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Protein
Submitted name:

Neural cell adhesion molecule L1

Gene

L1cam

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-373760. L1CAM interactions.
R-MMU-437239. Recycling pathway of L1.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion molecule L1Imported
Gene namesi
Name:L1camImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:96721. L1cam.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1124 – 114522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 12551236Sequence analysisPRO_5002642665Add
BLAST

Proteomic databases

MaxQBiA2AFG8.
PaxDbiA2AFG8.
PRIDEiA2AFG8.

Expressioni

Gene expression databases

BgeeiA2AFG8.
ExpressionAtlasiA2AFG8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099935.

Structurei

3D structure databases

ProteinModelPortaliA2AFG8.
SMRiA2AFG8. Positions 33-1005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13096Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini138 – 22588Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini239 – 32789Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini332 – 41988Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini424 – 50683Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini517 – 60084Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini613 – 71199Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini716 – 80994Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini811 – 916106Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini919 – 101496Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
OrthoDBiEOG7R56RM.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AFG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMLRYVWP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT
60 70 80 90 100
DDISLKCEAR GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN
110 120 130 140 150
NSFAQRFQGI YRCYASNKLG TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG
160 170 180 190 200
ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ DERVSMGQNG DLYFANVLTS
210 220 230 240 250
DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR LLFPTNSSSR
260 270 280 290 300
LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN
310 320 330 340 350
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR
360 370 380 390 400
LDCQVQGRPQ PEITWRINGM SMETVNKDQK YRIEQGSLIL SNVQPSDTMV
410 420 430 440 450
TQCEARNQHG LLLANAYIYV VQLPARILTK DNQTYMAVEG STAYLLCKAF
460 470 480 490 500
GAPVPSVQWL DEEGTTVLQD ERFFPYANGT LSIRDLQAND TGRYFCQAAN
510 520 530 540 550
DQNNVTILAN LQVKEATQIT QGPRSAIEKK GARVTFTCQA SFDPSLQASI
560 570 580 590 600
TWRGDGRDLQ ERGDSDKYFI EDGKLVIQSL DYSDQGNYSC VASTELDEVE
610 620 630 640 650
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE
660 670 680 690 700
FEDKEMAPEK WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS
710 720 730 740 750
PVSETVVTPE AAPEKNPVDV RGEGNETNNM VITWKPLRWM DWNAPQIQYR
760 770 780 790 800
VQWRPQGKQE TWREQTVSDP FLVVSNTSTF VPYEIKVQAV NNQGKGPEPQ
810 820 830 840 850
VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV KGHLKGYNVT
860 870 880 890 900
YWWKGSQRKH SKRHIHKSHI VVPANTTSAI LSGLRPYSSY HVEVQAFNGR
910 920 930 940 950
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY
960 970 980 990 1000
LLSYHPVEGE SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTQQGP
1010 1020 1030 1040 1050
GEAIVREGGT MALFGKPDFG NISATAGENY SVVSWVPRKG QCNFRFHILF
1060 1070 1080 1090 1100
KALPEGKVSP DHQPQPQYVS YNQSSYTQWN LQPDTKYEIH LIKEKVLLHH
1110 1120 1130 1140 1150
LDVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL ILCFIKRSKG
1160 1170 1180 1190 1200
GKYSVKDKED TQVDSEARPM KDETFGEYSD NEEKAFGSSQ PSLNGDIKPL
1210 1220 1230 1240 1250
GSDDSLADYG GSVDVQFNED GSFIGQYSGK KEKEAAGGND SSGATSPINP

AVALE
Length:1,255
Mass (Da):140,431
Last modified:February 20, 2007 - v1
Checksum:iF353B5FE357CE57B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AL672094 Genomic DNA. No translation available.
RefSeqiXP_006527922.1. XM_006527859.2.
UniGeneiMm.260568.

Genome annotation databases

EnsembliENSMUST00000114430; ENSMUSP00000110073; ENSMUSG00000031391.
GeneIDi16728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AL672094 Genomic DNA. No translation available.
RefSeqiXP_006527922.1. XM_006527859.2.
UniGeneiMm.260568.

3D structure databases

ProteinModelPortaliA2AFG8.
SMRiA2AFG8. Positions 33-1005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099935.

Proteomic databases

MaxQBiA2AFG8.
PaxDbiA2AFG8.
PRIDEiA2AFG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114430; ENSMUSP00000110073; ENSMUSG00000031391.
GeneIDi16728.

Organism-specific databases

CTDi3897.
MGIiMGI:96721. L1cam.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
OrthoDBiEOG7R56RM.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-373760. L1CAM interactions.
R-MMU-437239. Recycling pathway of L1.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-445144. Signal transduction by L1.

Miscellaneous databases

ChiTaRSiL1cam. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiA2AFG8.
ExpressionAtlasiA2AFG8. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AFG8_MOUSE
AccessioniPrimary (citable) accession number: A2AFG8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.