Mediator of RNA polymerase II transcription subunit 12

Preferred order of sections

Names and origin

Protein names

Recommended name:
Mediator of RNA polymerase II transcription subunit 12

Alternative name(s):
Mediator complex subunit 12
OPA-containing protein
Thyroid hormone receptor-associated protein complex 230 kDa component
Short name=Trap230
Trinucleotide repeat-containing gene 11 protein

Gene names

Name:	Med12
Synonyms:	Kiaa0192, Mopa, Tnrc11, Trap230

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2190 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway By similarity.
Subunit structure	Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3 By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Mediator complex subunit 12 family.
Sequence caution	The sequence AAC83164.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Activator Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway, planar cell polarity pathway Inferred from mutant phenotype PubMed 20630950. Source: MGI androgen receptor signaling pathway Inferred from electronic annotation. Source: Compara axis elongation involved in somitogenesis Inferred from mutant phenotype PubMed 20630950. Source: MGI canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 20630950. Source: MGI heart development Inferred from mutant phenotype PubMed 20630950. Source: MGI negative regulation of Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara neural tube closure Inferred from mutant phenotype PubMed 20630950. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara stem cell maintenance Inferred from mutant phenotype PubMed 20720539. Source: MGI transcription initiation from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara
Cellular_component	mediator complex Inferred from direct assay PubMed 15340084 PubMed 20508642. Source: MGI
Molecular_function	RNA polymerase II transcription cofactor activity Inferred from electronic annotation. Source: Compara chromatin binding Inferred from direct assay PubMed 20720539. Source: MGI receptor activity Inferred from electronic annotation. Source: Compara transcription coactivator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A2AGH6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A2AGH6-2) The sequence of this isoform differs from the canonical sequence as follows: 1919-1921: Missing. 1946-1946: S → SQLSSPSL 1966-1990: Missing.
Note: No experimental confirmation available.

Isoform 3 (identifier: A2AGH6-3) The sequence of this isoform differs from the canonical sequence as follows: 1-1321: Missing. 1919-1921: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2190

2190

Mediator of RNA polymerase II transcription subunit 12

PRO_0000312957

Regions

Region

1617 – 2063

447

Interaction with CTNNB1 and GLI3 By similarity

Amino acid modifications

Modified residue

166

1

Phosphotyrosine By similarity

Modified residue

636

1

Phosphoserine By similarity

Modified residue

1259

1

Phosphoserine By similarity

Modified residue

1270

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 1321

1321

Missing in isoform 3.

VSP_029977

Alternative sequence

1919 – 1921

3

Missing in isoform 2 and isoform 3.

VSP_029978

Alternative sequence

1946

1

S → SQLSSPSL in isoform 2.

VSP_029979

Alternative sequence

1966 – 1990

25

Missing in isoform 2.

VSP_029980

Experimental info

Sequence conflict

674

1

S → T in AAC83164. Ref.2

Sequence conflict

1597

1

A → T in BAD90141. Ref.4

Sequence conflict

2171

1

L → I in AAC83164. Ref.2

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 146E05DCCFF38DB4 Show »	FASTA	2,190	244,561
10 20 30 40 50 60 MAAFGILSYE HRPLKRLRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA VSGDEHGSAK 70 80 90 100 110 120 NVNFNPAKIS SNFSSIIAEK LRCNTLSDTG RRKSLMNQKD NFWLVTARSQ SAINTWFTDL 130 140 150 160 170 180 AGTKPLTHLA KKVPIFSKKE EVFGYLAKYT VPVMRAAWLI KMTCAYYAAM SETKVKKKNT 190 200 210 220 230 240 ADPFTEWTQI ITKYLWEQLQ KMAEYYRPGP AGSGGCGSTI GPLPHDVEMA IRQWDYNEKL 250 260 270 280 290 300 ALFMFQDGML DRHEFLTWVL ECFEKIRPGE DELLKLLLPL LLRYSGEFVQ SAYLSRRLAY 310 320 330 340 350 360 FCTRRLALQL DGVSSHSSHV IAAQSTSSLP TTPAPQPPTS STPSTPFSDL LMCPQHRPLV 370 380 390 400 410 420 FGLSCILQTI LLCCPSALVW HYSLTDSRIK TGSPLDHLPI APSNLPMPEG NSAFTQQVRA 430 440 450 460 470 480 KLREIEQQIK ERGQAVEVRW SFDKCQEATA GFTIGRVLHT LEVLDSHSFE RSDFSNSLDS 490 500 510 520 530 540 LCNRIFGLGP SKDGHEISSD DDAVVSLLCE WAVSCKRSGR HRAMVVAKLL EKRQAEIEAE 550 560 570 580 590 600 RCGESEAADE KGSVASGSLS APSAPIFQDV LLQFLDTQAP MLTDPRSESE RVEFFNLVLL 610 620 630 640 650 660 FCELIRHDVF SHNMYTCTLI SRGDLAFGAP GPRPPSPFDD PTDDPERKEA EGSSSSKLED 670 680 690 700 710 720 PGLSESMDID PSSSVLFEDM EKPDFSLFSP TMPCEGKGSP SPEKPDVEKE VKPPAKEKIE 730 740 750 760 770 780 GTLGILYDQP RHVQYATHFP IPQEESCSHE CNQRLVVLFG VGKQRDDARH AIKKITKDIL 790 800 810 820 830 840 KVLNRKGTAE TDQLAPIVPL NPGDLTFLGG EDGQKRRRNR PEAFPTAEDI FAKFQHLSHY 850 860 870 880 890 900 DQHQVTAQVS RNVLEQITSF ALGMSYHLPL VQHVQFIFDL MEYSLSISGL IDFAIQLLNE 910 920 930 940 950 960 LSVVEAELLL KSSDLVGSYT TSLCLCIVAV LRHYHACLIL NQDQMAQVFE GLCGVVKHGM 970 980 990 1000 1010 1020 NRSDGSSAER CILAYLYDLY TSCSHLKSKF GELFSDFCSK VKNTIYCNVE PSESNMRWAP 1030 1040 1050 1060 1070 1080 EFMIDTLENP AAHTFTYTGL GKSLSENPAN RYSFVCNALM HVCVGHHDPD RVNDIAILCA 1090 1100 1110 1120 1130 1140 ELTGYCKSLS AEWLGVLKAL CCSSNNGTCG FNDLLCNVDV SDLSFHDSLA TFVAILIARQ 1150 1160 1170 1180 1190 1200 CLLLEDLIRC AAIPSLLNAA CSEQDSEPGA RLTCRILLHL FKTPQLNPCQ SDGNKPTVGI 1210 1220 1230 1240 1250 1260 RSSCDRHLLA ASQNRIVDGA VFAVLKAVFV LGDAELKGSG FTVPGGTEEL PEEEGGGGSS 1270 1280 1290 1300 1310 1320 GRRQGGRNIS VETASLDVYA KYVLRSICQQ EWVGERCLKS LCEDSNDLQD PVLSSAQAQR 1330 1340 1350 1360 1370 1380 LMQLICYPHR LLDNEDGENP QRQRIKRILK NLDQWTMRQS SLELQLMIKQ TPNTEMNSLL 1390 1400 1410 1420 1430 1440 ENIAKATIEV FQQSAETGSS SGSTASNMPS SSKTKPVLSS LERSGVWLVA PLIAKLPTSV 1450 1460 1470 1480 1490 1500 QGHVLKAAGE ELEKGQHLGS SSRKERDRQK QKSMSLLSQQ PFLSLVLTCL KGQDEQREGL 1510 1520 1530 1540 1550 1560 LASLHSQVHQ IVINWRENQY LDDCKPKQLM HEALKLRLNL VGGMFDTVQR STQQTTEWAQ 1570 1580 1590 1600 1610 1620 LLLEIIISGT VDMQSNNELF TTVLDMLSVL INGTLAADMS SISQGSMEEN KRAYMNLVKK 1630 1640 1650 1660 1670 1680 LQKDLGERQS DSLEKVHQLL PLPKQNRDVI TCEPQGSLID TKGNKIAGFD SIFKKEGLQV 1690 1700 1710 1720 1730 1740 STKQKISPWE LFEGLKPSTA PLSWAWFGTV RVDRRVARGE EQQRLLLYHT HLRPRPRAYY 1750 1760 1770 1780 1790 1800 LEPLPLPPED EEPPAPALLE PEKKAPEPPK TDKPGAAPPS TEERKKKSTK GKKRSQPATK 1810 1820 1830 1840 1850 1860 NEDYGMGPGR SGPYGVTVPP DLLHHANPGS ISHLSYRQSS MGLYTQNQPL PAGGPRVDPY 1870 1880 1890 1900 1910 1920 RPVRLPMQKL PTRPTYPGVL PTTMSTVMGL EPSSYKTSVY RQQQPTVPQG QRLRQQLQAK 1930 1940 1950 1960 1970 1980 IQSQGMLGQS SVHQMTPSSS YGLQTSQGYT SYVSHVGLQQ HTGPAGTMVP PSYSSQPYQS 1990 2000 2010 2020 2030 2040 THPSTNPTLV DPTRHLQQRP SGYVHQQAPT YGHGLTSTQR FSHQTLQQTP MMGTMTPLSA 2050 2060 2070 2080 2090 2100 QGVQAGVRST SILPEQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQYH IRQQQQQQQM 2110 2120 2130 2140 2150 2160 LRQQQQQQQQ QQQQQQQQQQ QQQQQQQQQP HQQQQQAAPP QPQPQSQPQF QRQGLQQTQQ 2170 2180 2190 QQQTAALVRQ LQQQLSNTQP QPSTNIFGRY « Hide
Isoform 2 [UniParc]. Checksum: 8BE79B8DEFD56844 Show »	FASTA	2,169	242,303
10 20 30 40 50 60 MAAFGILSYE HRPLKRLRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA VSGDEHGSAK 70 80 90 100 110 120 NVNFNPAKIS SNFSSIIAEK LRCNTLSDTG RRKSLMNQKD NFWLVTARSQ SAINTWFTDL 130 140 150 160 170 180 AGTKPLTHLA KKVPIFSKKE EVFGYLAKYT VPVMRAAWLI KMTCAYYAAM SETKVKKKNT 190 200 210 220 230 240 ADPFTEWTQI ITKYLWEQLQ KMAEYYRPGP AGSGGCGSTI GPLPHDVEMA IRQWDYNEKL 250 260 270 280 290 300 ALFMFQDGML DRHEFLTWVL ECFEKIRPGE DELLKLLLPL LLRYSGEFVQ SAYLSRRLAY 310 320 330 340 350 360 FCTRRLALQL DGVSSHSSHV IAAQSTSSLP TTPAPQPPTS STPSTPFSDL LMCPQHRPLV 370 380 390 400 410 420 FGLSCILQTI LLCCPSALVW HYSLTDSRIK TGSPLDHLPI APSNLPMPEG NSAFTQQVRA 430 440 450 460 470 480 KLREIEQQIK ERGQAVEVRW SFDKCQEATA GFTIGRVLHT LEVLDSHSFE RSDFSNSLDS 490 500 510 520 530 540 LCNRIFGLGP SKDGHEISSD DDAVVSLLCE WAVSCKRSGR HRAMVVAKLL EKRQAEIEAE 550 560 570 580 590 600 RCGESEAADE KGSVASGSLS APSAPIFQDV LLQFLDTQAP MLTDPRSESE RVEFFNLVLL 610 620 630 640 650 660 FCELIRHDVF SHNMYTCTLI SRGDLAFGAP GPRPPSPFDD PTDDPERKEA EGSSSSKLED 670 680 690 700 710 720 PGLSESMDID PSSSVLFEDM EKPDFSLFSP TMPCEGKGSP SPEKPDVEKE VKPPAKEKIE 730 740 750 760 770 780 GTLGILYDQP RHVQYATHFP IPQEESCSHE CNQRLVVLFG VGKQRDDARH AIKKITKDIL 790 800 810 820 830 840 KVLNRKGTAE TDQLAPIVPL NPGDLTFLGG EDGQKRRRNR PEAFPTAEDI FAKFQHLSHY 850 860 870 880 890 900 DQHQVTAQVS RNVLEQITSF ALGMSYHLPL VQHVQFIFDL MEYSLSISGL IDFAIQLLNE 910 920 930 940 950 960 LSVVEAELLL KSSDLVGSYT TSLCLCIVAV LRHYHACLIL NQDQMAQVFE GLCGVVKHGM 970 980 990 1000 1010 1020 NRSDGSSAER CILAYLYDLY TSCSHLKSKF GELFSDFCSK VKNTIYCNVE PSESNMRWAP 1030 1040 1050 1060 1070 1080 EFMIDTLENP AAHTFTYTGL GKSLSENPAN RYSFVCNALM HVCVGHHDPD RVNDIAILCA 1090 1100 1110 1120 1130 1140 ELTGYCKSLS AEWLGVLKAL CCSSNNGTCG FNDLLCNVDV SDLSFHDSLA TFVAILIARQ 1150 1160 1170 1180 1190 1200 CLLLEDLIRC AAIPSLLNAA CSEQDSEPGA RLTCRILLHL FKTPQLNPCQ SDGNKPTVGI 1210 1220 1230 1240 1250 1260 RSSCDRHLLA ASQNRIVDGA VFAVLKAVFV LGDAELKGSG FTVPGGTEEL PEEEGGGGSS 1270 1280 1290 1300 1310 1320 GRRQGGRNIS VETASLDVYA KYVLRSICQQ EWVGERCLKS LCEDSNDLQD PVLSSAQAQR 1330 1340 1350 1360 1370 1380 LMQLICYPHR LLDNEDGENP QRQRIKRILK NLDQWTMRQS SLELQLMIKQ TPNTEMNSLL 1390 1400 1410 1420 1430 1440 ENIAKATIEV FQQSAETGSS SGSTASNMPS SSKTKPVLSS LERSGVWLVA PLIAKLPTSV 1450 1460 1470 1480 1490 1500 QGHVLKAAGE ELEKGQHLGS SSRKERDRQK QKSMSLLSQQ PFLSLVLTCL KGQDEQREGL 1510 1520 1530 1540 1550 1560 LASLHSQVHQ IVINWRENQY LDDCKPKQLM HEALKLRLNL VGGMFDTVQR STQQTTEWAQ 1570 1580 1590 1600 1610 1620 LLLEIIISGT VDMQSNNELF TTVLDMLSVL INGTLAADMS SISQGSMEEN KRAYMNLVKK 1630 1640 1650 1660 1670 1680 LQKDLGERQS DSLEKVHQLL PLPKQNRDVI TCEPQGSLID TKGNKIAGFD SIFKKEGLQV 1690 1700 1710 1720 1730 1740 STKQKISPWE LFEGLKPSTA PLSWAWFGTV RVDRRVARGE EQQRLLLYHT HLRPRPRAYY 1750 1760 1770 1780 1790 1800 LEPLPLPPED EEPPAPALLE PEKKAPEPPK TDKPGAAPPS TEERKKKSTK GKKRSQPATK 1810 1820 1830 1840 1850 1860 NEDYGMGPGR SGPYGVTVPP DLLHHANPGS ISHLSYRQSS MGLYTQNQPL PAGGPRVDPY 1870 1880 1890 1900 1910 1920 RPVRLPMQKL PTRPTYPGVL PTTMSTVMGL EPSSYKTSVY RQQQPTVPQG QRLRQQLQQS 1930 1940 1950 1960 1970 1980 QGMLGQSSVH QMTPSSSYGL QTSQLSSPSL QGYTSYVSHV GLQQHTGPAD PTRHLQQRPS 1990 2000 2010 2020 2030 2040 GYVHQQAPTY GHGLTSTQRF SHQTLQQTPM MGTMTPLSAQ GVQAGVRSTS ILPEQQQQQQ 2050 2060 2070 2080 2090 2100 QQQQQQQQQQ QQQQQQQQQQ QQQQQQQYHI RQQQQQQQML RQQQQQQQQQ QQQQQQQQQQ 2110 2120 2130 2140 2150 2160 QQQQQQQQPH QQQQQAAPPQ PQPQSQPQFQ RQGLQQTQQQ QQTAALVRQL QQQLSNTQPQ PSTNIFGRY « Hide
Isoform 3 [UniParc]. Checksum: 4A782193143882B0 Show »	FASTA	866	97,885
10 20 30 40 50 60 MQLICYPHRL LDNEDGENPQ RQRIKRILKN LDQWTMRQSS LELQLMIKQT PNTEMNSLLE 70 80 90 100 110 120 NIAKATIEVF QQSAETGSSS GSTASNMPSS SKTKPVLSSL ERSGVWLVAP LIAKLPTSVQ 130 140 150 160 170 180 GHVLKAAGEE LEKGQHLGSS SRKERDRQKQ KSMSLLSQQP FLSLVLTCLK GQDEQREGLL 190 200 210 220 230 240 ASLHSQVHQI VINWRENQYL DDCKPKQLMH EALKLRLNLV GGMFDTVQRS TQQTTEWAQL 250 260 270 280 290 300 LLEIIISGTV DMQSNNELFT TVLDMLSVLI NGTLAADMSS ISQGSMEENK RAYMNLVKKL 310 320 330 340 350 360 QKDLGERQSD SLEKVHQLLP LPKQNRDVIT CEPQGSLIDT KGNKIAGFDS IFKKEGLQVS 370 380 390 400 410 420 TKQKISPWEL FEGLKPSTAP LSWAWFGTVR VDRRVARGEE QQRLLLYHTH LRPRPRAYYL 430 440 450 460 470 480 EPLPLPPEDE EPPAPALLEP EKKAPEPPKT DKPGAAPPST EERKKKSTKG KKRSQPATKN 490 500 510 520 530 540 EDYGMGPGRS GPYGVTVPPD LLHHANPGSI SHLSYRQSSM GLYTQNQPLP AGGPRVDPYR 550 560 570 580 590 600 PVRLPMQKLP TRPTYPGVLP TTMSTVMGLE PSSYKTSVYR QQQPTVPQGQ RLRQQLQQSQ 610 620 630 640 650 660 GMLGQSSVHQ MTPSSSYGLQ TSQGYTSYVS HVGLQQHTGP AGTMVPPSYS SQPYQSTHPS 670 680 690 700 710 720 TNPTLVDPTR HLQQRPSGYV HQQAPTYGHG LTSTQRFSHQ TLQQTPMMGT MTPLSAQGVQ 730 740 750 760 770 780 AGVRSTSILP EQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQYHIRQQ QQQQQMLRQQ 790 800 810 820 830 840 QQQQQQQQQQ QQQQQQQQQQ QQQQQPHQQQ QQAAPPQPQP QSQPQFQRQG LQQTQQQQQT 850 860 AALVRQLQQQ LSNTQPQPST NIFGRY « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-2190 (ISOFORM 1). Strain: C57BL/6. Tissue: Brain.
[3]	"Association of an X-chromosome dodecamer insertional variant allele with mental retardation." Philibert R.A., King B.H., Cook E.H., Lee Y.-H., Stubblefield B., Damschroder-Williams P., Dea C., Palotie A., Tengstrom C., Martin B.M., Ginns E.I. Mol. Psychiatry 3:303-309(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-2190 (ISOFORM 2).
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1045-2190 (ISOFORM 1). Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL683892 Genomic DNA. Translation: CAM24445.1. AL683892 Genomic DNA. Translation: CAM24446.1. BC057085 mRNA. Translation: AAH57085.1. BC057119 mRNA. Translation: AAH57119.1. AF071310 mRNA. Translation: AAC83164.1. Different initiation. AK220216 mRNA. Translation: BAD90141.1.
IPI	IPI00620781. IPI00625430. IPI00882323.
RefSeq	NP_067496.2. NM_021521.2.
UniGene	Mm.20873. Mm.490933.
3D structure databases
ProteinModelPortal	A2AGH6.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59233N.
IntAct	A2AGH6. 1 interaction.
PTM databases
PhosphoSite	A2AGH6.
Proteomic databases
PaxDb	A2AGH6.
PRIDE	A2AGH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000087948; ENSMUSP00000085260; ENSMUSG00000079487. ENSMUST00000087956; ENSMUSP00000085269; ENSMUSG00000079487.
GeneID	59024.
KEGG	mmu:59024.
UCSC	uc009txe.1. mouse. uc009txf.1. mouse.
Organism-specific databases
CTD	9968.
MGI	MGI:1926212. Med12.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG319131.
GeneTree	ENSGT00440000037505.
HOGENOM	HOG000231423.
HOVERGEN	HBG052447.
InParanoid	A2AGH6.
KO	K15162.
OrthoDB	EOG4X3H0F.
Enzyme and pathway databases
Reactome	REACT_127416. Developmental Biology. REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.
Gene expression databases
ArrayExpress	A2AGH6.
Bgee	A2AGH6.
Genevestigator	A2AGH6.
Family and domain databases
InterPro	IPR019035. Mediator_Med12. IPR021989. Mediator_Med12_catenin-bd. IPR021990. Mediator_Med12_LCEWAV. [Graphical view]
Pfam	PF09497. Med12. 1 hit. PF12145. Med12-LCEWAV. 1 hit. PF12144. Med12-PQL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	314592.
SOURCE	Search...

Entry information

Entry name

MED12_MOUSE

Accession

Primary (citable) accession number: A2AGH6
Secondary accession number(s): A2AGH7

Q6PGD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents