ID A2AE21_MOUSE Unreviewed; 645 AA. AC A2AE21; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 27-MAR-2024, entry version 130. DE SubName: Full=Zinc finger protein 300 {ECO:0000313|Ensembl:ENSMUSP00000046514.7}; GN Name=Zfp300 {ECO:0000313|Ensembl:ENSMUSP00000046514.7, GN ECO:0000313|MGI:MGI:3045326}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000046514.7, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000046514.7, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000046514.7, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000046514.7} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000046514.7}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_899008.2; NM_183185.3. DR AlphaFoldDB; A2AE21; -. DR SMR; A2AE21; -. DR PhosphoSitePlus; A2AE21; -. DR PaxDb; 10090-ENSMUSP00000046514; -. DR DNASU; 245368; -. DR Ensembl; ENSMUST00000040667.13; ENSMUSP00000046514.7; ENSMUSG00000031079.13. DR GeneID; 245368; -. DR UCSC; uc009sum.1; mouse. DR AGR; MGI:3045326; -. DR CTD; 245368; -. DR MGI; MGI:3045326; Zfp300. DR VEuPathDB; HostDB:ENSMUSG00000031079; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000162921; -. DR HOGENOM; CLU_002678_44_5_1; -. DR InParanoid; A2AE21; -. DR OMA; CYECNGC; -. DR OrthoDB; 2997404at2759; -. DR PhylomeDB; A2AE21; -. DR TreeFam; TF337898; -. DR BioGRID-ORCS; 245368; 2 hits in 77 CRISPR screens. DR Proteomes; UP000000589; Chromosome X. DR RNAct; A2AE21; Protein. DR Bgee; ENSMUSG00000031079; Expressed in mesodermal cell in embryo and 44 other cell types or tissues. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd07765; KRAB_A-box; 1. DR Gene3D; 6.10.140.140; -; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24377; IP01015P-RELATED; 1. DR PANTHER; PTHR24377:SF900; ZINC FINGER PROTEIN 577; 1. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 11. DR Pfam; PF13912; zf-C2H2_6; 1. DR SMART; SM00349; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 14. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14. PE 4: Predicted; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00042}. FT DOMAIN 7..78 FT /note="KRAB" FT /evidence="ECO:0000259|PROSITE:PS50805" FT DOMAIN 215..242 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 243..270 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 271..298 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 299..326 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 327..354 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 355..382 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 383..410 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 411..438 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 439..466 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 467..494 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 495..522 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 526..553 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 554..581 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 582..609 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" SQ SEQUENCE 645 AA; 74941 MW; FAD5CAB86FBB159C CRC64; MQLQESVSFE DVSVDFTQEE WNQLDPIQRS LYRDVMLENY SHLVSLGYPI TKPEVIASLE KGVLGIIKRE IPSSSCTEDG QAEYNLAWHQ KNQNMHLEQA ISIIEKNVTE ERSYEYDGFV SPLSQSTWVV SSGPTPYMNN SFGESIKNNL GLVNPSSMSF AAQECYECNR CRKLLIPGRH EISDRMKSQE HNMFGKEHIY NFVQHDLTQL GDKTYECPEC RITLSPSSFL VVHQITHIGE KPYEWARCRE AFNNTAHLSL HQTMHTGDKL FECNECGKSF REESTLHIHQ RTHTGEKPYI CTECGNAFQE KTNLIIHRRT HKGEKPYKCT DCEKTFNQKA HLNVHQRTHT GEKPFECTNC GKYFREKSTL NIHQRTHTGE KPYVCNECGK AFREKTKLII HQRTHTGEKP YECSECGRAF NQKAHLSVHQ RTHTGEKPFE CNECGKAFRE KSTLRRHQRI HTGEKPYVCS ECGRAFTLKL SLSAHQRIHT GEKTDGCTVC GKVFSRKSYL MLHQRAHTKE RLEKSYECNE CDKAFLQKSY LIIHQRVHAG EKPYECNICE KSFSQKSYLI IHQRIHTGEK PYQCDKCSRA FREKSKLTVH QRTHIGEKPY DCPELERNFP EIKVPHGLEN SEMKENKELK MENLS //