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A2AE20

- LYZL5_MOUSE

UniProt

A2AE20 - LYZL5_MOUSE

Protein

Sperm acrosome-associated protein 5

Gene

Spaca5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm acrosome-associated protein 5 (EC:3.2.1.17)
    Alternative name(s):
    Lysozyme-like protein 5
    Gene namesi
    Name:Spaca5
    Synonyms:Gm718, Lyzl5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2685564. Spaca5.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 160139Sperm acrosome-associated protein 5PRO_0000284471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 147PROSITE-ProRule annotation
    Disulfide bondi51 ↔ 135PROSITE-ProRule annotation
    Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
    Disulfide bondi96 ↔ 114PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiA2AE20.
    PRIDEiA2AE20.

    Expressioni

    Gene expression databases

    BgeeiA2AE20.
    CleanExiMM_SPACA5.
    GenevestigatoriA2AE20.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000048721.

    Structurei

    3D structure databases

    ProteinModelPortaliA2AE20.
    SMRiA2AE20. Positions 22-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74463.
    GeneTreeiENSGT00550000074398.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiA2AE20.
    KOiK01185.
    OMAiTQNLCHM.
    OrthoDBiEOG7BW0M5.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2AE20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVCSIVVVI LAVLLIAKLD AKIYERCELA KKLEEAGLDG FKGYTVGDWL    50
    CVAHYESGFD TSFVDHNPDG SSEYGIFQLN SAWWCNNGIT PTQNLCNIDC 100
    NDLLNRHILD DIICAKRVAS SHKSMKAWDS WTQHCAGHDL SEWLKGCSVR 150
    LKTDSSYNNW 160
    Length:160
    Mass (Da):18,005
    Last modified:February 20, 2007 - v1
    Checksum:i6B29416231FA5C1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671853 Genomic DNA. Translation: CAM19341.1.
    CCDSiCCDS40888.1.
    RefSeqiNP_001078862.1. NM_001085393.2.

    Genome annotation databases

    EnsembliENSMUST00000040437; ENSMUSP00000048721; ENSMUSG00000037167.
    GeneIDi278203.
    KEGGimmu:278203.
    UCSCiuc009sul.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671853 Genomic DNA. Translation: CAM19341.1 .
    CCDSi CCDS40888.1.
    RefSeqi NP_001078862.1. NM_001085393.2.

    3D structure databases

    ProteinModelPortali A2AE20.
    SMRi A2AE20. Positions 22-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000048721.

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Proteomic databases

    PaxDbi A2AE20.
    PRIDEi A2AE20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040437 ; ENSMUSP00000048721 ; ENSMUSG00000037167 .
    GeneIDi 278203.
    KEGGi mmu:278203.
    UCSCi uc009sul.1. mouse.

    Organism-specific databases

    CTDi 389852.
    MGIi MGI:2685564. Spaca5.

    Phylogenomic databases

    eggNOGi NOG74463.
    GeneTreei ENSGT00550000074398.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi A2AE20.
    KOi K01185.
    OMAi TQNLCHM.
    OrthoDBi EOG7BW0M5.
    TreeFami TF324882.

    Miscellaneous databases

    NextBioi 393900.
    PROi A2AE20.
    SOURCEi Search...

    Gene expression databases

    Bgeei A2AE20.
    CleanExi MM_SPACA5.
    Genevestigatori A2AE20.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiLYZL5_MOUSE
    AccessioniPrimary (citable) accession number: A2AE20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3