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Protein

5-aminolevulinate synthase

Gene

Alas2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: MGI
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. cellular iron ion homeostasis Source: MGI
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
  3. response to hypoxia Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Heme biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthaseUniRule annotation (EC:2.3.1.37UniRule annotation)
Alternative name(s):
5-aminolevulinic acid synthaseUniRule annotation
Delta-ALA synthaseUniRule annotation
Delta-aminolevulinate synthaseUniRule annotation
Gene namesi
Name:Alas2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:87990. Alas2.

Subcellular locationi

  1. Mitochondrion matrix UniRule annotation

GO - Cellular componenti

  1. mitochondrial inner membrane Source: MGI
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiA2AFM1.

Expressioni

Gene expression databases

BgeeiA2AFM1.
ExpressionAtlasiA2AFM1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2AFM1.
SMRiA2AFM1. Positions 1-49, 136-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063111.
HOGENOMiHOG000221020.
HOVERGENiHBG005954.
KOiK00643.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AFM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAAAMLLRS CPVLSQGPTG LLGKVAKTYQ FLFSIGRCPI LATQGPTCSQ
60 70 80 90 100
IHLKATKAGG ELQDRKSKIV QRAAPEVQED VKTFKTDLLS TMDSTTRSHS
110 120 130 140 150
FPSFQEPEQT EGAVPHLIQN NMTGSQAFGY DQFFRDKIME KKQDHTYRVF
160 170 180 190 200
KTVNRWANAY PFAQHFSEAS MASKDVSVWC SNDYLGISRH PRVLQAIEET
210 220 230 240 250
LKNHGAGAGG TRNISGTSKF HVELEQELAE LHQKDSALLF SSCFVANDST
260 270 280 290 300
LFTLAKLLPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN DPGHLKKLLE
310 320 330 340 350
KSDPKTPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF VDEVHAVGLY
360 370 380 390 400
GARGAGIGER DGIMHKLDII SGTLGKAFGC VGGYIASTRD LVDMVRSYAA
410 420 430 440 450
GFIFTTSLPP MVLSGALESV RLLKGEEGQA LRRAHQRNVK HMRQLLMDRG
460 470 480 490 500
FPVIPCPSHI IPIRVGNAAL NSKICDLLLS KHSIYVQAIN YPTVPRGEEL
510 520 530 540 550
LRLAPSPHHS PQMMENFVEK LLLAWTEVGL PLQDVSVAAC NFCHRPVHFE
560 570
LMSEWERSYF GNMGPQYVTT YA
Length:572
Mass (Da):63,078
Last modified:February 20, 2007 - v1
Checksum:iF4B49A3A2F39F989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672150 Genomic DNA. No translation available.
AL808140 Genomic DNA. No translation available.
RefSeqiNP_001095916.1. NM_001102446.1.
UniGeneiMm.302724.

Genome annotation databases

EnsembliENSMUST00000112715; ENSMUSP00000108335; ENSMUSG00000025270.
GeneIDi11656.
KEGGimmu:11656.
UCSCiuc009uok.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672150 Genomic DNA. No translation available.
AL808140 Genomic DNA. No translation available.
RefSeqiNP_001095916.1. NM_001102446.1.
UniGeneiMm.302724.

3D structure databases

ProteinModelPortaliA2AFM1.
SMRiA2AFM1. Positions 1-49, 136-525.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA2AFM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112715; ENSMUSP00000108335; ENSMUSG00000025270.
GeneIDi11656.
KEGGimmu:11656.
UCSCiuc009uok.1. mouse.

Organism-specific databases

CTDi212.
MGIiMGI:87990. Alas2.

Phylogenomic databases

GeneTreeiENSGT00530000063111.
HOGENOMiHOG000221020.
HOVERGENiHBG005954.
KOiK00643.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Miscellaneous databases

NextBioi279269.
SOURCEiSearch...

Gene expression databases

BgeeiA2AFM1.
ExpressionAtlasiA2AFM1. baseline and differential.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AFM1_MOUSE
AccessioniPrimary (citable) accession number: A2AFM1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 1, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.UniRule annotation

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.