A2AE20 (LYZL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sperm acrosome-associated protein 5
EC=3.2.1.17

Alternative name(s):
Lysozyme-like protein 5

Gene names

Name:	Spaca5
Synonyms:	Gm718, Lyzl5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 160	139	Sperm acrosome-associated protein 5		PRO_0000284471
Sites
	Active site	56	1	By similarity
Amino acid modifications
	Disulfide bond	27 ↔ 147		By similarity
	Disulfide bond	51 ↔ 135		By similarity
	Disulfide bond	85 ↔ 100		By similarity
	Disulfide bond	96 ↔ 114		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2AE20 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 6B29416231FA5C1E	FASTA	160	18,005
	10 20 30 40 50 60 MKVCSIVVVI LAVLLIAKLD AKIYERCELA KKLEEAGLDG FKGYTVGDWL CVAHYESGFD 70 80 90 100 110 120 TSFVDHNPDG SSEYGIFQLN SAWWCNNGIT PTQNLCNIDC NDLLNRHILD DIICAKRVAS 130 140 150 160 SHKSMKAWDS WTQHCAGHDL SEWLKGCSVR LKTDSSYNNW

References

[1]

"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL671853 Genomic DNA. Translation: CAM19341.1.
IPI	IPI00751093.
RefSeq	NP_001078862.1. NM_001085393.1.
UniGene	Mm.457905.
3D structure databases
ProteinModelPortal	A2AE20.
SMR	A2AE20. Positions 22-149.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000048721.
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Proteomic databases
PaxDb	A2AE20.
PRIDE	A2AE20.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000040437; ENSMUSP00000048721; ENSMUSG00000037167.
GeneID	278203.
KEGG	mmu:278203.
UCSC	uc009sul.1. mouse.
Organism-specific databases
CTD	389852.
MGI	MGI:2685564. Spaca5.
Phylogenomic databases
eggNOG	NOG74463.
GeneTree	ENSGT00550000074398.
HOGENOM	HOG000037357.
HOVERGEN	HBG052297.
InParanoid	A2AE20.
KO	K01185.
OrthoDB	EOG4QVCD8.
Gene expression databases
Bgee	A2AE20.
CleanEx	MM_SPACA5.
Genevestigator	A2AE20.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. False negative. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	393900.
SOURCE	Search...

Entry information

Entry name

LYZL5_MOUSE

Accession

Primary (citable) accession number: A2AE20

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program