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Protein

Dedicator of cytokinesis protein 11

Gene

Dock11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.2 Publications

GO - Molecular functioni

  • Rho GTPase binding Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 11
Alternative name(s):
Activated Cdc42-associated guanine nucleotide exchange factor
Short name:
ACG
Zizimin-2
Gene namesi
Name:Dock11
Synonyms:Ziz2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1923224. Dock11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995591 – 2073Dedicator of cytokinesis protein 11Add BLAST2073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei16PhosphothreonineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei248PhosphotyrosineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei445PhosphoserineCombined sources1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1240PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA2AF47.
MaxQBiA2AF47.
PaxDbiA2AF47.
PeptideAtlasiA2AF47.
PRIDEiA2AF47.

PTM databases

iPTMnetiA2AF47.
PhosphoSitePlusiA2AF47.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, bone marrow and peripheral blood lymphocytes. Enriched in B-cells from germinal centers.1 Publication

Gene expression databases

BgeeiENSMUSG00000031093.
CleanExiMM_DOCK11.
ExpressionAtlasiA2AF47. baseline and differential.
GenevisibleiA2AF47. MM.

Interactioni

Subunit structurei

Interacts with CDC42.2 Publications

GO - Molecular functioni

  • Rho GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi217880. 1 interactor.
STRINGi10090.ENSMUSP00000033419.

Structurei

3D structure databases

ProteinModelPortaliA2AF47.
SMRiA2AF47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 272PHPROSITE-ProRule annotationAdd BLAST108
Domaini640 – 818DHR-1PROSITE-ProRule annotationAdd BLAST179
Domaini1609 – 2036DHR-2PROSITE-ProRule annotationAdd BLAST428

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 126Interaction with activated CDC42Add BLAST61

Domaini

The DHR-2 domain is necessary for the GEF activity.

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation
Contains 1 DHR-1 domain.PROSITE-ProRule annotation
Contains 1 DHR-2 domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1997. Eukaryota.
ENOG410XNVY. LUCA.
GeneTreeiENSGT00760000119234.
HOGENOMiHOG000231373.
HOVERGENiHBG107819.
InParanoidiA2AF47.
OMAiGNIAHCA.
OrthoDBiEOG091G03FS.
TreeFamiTF313629.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 3 hits.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AF47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKLV EPLDYENVIT
60 70 80 90 100
QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF
110 120 130 140 150
VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC
160 170 180 190 200
EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD
210 220 230 240 250
GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH
260 270 280 290 300
YLAAETEQEM EEWLIMLKKI IQINTDSLVQ EKKDTVEAIQ EEETSSQGKA
310 320 330 340 350
ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS
360 370 380 390 400
GIEPDVKPFE EKCNKRFMVN CHDLTFNILG HIGDNAKGPP TNVEPFFINL
410 420 430 440 450
ALFDVKNNCK ISADFHVDLN PPSVREMLWG TSTQLSNDGN AKGFSPESLI
460 470 480 490 500
HGIAESQLCY IKQGIFSVTN PHPEIFLVVR IEKVLQGNIT HCAEPYIKNS
510 520 530 540 550
DPIKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDVQG SLDLDGRFSP
560 570 580 590 600
LYKQDSSKLS NEDILKLLSE YKKPEKTKLQ IIPGQLSITV ECVPVDLPNC
610 620 630 640 650
ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL
660 670 680 690 700
KYDSQKSFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV
710 720 730 740 750
VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT
760 770 780 790 800
VETPVGFAWV PLLKDGRVIT LEQQLPVSAN LPPGYLNVND AESRRQSNAD
810 820 830 840 850
IKWVDGAKPL LKIKTHLEST IYTQDLHVHK FFHHCQLIQS GSKEVPGELI
860 870 880 890 900
KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV
910 920 930 940 950
SKCHEEGLES YLRSFIKYSF RPEKPSTLQA QLIHETLATT MIAILKQSAD
960 970 980 990 1000
FLAINKLLKY SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PEAYHHVLHS
1010 1020 1030 1040 1050
LLLAIIPHVT IRYAEIPDES RNGNYSLASF LKRCLTLMDR GFVFNLINDY
1060 1070 1080 1090 1100
ISGFSPKDPK VLAEYKFEFL QTICNHEHYI PLNLPMAFAK PKLQRVQDSN
1110 1120 1130 1140 1150
LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV IKNLLIKHAF
1160 1170 1180 1190 1200
DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPSSASRD
1210 1220 1230 1240 1250
EFPCGFVSPT NRGSLASDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP
1260 1270 1280 1290 1300
DPGSTSENTR QSSSRSSVSQ YNRLDQYEIR NLLMCYLYIV KMISEDTLLT
1310 1320 1330 1340 1350
YWNKVSPQEL INILVLLEVC LFHFRYMGKR NIARVHDAWL SKHFGIDRKS
1360 1370 1380 1390 1400
QTMPALRNRS GVMQARLQHL SSLESSFTLN HSSATTEADI FHQALLEGNT
1410 1420 1430 1440 1450
ATEVSLTVLD TISFFTQCFK NQLLNNDGHN PLMKKVFDIH LAFLKNGQSE
1460 1470 1480 1490 1500
VSLKHVFASL RSFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE
1510 1520 1530 1540 1550
ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES
1560 1570 1580 1590 1600
LFIINNFANS DRPMKATAFP TEVKDLTKRI RTVLMATAQM KEHEKDPEML
1610 1620 1630 1640 1650
IDLQYSLAKS YASTPELRKT WLDSMAKIHI KNGDFSEAAM CYVHVAALVA
1660 1670 1680 1690 1700
EFLHRKKLFP SGCSAFKKIT PNIDEEGAMK EDAGMMDVHY SEEVLLELLE
1710 1720 1730 1740 1750
QCVDGLWKAE RYEVISEISK LIIPIYEKRR EFEKLTQVYR TLHGAYTKIL
1760 1770 1780 1790 1800
EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV
1810 1820 1830 1840 1850
KLYGEKFGTE NVKIIQDSDK VNAKELDPKF AHIQVTYVKP YFDDKELTER
1860 1870 1880 1890 1900
KTEFERNHNI NRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK
1910 1920 1930 1940 1950
RIPINCEQQV NLKPIDVATD EIKDKTAELH KLCSSVDVDM IQLQLKLQGC
1960 1970 1980 1990 2000
VSVQVNAGPL AYARAFLNES QANKYPPKKV NELKDMFRKF IQACSIALEL
2010 2020 2030 2040 2050
NERLIKEDQI EYHEGLKSNF RDMVKELSDI IHEQILQEDT MHSPWMNNTL
2060 2070
HVFCAISGTS SNRGYGSPRY AEV
Length:2,073
Mass (Da):237,771
Last modified:February 20, 2007 - v1
Checksum:i2907066969A6A8F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1608A → T in BAD83670 (PubMed:15710388).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116935 mRNA. Translation: BAD83670.1.
AL672038, AL672023 Genomic DNA. Translation: CAM20638.1.
AL672023, AL672038 Genomic DNA. Translation: CAM21480.1.
CCDSiCCDS40923.1.
RefSeqiNP_001009947.2. NM_001009947.3.
UniGeneiMm.32873.

Genome annotation databases

EnsembliENSMUST00000033419; ENSMUSP00000033419; ENSMUSG00000031093.
GeneIDi75974.
KEGGimmu:75974.
UCSCiuc009sxi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116935 mRNA. Translation: BAD83670.1.
AL672038, AL672023 Genomic DNA. Translation: CAM20638.1.
AL672023, AL672038 Genomic DNA. Translation: CAM21480.1.
CCDSiCCDS40923.1.
RefSeqiNP_001009947.2. NM_001009947.3.
UniGeneiMm.32873.

3D structure databases

ProteinModelPortaliA2AF47.
SMRiA2AF47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217880. 1 interactor.
STRINGi10090.ENSMUSP00000033419.

PTM databases

iPTMnetiA2AF47.
PhosphoSitePlusiA2AF47.

Proteomic databases

EPDiA2AF47.
MaxQBiA2AF47.
PaxDbiA2AF47.
PeptideAtlasiA2AF47.
PRIDEiA2AF47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033419; ENSMUSP00000033419; ENSMUSG00000031093.
GeneIDi75974.
KEGGimmu:75974.
UCSCiuc009sxi.1. mouse.

Organism-specific databases

CTDi139818.
MGIiMGI:1923224. Dock11.

Phylogenomic databases

eggNOGiKOG1997. Eukaryota.
ENOG410XNVY. LUCA.
GeneTreeiENSGT00760000119234.
HOGENOMiHOG000231373.
HOVERGENiHBG107819.
InParanoidiA2AF47.
OMAiGNIAHCA.
OrthoDBiEOG091G03FS.
TreeFamiTF313629.

Enzyme and pathway databases

ReactomeiR-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiA2AF47.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031093.
CleanExiMM_DOCK11.
ExpressionAtlasiA2AF47. baseline and differential.
GenevisibleiA2AF47. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 3 hits.
PfamiPF06920. DHR-2. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOC11_MOUSE
AccessioniPrimary (citable) accession number: A2AF47
Secondary accession number(s): Q5KTP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Zizim' means 'spike' in Hebrew.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.