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A2AEE7 (A2AEE7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Cadherin EGF LAG seven-pass G-type receptor 2 EMBL EDL01967.1 Ensembl ENSMUSP00000088046
Gene names
Name:Celsr2 EMBL EDL01967.1 Ensembl ENSMUSP00000088046 MGI 1858235
ORF Names:mCG_4064 EMBL EDL01967.1
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000088046
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length2919 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Sequence similarities

Contains 1 GPS domain. SAAS SAAS000203

Ontologies

Keywords
   Cellular componentCell membrane SAAS SAAS000203
Membrane
   DomainEGF-like domain SAAS SAAS000152 RuleBase RU000460
Repeat SAAS SAAS002049
Transmembrane
Transmembrane helix SAAS SAAS000203
   LigandCalcium SAAS SAAS020894 RuleBase RU000484
   Molecular functionG-protein coupled receptor SAAS SAAS001879
Receptor
Transducer
   PTMDisulfide bond SAAS SAAS002049
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcerebrospinal fluid secretion

Inferred from genetic interaction PubMed 20473291. Source: MGI

cilium assembly

Inferred from mutant phenotype PubMed 20473291. Source: MGI

cilium movement

Inferred from mutant phenotype PubMed 20473291. Source: MGI

homophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

neuron migration

Inferred from mutant phenotype PubMed 20631168. Source: MGI

neuropeptide signaling pathway

Inferred from electronic annotation. Source: InterPro

regulation of protein localization

Inferred from mutant phenotype PubMed 20473291. Source: MGI

ventricular system development

Inferred from mutant phenotype PubMed 21746835. Source: MGI

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence orthology PubMed 19474315. Source: MGI

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

calcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A2AEE7 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: A8F35C88C5808300

FASTA2,919316,986
        10         20         30         40         50         60 
MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRSSSGA CAPVGWLCPA 

        70         80         90        100        110        120 
SASNLWLYTS RCRESGIELT GHLVPHHDGL RVWCPESGAH IPLPPSSEGC PWSCRLLGIG 

       130        140        150        160        170        180 
GHLSPQGTLT LPEEHPCLKA PRLRCQSCKL AQAPGLRAGE GSPEESLGGR RKRNVNTAPQ 

       190        200        210        220        230        240 
FQPPSYQATV PENQPAGTSV ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGV 

       250        260        270        280        290        300 
VTTAEELDRE TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 

       310        320        330        340        350        360 
NLEVGYEVLT VRATDGDAPP NANILYRLLE GAGGSPSDAF EIDPRSGVIR TRGPVDREEV 

       370        380        390        400        410        420 
ESYKLTVEAS DQGRDPGPRS STAIVFLSVE DDNDNAPQFS EKRYVVQVRE DVTPGAPVLR 

       430        440        450        460        470        480 
VTASDRDKGS NALVHYSIMS GNARGQFYLD AQTGALDVVS PLDYETTKEY TLRIRAQDGG 

       490        500        510        520        530        540 
RPPLSNVSGL VTVQVLDIND NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL 

       550        560        570        580        590        600 
EYSLAGVGHD FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI 

       610        620        630        640        650        660 
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG NTRNRFSITS 

       670        680        690        700        710        720 
QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV NVTDANTHRP VFQSSHYTVN 

       730        740        750        760        770        780 
VNEDRPAGTT VVLISATDED TGENARITYF MEDSIPQFRI DADTGAVTTQ AELDYEDQVS 

       790        800        810        820        830        840 
YTLAITARDN GIPQKSDTTY LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT 

       850        860        870        880        890        900 
DRDSGLNGRV FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 

       910        920        930        940        950        960 
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE GTNAQIMYQI 

       970        980        990       1000       1010       1020 
VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS APLVSRATVH VRLLDRNDNP 

      1030       1040       1050       1060       1070       1080 
PVLGNFEILF NNYVTNRSSS FPGGAIGRVP AHDPDISDSL TYSFERGNEL SLVLLNASTG 

      1090       1100       1110       1120       1130       1140 
ELRLSRALDN NRPLEAIMSV LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER 

      1150       1160       1170       1180       1190       1200 
FLSPLLGLFI QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 

      1210       1220       1230       1240       1250       1260 
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD SSAPFIASSS 

      1270       1280       1290       1300       1310       1320 
VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH GRCRSREGGY TCLCLDGYTG 

      1330       1340       1350       1360       1370       1380 
EHCEASTHSG RCTPGVCKNG GTCVNLLVGG FKCDCPSGDF EKPFCQVTTR SFPARSFITF 

      1390       1400       1410       1420       1430       1440 
RGLRQRFHFT LALSFATKER NGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS 

      1450       1460       1470       1480       1490       1500 
PFVPGGVSDG QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG 

      1510       1520       1530       1540       1550       1560 
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKDLQ VDSRHIDMAD 

      1570       1580       1590       1600       1610       1620 
FIANNGTVPG CPTKKIVCDS SICHNGGTCV NQWNAFSCEC PLGFGGKSCA QEMANPQRFL 

      1630       1640       1650       1660       1670       1680 
GSSLVAWHGL SLPISQPWHL SLMFRTRQAD GVLLQAVTRG RSTITLQLRA GHVVLSVEGT 

      1690       1700       1710       1720       1730       1740 
GLQASSLRLE PGRANDGDWH HAQLALGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS 

      1750       1760       1770       1780       1790       1800 
NITVGGVPGP ASGVARGFRG CLQGVRVSET PEGISSLDPS RGESINVEPG CSWPDPCDSN 

      1810       1820       1830       1840       1850       1860 
PCPTNSYCSN DWDSYSCSCV LGYYGDNCTN VCDLNPCEHQ SVCTRKPNTP HGYICECLPN 

      1870       1880       1890       1900       1910       1920 
YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN KTSGECHCKE NHYRPPGSPT 

      1930       1940       1950       1960       1970       1980 
CLLCDCYPTG SLSRVCDPED GQCPCKPGVI GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI 

      1990       2000       2010       2020       2030       2040 
EAGIWWPRTR FGLPAAAPCP KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL 

      2050       2060       2070       2080       2090       2100 
QRNESGLDSG RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ 

      2110       2120       2130       2140       2150       2160 
DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ NMRHTYLSPF 

      2170       2180       2190       2200       2210       2220 
TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET TVILPESVFR EMPSMVRSAG 

      2230       2240       2250       2260       2270       2280 
PGEAQETEEL ARRQRRHPEL SQGEAVASVI IYHTLAGLLP HNYDPDKRSL RVPKRPVINT 

      2290       2300       2310       2320       2330       2340 
PVVSISVHDD EELLPRALDK PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE 

      2350       2360       2370       2380       2390       2400 
VVFRNESHVS CQCNHMTSFA VLMDMSRREN GEILPLKTLT YVALGVTLAA LMLTFLFLTL 

      2410       2420       2430       2440       2450       2460 
LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY LCTFSWALLE 

      2470       2480       2490       2500       2510       2520 
ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL DPEGYGNPDF CWLSVYDTLI 

      2530       2540       2550       2560       2570       2580 
WSFAGPVAFA VSMSVFLYIL SARASCAAQR QGFEKKGPVS GLRSSFTVLL LLSATWLLAL 

      2590       2600       2610       2620       2630       2640 
LSVNSDTLLF HYLFAACNCV QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL 

      2650       2660       2670       2680       2690       2700 
TSSYNCPSPY ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG 

      2710       2720       2730       2740       2750       2760 
DPSGLFLEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA FPGEQGWDSL 

      2770       2780       2790       2800       2810       2820 
LGPGAERLPL HSTPKDGGPG SGKVPWLGDF GTTTKENSGS GPLEERPREN GDALTREGSL 

      2830       2840       2850       2860       2870       2880 
GPLPGPSTQP HKGILKKKCL PTISEKSSLL RLPLEQGTGS SRGSSISEGS RHGPPPRPPP 

      2890       2900       2910 
RQSLQEQLNG VMPVAMSIKA GTVDEDSSGS EFLFFNFLH

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL01967.1.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL01967.1.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000088046.
[4]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000088046.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL671899 Genomic DNA. No translation available.
AL672200 Genomic DNA. No translation available.
CH466607 Genomic DNA. Translation: EDL01967.1.
IPIIPI00649043.
RefSeqNP_059088.2. NM_017392.3.
UniGeneMm.39728.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740.
GeneID53883.
KEGGmmu:53883.
UCSCuc008qyx.1. mouse.

Organism-specific databases

CTD1952.
MGIMGI:1858235. Celsr2.

Phylogenomic databases

GeneTreeENSGT00700000104170.
HOVERGENHBG050887.
InParanoidA2AEE7.
KOK04601.
OMAYILRAYA.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS_dom.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 2 hits.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTSM00112. CA. 9 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view]
SUPFAMSSF49313. Cadherin. 9 hits.
SSF49899. ConA_like_lec_gl. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio310761.
SOURCESearch...

Entry information

Entry nameA2AEE7_MOUSE
AccessionPrimary (citable) accession number: A2AEE7
Entry history
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info