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Protein

Transmembrane protein 185A

Gene

Tmem185a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 185A
Alternative name(s):
Erythropoietin-induced EST 3
Protein FAM11A
Gene namesi
Name:Tmem185a
Synonyms:Ee3, Fam11a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2448555. Tmem185a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • dendrite Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237801 – 350Transmembrane protein 185AAdd BLAST350

Proteomic databases

PRIDEiA2AF53.

PTM databases

iPTMnetiA2AF53.
PhosphoSitePlusiA2AF53.

Expressioni

Tissue specificityi

Broadly expressed in brain where it is specifically expressed by neurons (at protein level). Also detected in some cells of arterioles, intestine, lung and testis (at protein level).1 Publication

Developmental stagei

Detected at E7, levels increase from E11 to E17.1 Publication

Inductioni

Up-regulated by erythropoietin (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000073139.
ExpressionAtlasiA2AF53. baseline and differential.

Interactioni

Subunit structurei

Interacts with MAP1B.By similarity

Structurei

3D structure databases

ProteinModelPortaliA2AF53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 350Mediates interaction with MAP1BBy similarityAdd BLAST53

Sequence similaritiesi

Belongs to the TMEM185 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008194.
HOGENOMiHOG000231372.
HOVERGENiHBG051528.
InParanoidiA2AF53.
OMAiQSPGKYF.
OrthoDBiEOG091G0CR4.

Family and domain databases

InterProiView protein in InterPro
IPR019396. TM_Fragile-X-F-assoc.
PfamiView protein in Pfam
PF10269. Tmemb_185A. 1 hit.

Sequencei

Sequence statusi: Complete.

A2AF53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW
60 70 80 90 100
KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL
110 120 130 140 150
VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI
160 170 180 190 200
LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM
210 220 230 240 250
DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSCIPIFVPL
260 270 280 290 300
WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
310 320 330 340 350
HEDSEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
Length:350
Mass (Da):40,620
Last modified:February 20, 2007 - v1
Checksum:i13FFC0BA9F8328B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672026 Genomic DNA. No translation available.
BC138670 mRNA. Translation: AAI38671.1.
BC145368 mRNA. Translation: AAI45369.1.
RefSeqiXP_006528044.1. XM_006527981.2.
UniGeneiMm.24569.

Genome annotation databases

EnsembliENSMUST00000114630; ENSMUSP00000110277; ENSMUSG00000073139.
GeneIDi236848.
UCSCiuc012hjm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672026 Genomic DNA. No translation available.
BC138670 mRNA. Translation: AAI38671.1.
BC145368 mRNA. Translation: AAI45369.1.
RefSeqiXP_006528044.1. XM_006527981.2.
UniGeneiMm.24569.

3D structure databases

ProteinModelPortaliA2AF53.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA2AF53.
PhosphoSitePlusiA2AF53.

Proteomic databases

PRIDEiA2AF53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114630; ENSMUSP00000110277; ENSMUSG00000073139.
GeneIDi236848.
UCSCiuc012hjm.1. mouse.

Organism-specific databases

CTDi84548.
MGIiMGI:2448555. Tmem185a.

Phylogenomic databases

GeneTreeiENSGT00390000008194.
HOGENOMiHOG000231372.
HOVERGENiHBG051528.
InParanoidiA2AF53.
OMAiQSPGKYF.
OrthoDBiEOG091G0CR4.

Miscellaneous databases

PROiA2AF53.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073139.
ExpressionAtlasiA2AF53. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR019396. TM_Fragile-X-F-assoc.
PfamiView protein in Pfam
PF10269. Tmemb_185A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiT185A_MOUSE
AccessioniPrimary (citable) accession number: A2AF53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: February 20, 2007
Last modified: March 15, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.