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Protein
Submitted name:

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

Celsr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotation, Receptor, Transducer

Keywords - Ligandi

CalciumSAAS annotation

Protein family/group databases

MEROPSiP02.006.

Names & Taxonomyi

Protein namesi
Submitted name:
Cadherin EGF LAG seven-pass G-type receptor 2Imported
Gene namesi
Name:Celsr2Imported
ORF Names:mCG_4064Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1858235. Celsr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2379 – 2401HelicalSequence analysisAdd BLAST23
Transmembranei2413 – 2429HelicalSequence analysisAdd BLAST17
Transmembranei2435 – 2459HelicalSequence analysisAdd BLAST25
Transmembranei2480 – 2500HelicalSequence analysisAdd BLAST21
Transmembranei2520 – 2540HelicalSequence analysisAdd BLAST21
Transmembranei2561 – 2583HelicalSequence analysisAdd BLAST23
Transmembranei2589 – 2612HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_500875413932 – 2919Sequence analysisAdd BLAST2888

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000068740.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088046.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 289CadherinInterPro annotationAdd BLAST108
Domaini290 – 399CadherinInterPro annotationAdd BLAST110
Domaini400 – 505CadherinInterPro annotationAdd BLAST106
Domaini506 – 610CadherinInterPro annotationAdd BLAST105
Domaini611 – 712CadherinInterPro annotationAdd BLAST102
Domaini713 – 815CadherinInterPro annotationAdd BLAST103
Domaini816 – 921CadherinInterPro annotationAdd BLAST106
Domaini922 – 1023CadherinInterPro annotationAdd BLAST102
Domaini1042 – 1146CadherinInterPro annotationAdd BLAST105
Domaini1228 – 1286EGF-likeInterPro annotationAdd BLAST59
Domaini1288 – 1324EGF-likeInterPro annotationAdd BLAST37
Domaini1328 – 1366EGF-likeInterPro annotationAdd BLAST39
Domaini1367 – 1571LAM_G_DOMAINInterPro annotationAdd BLAST205
Domaini1574 – 1610EGF-likeInterPro annotationAdd BLAST37
Domaini1614 – 1791LAM_G_DOMAINInterPro annotationAdd BLAST178
Domaini1793 – 1829EGF-likeInterPro annotationAdd BLAST37
Domaini1830 – 1867EGF-likeInterPro annotationAdd BLAST38
Domaini1924 – 1971Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1956 – 2029G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST74
Domaini2316 – 2368GPSInterPro annotationAdd BLAST53
Domaini2376 – 2613G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST238

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

EGF-like domainSAAS annotation, Laminin EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
HOVERGENiHBG050887.
OMAiHYSIMSG.
OrthoDBiEOG091G0039.
TreeFamiTF320624.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2AEE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRSSSGA
60 70 80 90 100
CAPVGWLCPA SASNLWLYTS RCRESGIELT GHLVPHHDGL RVWCPESGAH
110 120 130 140 150
IPLPPSSEGC PWSCRLLGIG GHLSPQGTLT LPEEHPCLKA PRLRCQSCKL
160 170 180 190 200
AQAPGLRAGE GSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTSV
210 220 230 240 250
ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGV VTTAEELDRE
260 270 280 290 300
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE
310 320 330 340 350
NLEVGYEVLT VRATDGDAPP NANILYRLLE GAGGSPSDAF EIDPRSGVIR
360 370 380 390 400
TRGPVDREEV ESYKLTVEAS DQGRDPGPRS STAIVFLSVE DDNDNAPQFS
410 420 430 440 450
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NALVHYSIMS GNARGQFYLD
460 470 480 490 500
AQTGALDVVS PLDYETTKEY TLRIRAQDGG RPPLSNVSGL VTVQVLDIND
510 520 530 540 550
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYSLAGVGHD
560 570 580 590 600
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI
610 620 630 640 650
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG
660 670 680 690 700
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV
710 720 730 740 750
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF
760 770 780 790 800
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY
810 820 830 840 850
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV
860 870 880 890 900
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP
910 920 930 940 950
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE
960 970 980 990 1000
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS
1010 1020 1030 1040 1050
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP
1060 1070 1080 1090 1100
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELRLSRALDN NRPLEAIMSV
1110 1120 1130 1140 1150
LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI
1160 1170 1180 1190 1200
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL
1210 1220 1230 1240 1250
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD
1260 1270 1280 1290 1300
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH
1310 1320 1330 1340 1350
GRCRSREGGY TCLCLDGYTG EHCEASTHSG RCTPGVCKNG GTCVNLLVGG
1360 1370 1380 1390 1400
FKCDCPSGDF EKPFCQVTTR SFPARSFITF RGLRQRFHFT LALSFATKER
1410 1420 1430 1440 1450
NGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG
1460 1470 1480 1490 1500
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG
1510 1520 1530 1540 1550
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKDLQ
1560 1570 1580 1590 1600
VDSRHIDMAD FIANNGTVPG CPTKKIVCDS SICHNGGTCV NQWNAFSCEC
1610 1620 1630 1640 1650
PLGFGGKSCA QEMANPQRFL GSSLVAWHGL SLPISQPWHL SLMFRTRQAD
1660 1670 1680 1690 1700
GVLLQAVTRG RSTITLQLRA GHVVLSVEGT GLQASSLRLE PGRANDGDWH
1710 1720 1730 1740 1750
HAQLALGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS NITVGGVPGP
1760 1770 1780 1790 1800
ASGVARGFRG CLQGVRVSET PEGISSLDPS RGESINVEPG CSWPDPCDSN
1810 1820 1830 1840 1850
PCPTNSYCSN DWDSYSCSCV LGYYGDNCTN VCDLNPCEHQ SVCTRKPNTP
1860 1870 1880 1890 1900
HGYICECLPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN
1910 1920 1930 1940 1950
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI
1960 1970 1980 1990 2000
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP
2010 2020 2030 2040 2050
KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL QRNESGLDSG
2060 2070 2080 2090 2100
RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ
2110 2120 2130 2140 2150
DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ
2160 2170 2180 2190 2200
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET
2210 2220 2230 2240 2250
TVILPESVFR EMPSMVRSAG PGEAQETEEL ARRQRRHPEL SQGEAVASVI
2260 2270 2280 2290 2300
IYHTLAGLLP HNYDPDKRSL RVPKRPVINT PVVSISVHDD EELLPRALDK
2310 2320 2330 2340 2350
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS
2360 2370 2380 2390 2400
CQCNHMTSFA VLMDMSRREN GEILPLKTLT YVALGVTLAA LMLTFLFLTL
2410 2420 2430 2440 2450
LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY
2460 2470 2480 2490 2500
LCTFSWALLE ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL
2510 2520 2530 2540 2550
DPEGYGNPDF CWLSVYDTLI WSFAGPVAFA VSMSVFLYIL SARASCAAQR
2560 2570 2580 2590 2600
QGFEKKGPVS GLRSSFTVLL LLSATWLLAL LSVNSDTLLF HYLFAACNCV
2610 2620 2630 2640 2650
QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL TSSYNCPSPY
2660 2670 2680 2690 2700
ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG
2710 2720 2730 2740 2750
DPSGLFLEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA
2760 2770 2780 2790 2800
FPGEQGWDSL LGPGAERLPL HSTPKDGGPG SGKVPWLGDF GTTTKENSGS
2810 2820 2830 2840 2850
GPLEERPREN GDALTREGSL GPLPGPSTQP HKGILKKKCL PTISEKSSLL
2860 2870 2880 2890 2900
RLPLEQGTGS SRGSSISEGS RHGPPPRPPP RQSLQEQLNG VMPVAMSIKA
2910
GTVDEDSSGS EFLFFNFLH
Length:2,919
Mass (Da):316,986
Last modified:February 20, 2007 - v1
Checksum:iA8F35C88C5808300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671899 Genomic DNA. No translation available.
AL672200 Genomic DNA. No translation available.
CH466607 Genomic DNA. Translation: EDL01967.1.
RefSeqiNP_059088.2. NM_017392.3.
UniGeneiMm.39728.

Genome annotation databases

EnsembliENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740.
GeneIDi53883.
UCSCiuc008qyx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671899 Genomic DNA. No translation available.
AL672200 Genomic DNA. No translation available.
CH466607 Genomic DNA. Translation: EDL01967.1.
RefSeqiNP_059088.2. NM_017392.3.
UniGeneiMm.39728.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088046.

Protein family/group databases

MEROPSiP02.006.
GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740.
GeneIDi53883.
UCSCiuc008qyx.1. mouse.

Organism-specific databases

CTDi1952.
MGIiMGI:1858235. Celsr2.

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
HOVERGENiHBG050887.
OMAiHYSIMSG.
OrthoDBiEOG091G0039.
TreeFamiTF320624.

Miscellaneous databases

ChiTaRSiCelsr2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068740.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2AEE7_MOUSE
AccessioniPrimary (citable) accession number: A2AEE7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.