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A2AFM1 (A2AFM1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-aminolevulinate synthase RuleBase RU910713

EC=2.3.1.37 RuleBase RU910713
Alternative name(s):
5-aminolevulinic acid synthase RuleBase RU910713
Delta-ALA synthase RuleBase RU910713
Delta-aminolevulinate synthase RuleBase RU910713
Gene names
Name:Alas2 Ensembl ENSMUSP00000108335 MGI 87990
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000108335
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2. RuleBase RU910713

Cofactor

Pyridoxal phosphate By similarity. RuleBase RU003693

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. RuleBase RU910713

Subcellular location

Mitochondrion matrix By similarity RuleBase RU910713.

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues By similarity. RuleBase RU910713

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000108335

Sequences

Sequence LengthMass (Da)Tools
A2AFM1 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: F4B49A3A2F39F989

FASTA57263,078
        10         20         30         40         50         60 
MVAAAMLLRS CPVLSQGPTG LLGKVAKTYQ FLFSIGRCPI LATQGPTCSQ IHLKATKAGG 

        70         80         90        100        110        120 
ELQDRKSKIV QRAAPEVQED VKTFKTDLLS TMDSTTRSHS FPSFQEPEQT EGAVPHLIQN 

       130        140        150        160        170        180 
NMTGSQAFGY DQFFRDKIME KKQDHTYRVF KTVNRWANAY PFAQHFSEAS MASKDVSVWC 

       190        200        210        220        230        240 
SNDYLGISRH PRVLQAIEET LKNHGAGAGG TRNISGTSKF HVELEQELAE LHQKDSALLF 

       250        260        270        280        290        300 
SSCFVANDST LFTLAKLLPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN DPGHLKKLLE 

       310        320        330        340        350        360 
KSDPKTPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF VDEVHAVGLY GARGAGIGER 

       370        380        390        400        410        420 
DGIMHKLDII SGTLGKAFGC VGGYIASTRD LVDMVRSYAA GFIFTTSLPP MVLSGALESV 

       430        440        450        460        470        480 
RLLKGEEGQA LRRAHQRNVK HMRQLLMDRG FPVIPCPSHI IPIRVGNAAL NSKICDLLLS 

       490        500        510        520        530        540 
KHSIYVQAIN YPTVPRGEEL LRLAPSPHHS PQMMENFVEK LLLAWTEVGL PLQDVSVAAC 

       550        560        570 
NFCHRPVHFE LMSEWERSYF GNMGPQYVTT YA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL672150 Genomic DNA. No translation available.
AL808140 Genomic DNA. No translation available.
RefSeqNP_001095916.1. NM_001102446.1.
UniGeneMm.302724.

3D structure databases

ProteinModelPortalA2AFM1.
SMRA2AFM1. Positions 1-49, 136-525.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA2AFM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000112715; ENSMUSP00000108335; ENSMUSG00000025270.
GeneID11656.
KEGGmmu:11656.
UCSCuc009uok.1. mouse.

Organism-specific databases

CTD212.
MGIMGI:87990. Alas2.

Phylogenomic databases

GeneTreeENSGT00530000063111.
HOGENOMHOG000221020.
HOVERGENHBG005954.
KOK00643.

Enzyme and pathway databases

UniPathwayUPA00251; UER00375.

Gene expression databases

ArrayExpressA2AFM1.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01821. 5aminolev_synth. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279269.
SOURCESearch...

Entry information

Entry nameA2AFM1_MOUSE
AccessionPrimary (citable) accession number: A2AFM1
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)