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A2AE20 (LYZL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sperm acrosome-associated protein 5

EC=3.2.1.17
Alternative name(s):
Lysozyme-like protein 5
Gene names
Name:Spaca5
Synonyms:Gm718, Lyzl5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell wall macromolecule catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysozyme activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 160139Sperm acrosome-associated protein 5
PRO_0000284471

Sites

Active site561 By similarity

Amino acid modifications

Disulfide bond27 ↔ 147 By similarity
Disulfide bond51 ↔ 135 By similarity
Disulfide bond85 ↔ 100 By similarity
Disulfide bond96 ↔ 114 By similarity

Sequences

Sequence LengthMass (Da)Tools
A2AE20 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 6B29416231FA5C1E

FASTA16018,005
        10         20         30         40         50         60 
MKVCSIVVVI LAVLLIAKLD AKIYERCELA KKLEEAGLDG FKGYTVGDWL CVAHYESGFD 

        70         80         90        100        110        120 
TSFVDHNPDG SSEYGIFQLN SAWWCNNGIT PTQNLCNIDC NDLLNRHILD DIICAKRVAS 

       130        140        150        160 
SHKSMKAWDS WTQHCAGHDL SEWLKGCSVR LKTDSSYNNW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL671853 Genomic DNA. Translation: CAM19341.1.
CCDSCCDS40888.1.
RefSeqNP_001078862.1. NM_001085393.2.

3D structure databases

ProteinModelPortalA2AE20.
SMRA2AE20. Positions 22-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000048721.

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbA2AE20.
PRIDEA2AE20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040437; ENSMUSP00000048721; ENSMUSG00000037167.
GeneID278203.
KEGGmmu:278203.
UCSCuc009sul.1. mouse.

Organism-specific databases

CTD389852.
MGIMGI:2685564. Spaca5.

Phylogenomic databases

eggNOGNOG74463.
GeneTreeENSGT00550000074398.
HOGENOMHOG000037357.
HOVERGENHBG052297.
InParanoidA2AE20.
KOK01185.
OMATQNLCHM.
OrthoDBEOG7BW0M5.
TreeFamTF324882.

Gene expression databases

BgeeA2AE20.
CleanExMM_SPACA5.
GenevestigatorA2AE20.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio393900.
PROA2AE20.
SOURCESearch...

Entry information

Entry nameLYZL5_MOUSE
AccessionPrimary (citable) accession number: A2AE20
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries