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A2AFM1

- A2AFM1_MOUSE

UniProt

A2AFM1 - A2AFM1_MOUSE

Protein

5-aminolevulinate synthase

Gene

Alas2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: MGI
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular iron ion homeostasis Source: MGI
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Heme biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthaseUniRule annotation (EC:2.3.1.37UniRule annotation)
    Alternative name(s):
    5-aminolevulinic acid synthaseUniRule annotation
    Delta-ALA synthaseUniRule annotation
    Delta-aminolevulinate synthaseUniRule annotation
    Gene namesi
    Name:Alas2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:87990. Alas2.

    Subcellular locationi

    Mitochondrion matrix UniRule annotation

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    MitochondrionUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiA2AFM1.

    Expressioni

    Gene expression databases

    ArrayExpressiA2AFM1.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AFM1.
    SMRiA2AFM1. Positions 1-49, 136-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000063111.
    HOGENOMiHOG000221020.
    HOVERGENiHBG005954.
    KOiK00643.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2AFM1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAAAMLLRS CPVLSQGPTG LLGKVAKTYQ FLFSIGRCPI LATQGPTCSQ    50
    IHLKATKAGG ELQDRKSKIV QRAAPEVQED VKTFKTDLLS TMDSTTRSHS 100
    FPSFQEPEQT EGAVPHLIQN NMTGSQAFGY DQFFRDKIME KKQDHTYRVF 150
    KTVNRWANAY PFAQHFSEAS MASKDVSVWC SNDYLGISRH PRVLQAIEET 200
    LKNHGAGAGG TRNISGTSKF HVELEQELAE LHQKDSALLF SSCFVANDST 250
    LFTLAKLLPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN DPGHLKKLLE 300
    KSDPKTPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF VDEVHAVGLY 350
    GARGAGIGER DGIMHKLDII SGTLGKAFGC VGGYIASTRD LVDMVRSYAA 400
    GFIFTTSLPP MVLSGALESV RLLKGEEGQA LRRAHQRNVK HMRQLLMDRG 450
    FPVIPCPSHI IPIRVGNAAL NSKICDLLLS KHSIYVQAIN YPTVPRGEEL 500
    LRLAPSPHHS PQMMENFVEK LLLAWTEVGL PLQDVSVAAC NFCHRPVHFE 550
    LMSEWERSYF GNMGPQYVTT YA 572
    Length:572
    Mass (Da):63,078
    Last modified:February 20, 2007 - v1
    Checksum:iF4B49A3A2F39F989
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672150 Genomic DNA. No translation available.
    AL808140 Genomic DNA. No translation available.
    RefSeqiNP_001095916.1. NM_001102446.1.
    UniGeneiMm.302724.

    Genome annotation databases

    EnsembliENSMUST00000112715; ENSMUSP00000108335; ENSMUSG00000025270.
    GeneIDi11656.
    KEGGimmu:11656.
    UCSCiuc009uok.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672150 Genomic DNA. No translation available.
    AL808140 Genomic DNA. No translation available.
    RefSeqi NP_001095916.1. NM_001102446.1.
    UniGenei Mm.302724.

    3D structure databases

    ProteinModelPortali A2AFM1.
    SMRi A2AFM1. Positions 1-49, 136-525.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2AFM1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112715 ; ENSMUSP00000108335 ; ENSMUSG00000025270 .
    GeneIDi 11656.
    KEGGi mmu:11656.
    UCSCi uc009uok.1. mouse.

    Organism-specific databases

    CTDi 212.
    MGIi MGI:87990. Alas2.

    Phylogenomic databases

    GeneTreei ENSGT00530000063111.
    HOGENOMi HOG000221020.
    HOVERGENi HBG005954.
    KOi K00643.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Miscellaneous databases

    NextBioi 279269.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AFM1.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2AFM1_MOUSE
    AccessioniPrimary (citable) accession number: A2AFM1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.UniRule annotation

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3