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A2AFM0

- A2AFM0_MOUSE

UniProt

A2AFM0 - A2AFM0_MOUSE

Protein

5-aminolevulinate synthase

Gene

Alas2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: MGI
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular iron ion homeostasis Source: MGI
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    3. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Heme biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthaseUniRule annotation (EC:2.3.1.37UniRule annotation)
    Alternative name(s):
    5-aminolevulinic acid synthaseUniRule annotation
    Delta-ALA synthaseUniRule annotation
    Delta-aminolevulinate synthaseUniRule annotation
    Gene namesi
    Name:Alas2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:87990. Alas2.

    Subcellular locationi

    Mitochondrion matrix UniRule annotation
    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    MitochondrionUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiA2AFM0.

    Expressioni

    Gene expression databases

    ArrayExpressiA2AFM0.
    GenevestigatoriA2AFM0.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AFM0.
    SMRiA2AFM0. Positions 1-49, 151-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG005954.
    InParanoidiA2AFM0.
    KOiK00643.
    OMAiHYLQSIN.
    PhylomeDBiA2AFM0.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2AFM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAAAMLLRS CPVLSQGPTG LLGKVAKTYQ FLFSIGRCPI LATQGPTCSQ    50
    IHLKATKAGG DSPSWAKSHC PFMLSELQDR KSKIVQRAAP EVQEDVKTFK 100
    TDLLSTMDST TRSHSFPSFQ EPEQTEGAVP HLIQNNMTGS QAFGYDQFFR 150
    DKIMEKKQDH TYRVFKTVNR WANAYPFAQH FSEASMASKD VSVWCSNDYL 200
    GISRHPRVLQ AIEETLKNHG AGAGGTRNIS GTSKFHVELE QELAELHQKD 250
    SALLFSSCFV ANDSTLFTLA KLLPGCEIYS DAGNHASMIQ GIRNSGAAKF 300
    VFRHNDPGHL KKLLEKSDPK TPKIVAFETV HSMDGAICPL EELCDVAHQY 350
    GALTFVDEVH AVGLYGARGA GIGERDGIMH KLDIISGTLG KAFGCVGGYI 400
    ASTRDLVDMV RSYAAGFIFT TSLPPMVLSG ALESVRLLKG EEGQALRRAH 450
    QRNVKHMRQL LMDRGFPVIP CPSHIIPIRV GNAALNSKIC DLLLSKHSIY 500
    VQAINYPTVP RGEELLRLAP SPHHSPQMME NFVEKLLLAW TEVGLPLQDV 550
    SVAACNFCHR PVHFELMSEW ERSYFGNMGP QYVTTYA 587
    Length:587
    Mass (Da):64,753
    Last modified:February 20, 2007 - v1
    Checksum:iA878D79FAD5B9856
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC150870 mRNA. Translation: AAI50871.1.
    RefSeqiNP_033783.1. NM_009653.3.
    UniGeneiMm.302724.

    Genome annotation databases

    GeneIDi11656.
    KEGGimmu:11656.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC150870 mRNA. Translation: AAI50871.1 .
    RefSeqi NP_033783.1. NM_009653.3.
    UniGenei Mm.302724.

    3D structure databases

    ProteinModelPortali A2AFM0.
    SMRi A2AFM0. Positions 1-49, 151-540.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2AFM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11656.
    KEGGi mmu:11656.

    Organism-specific databases

    CTDi 212.
    MGIi MGI:87990. Alas2.

    Phylogenomic databases

    HOVERGENi HBG005954.
    InParanoidi A2AFM0.
    KOi K00643.
    OMAi HYLQSIN.
    PhylomeDBi A2AFM0.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Miscellaneous databases

    NextBioi 279269.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AFM0.
    Genevestigatori A2AFM0.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiA2AFM0_MOUSE
    AccessioniPrimary (citable) accession number: A2AFM0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.UniRule annotation
    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues By similarity.

    External Data

    Dasty 3