2030 2040 MFNLLRRQYD SIGELLQALR KTYTISQASV NDTINLLAAL GQIRSLLSVR MGREEELLMI 2050 2060 2070 2080 2090 2100 NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC 2110 2120 2130 2140 2150 2160 RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA LGLEEPDLEK 2170 2180 2190 2200 2210 2220 VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL 2230 2240 2250 2260 2270 2280 IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG 2290 2300 2310 2320 2330 2340 NAIMSFYSAL IDLLGRCAPE MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL 2350 2360 2370 2380 2390 2400 NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV 2410 2420 2430 2440 2450 2460 SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI DSTLQTIYRL SKGRSLTKAQ 2470 2480 2490 2500 2510 2520 RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM PLKLLTNHYE QCWKYYCLPS 2530 2540 2550 2560 2570 2580 GWGSYGLAVE EELHLTEKLF WGIFDSLSHK KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI 2590 2600 2610 2620 2630 2640 TATLEKQVSV DADGNFDPKP INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSHSGWKYGI 2650 2660 2670 2680 2690 2700 SLDENVKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE 2710 2720 2730 2740 2750 2760 KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK LELESKGGGS 2770 2780 2790 2800 2810 2820 HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM KDLELDASSM EKRFAYKFLK 2830 2840 2850 2860 2870 2880 KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP 2890 2900 2910 2920 2930 2940 LKPLSSSGYA SHKEKEMVAS LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM 2950 2960 2970 2980 2990 3000 KSGSELVKAG LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT 3010 3020 3030 3040 3050 3060 SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI YVERQRPALG ECLASLAAAI 3070 3080 3090 3100 3110 3120 PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP DIPQLEGLMK EINDLAESGA 3130 3140 3150 3160 3170 3180 RYTEMPHVIE VILPMLCNYL SYWWERGPEN LPPSTGPCCT KVTSEHLSLI LGNILKIINN 3190 3200 3210 3220 3230 3240 NLGIDEASWM KRIAVYAQPI ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKTDGKG 3250 3260 3270 3280 3290 3300 DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDPDSDQLF RMVAEVFILW 3310 3320 3330 3340 3350 3360 CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKSGGQD QERKKTKRRG DLYSIQTSLI 3370 3380 3390 3400 3410 3420 VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SCRDTDEEVK EHLRNNLHLQ EKSDDPAVKW 3430 3440 3450 3460 3470 3480 QLNLYKDVLR NDEPSNPEKT VERVQSISAA LFHLEQVEQP LRSKKAVWHK LLSKQRKRAV 3490 3500 3510 3520 3530 3540 VACFRMAPLY NLPRHRSINL FLHGYQRFWI ETEAHFFEEK LVQDLAKSPR VEDEEEEETE 3550 3560 3570 3580 3590 3600 RQPDPLHQII LHFSRNALTE RSKLEDDPLY TSYSSMMAKS CQSGEDEEEE EDKEKTFEEK 3610 3620 3630 3640 3650 3660 EMEKQKTLYQ QARLHERGAA EMVLQMISAS KGEMSPMVVE TLKLGIAILN GGNAGVQQKM 3670 3680 3690 3700 3710 3720 LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA FERQNKAEGL GMVTEEGTLI VRERGEKVLQ 3730 3740 3750 3760 3770 3780 NDEFTQDLFR FLQLLCEGHN SDFQNFLRTQ MGNTTTVNII ISTVDYLLRL QESISDFYWY 3790 3800 3810 3820 3830 3840 YSGKDIIDES GQHNFSKALA VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF 3850 3860 3870 3880 3890 3900 ANMQMKLSQD SSQIELLKEL LDLLQDMVVM LLSLLEGNVV NGTIGKQMVD TLVESSTNVE 3910 3920 3930 3940 3950 3960 MILKFFDMFL KLKDLTSSDT FKEYDPDGKG IISRKEFQKA MEGLKQYTQS EIDFLLSCTE 3970 3980 3990 4000 4010 4020 ADENDMFNYV DFVERFHEPA KDIGFNVAVL LTNLSEHMPN DSRLKSLLDP AESVLNYFEP 4030 4040 4050 4060 4070 4080 YLGRIEIMGG AKKIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EQEKMELFVN 4090 4100 4110 4120 4130 4140 FCEDTIFEMQ LASQISESDS TDRPEEEEEE DEDSAYSIET EGEEEEKSFE SASAFTMACV 4150 4160 4170 4180 4190 4200 SVKRNVTKFL KRATLKNLRK QYRNVKKMSA KELVKVFFSF FWMLFVGLFQ LLFTIFGGIF 4210 4220 4230 4240 4250 4260 QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDV IETDRAEVTE PGVTTELVHF 4270 4280 4290 4300 4310 4320 VKGEAGDTDI MSDLFGIHSK KEGGLKQGPE VGLGDLSEII GKDEPPTLES TVRKKRKAQA 4330 4340 4350 4360 4370 4380 AEMKAVHEAE GKAESEKADM EDREKEDKIK EEGQTDYLWA DVTVKKTRRR GQKAEKPEAF 4390 4400 4410 4420 4430 4440 MANFFKGLEI YQTKLLHYLA RNFYNLRFLA LFVAFAINFI LLFYKVTEEP LEEETEDVAN 4450 4460 4470 4480 4490 4500 LWNSFNDDDE EEAMVFFVLQ ESTGYMAPTL RALAIVHTII SLVCVVGYYC LKVPLVVFKR 4510 4520 4530 4540 4550 4560 EKEIARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK VINKYGDLYG 4570 4580 4590 4600 4610 4620 AERIAELLGL DKNALDFSPV EEAKAEAASL VSWLSSIDMK YHIWKLGVVF TDNSFLYLAW 4630 4640 4650 4660 4670 4680 YTTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV 4690 4700 4710 4720 4730 4740 AFNFFRKFYN KSEDDDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI 4750 4760 4770 4780 4790 4800 VFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG 4810 4820 4830 4840 4850 4860 FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLG
	Isoform 2 (RYR3S) [UniParc]. Checksum: ED773D40A48B773A	FASTA	4,834	547,747
	10 20 30 40 50 60 MAEAGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP 70 80 90 100 110 120 PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL 130 140 150 160 170 180 TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER 190 200 210 220 230 240 YLHLSISNGS IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD 250 260 270 280 290 300 QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 310 320 330 340 350 360 QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD SVCFVQHVAS 370 380 390 400 410 420 GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QQEESQAARI IRNTTALFSQ 430 440 450 460 470 480 FVSGNNRTTA PVALPTEEVL QTLQDLIAYF QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG 490 500 510 520 530 540 MLALVLNCID RLNIYNSVAH FAGIVREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN 550 560 570 580 590 600 NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV 610 620 630 640 650 660 LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSPQYKKW 670 680 690 700 710 720 YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW 730 740 750 760 770 780 SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS 790 800 810 820 830 840 FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT 850 860 870 880 890 900 TQFLSQASFI PCPIDTSQVV LPLHLEKIRD RLAENIHELW GMNKIELGWT YGKVRDDNKR 910 920 930 940 950 960 QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS 970 980 990 1000 1010 1020 NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV 1030 1040 1050 1060 1070 1080 PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD PTVEKVSIDK IRFFRVERSY 1090 1100 1110 1120 1130 1140 AVKSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR 1150 1160 1170 1180 1190 1200 TWQPGDVVGC MINLDDASMV FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR 1210 1220 1230 1240 1250 1260 MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR LPTFVNVPKD HPHIEVVRID 1270 1280 1290 1300 1310 1320 GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI 1330 1340 1350 1360 1370 1380 LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE 1390 1400 1410 1420 1430 1440 SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLLDLAMG MLSFSANGKE LGTCYQVEPN 1450 1460 1470 1480 1490 1500 TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPTPQCPPRL DVQTIQPVLW 1510 1520 1530 1540 1550 1560 SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMQFHYH 1570 1580 1590 1600 1610 1620 TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLANAKE 1630 1640 1650 1660 1670 1680 RKLMMKNEYI IPITSATRNI RLYPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ 1690 1700 1710 1720 1730 1740 KQSPEIPLQI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD 1750 1760 1770 1780 1790 1800 DDVRQILLLI DPSVFGEHSG ETEEGVEKEV THAEEKAVEA GEKACKEAPV KGLLQTRLPE 1810 1820 1830 1840 1850 1860 SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA LNMSAALTAR 1870 1880 1890 1900 1910 1920 KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE DLLVHCGVPL EEEEEEEEDT 1930 1940 1950 1960 1970 1980 SWTGKLCALV YKIKGPPKPE KEQPTEEEKP YPTTLKELVS QTMIRWAQEN QIQDAELVRM 1990 2000 2010 2020 2030 2040 MFNLLRRQYD SIGELLQALR KTYTISQASV NDTINLLAAL GQIRSLLSVR MGREEELLMI 2050 2060 2070 2080 2090 2100 NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC 2110 2120 2130 2140 2150 2160 RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA LGLEEPDLEK 2170 2180 2190 2200 2210 2220 VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL 2230 2240 2250 2260 2270 2280 IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG 2290 2300 2310 2320 2330 2340 NAIMSFYSAL IDLLGRCAPE MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL 2350 2360 2370 2380 2390 2400 NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV 2410 2420 2430 2440 2450 2460 SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI DSTLQTIYRL SKGRSLTKAQ 2470 2480 2490 2500 2510 2520 RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM PLKLLTNHYE QCWKYYCLPS 2530 2540 2550 2560 2570 2580 GWGSYGLAVE EELHLTEKLF WGIFDSLSHK KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI 2590 2600 2610 2620 2630 2640 TATLEKQVSV DADGNFDPKP INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSHSGWKYGI 2650 2660 2670 2680 2690 2700 SLDENVKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE 2710 2720 2730 2740 2750 2760 KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK LELESKGGGS 2770 2780 2790 2800 2810 2820 HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM KDLELDASSM EKRFAYKFLK 2830 2840 2850 2860 2870 2880 KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP 2890 2900 2910 2920 2930 2940 LKPLSSSGYA SHKEKEMVAS LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM 2950 2960 2970 2980 2990 3000 KSGSELVKAG LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT 3010 3020 3030 3040 3050 3060 SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI YVERQRPALG ECLASLAAAI 3070 3080 3090 3100 3110 3120 PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP DIPQLEGLMK EINDLAESGA 3130 3140 3150 3160 3170 3180 RYTEMPHVIE VILPMLCNYL SYWWERGPEN LPPSTGPCCT KVTSEHLSLI LGNILKIINN 3190 3200 3210 3220 3230 3240 NLGIDEASWM KRIAVYAQPI ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKTDGKG 3250 3260 3270 3280 3290 3300 DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDPDSDQLF RMVAEVFILW 3310 3320 3330 3340 3350 3360 CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKSGGQD QERKKTKRRG DLYSIQTSLI 3370 3380 3390 3400 3410 3420 VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SCRDTDEEVK EHLRNNLHLQ EKSDDPAVKW 3430 3440 3450 3460 3470 3480 QLNLYKDVLR NDEPSNPEKT VERVQSISAA LFHLEQVEQP LRSKKAVWHK LLSKQRKRAV 3490 3500 3510 3520 3530 3540 VACFRMAPLY NLPRHRSINL FLHGYQRFWI ETEAHFFEEK LVQDLAKSPR VEDEEEEETE 3550 3560 3570 3580 3590 3600 RQPDPLHQII LHFSRNALTE RSKLEDDPLY TSYSSMMAKS CQSGEDEEEE EDKEKTFEEK 3610 3620 3630 3640 3650 3660 EMEKQKTLYQ QARLHERGAA EMVLQMISAS KGEMSPMVVE TLKLGIAILN GGNAGVQQKM 3670 3680 3690 3700 3710 3720 LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA FERQNKAEGL GMVTEEGTLI VRERGEKVLQ 3730 3740 3750 3760 3770 3780 NDEFTQDLFR FLQLLCEGHN SDFQNFLRTQ MGNTTTVNII ISTVDYLLRL QESISDFYWY 3790 3800 3810 3820 3830 3840 YSGKDIIDES GQHNFSKALA VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF 3850 3860 3870 3880 3890 3900 ANMQMKLSQD SSQIELLKEL LDLLQDMVVM LLSLLEGNVV NGTIGKQMVD TLVESSTNVE 3910 3920 3930 3940 3950 3960 MILKFFDMFL KLKDLTSSDT FKEYDPDGKG IISRKEFQKA MEGLKQYTQS EIDFLLSCTE 3970 3980 3990 4000 4010 4020 ADENDMFNYV DFVERFHEPA KDIGFNVAVL LTNLSEHMPN DSRLKSLLDP AESVLNYFEP 4030 4040 4050 4060 4070 4080 YLGRIEIMGG AKKIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EQEKMELFVN 4090 4100 4110 4120 4130 4140 FCEDTIFEMQ LASQISESDS TDRPEEEEEE DEDSAYSIET EGEEEEKSFE SASAFTMACV 4150 4160 4170 4180 4190 4200 SVKRNVTKFL KRATLKNLRK QYRNVKKMSA KELVKVFFSF FWMLFVGLFQ LLFTIFGGIF 4210 4220 4230 4240 4250 4260 QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDV IETDRAEVTE PGVTTELVHF 4270 4280 4290 4300 4310 4320 VKGEAGDTDI MSDLFGIHSK KEGGLKQGPE VGLGDLSEII GKDEPPTLES TVRKKRKAQA 4330 4340 4350 4360 4370 4380 AEMKAVHEAE GKAESEKADM EDREKEDKIK EEGQTDYLWA DVTVKKTRRR GQKAEKPEAF 4390 4400 4410 4420 4430 4440 MANFFKGLEI YQTKLLVTEE PLEEETEDVA NLWNSFNDDD EEEAMVFFVL QESTGYMAPT 4450 4460 4470 4480 4490 4500 LRALAIVHTI ISLVCVVGYY CLKVPLVVFK REKEIARKLE FDGLYITEQP SEDDIKGQWD 4510 4520 4530 4540 4550 4560 RLVINTPSFP NNYWDKFVKR KVINKYGDLY GAERIAELLG LDKNALDFSP VEEAKAEAAS 4570 4580 4590 4600 4610 4620 LVSWLSSIDM KYHIWKLGVV FTDNSFLYLA WYTTMSVLGH YNNFFFAAHL LDIAMGFKTL 4630 4640 4650 4660 4670 4680 RTILSSVTHN GKQLVLTVGL LAVVVYLYTV VAFNFFRKFY NKSEDDDEPD MKCDDMMTCY 4690 4700 4710 4720 4730 4740 LFHMYVGVRA GGGIGDEIED PAGDPYEMYR IVFDITFFFF VIVILLAIIQ GLIIDAFGEL 4750 4760 4770 4780 4790 4800 RDQQEQVRED METKCFICGI GNDYFDTTPH GFETHTLQEH NLANYLFFLM YLINKDETEH 4810 4820 4830 TGQESYVWKM YQERCWDFFP AGDCFRKQYE DQLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Generation and characterization of mutant mice lacking ryanodine receptor type 3." Takeshima H., Ikemoto T., Nishi M., Nishiyama N., Shimuta M., Sugitani Y., Kuno J., Saito I., Saito H., Endo M., Iino M., Noda T. J. Biol. Chem. 271:19649-19652(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-67, FUNCTION, DISRUPTION PHENOTYPE. Tissue: Brain.
[3]	"Calcium-induced calcium release dependent on ryanodine receptor type 3 (RyR3) modulates both neuronal excitability and transmitter release." Chameau P., Van de Vrede Y., Lucas-Meunier E., Fossier P., Denizot J.-P., Shimahara T., Tauc L., Baux G. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4088-4541 (ISOFORM 1). Strain: Swiss. Tissue: Brain.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4220-4863 (ISOFORM 2). Strain: C57BL/6J. Tissue: Skin.
[5]	"The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues." Giannini G., Conti A., Mammarella S., Scrobogna M., Sorrentino V. J. Cell Biol. 128:893-904(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4405-4692 (ISOFORM 1), TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Brain.
[6]	"Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs." Ayabe T., Kopf G.S., Schultz R.M. Development 121:2233-2244(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4598-4841, SUBUNIT, TISSUE SPECIFICITY. Tissue: Egg.
[7]	"Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor." Takeshima H., Yamazawa T., Ikemoto T., Takekura H., Nishi M., Noda T., Iino M. EMBO J. 14:2999-3006(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4741-4863, FUNCTION, TISSUE SPECIFICITY. Strain: C57BL/6J. Tissue: Brain.
[8]	"Functional properties of the ryanodine receptor type 3 (RyR3) Ca2+ release channel." Sonnleitner A., Conti A., Bertocchini F., Schindler H., Sorrentino V. EMBO J. 17:2790-2798(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[9]	"Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells." Lohn M., Jessner W., Furstenau M., Wellner M., Sorrentino V., Haller H., Luft F.C., Gollasch M. Circ. Res. 89:1051-1057(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[10]	"RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle." Yang D., Pan Z., Takeshima H., Wu C., Nagaraj R.Y., Ma J., Cheng H. J. Biol. Chem. 276:40210-40214(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometrium." Dabertrand F., Fritz N., Mironneau J., Macrez N., Morel J.L. Am. J. Physiol. 293:C848-C854(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CHARACTERIZATION OF ISOFORM 2, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[12]	"Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests." Matsuo N., Tanda K., Nakanishi K., Yamasaki N., Toyama K., Takao K., Takeshima H., Miyakawa T. Front. Behav. Neurosci. 3:3-3(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[13]	"Ryanodine receptor studies using genetically engineered mice." Kushnir A., Betzenhauser M.J., Marks A.R. FEBS Lett. 584:1956-1965(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL929348 Genomic DNA. No translation available. AL672250 , AL691423, AL732316, BX649564 Genomic DNA. Translation: CAM15357.1. AL691423 , AL672250, AL732316, BX649564 Genomic DNA. Translation: CAM17843.1. AL732316 , AL672250, AL691423, BX649564 Genomic DNA. Translation: CAM22353.1. BX649564 , AL672250, AL691423, AL732316 Genomic DNA. Translation: CAM23489.1. D84237 mRNA. Translation: BAA12286.1. AF111166 mRNA. Translation: AAF21940.1. AK132464 mRNA. Translation: BAE21181.1. X83934 mRNA. Translation: CAA58786.1. U23756 mRNA. Translation: AAA64957.1. D38218 mRNA. Translation: BAA07393.1.
IPI	IPI00404991. IPI00606638.
PIR	I48743. S56107.
UniGene	Mm.436657.
3D structure databases
ProteinModelPortal	A2AGL3.
SMR	A2AGL3. Positions 13-530, 2596-2798, 3462-3488.
ModBase	Search...
Proteomic databases
PaxDb	A2AGL3.
PRIDE	A2AGL3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000080673; ENSMUSP00000079503; ENSMUSG00000057378.
UCSC	uc008lpg.1. mouse.
Organism-specific databases
MGI	MGI:99684. Ryr3.
Phylogenomic databases
eggNOG	NOG247670.
GeneTree	ENSGT00690000101961.
HOGENOM	HOG000231428.
HOVERGEN	HBG006699.
OrthoDB	EOG4548XN.
Gene expression databases
ArrayExpress	A2AGL3.
Bgee	A2AGL3.
Genevestigator	A2AGL3.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR000699. Ca-rel_channel. IPR008985. ConA-like_lec_gl_sf. IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR014821. Ins145_P3_rcpt. IPR005821. Ion_trans_dom. IPR016093. MIR_motif. IPR013662. RIH_assoc-dom. IPR013333. Ryan_recept. IPR003032. Ryanodine_rcpt. IPR015925. Ryanodine_recept-rel. IPR009460. Ryanrecept_TM4-6. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. [Graphical view]
PANTHER	PTHR13715. PTHR13715. 1 hit.
Pfam	PF08709. Ins145_P3_rec. 1 hit. PF00520. Ion_trans. 1 hit. PF02815. MIR. 1 hit. PF08454. RIH_assoc. 1 hit. PF06459. RR_TM4-6. 1 hit. PF01365. RYDR_ITPR. 2 hits. PF02026. RyR. 4 hits. PF00622. SPRY. 3 hits. [Graphical view]
PRINTS	PR00795. RYANODINER.
SMART	SM00472. MIR. 4 hits. SM00449. SPRY. 3 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 3 hits. SSF82109. MIR. 1 hit.
PROSITE	PS50188. B302_SPRY. 3 hits. PS50919. MIR. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL2365.
ChiTaRS	RYR3. mouse.
SOURCE	Search...

Entry information

Entry name

RYR3_MOUSE

Accession

Primary (citable) accession number: A2AGL3
Secondary accession number(s): P70184 , P70185, Q3V1H0, Q4JFC4, Q60836, Q62175, Q62198, Q9QY91

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 22, 2012
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program