Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-aminolevulinate synthase

Gene

Alas2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.UniRule annotation

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas1), 5-aminolevulinate synthase, erythroid-specific, mitochondrial (Alas2), 5-aminolevulinate synthase, nonspecific, mitochondrial (Alas1), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas1)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processHeme biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthaseUniRule annotation (EC:2.3.1.37UniRule annotation)
Alternative name(s):
5-aminolevulinic acid synthaseUniRule annotation
Delta-ALA synthaseUniRule annotation
Delta-aminolevulinate synthaseUniRule annotation
Gene namesi
Name:Alas2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:87990 Alas2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiA2AFM1

Expressioni

Gene expression databases

BgeeiENSMUSG00000025270
ExpressionAtlasiA2AFM1 baseline and differential
GenevisibleiA2AFM1 MM

Structurei

3D structure databases

ProteinModelPortaliA2AFM1
SMRiA2AFM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 521Aminotran_1_2InterPro annotationAdd BLAST347

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1360 Eukaryota
COG0156 LUCA
GeneTreeiENSGT00530000063111
HOGENOMiHOG000221020
HOVERGENiHBG005954

Family and domain databases

Gene3Di3.40.640.101 hit
3.90.1150.102 hits
InterProiView protein in InterPro
IPR010961 4pyrrol_synth_NH2levulA_synth
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01821 5aminolev_synth, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2AFM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAAAMLLRS CPVLSQGPTG LLGKVAKTYQ FLFSIGRCPI LATQGPTCSQ
60 70 80 90 100
IHLKATKAGG ELQDRKSKIV QRAAPEVQED VKTFKTDLLS TMDSTTRSHS
110 120 130 140 150
FPSFQEPEQT EGAVPHLIQN NMTGSQAFGY DQFFRDKIME KKQDHTYRVF
160 170 180 190 200
KTVNRWANAY PFAQHFSEAS MASKDVSVWC SNDYLGISRH PRVLQAIEET
210 220 230 240 250
LKNHGAGAGG TRNISGTSKF HVELEQELAE LHQKDSALLF SSCFVANDST
260 270 280 290 300
LFTLAKLLPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN DPGHLKKLLE
310 320 330 340 350
KSDPKTPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF VDEVHAVGLY
360 370 380 390 400
GARGAGIGER DGIMHKLDII SGTLGKAFGC VGGYIASTRD LVDMVRSYAA
410 420 430 440 450
GFIFTTSLPP MVLSGALESV RLLKGEEGQA LRRAHQRNVK HMRQLLMDRG
460 470 480 490 500
FPVIPCPSHI IPIRVGNAAL NSKICDLLLS KHSIYVQAIN YPTVPRGEEL
510 520 530 540 550
LRLAPSPHHS PQMMENFVEK LLLAWTEVGL PLQDVSVAAC NFCHRPVHFE
560 570
LMSEWERSYF GNMGPQYVTT YA
Length:572
Mass (Da):63,078
Last modified:February 20, 2007 - v1
Checksum:iF4B49A3A2F39F989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672150 Genomic DNA No translation available.
AL808140 Genomic DNA No translation available.
RefSeqiNP_001095916.1, NM_001102446.1
UniGeneiMm.302724

Genome annotation databases

EnsembliENSMUST00000112715; ENSMUSP00000108335; ENSMUSG00000025270
GeneIDi11656
UCSCiuc009uok.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA2AFM1_MOUSE
AccessioniPrimary (citable) accession number: A2AFM1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported