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Protein
Submitted name:

Solute carrier family 12 member 6

Gene

Slc12a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 12 member 6Imported
Gene namesi
Name:Slc12a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2135960. Slc12a6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei197 – 219HelicalSequence analysisAdd BLAST23
Transmembranei257 – 282HelicalSequence analysisAdd BLAST26
Transmembranei303 – 322HelicalSequence analysisAdd BLAST20
Transmembranei328 – 347HelicalSequence analysisAdd BLAST20
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Transmembranei501 – 527HelicalSequence analysisAdd BLAST27
Transmembranei606 – 624HelicalSequence analysisAdd BLAST19
Transmembranei630 – 651HelicalSequence analysisAdd BLAST22
Transmembranei663 – 680HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiA2AGJ9.
PaxDbiA2AGJ9.
PeptideAtlasiA2AGJ9.
PRIDEiA2AGJ9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027130.
ExpressionAtlasiA2AGJ9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124314.

Structurei

3D structure databases

ProteinModelPortaliA2AGJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 348AA_permeaseInterPro annotationAdd BLAST174
Domaini467 – 745AA_permeaseInterPro annotationAdd BLAST279
Domaini759 – 877SLC12InterPro annotationAdd BLAST119

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2082. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000092644.
HOVERGENiHBG052852.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR030364. KCC3.
IPR000076. KCL_cotranspt.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF66. PTHR11827:SF66. 3 hits.
PfamiPF00324. AA_permease. 2 hits.
PF03522. SLC12. 1 hit.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

A2AGJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPPEATTKM SSVRFMVTPT KIDDIPGLSD TSPDLSSRSS SRVRFSSRES
60 70 80 90 100
VPETSRSEPM SELSGATTSL ATVALDPSSD RTSNPQDVTE DDGHKKARNA
110 120 130 140 150
YLNNSNYEEG DEYFDKNLAL FEEEMDTRPK VSSLLNRMAN YTNLTQGAKE
160 170 180 190 200
HEEAENITEG KKKPTKSPQM GTFMGVYLPC LQNIFGVILF LRLTWVVGTA
210 220 230 240 250
GILQAFAIVL ICCCCTMLTA ISMSAIATNG VVPAGGSYFM ISRALGPEFG
260 270 280 290 300
GAVGLCFYLG TTFAAAMYIL GAIEIFLVYI VPRAAIFRSD DALKESAAML
310 320 330 340 350
NNMRVYGTAF LVLMVLVVFI GVRYVNKFAS LFLACVIVSI LAIYAGAIKS
360 370 380 390 400
SFAPPHFPVC MLGNRTLSSR HLDICSKTKE VDNMTVPSKL WGFFCNSSQF
410 420 430 440 450
FNATCDEYFV HNNVISIQGI PGLASGIITE NLWSNYLPKG EIIEKPSAKS
460 470 480 490 500
SDVLGNLNHE YVLADITTSF TLLVGIFFPS VTGIMAGSNR SGDLKDAQKS
510 520 530 540 550
IPIGTILAIL TTSFVYLSNV VLFGACIEGV VLRDKFGDAV KGNLVVGTLS
560 570 580 590 600
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHSKA
610 620 630 640 650
NGEPTWALLL TAAIAELGIL IASLDLVAPI LSMFFLMCYL FVNLACALQT
660 670 680 690 700
LLRTPNWRPR FRYYHWALSF MGMSICLALM FISSWYYAIV AMVIAGMIYK
710 720 730 740 750
YIEYQGAEKE WGDGIRGLSL SAARFALLRL EEGPPHTKNW RPQLLVLLKL
760 770 780 790 800
DEDLHVKHPR LLTFASQLKA GKGLTIVGSV IVGNFLENYG DALAAEQTIK
810 820 830 840 850
HLMEAEKVKG FCQLVVAAKL KEGISHLIQS CGLGGMKHNT VVMGWPNGWR
860 870 880 890 900
QSEDARAWKT FIGTVRVTTA AHLALLVAKN VSFFPSNVEQ FSEGNIDVWW
910 920 930 940
IVHDGGMLML LPFLLKQHKV FWVTTLPLAV MVGLNLKRQG LFLAVP
Length:946
Mass (Da):103,613
Last modified:February 20, 2007 - v1
Checksum:iAC923088BBF65FFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683897 Genomic DNA. No translation available.
AL713853 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000110987; ENSMUSP00000106615; ENSMUSG00000027130.
UCSCiuc008los.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683897 Genomic DNA. No translation available.
AL713853 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA2AGJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124314.

Proteomic databases

MaxQBiA2AGJ9.
PaxDbiA2AGJ9.
PeptideAtlasiA2AGJ9.
PRIDEiA2AGJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110987; ENSMUSP00000106615; ENSMUSG00000027130.
UCSCiuc008los.2. mouse.

Organism-specific databases

MGIiMGI:2135960. Slc12a6.

Phylogenomic databases

eggNOGiKOG2082. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000092644.
HOVERGENiHBG052852.

Miscellaneous databases

ChiTaRSiSlc12a6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027130.
ExpressionAtlasiA2AGJ9. baseline and differential.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR030364. KCC3.
IPR000076. KCL_cotranspt.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF66. PTHR11827:SF66. 3 hits.
PfamiPF00324. AA_permease. 2 hits.
PF03522. SLC12. 1 hit.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA2AGJ9_MOUSE
AccessioniPrimary (citable) accession number: A2AGJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.