A2AFM1 (A2AFM1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial Ensembl ENSMUSP00000108335

Gene names

Name:

Alas2 Ensembl ENSMUSP00000108335 MGI 87990

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000108335

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000108335

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from mutant phenotype PubMed 10562540. Source: MGI porphyrin-containing compound metabolic process Inferred from electronic annotation. Source: InterPro tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: InterPro mitochondrion Inferred from direct assay PubMed 14651853PubMed 18614015. Source: MGI
Molecular_function	5-aminolevulinate synthase activity Inferred from mutant phenotype PubMed 7620186. Source: MGI pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2AFM1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: F4B49A3A2F39F989	FASTA	572	63,078
	10 20 30 40 50 60 MVAAAMLLRS CPVLSQGPTG LLGKVAKTYQ FLFSIGRCPI LATQGPTCSQ IHLKATKAGG 70 80 90 100 110 120 ELQDRKSKIV QRAAPEVQED VKTFKTDLLS TMDSTTRSHS FPSFQEPEQT EGAVPHLIQN 130 140 150 160 170 180 NMTGSQAFGY DQFFRDKIME KKQDHTYRVF KTVNRWANAY PFAQHFSEAS MASKDVSVWC 190 200 210 220 230 240 SNDYLGISRH PRVLQAIEET LKNHGAGAGG TRNISGTSKF HVELEQELAE LHQKDSALLF 250 260 270 280 290 300 SSCFVANDST LFTLAKLLPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN DPGHLKKLLE 310 320 330 340 350 360 KSDPKTPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF VDEVHAVGLY GARGAGIGER 370 380 390 400 410 420 DGIMHKLDII SGTLGKAFGC VGGYIASTRD LVDMVRSYAA GFIFTTSLPP MVLSGALESV 430 440 450 460 470 480 RLLKGEEGQA LRRAHQRNVK HMRQLLMDRG FPVIPCPSHI IPIRVGNAAL NSKICDLLLS 490 500 510 520 530 540 KHSIYVQAIN YPTVPRGEEL LRLAPSPHHS PQMMENFVEK LLLAWTEVGL PLQDVSVAAC 550 560 570 NFCHRPVHFE LMSEWERSYF GNMGPQYVTT YA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000108335.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000108335.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL672150 Genomic DNA. No translation available. AL808140 Genomic DNA. No translation available.
IPI	IPI00830589.
RefSeq	NP_001095916.1. NM_001102446.1.
UniGene	Mm.302724.
3D structure databases
ProteinModelPortal	A2AFM1.
SMR	A2AFM1. Positions 1-49, 136-525.
ModBase	Search...
Proteomic databases
PRIDE	A2AFM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112715; ENSMUSP00000108335; ENSMUSG00000025270.
GeneID	11656.
KEGG	mmu:11656.
UCSC	uc009uok.1. mouse.
Organism-specific databases
CTD	212.
MGI	MGI:87990. Alas2.
Phylogenomic databases
GeneTree	ENSGT00530000063111.
HOGENOM	HOG000221020.
HOVERGEN	HBG005954.
KO	K00643.
Gene expression databases
ArrayExpress	A2AFM1.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR010961. 4pyrrol_synth_NH2levulA_synth. IPR015118. 5aminolev_synth_preseq. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00155. Aminotran_1_2. 1 hit. PF09029. Preseq_ALAS. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01821. 5aminolev_synth. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279269.
SOURCE	Search...

Entry information

Entry name

A2AFM1_MOUSE

Accession

Primary (citable) accession number: A2AFM1

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)