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Protein

Sperm acrosome-associated protein 5

Gene

Spaca5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 5 (EC:3.2.1.17)
Alternative name(s):
Lysozyme-like protein 5
Gene namesi
Name:Spaca5
Synonyms:Gm718, Lyzl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2685564. Spaca5.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 160139Sperm acrosome-associated protein 5PRO_0000284471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 147PROSITE-ProRule annotation
Disulfide bondi51 ↔ 135PROSITE-ProRule annotation
Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
Disulfide bondi96 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA2AE20.
PRIDEiA2AE20.

Expressioni

Gene expression databases

BgeeiA2AE20.
CleanExiMM_SPACA5.
GenevestigatoriA2AE20.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048721.

Structurei

3D structure databases

ProteinModelPortaliA2AE20.
SMRiA2AE20. Positions 22-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74463.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiA2AE20.
KOiK01185.
OMAiIGDWLCM.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030064. LYZL5.
[Graphical view]
PANTHERiPTHR11407:SF12. PTHR11407:SF12. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2AE20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVCSIVVVI LAVLLIAKLD AKIYERCELA KKLEEAGLDG FKGYTVGDWL
60 70 80 90 100
CVAHYESGFD TSFVDHNPDG SSEYGIFQLN SAWWCNNGIT PTQNLCNIDC
110 120 130 140 150
NDLLNRHILD DIICAKRVAS SHKSMKAWDS WTQHCAGHDL SEWLKGCSVR
160
LKTDSSYNNW
Length:160
Mass (Da):18,005
Last modified:February 20, 2007 - v1
Checksum:i6B29416231FA5C1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671853 Genomic DNA. Translation: CAM19341.1.
CCDSiCCDS40888.1.
RefSeqiNP_001078862.1. NM_001085393.2.

Genome annotation databases

EnsembliENSMUST00000040437; ENSMUSP00000048721; ENSMUSG00000037167.
GeneIDi278203.
KEGGimmu:278203.
UCSCiuc009sul.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671853 Genomic DNA. Translation: CAM19341.1.
CCDSiCCDS40888.1.
RefSeqiNP_001078862.1. NM_001085393.2.

3D structure databases

ProteinModelPortaliA2AE20.
SMRiA2AE20. Positions 22-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048721.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbiA2AE20.
PRIDEiA2AE20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040437; ENSMUSP00000048721; ENSMUSG00000037167.
GeneIDi278203.
KEGGimmu:278203.
UCSCiuc009sul.1. mouse.

Organism-specific databases

CTDi389852.
MGIiMGI:2685564. Spaca5.

Phylogenomic databases

eggNOGiNOG74463.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiA2AE20.
KOiK01185.
OMAiIGDWLCM.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Miscellaneous databases

NextBioi393900.
PROiA2AE20.
SOURCEiSearch...

Gene expression databases

BgeeiA2AE20.
CleanExiMM_SPACA5.
GenevestigatoriA2AE20.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030064. LYZL5.
[Graphical view]
PANTHERiPTHR11407:SF12. PTHR11407:SF12. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiLYZL5_MOUSE
AccessioniPrimary (citable) accession number: A2AE20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: April 29, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.