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Protein
Submitted name:

Neural cell adhesion molecule L1

Gene

L1cam

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-373760. L1CAM interactions.
R-MMU-437239. Recycling pathway of L1.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion molecule L1Imported
Gene namesi
Name:L1camImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:96721. L1cam.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1119 – 1140HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500264225220 – 1250Sequence analysisAdd BLAST1231

Proteomic databases

MaxQBiA2AFG7.
PaxDbiA2AFG7.
PeptideAtlasiA2AFG7.
PRIDEiA2AFG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031391.
ExpressionAtlasiA2AFG7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA2AFG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 125Ig-likeInterPro annotationAdd BLAST96
Domaini133 – 220Ig-likeInterPro annotationAdd BLAST88
Domaini234 – 322Ig-likeInterPro annotationAdd BLAST89
Domaini327 – 414Ig-likeInterPro annotationAdd BLAST88
Domaini419 – 501Ig-likeInterPro annotationAdd BLAST83
Domaini512 – 595Ig-likeInterPro annotationAdd BLAST84
Domaini608 – 706Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini711 – 804Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini806 – 911Fibronectin type-IIIInterPro annotationAdd BLAST106
Domaini914 – 1009Fibronectin type-IIIInterPro annotationAdd BLAST96

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 11 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
PfamiView protein in Pfam
PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
SMARTiView protein in SMART
SM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.

Sequencei

Sequence statusi: Complete.

A2AFG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMLRYVWP LLLCSPCLLI QIPDELLEPP VITEQSPRRL VVFPTDDISL
60 70 80 90 100
KCEARGRPQV EFRWTKDGIH FKPKEELGVV VHEAPYSGSF TIEGNNSFAQ
110 120 130 140 150
RFQGIYRCYA SNKLGTAMSH EIQLVAEGAP KWPKETVKPV EVEEGESVVL
160 170 180 190 200
PCNPPPSAAP LRIYWMNSKI LHIKQDERVS MGQNGDLYFA NVLTSDNHSD
210 220 230 240 250
YICNAHFPGT RTIIQKEPID LRVKPTNSMI DRKPRLLFPT NSSSRLVALQ
260 270 280 290 300
GQSLILECIA EGFPTPTIKW LHPSDPMPTD RVIYQNHNKT LQLLNVGEED
310 320 330 340 350
DGEYTCLAEN SLGSARHAYY VTVEAAPYWL QKPQSHLYGP GETARLDCQV
360 370 380 390 400
QGRPQPEITW RINGMSMETV NKDQKYRIEQ GSLILSNVQP SDTMVTQCEA
410 420 430 440 450
RNQHGLLLAN AYIYVVQLPA RILTKDNQTY MAVEGSTAYL LCKAFGAPVP
460 470 480 490 500
SVQWLDEEGT TVLQDERFFP YANGTLSIRD LQANDTGRYF CQAANDQNNV
510 520 530 540 550
TILANLQVKE ATQITQGPRS AIEKKGARVT FTCQASFDPS LQASITWRGD
560 570 580 590 600
GRDLQERGDS DKYFIEDGKL VIQSLDYSDQ GNYSCVASTE LDEVESRAQL
610 620 630 640 650
LVVGSPGPVP HLELSDRHLL KQSQVHLSWS PAEDHNSPIE KYDIEFEDKE
660 670 680 690 700
MAPEKWFSLG KVPGNQTSTT LKLSPYVHYT FRVTAINKYG PGEPSPVSET
710 720 730 740 750
VVTPEAAPEK NPVDVRGEGN ETNNMVITWK PLRWMDWNAP QIQYRVQWRP
760 770 780 790 800
QGKQETWREQ TVSDPFLVVS NTSTFVPYEI KVQAVNNQGK GPEPQVTIGY
810 820 830 840 850
SGEDYPQVSP ELEDITIFNS STVLVRWRPV DLAQVKGHLK GYNVTYWWKG
860 870 880 890 900
SQRKHSKRHI HKSHIVVPAN TTSAILSGLR PYSSYHVEVQ AFNGRGLGPA
910 920 930 940 950
SEWTFSTPEG VPGHPEALHL ECQSDTSLLL HWQPPLSHNG VLTGYLLSYH
960 970 980 990 1000
PVEGESKEQL FFNLSDPELR THNLTNLNPD LQYRFQLQAT TQQGPGEAIV
1010 1020 1030 1040 1050
REGGTMALFG KPDFGNISAT AGENYSVVSW VPRKGQCNFR FHILFKALPE
1060 1070 1080 1090 1100
GKVSPDHQPQ PQYVSYNQSS YTQWNLQPDT KYEIHLIKEK VLLHHLDVKT
1110 1120 1130 1140 1150
NGTGPVRVST TGSFASEGWF IAFVSAIILL LLILLILCFI KRSKGGKYSV
1160 1170 1180 1190 1200
KDKEDTQVDS EARPMKDETF GEYSDNEEKA FGSSQPSLNG DIKPLGSDDS
1210 1220 1230 1240 1250
LADYGGSVDV QFNEDGSFIG QYSGKKEKEA AGGNDSSGAT SPINPAVALE
Length:1,250
Mass (Da):139,822
Last modified:February 20, 2007 - v1
Checksum:iA7AD1EF63DA7B38D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AL672094 Genomic DNA. No translation available.
RefSeqiXP_006527924.1. XM_006527861.3.
UniGeneiMm.260568.

Genome annotation databases

EnsembliENSMUST00000066576; ENSMUSP00000068135; ENSMUSG00000031391.
GeneIDi16728.

Similar proteinsi

Entry informationi

Entry nameiA2AFG7_MOUSE
AccessioniPrimary (citable) accession number: A2AFG7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported