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Protein
Submitted name:

Copper-transporting ATPase 1

Gene

Atp7a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Copper-transporting ATPase 1Imported
Gene namesi
Name:Atp7aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:99400. Atp7a.

Subcellular locationi

  • Membrane UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei646 – 66520HelicalUniRule annotationAdd
BLAST
Transmembranei697 – 72428HelicalUniRule annotationAdd
BLAST
Transmembranei736 – 76227HelicalUniRule annotationAdd
BLAST
Transmembranei932 – 95625HelicalUniRule annotationAdd
BLAST
Transmembranei976 – 99924HelicalUniRule annotationAdd
BLAST
Transmembranei1351 – 137323HelicalUniRule annotationAdd
BLAST
Transmembranei1379 – 139921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA2AG68.
PeptideAtlasiA2AG68.

PTM databases

SwissPalmiA2AG68.

Expressioni

Gene expression databases

BgeeiA2AG68.
ExpressionAtlasiA2AG68. baseline and differential.
GenevisibleiA2AG68. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058840.

Structurei

3D structure databases

ProteinModelPortaliA2AG68.
SMRiA2AG68. Positions 8-625, 705-1405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 7567HMAInterPro annotationAdd
BLAST
Domaini172 – 23867HMAInterPro annotationAdd
BLAST
Domaini278 – 33659HMAInterPro annotationAdd
BLAST
Domaini378 – 44467HMAInterPro annotationAdd
BLAST
Domaini481 – 54767HMAInterPro annotationAdd
BLAST
Domaini557 – 62367HMAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation
Contains 6 HMA domains.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0207. Eukaryota.
COG2217. LUCA.
GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
HOVERGENiHBG050616.
OMAiHWIPKGM.
TreeFamiTF300460.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AG68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSVDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATI
60 70 80 90 100
IYDPKLQTPK TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLTLPW
110 120 130 140 150
DHIQSTLLKT KGVTGVKISP QQRSAVVTII PSVVSASQIV ELVPDLSLDM
160 170 180 190 200
GTQEKKSGAC EEHSTPQAGE VMLKMKVEGM TCHSCTSTIE GKVGKLQGVQ
210 220 230 240 250
RIKVSLDNQE ATIVFQPHLI TAEEIKKQIE AVGFPAFIKK QPKYLKLGAI
260 270 280 290 300
DVERLKNTPV KSSEGSQQKS PSYPSDSTTM FTIEGMHCKS CVSNIESALS
310 320 330 340 350
TLQYVSSIVV SLENRSAIVK YNASLVTPEM LRKAIEAISP GQYRVSIASE
360 370 380 390 400
VESTASSPSS SSLQKMPLNI VSQPLTQEAV ININGMTCNS CVQSIEGVIS
410 420 430 440 450
KKPGVKSIHV SLANSTGTIE FDPLLTSPET LREAIEDMGF DAALPADMKE
460 470 480 490 500
PLVVIAQPSL ETPLLPSSNE LENVMTSVQN KCYIQVSGMT CASCVANIER
510 520 530 540 550
NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAEFIRE LGFGAMVMEN
560 570 580 590 600
AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY
610 620 630 640 650
DPEIIGPRDI IHTIGSLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL
660 670 680 690 700
FFCIPVMGLM VYMMVMDHHL ATLHHNQNMS NEEMINMHSA MFLERQILPG
710 720 730 740 750
LSIMNLLSLL LCLPVQFCGG WYFYIQAYKA LKHKTANMDV LIVLATTIAF
760 770 780 790 800
AYSLVILLVA MFERAKVNPI TFFDTPPMLF VFIALGRWLE HIAKGKTSEA
810 820 830 840 850
LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII KVVPGGKFPV
860 870 880 890 900
DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG
910 920 930 940 950
ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII
960 970 980 990 1000
IGFQNFEIVE TYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT
1010 1020 1030 1040 1050
PTAVMVGTGV GAQNGILIKG GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ
1060 1070 1080 1090 1100
VKVLVESNKI SRNKILAIVG TAESNSEHPL GAAVTKYCKK ELDTETLGTC
1110 1120 1130 1140 1150
TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV QIDAINEQSS
1160 1170 1180 1190 1200
TSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER
1210 1220 1230 1240 1250
RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS
1260 1270 1280 1290 1300
KTARSIASQV GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA
1310 1320 1330 1340 1350
LAMANVGIAI GTGTDVAIEA ADVVLIRNDL LDVVASIDLS RKTVKRIRIN
1360 1370 1380 1390 1400
FVFALIYNLV GIPIAAGVFL PIGLVLQPWM GSAAMAASSV SVVLSSLFLK
1410 1420 1430 1440 1450
LYRKPTYDNY ELHPRSHTGQ RSPSEISVHV GIDDTSRNSP RLGLLDRIVN
1460 1470 1480 1490
YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL
Length:1,492
Mass (Da):162,030
Last modified:February 20, 2007 - v1
Checksum:i8E5C450EA9589B90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672288 Genomic DNA. No translation available.
RefSeqiNP_001103227.1. NM_001109757.2.
UniGeneiMm.254297.

Genome annotation databases

EnsembliENSMUST00000055941; ENSMUSP00000058840; ENSMUSG00000033792.
GeneIDi11977.
UCSCiuc009ubl.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672288 Genomic DNA. No translation available.
RefSeqiNP_001103227.1. NM_001109757.2.
UniGeneiMm.254297.

3D structure databases

ProteinModelPortaliA2AG68.
SMRiA2AG68. Positions 8-625, 705-1405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058840.

PTM databases

SwissPalmiA2AG68.

Proteomic databases

PaxDbiA2AG68.
PeptideAtlasiA2AG68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055941; ENSMUSP00000058840; ENSMUSG00000033792.
GeneIDi11977.
UCSCiuc009ubl.3. mouse.

Organism-specific databases

CTDi538.
MGIiMGI:99400. Atp7a.

Phylogenomic databases

eggNOGiKOG0207. Eukaryota.
COG2217. LUCA.
GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
HOVERGENiHBG050616.
OMAiHWIPKGM.
TreeFamiTF300460.

Miscellaneous databases

ChiTaRSiAtp7a. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiA2AG68.
ExpressionAtlasiA2AG68. baseline and differential.
GenevisibleiA2AG68. MM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AG68_MOUSE
AccessioniPrimary (citable) accession number: A2AG68
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.