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Protein
Submitted name:

Neural cell adhesion molecule L1

Gene

L1cam

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-373760. L1CAM interactions.
R-MMU-437239. Recycling pathway of L1.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion molecule L1Imported
Gene namesi
Name:L1camImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:96721. L1cam.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1119 – 114022HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 12501231Sequence analysisPRO_5002642252Add
BLAST

Proteomic databases

PaxDbiA2AFG7.
PRIDEiA2AFG7.

Expressioni

Gene expression databases

BgeeiA2AFG7.
ExpressionAtlasiA2AFG7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099935.

Structurei

3D structure databases

ProteinModelPortaliA2AFG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12596Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini133 – 22088Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini234 – 32289Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini327 – 41488Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini419 – 50183Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini512 – 59584Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini608 – 70699Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini711 – 80494Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini806 – 911106Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini914 – 100996Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AFG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMLRYVWP LLLCSPCLLI QIPDELLEPP VITEQSPRRL VVFPTDDISL
60 70 80 90 100
KCEARGRPQV EFRWTKDGIH FKPKEELGVV VHEAPYSGSF TIEGNNSFAQ
110 120 130 140 150
RFQGIYRCYA SNKLGTAMSH EIQLVAEGAP KWPKETVKPV EVEEGESVVL
160 170 180 190 200
PCNPPPSAAP LRIYWMNSKI LHIKQDERVS MGQNGDLYFA NVLTSDNHSD
210 220 230 240 250
YICNAHFPGT RTIIQKEPID LRVKPTNSMI DRKPRLLFPT NSSSRLVALQ
260 270 280 290 300
GQSLILECIA EGFPTPTIKW LHPSDPMPTD RVIYQNHNKT LQLLNVGEED
310 320 330 340 350
DGEYTCLAEN SLGSARHAYY VTVEAAPYWL QKPQSHLYGP GETARLDCQV
360 370 380 390 400
QGRPQPEITW RINGMSMETV NKDQKYRIEQ GSLILSNVQP SDTMVTQCEA
410 420 430 440 450
RNQHGLLLAN AYIYVVQLPA RILTKDNQTY MAVEGSTAYL LCKAFGAPVP
460 470 480 490 500
SVQWLDEEGT TVLQDERFFP YANGTLSIRD LQANDTGRYF CQAANDQNNV
510 520 530 540 550
TILANLQVKE ATQITQGPRS AIEKKGARVT FTCQASFDPS LQASITWRGD
560 570 580 590 600
GRDLQERGDS DKYFIEDGKL VIQSLDYSDQ GNYSCVASTE LDEVESRAQL
610 620 630 640 650
LVVGSPGPVP HLELSDRHLL KQSQVHLSWS PAEDHNSPIE KYDIEFEDKE
660 670 680 690 700
MAPEKWFSLG KVPGNQTSTT LKLSPYVHYT FRVTAINKYG PGEPSPVSET
710 720 730 740 750
VVTPEAAPEK NPVDVRGEGN ETNNMVITWK PLRWMDWNAP QIQYRVQWRP
760 770 780 790 800
QGKQETWREQ TVSDPFLVVS NTSTFVPYEI KVQAVNNQGK GPEPQVTIGY
810 820 830 840 850
SGEDYPQVSP ELEDITIFNS STVLVRWRPV DLAQVKGHLK GYNVTYWWKG
860 870 880 890 900
SQRKHSKRHI HKSHIVVPAN TTSAILSGLR PYSSYHVEVQ AFNGRGLGPA
910 920 930 940 950
SEWTFSTPEG VPGHPEALHL ECQSDTSLLL HWQPPLSHNG VLTGYLLSYH
960 970 980 990 1000
PVEGESKEQL FFNLSDPELR THNLTNLNPD LQYRFQLQAT TQQGPGEAIV
1010 1020 1030 1040 1050
REGGTMALFG KPDFGNISAT AGENYSVVSW VPRKGQCNFR FHILFKALPE
1060 1070 1080 1090 1100
GKVSPDHQPQ PQYVSYNQSS YTQWNLQPDT KYEIHLIKEK VLLHHLDVKT
1110 1120 1130 1140 1150
NGTGPVRVST TGSFASEGWF IAFVSAIILL LLILLILCFI KRSKGGKYSV
1160 1170 1180 1190 1200
KDKEDTQVDS EARPMKDETF GEYSDNEEKA FGSSQPSLNG DIKPLGSDDS
1210 1220 1230 1240 1250
LADYGGSVDV QFNEDGSFIG QYSGKKEKEA AGGNDSSGAT SPINPAVALE
Length:1,250
Mass (Da):139,822
Last modified:February 20, 2007 - v1
Checksum:iA7AD1EF63DA7B38D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AL672094 Genomic DNA. No translation available.
RefSeqiXP_006527924.1. XM_006527861.2.
UniGeneiMm.260568.

Genome annotation databases

EnsembliENSMUST00000066576; ENSMUSP00000068135; ENSMUSG00000031391.
GeneIDi16728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AL672094 Genomic DNA. No translation available.
RefSeqiXP_006527924.1. XM_006527861.2.
UniGeneiMm.260568.

3D structure databases

ProteinModelPortaliA2AFG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099935.

Proteomic databases

PaxDbiA2AFG7.
PRIDEiA2AFG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066576; ENSMUSP00000068135; ENSMUSG00000031391.
GeneIDi16728.

Organism-specific databases

CTDi3897.
MGIiMGI:96721. L1cam.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-373760. L1CAM interactions.
R-MMU-437239. Recycling pathway of L1.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-445144. Signal transduction by L1.

Miscellaneous databases

ChiTaRSiL1cam. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiA2AFG7.
ExpressionAtlasiA2AFG7. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2AFG7_MOUSE
AccessioniPrimary (citable) accession number: A2AFG7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.