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Protein
Submitted name:

HLA class II histocompatibility antigen, DQ beta 2 chain

Gene

HLA-DQB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class II histocompatibility antigen, DQ beta 2 chainImported
Submitted name:
cDNA FLJ40688 fis, clone THYMU2024185, highly similar to HLA class II histocompatibility antigen, DX beta chainImported
Gene namesi
Name:HLA-DQB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000232629.8.
HGNCiHGNC:4945. HLA-DQB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501010233529 – 275Sequence analysisAdd BLAST247

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000232629.
ExpressionAtlasiA2ADX3. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 212Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140849.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
OMAiDWNNYKD.
OrthoDBiEOG091G0SXL.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328. MHC_II_b_N. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

A2ADX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQIPGGFW AAAVTVMLVM LSTPVAEARD FPKDFLVQFK GMCYFTNGTE
60 70 80 90 100
RVRGVARYIY NREEYGRFDS DVGEFQAVTE LGRSIEDWNN YKDFLEQERA
110 120 130 140 150
AVDKVCRHNY EAELRTTLQR QVEPTVTISP SRTEALNHHN LLVCSVTDFY
160 170 180 190 200
PAQIKVRWFR NDQEETAGVV STSLIRNGDW TFQILVMLEI TPQRGDIYTC
210 220 230 240 250
QVEHPSLQSP ITVEWRAQSE SAQSKMLSGI GGFVLGLIFL GLGLIIRHRG
260 270
QKGPRGPPPA GNISAMIQSG ERAQA
Length:275
Mass (Da):30,948
Last modified:February 20, 2007 - v1
Checksum:i6E1A385D96839EE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671681 Genomic DNA. No translation available.
AL672104 Genomic DNA. No translation available.
AL713890 Genomic DNA. No translation available.
BX296564 Genomic DNA. No translation available.
CR936921 Genomic DNA. No translation available.
AK098007 mRNA. Translation: BAG53563.1.
RefSeqiXP_005249108.1. XM_005249051.4.
UniGeneiHs.731563.

Genome annotation databases

EnsembliENST00000415137; ENSP00000387578; ENSG00000224305.
ENST00000435145; ENSP00000410512; ENSG00000232629.
ENST00000442806; ENSP00000394759; ENSG00000226165.
ENST00000455520; ENSP00000409159; ENSG00000230675.
GeneIDi3120.
UCSCiuc003obz.3. human.

Similar proteinsi

Entry informationi

Entry nameiA2ADX3_HUMAN
AccessioniPrimary (citable) accession number: A2ADX3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported