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Protein

Acyl-CoA wax alcohol acyltransferase 1

Gene

Awat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20) (By similarity).By similarity

Catalytic activityi

Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.75. 3474.
ReactomeiR-MMU-2142753. Arachidonic acid metabolism.
R-MMU-8848584. Wax biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA wax alcohol acyltransferase 1 (EC:2.3.1.75)
Alternative name(s):
Diacylglycerol O-acyltransferase 2-like protein 3
Long-chain-alcohol O-fatty-acyltransferase 1
Gene namesi
Name:Awat1
Synonyms:Dgat2l3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3588200. Awat1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei34 – 5320HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Acyl-CoA wax alcohol acyltransferase 1PRO_0000320296Add
BLAST

Proteomic databases

PaxDbiA2ADU9.
PRIDEiA2ADU9.

Expressioni

Gene expression databases

BgeeiA2ADU9.
CleanExiMM_DGAT2L3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094088.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiA2ADU9.
KOiK11171.
OMAiLQWPLSY.
OrthoDBiEOG7KH9KB.
TreeFamiTF314707.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ADU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCSMKTEHL QSLSLLQWPL SYVAMFWIVQ PLLICLLFTP LWPLPTVYFV
60 70 80 90 100
WLLLDWKTPD KGGRRSDWVR NWNVWNHIRD YFPITILKTK DLSPSENYIM
110 120 130 140 150
GVHPHGLLTF GAFCNFCTEA TGFSKTFPGI TPHLATLSWF FKIPIIRDYI
160 170 180 190 200
MAKGLCSVSQ ASIDYLLSHG TGNLVGIVVG GVGEALQSVP NTTTLLLKKR
210 220 230 240 250
KGFVRTALQH GAHLVPTFTF GETEVYDQVL FHEDSRMFKF QSLFRRIFGF
260 270 280 290 300
YCCVFYGQGF HQDCKGLLPY HKPIITVVGE ALPLPQVKNP SPEIVDKYHA
310 320
LYMDALYKLF EQHKVQYGCS NTQKLIFL
Length:328
Mass (Da):37,573
Last modified:February 20, 2007 - v1
Checksum:i6CCFBAA4B4579FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671299 Genomic DNA. Translation: CAM19589.1.
BC147680 mRNA. Translation: AAI47681.1.
BC147683 mRNA. Translation: AAI47684.1.
BC147829 mRNA. Translation: AAI47830.1.
BC147832 mRNA. Translation: AAI47833.1.
CCDSiCCDS41074.1.
RefSeqiNP_001074605.1. NM_001081136.1.
UniGeneiMm.77759.

Genome annotation databases

EnsembliENSMUST00000096361; ENSMUSP00000094088; ENSMUSG00000015665.
GeneIDi245533.
KEGGimmu:245533.
UCSCiuc009twb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671299 Genomic DNA. Translation: CAM19589.1.
BC147680 mRNA. Translation: AAI47681.1.
BC147683 mRNA. Translation: AAI47684.1.
BC147829 mRNA. Translation: AAI47830.1.
BC147832 mRNA. Translation: AAI47833.1.
CCDSiCCDS41074.1.
RefSeqiNP_001074605.1. NM_001081136.1.
UniGeneiMm.77759.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094088.

Proteomic databases

PaxDbiA2ADU9.
PRIDEiA2ADU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096361; ENSMUSP00000094088; ENSMUSG00000015665.
GeneIDi245533.
KEGGimmu:245533.
UCSCiuc009twb.1. mouse.

Organism-specific databases

CTDi158833.
MGIiMGI:3588200. Awat1.

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiA2ADU9.
KOiK11171.
OMAiLQWPLSY.
OrthoDBiEOG7KH9KB.
TreeFamiTF314707.

Enzyme and pathway databases

BRENDAi2.3.1.75. 3474.
ReactomeiR-MMU-2142753. Arachidonic acid metabolism.
R-MMU-8848584. Wax biosynthesis.

Miscellaneous databases

PROiA2ADU9.
SOURCEiSearch...

Gene expression databases

BgeeiA2ADU9.
CleanExiMM_DGAT2L3.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAWAT1_MOUSE
AccessioniPrimary (citable) accession number: A2ADU9
Secondary accession number(s): B2RW94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.