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Protein
Submitted name:

Cerberus 1 homolog (Xenopus laevis)

Gene

Cer1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. BMP binding Source: MGI
  2. morphogen activity Source: MGI

GO - Biological processi

  1. anterior/posterior axis specification Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. bone mineralization Source: MGI
  4. cell migration involved in gastrulation Source: MGI
  5. cellular response to BMP stimulus Source: Ensembl
  6. determination of dorsal identity Source: MGI
  7. gastrulation Source: MGI
  8. negative regulation of activin receptor signaling pathway Source: MGI
  9. negative regulation of BMP signaling pathway Source: MGI
  10. negative regulation of cell proliferation Source: MGI
  11. negative regulation of mesoderm development Source: MGI
  12. nervous system development Source: MGI
  13. sequestering of BMP in extracellular matrix Source: MGI
  14. signal transduction involved in regulation of gene expression Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cerberus 1 homolog (Xenopus laevis)Imported
Gene namesi
Name:Cer1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201414. Cer1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriA2ADM9.

Family & Domainsi

Sequence similaritiesi

Contains CTCK (C-terminal cystine knot-like) domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG050902.
KOiK01645.
OMAiCFGKCGS.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ADM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLLVQLLV LLPLGKADLC VDGCQSQGSL SFPLLERGRR DLHVANHEEA
60 70 80 90 100
EDKPDLFVAV PHLMGTSLAG EGQRQRGKML SRLGRFWKKP ETEFYPPRDV
110 120 130 140 150
ESDHVSSGMQ AVTQPADGRK VERSPLQEEA KRFWHRFMFR KGPAFQGVIL
160 170 180 190 200
PIKSHEVHWE TCRTVPFNQT IAHEDCQKVV VQNNLCFGKC SSIRFPGEGA
210 220 230 240 250
DAHSFCSHCS PTKFTTVHLM LNCTSPTPVV KMVMQVEECQ CMVKTERGEE
260 270
RLLLAGSQGS FIPGLPASKT NP
Length:272
Mass (Da):30,431
Last modified:February 20, 2007 - v1
Checksum:iDD0842A2619AF057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132431 mRNA. Translation: AAI32432.1.
BC145993 mRNA. Translation: AAI45994.1.
RefSeqiNP_034017.1. NM_009887.2.
UniGeneiMm.6780.

Genome annotation databases

GeneIDi12622.
KEGGimmu:12622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132431 mRNA. Translation: AAI32432.1.
BC145993 mRNA. Translation: AAI45994.1.
RefSeqiNP_034017.1. NM_009887.2.
UniGeneiMm.6780.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12622.
KEGGimmu:12622.

Organism-specific databases

CTDi9350.
MGIiMGI:1201414. Cer1.

Phylogenomic databases

HOVERGENiHBG050902.
KOiK01645.
OMAiCFGKCGS.

Miscellaneous databases

NextBioi281790.
SOURCEiSearch...

Gene expression databases

GenevestigatoriA2ADM9.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiA2ADM9_MOUSE
AccessioniPrimary (citable) accession number: A2ADM9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 29, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.