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A2AF47

- DOC11_MOUSE

UniProt

A2AF47 - DOC11_MOUSE

Protein

Dedicator of cytokinesis protein 11

Gene

Dock11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.2 Publications

    GO - Molecular functioni

    1. Rho GTPase binding Source: MGI
    2. Rho guanyl-nucleotide exchange factor activity Source: MGI

    GO - Biological processi

    1. positive regulation of Rho GTPase activity Source: GOC
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dedicator of cytokinesis protein 11
    Alternative name(s):
    Activated Cdc42-associated guanine nucleotide exchange factor
    Short name:
    ACG
    Zizimin-2
    Gene namesi
    Name:Dock11
    Synonyms:Ziz2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1923224. Dock11.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20732073Dedicator of cytokinesis protein 11PRO_0000299559Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei161 – 1611PhosphoserineBy similarity
    Modified residuei248 – 2481PhosphotyrosineBy similarity
    Modified residuei251 – 2511PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiA2AF47.
    PaxDbiA2AF47.
    PRIDEiA2AF47.

    PTM databases

    PhosphoSiteiA2AF47.

    Expressioni

    Tissue specificityi

    Expressed in spleen, thymus, bone marrow and peripheral blood lymphocytes. Enriched in B-cells from germinal centers.1 Publication

    Gene expression databases

    ArrayExpressiA2AF47.
    BgeeiA2AF47.
    CleanExiMM_DOCK11.
    GenevestigatoriA2AF47.

    Interactioni

    Subunit structurei

    Interacts with CDC42.2 Publications

    Protein-protein interaction databases

    BioGridi217880. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AF47.
    SMRiA2AF47. Positions 162-298, 1613-2035.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 272108PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini640 – 818179DHR-1Add
    BLAST
    Domaini1609 – 2036428DHR-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 12661Interaction with activated CDC42Add
    BLAST

    Domaini

    The DHR-2 domain is necessary for the GEF activity.

    Sequence similaritiesi

    Belongs to the DOCK family.Curated
    Contains 1 DHR-1 domain.Curated
    Contains 1 DHR-2 domain.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242127.
    GeneTreeiENSGT00750000117541.
    HOGENOMiHOG000231373.
    HOVERGENiHBG107819.
    InParanoidiA2AF47.
    OMAiMAKIHIK.
    OrthoDBiEOG76DTRQ.
    TreeFamiTF313629.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR021816. DOCK_C/D_N.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR23317. PTHR23317. 1 hit.
    PfamiPF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF11878. DUF3398. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.
    PROSITEiPS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2AF47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKLV EPLDYENVIT     50
    QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF 100
    VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC 150
    EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD 200
    GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH 250
    YLAAETEQEM EEWLIMLKKI IQINTDSLVQ EKKDTVEAIQ EEETSSQGKA 300
    ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS 350
    GIEPDVKPFE EKCNKRFMVN CHDLTFNILG HIGDNAKGPP TNVEPFFINL 400
    ALFDVKNNCK ISADFHVDLN PPSVREMLWG TSTQLSNDGN AKGFSPESLI 450
    HGIAESQLCY IKQGIFSVTN PHPEIFLVVR IEKVLQGNIT HCAEPYIKNS 500
    DPIKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDVQG SLDLDGRFSP 550
    LYKQDSSKLS NEDILKLLSE YKKPEKTKLQ IIPGQLSITV ECVPVDLPNC 600
    ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL 650
    KYDSQKSFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV 700
    VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT 750
    VETPVGFAWV PLLKDGRVIT LEQQLPVSAN LPPGYLNVND AESRRQSNAD 800
    IKWVDGAKPL LKIKTHLEST IYTQDLHVHK FFHHCQLIQS GSKEVPGELI 850
    KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV 900
    SKCHEEGLES YLRSFIKYSF RPEKPSTLQA QLIHETLATT MIAILKQSAD 950
    FLAINKLLKY SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PEAYHHVLHS 1000
    LLLAIIPHVT IRYAEIPDES RNGNYSLASF LKRCLTLMDR GFVFNLINDY 1050
    ISGFSPKDPK VLAEYKFEFL QTICNHEHYI PLNLPMAFAK PKLQRVQDSN 1100
    LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV IKNLLIKHAF 1150
    DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPSSASRD 1200
    EFPCGFVSPT NRGSLASDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP 1250
    DPGSTSENTR QSSSRSSVSQ YNRLDQYEIR NLLMCYLYIV KMISEDTLLT 1300
    YWNKVSPQEL INILVLLEVC LFHFRYMGKR NIARVHDAWL SKHFGIDRKS 1350
    QTMPALRNRS GVMQARLQHL SSLESSFTLN HSSATTEADI FHQALLEGNT 1400
    ATEVSLTVLD TISFFTQCFK NQLLNNDGHN PLMKKVFDIH LAFLKNGQSE 1450
    VSLKHVFASL RSFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE 1500
    ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES 1550
    LFIINNFANS DRPMKATAFP TEVKDLTKRI RTVLMATAQM KEHEKDPEML 1600
    IDLQYSLAKS YASTPELRKT WLDSMAKIHI KNGDFSEAAM CYVHVAALVA 1650
    EFLHRKKLFP SGCSAFKKIT PNIDEEGAMK EDAGMMDVHY SEEVLLELLE 1700
    QCVDGLWKAE RYEVISEISK LIIPIYEKRR EFEKLTQVYR TLHGAYTKIL 1750
    EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV 1800
    KLYGEKFGTE NVKIIQDSDK VNAKELDPKF AHIQVTYVKP YFDDKELTER 1850
    KTEFERNHNI NRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK 1900
    RIPINCEQQV NLKPIDVATD EIKDKTAELH KLCSSVDVDM IQLQLKLQGC 1950
    VSVQVNAGPL AYARAFLNES QANKYPPKKV NELKDMFRKF IQACSIALEL 2000
    NERLIKEDQI EYHEGLKSNF RDMVKELSDI IHEQILQEDT MHSPWMNNTL 2050
    HVFCAISGTS SNRGYGSPRY AEV 2073
    Length:2,073
    Mass (Da):237,771
    Last modified:February 20, 2007 - v1
    Checksum:i2907066969A6A8F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1608 – 16081A → T in BAD83670. (PubMed:15710388)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB116935 mRNA. Translation: BAD83670.1.
    AL672038, AL672023 Genomic DNA. Translation: CAM20638.1.
    AL672023, AL672038 Genomic DNA. Translation: CAM21480.1.
    CCDSiCCDS40923.1.
    RefSeqiNP_001009947.2. NM_001009947.3.
    UniGeneiMm.32873.

    Genome annotation databases

    EnsembliENSMUST00000033419; ENSMUSP00000033419; ENSMUSG00000031093.
    GeneIDi75974.
    KEGGimmu:75974.
    UCSCiuc009sxi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB116935 mRNA. Translation: BAD83670.1 .
    AL672038 , AL672023 Genomic DNA. Translation: CAM20638.1 .
    AL672023 , AL672038 Genomic DNA. Translation: CAM21480.1 .
    CCDSi CCDS40923.1.
    RefSeqi NP_001009947.2. NM_001009947.3.
    UniGenei Mm.32873.

    3D structure databases

    ProteinModelPortali A2AF47.
    SMRi A2AF47. Positions 162-298, 1613-2035.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 217880. 1 interaction.

    PTM databases

    PhosphoSitei A2AF47.

    Proteomic databases

    MaxQBi A2AF47.
    PaxDbi A2AF47.
    PRIDEi A2AF47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033419 ; ENSMUSP00000033419 ; ENSMUSG00000031093 .
    GeneIDi 75974.
    KEGGi mmu:75974.
    UCSCi uc009sxi.1. mouse.

    Organism-specific databases

    CTDi 139818.
    MGIi MGI:1923224. Dock11.

    Phylogenomic databases

    eggNOGi NOG242127.
    GeneTreei ENSGT00750000117541.
    HOGENOMi HOG000231373.
    HOVERGENi HBG107819.
    InParanoidi A2AF47.
    OMAi MAKIHIK.
    OrthoDBi EOG76DTRQ.
    TreeFami TF313629.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 344361.
    PROi A2AF47.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2AF47.
    Bgeei A2AF47.
    CleanExi MM_DOCK11.
    Genevestigatori A2AF47.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR021816. DOCK_C/D_N.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR23317. PTHR23317. 1 hit.
    Pfami PF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF11878. DUF3398. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    PROSITEi PS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes."
      Nishikimi A., Meller N., Uekawa N., Isobe K., Schwartz M.A., Maruyama M.
      FEBS Lett. 579:1039-1046(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDC42, TISSUE SPECIFICITY, FUNCTION.
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42."
      Lin Q., Yang W., Baird D., Feng Q., Cerione R.A.
      J. Biol. Chem. 281:35253-35262(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH CDC42, FUNCTION.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiDOC11_MOUSE
    AccessioniPrimary (citable) accession number: A2AF47
    Secondary accession number(s): Q5KTP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    'Zizim' means 'spike' in Hebrew.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3