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A2AF47

- DOC11_MOUSE

UniProt

A2AF47 - DOC11_MOUSE

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Protein
Dedicator of cytokinesis protein 11
Gene
Dock11, Ziz2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.2 Publications

GO - Molecular functioni

  1. Rho GTPase binding Source: MGI
  2. Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  1. regulation of Rho GTPase activity Source: GOC
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 11
Alternative name(s):
Activated Cdc42-associated guanine nucleotide exchange factor
Short name:
ACG
Zizimin-2
Gene namesi
Name:Dock11
Synonyms:Ziz2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1923224. Dock11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20732073Dedicator of cytokinesis protein 11
PRO_0000299559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei161 – 1611Phosphoserine By similarity
Modified residuei248 – 2481Phosphotyrosine By similarity
Modified residuei251 – 2511Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AF47.
PaxDbiA2AF47.
PRIDEiA2AF47.

PTM databases

PhosphoSiteiA2AF47.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, bone marrow and peripheral blood lymphocytes. Enriched in B-cells from germinal centers.1 Publication

Gene expression databases

ArrayExpressiA2AF47.
BgeeiA2AF47.
CleanExiMM_DOCK11.
GenevestigatoriA2AF47.

Interactioni

Subunit structurei

Interacts with CDC42.2 Publications

Protein-protein interaction databases

BioGridi217880. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA2AF47.
SMRiA2AF47. Positions 162-298, 1613-2035.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 272108PH
Add
BLAST
Domaini640 – 818179DHR-1
Add
BLAST
Domaini1609 – 2036428DHR-2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 12661Interaction with activated CDC42
Add
BLAST

Domaini

The DHR-2 domain is necessary for the GEF activity.

Sequence similaritiesi

Belongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG242127.
GeneTreeiENSGT00750000117541.
HOGENOMiHOG000231373.
HOVERGENiHBG107819.
InParanoidiA2AF47.
OMAiMAKIHIK.
OrthoDBiEOG76DTRQ.
TreeFamiTF313629.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AF47-1 [UniParc]FASTAAdd to Basket

« Hide

MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKLV EPLDYENVIT     50
QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF 100
VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC 150
EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD 200
GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH 250
YLAAETEQEM EEWLIMLKKI IQINTDSLVQ EKKDTVEAIQ EEETSSQGKA 300
ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS 350
GIEPDVKPFE EKCNKRFMVN CHDLTFNILG HIGDNAKGPP TNVEPFFINL 400
ALFDVKNNCK ISADFHVDLN PPSVREMLWG TSTQLSNDGN AKGFSPESLI 450
HGIAESQLCY IKQGIFSVTN PHPEIFLVVR IEKVLQGNIT HCAEPYIKNS 500
DPIKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDVQG SLDLDGRFSP 550
LYKQDSSKLS NEDILKLLSE YKKPEKTKLQ IIPGQLSITV ECVPVDLPNC 600
ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL 650
KYDSQKSFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV 700
VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT 750
VETPVGFAWV PLLKDGRVIT LEQQLPVSAN LPPGYLNVND AESRRQSNAD 800
IKWVDGAKPL LKIKTHLEST IYTQDLHVHK FFHHCQLIQS GSKEVPGELI 850
KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV 900
SKCHEEGLES YLRSFIKYSF RPEKPSTLQA QLIHETLATT MIAILKQSAD 950
FLAINKLLKY SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PEAYHHVLHS 1000
LLLAIIPHVT IRYAEIPDES RNGNYSLASF LKRCLTLMDR GFVFNLINDY 1050
ISGFSPKDPK VLAEYKFEFL QTICNHEHYI PLNLPMAFAK PKLQRVQDSN 1100
LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV IKNLLIKHAF 1150
DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPSSASRD 1200
EFPCGFVSPT NRGSLASDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP 1250
DPGSTSENTR QSSSRSSVSQ YNRLDQYEIR NLLMCYLYIV KMISEDTLLT 1300
YWNKVSPQEL INILVLLEVC LFHFRYMGKR NIARVHDAWL SKHFGIDRKS 1350
QTMPALRNRS GVMQARLQHL SSLESSFTLN HSSATTEADI FHQALLEGNT 1400
ATEVSLTVLD TISFFTQCFK NQLLNNDGHN PLMKKVFDIH LAFLKNGQSE 1450
VSLKHVFASL RSFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE 1500
ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES 1550
LFIINNFANS DRPMKATAFP TEVKDLTKRI RTVLMATAQM KEHEKDPEML 1600
IDLQYSLAKS YASTPELRKT WLDSMAKIHI KNGDFSEAAM CYVHVAALVA 1650
EFLHRKKLFP SGCSAFKKIT PNIDEEGAMK EDAGMMDVHY SEEVLLELLE 1700
QCVDGLWKAE RYEVISEISK LIIPIYEKRR EFEKLTQVYR TLHGAYTKIL 1750
EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV 1800
KLYGEKFGTE NVKIIQDSDK VNAKELDPKF AHIQVTYVKP YFDDKELTER 1850
KTEFERNHNI NRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK 1900
RIPINCEQQV NLKPIDVATD EIKDKTAELH KLCSSVDVDM IQLQLKLQGC 1950
VSVQVNAGPL AYARAFLNES QANKYPPKKV NELKDMFRKF IQACSIALEL 2000
NERLIKEDQI EYHEGLKSNF RDMVKELSDI IHEQILQEDT MHSPWMNNTL 2050
HVFCAISGTS SNRGYGSPRY AEV 2073
Length:2,073
Mass (Da):237,771
Last modified:February 20, 2007 - v1
Checksum:i2907066969A6A8F8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1608 – 16081A → T in BAD83670. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB116935 mRNA. Translation: BAD83670.1.
AL672038, AL672023 Genomic DNA. Translation: CAM20638.1.
AL672023, AL672038 Genomic DNA. Translation: CAM21480.1.
CCDSiCCDS40923.1.
RefSeqiNP_001009947.2. NM_001009947.3.
UniGeneiMm.32873.

Genome annotation databases

EnsembliENSMUST00000033419; ENSMUSP00000033419; ENSMUSG00000031093.
GeneIDi75974.
KEGGimmu:75974.
UCSCiuc009sxi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB116935 mRNA. Translation: BAD83670.1 .
AL672038 , AL672023 Genomic DNA. Translation: CAM20638.1 .
AL672023 , AL672038 Genomic DNA. Translation: CAM21480.1 .
CCDSi CCDS40923.1.
RefSeqi NP_001009947.2. NM_001009947.3.
UniGenei Mm.32873.

3D structure databases

ProteinModelPortali A2AF47.
SMRi A2AF47. Positions 162-298, 1613-2035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 217880. 1 interaction.

PTM databases

PhosphoSitei A2AF47.

Proteomic databases

MaxQBi A2AF47.
PaxDbi A2AF47.
PRIDEi A2AF47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033419 ; ENSMUSP00000033419 ; ENSMUSG00000031093 .
GeneIDi 75974.
KEGGi mmu:75974.
UCSCi uc009sxi.1. mouse.

Organism-specific databases

CTDi 139818.
MGIi MGI:1923224. Dock11.

Phylogenomic databases

eggNOGi NOG242127.
GeneTreei ENSGT00750000117541.
HOGENOMi HOG000231373.
HOVERGENi HBG107819.
InParanoidi A2AF47.
OMAi MAKIHIK.
OrthoDBi EOG76DTRQ.
TreeFami TF313629.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 344361.
PROi A2AF47.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2AF47.
Bgeei A2AF47.
CleanExi MM_DOCK11.
Genevestigatori A2AF47.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR23317. PTHR23317. 1 hit.
Pfami PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes."
    Nishikimi A., Meller N., Uekawa N., Isobe K., Schwartz M.A., Maruyama M.
    FEBS Lett. 579:1039-1046(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDC42, TISSUE SPECIFICITY, FUNCTION.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42."
    Lin Q., Yang W., Baird D., Feng Q., Cerione R.A.
    J. Biol. Chem. 281:35253-35262(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CDC42, FUNCTION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDOC11_MOUSE
AccessioniPrimary (citable) accession number: A2AF47
Secondary accession number(s): Q5KTP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Zizim' means 'spike' in Hebrew.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi