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A2AF47

- DOC11_MOUSE

UniProt

A2AF47 - DOC11_MOUSE

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Protein

Dedicator of cytokinesis protein 11

Gene

Dock11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.2 Publications

GO - Molecular functioni

  1. Rho GTPase binding Source: MGI
  2. Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  1. positive regulation of Rho GTPase activity Source: GOC
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 11
Alternative name(s):
Activated Cdc42-associated guanine nucleotide exchange factor
Short name:
ACG
Zizimin-2
Gene namesi
Name:Dock11
Synonyms:Ziz2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1923224. Dock11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20732073Dedicator of cytokinesis protein 11PRO_0000299559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei161 – 1611PhosphoserineBy similarity
Modified residuei248 – 2481PhosphotyrosineBy similarity
Modified residuei251 – 2511PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2AF47.
PaxDbiA2AF47.
PRIDEiA2AF47.

PTM databases

PhosphoSiteiA2AF47.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, bone marrow and peripheral blood lymphocytes. Enriched in B-cells from germinal centers.1 Publication

Gene expression databases

BgeeiA2AF47.
CleanExiMM_DOCK11.
ExpressionAtlasiA2AF47. baseline and differential.
GenevestigatoriA2AF47.

Interactioni

Subunit structurei

Interacts with CDC42.2 Publications

Protein-protein interaction databases

BioGridi217880. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA2AF47.
SMRiA2AF47. Positions 162-298, 1613-2035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 272108PHPROSITE-ProRule annotationAdd
BLAST
Domaini640 – 818179DHR-1Add
BLAST
Domaini1609 – 2036428DHR-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 12661Interaction with activated CDC42Add
BLAST

Domaini

The DHR-2 domain is necessary for the GEF activity.

Sequence similaritiesi

Belongs to the DOCK family.Curated
Contains 1 DHR-1 domain.Curated
Contains 1 DHR-2 domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242127.
GeneTreeiENSGT00760000119234.
HOGENOMiHOG000231373.
HOVERGENiHBG107819.
InParanoidiA2AF47.
OMAiMAKIHIK.
OrthoDBiEOG76DTRQ.
TreeFamiTF313629.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AF47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKLV EPLDYENVIT
60 70 80 90 100
QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF
110 120 130 140 150
VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC
160 170 180 190 200
EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD
210 220 230 240 250
GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH
260 270 280 290 300
YLAAETEQEM EEWLIMLKKI IQINTDSLVQ EKKDTVEAIQ EEETSSQGKA
310 320 330 340 350
ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS
360 370 380 390 400
GIEPDVKPFE EKCNKRFMVN CHDLTFNILG HIGDNAKGPP TNVEPFFINL
410 420 430 440 450
ALFDVKNNCK ISADFHVDLN PPSVREMLWG TSTQLSNDGN AKGFSPESLI
460 470 480 490 500
HGIAESQLCY IKQGIFSVTN PHPEIFLVVR IEKVLQGNIT HCAEPYIKNS
510 520 530 540 550
DPIKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDVQG SLDLDGRFSP
560 570 580 590 600
LYKQDSSKLS NEDILKLLSE YKKPEKTKLQ IIPGQLSITV ECVPVDLPNC
610 620 630 640 650
ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL
660 670 680 690 700
KYDSQKSFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV
710 720 730 740 750
VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT
760 770 780 790 800
VETPVGFAWV PLLKDGRVIT LEQQLPVSAN LPPGYLNVND AESRRQSNAD
810 820 830 840 850
IKWVDGAKPL LKIKTHLEST IYTQDLHVHK FFHHCQLIQS GSKEVPGELI
860 870 880 890 900
KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV
910 920 930 940 950
SKCHEEGLES YLRSFIKYSF RPEKPSTLQA QLIHETLATT MIAILKQSAD
960 970 980 990 1000
FLAINKLLKY SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PEAYHHVLHS
1010 1020 1030 1040 1050
LLLAIIPHVT IRYAEIPDES RNGNYSLASF LKRCLTLMDR GFVFNLINDY
1060 1070 1080 1090 1100
ISGFSPKDPK VLAEYKFEFL QTICNHEHYI PLNLPMAFAK PKLQRVQDSN
1110 1120 1130 1140 1150
LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV IKNLLIKHAF
1160 1170 1180 1190 1200
DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPSSASRD
1210 1220 1230 1240 1250
EFPCGFVSPT NRGSLASDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP
1260 1270 1280 1290 1300
DPGSTSENTR QSSSRSSVSQ YNRLDQYEIR NLLMCYLYIV KMISEDTLLT
1310 1320 1330 1340 1350
YWNKVSPQEL INILVLLEVC LFHFRYMGKR NIARVHDAWL SKHFGIDRKS
1360 1370 1380 1390 1400
QTMPALRNRS GVMQARLQHL SSLESSFTLN HSSATTEADI FHQALLEGNT
1410 1420 1430 1440 1450
ATEVSLTVLD TISFFTQCFK NQLLNNDGHN PLMKKVFDIH LAFLKNGQSE
1460 1470 1480 1490 1500
VSLKHVFASL RSFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE
1510 1520 1530 1540 1550
ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES
1560 1570 1580 1590 1600
LFIINNFANS DRPMKATAFP TEVKDLTKRI RTVLMATAQM KEHEKDPEML
1610 1620 1630 1640 1650
IDLQYSLAKS YASTPELRKT WLDSMAKIHI KNGDFSEAAM CYVHVAALVA
1660 1670 1680 1690 1700
EFLHRKKLFP SGCSAFKKIT PNIDEEGAMK EDAGMMDVHY SEEVLLELLE
1710 1720 1730 1740 1750
QCVDGLWKAE RYEVISEISK LIIPIYEKRR EFEKLTQVYR TLHGAYTKIL
1760 1770 1780 1790 1800
EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV
1810 1820 1830 1840 1850
KLYGEKFGTE NVKIIQDSDK VNAKELDPKF AHIQVTYVKP YFDDKELTER
1860 1870 1880 1890 1900
KTEFERNHNI NRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK
1910 1920 1930 1940 1950
RIPINCEQQV NLKPIDVATD EIKDKTAELH KLCSSVDVDM IQLQLKLQGC
1960 1970 1980 1990 2000
VSVQVNAGPL AYARAFLNES QANKYPPKKV NELKDMFRKF IQACSIALEL
2010 2020 2030 2040 2050
NERLIKEDQI EYHEGLKSNF RDMVKELSDI IHEQILQEDT MHSPWMNNTL
2060 2070
HVFCAISGTS SNRGYGSPRY AEV
Length:2,073
Mass (Da):237,771
Last modified:February 20, 2007 - v1
Checksum:i2907066969A6A8F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1608 – 16081A → T in BAD83670. (PubMed:15710388)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116935 mRNA. Translation: BAD83670.1.
AL672038, AL672023 Genomic DNA. Translation: CAM20638.1.
AL672023, AL672038 Genomic DNA. Translation: CAM21480.1.
CCDSiCCDS40923.1.
RefSeqiNP_001009947.2. NM_001009947.3.
UniGeneiMm.32873.

Genome annotation databases

EnsembliENSMUST00000033419; ENSMUSP00000033419; ENSMUSG00000031093.
GeneIDi75974.
KEGGimmu:75974.
UCSCiuc009sxi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116935 mRNA. Translation: BAD83670.1 .
AL672038 , AL672023 Genomic DNA. Translation: CAM20638.1 .
AL672023 , AL672038 Genomic DNA. Translation: CAM21480.1 .
CCDSi CCDS40923.1.
RefSeqi NP_001009947.2. NM_001009947.3.
UniGenei Mm.32873.

3D structure databases

ProteinModelPortali A2AF47.
SMRi A2AF47. Positions 162-298, 1613-2035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 217880. 1 interaction.

PTM databases

PhosphoSitei A2AF47.

Proteomic databases

MaxQBi A2AF47.
PaxDbi A2AF47.
PRIDEi A2AF47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033419 ; ENSMUSP00000033419 ; ENSMUSG00000031093 .
GeneIDi 75974.
KEGGi mmu:75974.
UCSCi uc009sxi.1. mouse.

Organism-specific databases

CTDi 139818.
MGIi MGI:1923224. Dock11.

Phylogenomic databases

eggNOGi NOG242127.
GeneTreei ENSGT00760000119234.
HOGENOMi HOG000231373.
HOVERGENi HBG107819.
InParanoidi A2AF47.
OMAi MAKIHIK.
OrthoDBi EOG76DTRQ.
TreeFami TF313629.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 344361.
PROi A2AF47.
SOURCEi Search...

Gene expression databases

Bgeei A2AF47.
CleanExi MM_DOCK11.
ExpressionAtlasi A2AF47. baseline and differential.
Genevestigatori A2AF47.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR23317. PTHR23317. 1 hit.
Pfami PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes."
    Nishikimi A., Meller N., Uekawa N., Isobe K., Schwartz M.A., Maruyama M.
    FEBS Lett. 579:1039-1046(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDC42, TISSUE SPECIFICITY, FUNCTION.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42."
    Lin Q., Yang W., Baird D., Feng Q., Cerione R.A.
    J. Biol. Chem. 281:35253-35262(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CDC42, FUNCTION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDOC11_MOUSE
AccessioniPrimary (citable) accession number: A2AF47
Secondary accession number(s): Q5KTP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Zizim' means 'spike' in Hebrew.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3