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Protein

FERM and PDZ domain-containing protein 4

Gene

Frmpd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FERM and PDZ domain-containing protein 4
Alternative name(s):
PDZ domain-containing protein 10
PSD-95-interacting regulator of spine morphogenesis
Short name:
Preso
Gene namesi
Name:Frmpd4
Synonyms:Gm196, Kiaa0316, Pdzd10, Pdzk10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3042378. Frmpd4.

Subcellular locationi

  • Cell projectiondendritic spine By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320FERM and PDZ domain-containing protein 4PRO_0000307133Add
BLAST

Proteomic databases

MaxQBiA2AFR3.
PaxDbiA2AFR3.
PRIDEiA2AFR3.

PTM databases

iPTMnetiA2AFR3.
PhosphoSiteiA2AFR3.

Expressioni

Tissue specificityi

Expressed in various regions of the brain, including cortex, hippocampus, cerebellum, olfactory bulb and medial habenular nucleus.1 Publication

Gene expression databases

BgeeiA2AFR3.
CleanExiMM_FRMPD4.

Interactioni

Subunit structurei

Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain. Interacts with GPSM2 (via TPR repeat region).By similarity

Protein-protein interaction databases

IntActiA2AFR3. 1 interaction.
STRINGi10090.ENSMUSP00000107773.

Structurei

3D structure databases

ProteinModelPortaliA2AFR3.
SMRiA2AFR3. Positions 33-67, 87-151, 206-514, 986-1011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 6634WWPROSITE-ProRule annotationAdd
BLAST
Domaini78 – 15578PDZPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 519316FERMPROSITE-ProRule annotationAdd
BLAST

Domaini

The FERM domain mediates the interaction with phosphatidylinositol 4,5-bisphosphate.By similarity

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3552. Eukaryota.
ENOG410YV8Z. LUCA.
GeneTreeiENSGT00530000063201.
HOGENOMiHOG000090222.
HOVERGENiHBG106593.
InParanoidiA2AFR3.
OMAiHRHLYIE.
OrthoDBiEOG7W419W.
PhylomeDBiA2AFR3.
TreeFamiTF316497.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51045. SSF51045. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2AFR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVFSFVKIP KLSSHRTKSS GWPPPSGTWG LNQVPPYGWE MMTNRDGRDY
60 70 80 90 100
FINHMTQAIP FDDPRFDSCQ IIPPAPRKVE MRRDPVLGFG FVAGSEKPVV
110 120 130 140 150
VRSVTPGGPS EGKLIPGDQI VMINDEAVSA APRERVIDLV RSCKESILLT
160 170 180 190 200
VIQPYPSPKS AFISAAKKAR LKSNPVKVRF SEEVIINGQV SETVKDNSLL
210 220 230 240 250
FMPNVLKVYL ENGQTKSFRF DCSTSIKDVI LTLQEKLSIK GIEHFSLMLE
260 270 280 290 300
QRIEGAGTKL LLLHEQETLT QVTQRPSSHK MRCLFRISFV PKDPIDLLRR
310 320 330 340 350
DPVAFEYLYV QSCNDVVQER FGPELKYDIA LRLAALQMYI ATVTTKQTQK
360 370 380 390 400
ISLKYIEKEW GLETFLPSAV LQSMKEKNIK KALSHLVKAN QNLVPPGKKL
410 420 430 440 450
SALQAKVHYL KFLSDLRLYG GRVFKATLVQ AEKRSEVTLL VGPRYGISHV
460 470 480 490 500
INTKTNLVAL LADFSHVNRI EMFTEEESLV RVELHVLDVK PITLLMESSD
510 520 530 540 550
AMNLACLTAG YYRLLVDSRR SIFNMANKKN AGTQDTGSEN KGKHNLLGPD
560 570 580 590 600
WNCMPQMTTF IGEGEQEAQI TYIDSKQKTV EMTDSTLCPK EHRHLYIDNS
610 620 630 640 650
YSSDELNQPL TQPGDAPCEA DYRSLAQRSL LTLSGPDTLK KAQESPRGAK
660 670 680 690 700
VSFIFGDLAL DDGMSPPTIG YERMLEENPE MLEKQRNLYI SSANDMKNLD
710 720 730 740 750
LTPDTDSIQF VANSVYANIG DVKNFEAPEG IEEPLLHDIC YAENTDDAED
760 770 780 790 800
EDEVSCEEDL VVGEMNQPAI LDLSGSSDDI IDLTTLPPPE GDDNEDDFLL
810 820 830 840 850
RSLNMAIAAP PPGFRDSSDE EDTQSQATSF HEDKEQGSSL QNEEIPVSLI
860 870 880 890 900
DAVPTSAEGK CEKGLDPAVV STLEALEALS EEQQKSENSG VAILRAYSPE
910 920 930 940 950
SSSDSGNETN SSEMTEGSEL AAAQKQSESL SRMFLATHEG YHPLAEEQTE
960 970 980 990 1000
FPTSKAPSVG LPPKSSHGLA ARPATDLPPK VVPSKQILHS DHMEMEPETM
1010 1020 1030 1040 1050
ETKSVTDYFS KLHMGSVAYS CTSKRKSKLP EGEGKSPLSG NIPGKKQQGT
1060 1070 1080 1090 1100
KIAEIEEDTK GKAGTVSSRD NPHLSTFNLE RTAFRKDSQR WYVASDGGVV
1110 1120 1130 1140 1150
EKSGMEAPAM KVFPRGPGLG NREAEGKEDG TVEGGADDAS VLGQGDRFLT
1160 1170 1180 1190 1200
DMACVASAKD LDNPEDTDSP SCDHATKLSE AEDNVARLCD YHLAKRMSSL
1210 1220 1230 1240 1250
QSEGHFSLQS SQGSSVDTGC GPGSSSSACA TPVESPLCPS MGKHMIPDAS
1260 1270 1280 1290 1300
GKGGRYISPE ERAPGHPNHG ATFEELHPQT EGMCPRMTVP ALHTAINADP
1310 1320
LFGTLRDGCH RLPKIKETTV
Length:1,320
Mass (Da):144,978
Last modified:February 20, 2007 - v1
Checksum:iB8E9FE340BBF7475
GO
Isoform 2 (identifier: A2AFR3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: No experimental confirmation available.
Show »
Length:1,280
Mass (Da):140,494
Checksum:i94CD2828DB9CD200
GO
Isoform 3 (identifier: A2AFR3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MDVFSFVKIPKLSS → MRSHSC

Show »
Length:1,312
Mass (Da):144,100
Checksum:i0DDF52DEA2E4FCD0
GO

Sequence cautioni

The sequence BAC65526.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4040Missing in isoform 2. 1 PublicationVSP_028581Add
BLAST
Alternative sequencei1 – 1414MDVFS…PKLSS → MRSHSC in isoform 3. 2 PublicationsVSP_028582Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147370 mRNA. Translation: BAE27868.1.
AK147440 mRNA. Translation: BAE27913.1.
AL807744, AL807773, BX546498 Genomic DNA. Translation: CAM16366.1.
BX546498, AL807744, AL807773 Genomic DNA. Translation: CAM17768.1.
BX546498, AL807773 Genomic DNA. Translation: CAM17769.1.
BX546498, AL672186, AL807773 Genomic DNA. Translation: CAM17770.1.
AL807773, AL807744, BX546498 Genomic DNA. Translation: CAM18047.1.
AL807773, BX546498 Genomic DNA. Translation: CAM18048.1.
AL807773, AL672186, BX546498 Genomic DNA. Translation: CAM18049.1.
AL672186, AL807773, BX546498 Genomic DNA. Translation: CAM24062.1.
BC139429 mRNA. Translation: AAI39430.1.
AK122244 Transcribed RNA. Translation: BAC65526.1. Sequence problems.
CCDSiCCDS41210.1. [A2AFR3-3]
CCDS72470.1. [A2AFR3-2]
RefSeqiNP_001028502.1. NM_001033330.3. [A2AFR3-3]
NP_001277356.1. NM_001290427.1. [A2AFR3-3]
NP_001277357.1. NM_001290428.1. [A2AFR3-2]
UniGeneiMm.426168.

Genome annotation databases

EnsembliENSMUST00000112145; ENSMUSP00000107773; ENSMUSG00000049176. [A2AFR3-3]
ENSMUST00000112146; ENSMUSP00000107774; ENSMUSG00000049176. [A2AFR3-2]
ENSMUST00000112147; ENSMUSP00000107775; ENSMUSG00000049176. [A2AFR3-3]
ENSMUST00000112149; ENSMUSP00000107777; ENSMUSG00000049176. [A2AFR3-1]
GeneIDi333605.
KEGGimmu:333605.
UCSCiuc009uxf.2. mouse. [A2AFR3-1]
uc009uxg.2. mouse. [A2AFR3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147370 mRNA. Translation: BAE27868.1.
AK147440 mRNA. Translation: BAE27913.1.
AL807744, AL807773, BX546498 Genomic DNA. Translation: CAM16366.1.
BX546498, AL807744, AL807773 Genomic DNA. Translation: CAM17768.1.
BX546498, AL807773 Genomic DNA. Translation: CAM17769.1.
BX546498, AL672186, AL807773 Genomic DNA. Translation: CAM17770.1.
AL807773, AL807744, BX546498 Genomic DNA. Translation: CAM18047.1.
AL807773, BX546498 Genomic DNA. Translation: CAM18048.1.
AL807773, AL672186, BX546498 Genomic DNA. Translation: CAM18049.1.
AL672186, AL807773, BX546498 Genomic DNA. Translation: CAM24062.1.
BC139429 mRNA. Translation: AAI39430.1.
AK122244 Transcribed RNA. Translation: BAC65526.1. Sequence problems.
CCDSiCCDS41210.1. [A2AFR3-3]
CCDS72470.1. [A2AFR3-2]
RefSeqiNP_001028502.1. NM_001033330.3. [A2AFR3-3]
NP_001277356.1. NM_001290427.1. [A2AFR3-3]
NP_001277357.1. NM_001290428.1. [A2AFR3-2]
UniGeneiMm.426168.

3D structure databases

ProteinModelPortaliA2AFR3.
SMRiA2AFR3. Positions 33-67, 87-151, 206-514, 986-1011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AFR3. 1 interaction.
STRINGi10090.ENSMUSP00000107773.

PTM databases

iPTMnetiA2AFR3.
PhosphoSiteiA2AFR3.

Proteomic databases

MaxQBiA2AFR3.
PaxDbiA2AFR3.
PRIDEiA2AFR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112145; ENSMUSP00000107773; ENSMUSG00000049176. [A2AFR3-3]
ENSMUST00000112146; ENSMUSP00000107774; ENSMUSG00000049176. [A2AFR3-2]
ENSMUST00000112147; ENSMUSP00000107775; ENSMUSG00000049176. [A2AFR3-3]
ENSMUST00000112149; ENSMUSP00000107777; ENSMUSG00000049176. [A2AFR3-1]
GeneIDi333605.
KEGGimmu:333605.
UCSCiuc009uxf.2. mouse. [A2AFR3-1]
uc009uxg.2. mouse. [A2AFR3-3]

Organism-specific databases

CTDi9758.
MGIiMGI:3042378. Frmpd4.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3552. Eukaryota.
ENOG410YV8Z. LUCA.
GeneTreeiENSGT00530000063201.
HOGENOMiHOG000090222.
HOVERGENiHBG106593.
InParanoidiA2AFR3.
OMAiHRHLYIE.
OrthoDBiEOG7W419W.
PhylomeDBiA2AFR3.
TreeFamiTF316497.

Miscellaneous databases

ChiTaRSiFrmpd4. mouse.
PROiA2AFR3.
SOURCEiSearch...

Gene expression databases

BgeeiA2AFR3.
CleanExiMM_FRMPD4.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51045. SSF51045. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 523-1320.
    Tissue: Brain.
  5. "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis."
    Lee H.W., Choi J., Shin H., Kim K., Yang J., Na M., Choi S.Y., Kang G.B., Eom S.H., Kim H., Kim E.
    J. Neurosci. 28:14546-14556(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiFRPD4_MOUSE
AccessioniPrimary (citable) accession number: A2AFR3
Secondary accession number(s): B9EIG4
, Q3UHE4, Q3UHI9, Q80U41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.