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A2AE20

- LYZL5_MOUSE

UniProt

A2AE20 - LYZL5_MOUSE

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Protein

Sperm acrosome-associated protein 5

Gene

Spaca5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 5 (EC:3.2.1.17)
Alternative name(s):
Lysozyme-like protein 5
Gene namesi
Name:Spaca5
Synonyms:Gm718, Lyzl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2685564. Spaca5.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 160139Sperm acrosome-associated protein 5PRO_0000284471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 147PROSITE-ProRule annotation
Disulfide bondi51 ↔ 135PROSITE-ProRule annotation
Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
Disulfide bondi96 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA2AE20.
PRIDEiA2AE20.

Expressioni

Gene expression databases

BgeeiA2AE20.
CleanExiMM_SPACA5.
GenevestigatoriA2AE20.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048721.

Structurei

3D structure databases

ProteinModelPortaliA2AE20.
SMRiA2AE20. Positions 22-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74463.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiA2AE20.
KOiK01185.
OMAiTQNLCHM.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2AE20 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVCSIVVVI LAVLLIAKLD AKIYERCELA KKLEEAGLDG FKGYTVGDWL
60 70 80 90 100
CVAHYESGFD TSFVDHNPDG SSEYGIFQLN SAWWCNNGIT PTQNLCNIDC
110 120 130 140 150
NDLLNRHILD DIICAKRVAS SHKSMKAWDS WTQHCAGHDL SEWLKGCSVR
160
LKTDSSYNNW
Length:160
Mass (Da):18,005
Last modified:February 20, 2007 - v1
Checksum:i6B29416231FA5C1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL671853 Genomic DNA. Translation: CAM19341.1.
CCDSiCCDS40888.1.
RefSeqiNP_001078862.1. NM_001085393.2.

Genome annotation databases

EnsembliENSMUST00000040437; ENSMUSP00000048721; ENSMUSG00000037167.
GeneIDi278203.
KEGGimmu:278203.
UCSCiuc009sul.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL671853 Genomic DNA. Translation: CAM19341.1 .
CCDSi CCDS40888.1.
RefSeqi NP_001078862.1. NM_001085393.2.

3D structure databases

ProteinModelPortali A2AE20.
SMRi A2AE20. Positions 22-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000048721.

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbi A2AE20.
PRIDEi A2AE20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040437 ; ENSMUSP00000048721 ; ENSMUSG00000037167 .
GeneIDi 278203.
KEGGi mmu:278203.
UCSCi uc009sul.1. mouse.

Organism-specific databases

CTDi 389852.
MGIi MGI:2685564. Spaca5.

Phylogenomic databases

eggNOGi NOG74463.
GeneTreei ENSGT00550000074398.
HOGENOMi HOG000037357.
HOVERGENi HBG052297.
InParanoidi A2AE20.
KOi K01185.
OMAi TQNLCHM.
OrthoDBi EOG7BW0M5.
TreeFami TF324882.

Miscellaneous databases

NextBioi 393900.
PROi A2AE20.
SOURCEi Search...

Gene expression databases

Bgeei A2AE20.
CleanExi MM_SPACA5.
Genevestigatori A2AE20.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiLYZL5_MOUSE
AccessioniPrimary (citable) accession number: A2AE20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3