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A2AEE7

- A2AEE7_MOUSE

UniProt

A2AEE7 - A2AEE7_MOUSE

Protein
Submitted name:

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

Celsr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. cerebrospinal fluid secretion Source: MGI
    2. cilium assembly Source: MGI
    3. cilium movement Source: MGI
    4. homophilic cell adhesion Source: InterPro
    5. neuron migration Source: MGI
    6. neuropeptide signaling pathway Source: InterPro
    7. regulation of protein localization Source: MGI
    8. ventricular system development Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptorSAAS annotation, Receptor, Transducer

    Keywords - Ligandi

    CalciumUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cadherin EGF LAG seven-pass G-type receptor 2Imported
    Gene namesi
    Name:Celsr2Imported
    ORF Names:mCG_4064Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1858235. Celsr2.

    Subcellular locationi

    Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membraneSAAS annotation, Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains GPS domain.SAAS annotation

    Keywords - Domaini

    EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117340.
    HOVERGENiHBG050887.
    InParanoidiA2AEE7.
    KOiK04601.
    OMAiCKLAQAP.
    OrthoDBiEOG7BP81K.
    TreeFamiTF320624.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    2.60.40.60. 9 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR002049. EGF_laminin.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR001791. Laminin_G.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF00028. Cadherin. 8 hits.
    PF12003. DUF3497. 1 hit.
    PF00008. EGF. 2 hits.
    PF01825. GPS. 1 hit.
    PF00053. Laminin_EGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR00249. GPCRSECRETIN.
    SMARTiSM00112. CA. 9 hits.
    SM00181. EGF. 5 hits.
    SM00179. EGF_CA. 1 hit.
    SM00180. EGF_Lam. 1 hit.
    SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00282. LamG. 2 hits.
    SM00208. TNFR. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 9 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
    PS00232. CADHERIN_1. 7 hits.
    PS50268. CADHERIN_2. 9 hits.
    PS00022. EGF_1. 6 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2AEE7-1 [UniParc]FASTAAdd to Basket

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    MRSRAASAPL PTPLLPLLLL LLLLPPSPLL GDQVGPCRSL GSGGRSSSGA     50
    CAPVGWLCPA SASNLWLYTS RCRESGIELT GHLVPHHDGL RVWCPESGAH 100
    IPLPPSSEGC PWSCRLLGIG GHLSPQGTLT LPEEHPCLKA PRLRCQSCKL 150
    AQAPGLRAGE GSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTSV 200
    ASLRAIDPDE GEAGRLEYTM DALFDSRSNH FFSLDPITGV VTTAEELDRE 250
    TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 300
    NLEVGYEVLT VRATDGDAPP NANILYRLLE GAGGSPSDAF EIDPRSGVIR 350
    TRGPVDREEV ESYKLTVEAS DQGRDPGPRS STAIVFLSVE DDNDNAPQFS 400
    EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NALVHYSIMS GNARGQFYLD 450
    AQTGALDVVS PLDYETTKEY TLRIRAQDGG RPPLSNVSGL VTVQVLDIND 500
    NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYSLAGVGHD 550
    FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTI 600
    LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG 650
    NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV 700
    NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF 750
    MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY 800
    LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV 850
    FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 900
    ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE 950
    GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS 1000
    APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP 1050
    AHDPDISDSL TYSFERGNEL SLVLLNASTG ELRLSRALDN NRPLEAIMSV 1100
    LVSDGVHSVT AQCSLRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI 1150
    QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 1200
    PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD 1250
    SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH 1300
    GRCRSREGGY TCLCLDGYTG EHCEASTHSG RCTPGVCKNG GTCVNLLVGG 1350
    FKCDCPSGDF EKPFCQVTTR SFPARSFITF RGLRQRFHFT LALSFATKER 1400
    NGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG 1450
    QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVSVDGCDTG VALRFGAMLG 1500
    NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR HFVGCMKDLQ 1550
    VDSRHIDMAD FIANNGTVPG CPTKKIVCDS SICHNGGTCV NQWNAFSCEC 1600
    PLGFGGKSCA QEMANPQRFL GSSLVAWHGL SLPISQPWHL SLMFRTRQAD 1650
    GVLLQAVTRG RSTITLQLRA GHVVLSVEGT GLQASSLRLE PGRANDGDWH 1700
    HAQLALGASG GPGHAILSFD YGQQKAEGNL GPRLHGLHLS NITVGGVPGP 1750
    ASGVARGFRG CLQGVRVSET PEGISSLDPS RGESINVEPG CSWPDPCDSN 1800
    PCPTNSYCSN DWDSYSCSCV LGYYGDNCTN VCDLNPCEHQ SVCTRKPNTP 1850
    HGYICECLPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN 1900
    KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI 1950
    GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP 2000
    KGSFGTAVRH CDEHRGWLPP NLFNCTSVTF SELKGFAERL QRNESGLDSG 2050
    RSQRLALLLR NATQHTSGYF GSDVKVAYQL ATRLLAHESA QRGFGLSATQ 2100
    DVHFTENLLR VGSALLDAAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ 2150
    NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GTKLPRYEAL RGERPPDLET 2200
    TVILPESVFR EMPSMVRSAG PGEAQETEEL ARRQRRHPEL SQGEAVASVI 2250
    IYHTLAGLLP HNYDPDKRSL RVPKRPVINT PVVSISVHDD EELLPRALDK 2300
    PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS 2350
    CQCNHMTSFA VLMDMSRREN GEILPLKTLT YVALGVTLAA LMLTFLFLTL 2400
    LRALRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY 2450
    LCTFSWALLE ALHLYRALTE VRDVNASPMR FYYMLGWGVP AFITGLAVGL 2500
    DPEGYGNPDF CWLSVYDTLI WSFAGPVAFA VSMSVFLYIL SARASCAAQR 2550
    QGFEKKGPVS GLRSSFTVLL LLSATWLLAL LSVNSDTLLF HYLFAACNCV 2600
    QGPFIFLSYV VLSKEVRKAL KFACSRKPSP DPALTTKSTL TSSYNCPSPY 2650
    ADGRLYQPYG DSAGSLHSAS RSGKSQPSYI PFLLREESTL NPGQVPPGLG 2700
    DPSGLFLEGQ AQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEAA 2750
    FPGEQGWDSL LGPGAERLPL HSTPKDGGPG SGKVPWLGDF GTTTKENSGS 2800
    GPLEERPREN GDALTREGSL GPLPGPSTQP HKGILKKKCL PTISEKSSLL 2850
    RLPLEQGTGS SRGSSISEGS RHGPPPRPPP RQSLQEQLNG VMPVAMSIKA 2900
    GTVDEDSSGS EFLFFNFLH 2919
    Length:2,919
    Mass (Da):316,986
    Last modified:February 20, 2007 - v1
    Checksum:iA8F35C88C5808300
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671899 Genomic DNA. No translation available.
    AL672200 Genomic DNA. No translation available.
    CH466607 Genomic DNA. Translation: EDL01967.1.
    RefSeqiNP_059088.2. NM_017392.3.
    UniGeneiMm.39728.

    Genome annotation databases

    EnsembliENSMUST00000090558; ENSMUSP00000088046; ENSMUSG00000068740.
    GeneIDi53883.
    KEGGimmu:53883.
    UCSCiuc008qyx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671899 Genomic DNA. No translation available.
    AL672200 Genomic DNA. No translation available.
    CH466607 Genomic DNA. Translation: EDL01967.1 .
    RefSeqi NP_059088.2. NM_017392.3.
    UniGenei Mm.39728.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090558 ; ENSMUSP00000088046 ; ENSMUSG00000068740 .
    GeneIDi 53883.
    KEGGi mmu:53883.
    UCSCi uc008qyx.1. mouse.

    Organism-specific databases

    CTDi 1952.
    MGIi MGI:1858235. Celsr2.

    Phylogenomic databases

    GeneTreei ENSGT00750000117340.
    HOVERGENi HBG050887.
    InParanoidi A2AEE7.
    KOi K04601.
    OMAi CKLAQAP.
    OrthoDBi EOG7BP81K.
    TreeFami TF320624.

    Miscellaneous databases

    NextBioi 310761.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    2.60.40.60. 9 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR002049. EGF_laminin.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR001791. Laminin_G.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF00028. Cadherin. 8 hits.
    PF12003. DUF3497. 1 hit.
    PF00008. EGF. 2 hits.
    PF01825. GPS. 1 hit.
    PF00053. Laminin_EGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR00249. GPCRSECRETIN.
    SMARTi SM00112. CA. 9 hits.
    SM00181. EGF. 5 hits.
    SM00179. EGF_CA. 1 hit.
    SM00180. EGF_Lam. 1 hit.
    SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00282. LamG. 2 hits.
    SM00208. TNFR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 9 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
    PS00232. CADHERIN_1. 7 hits.
    PS50268. CADHERIN_2. 9 hits.
    PS00022. EGF_1. 6 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2AEE7_MOUSE
    AccessioniPrimary (citable) accession number: A2AEE7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3