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Protein

Solute carrier family 25 member 34

Gene

Slc25a34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 34
Gene namesi
Name:Slc25a34
Synonyms:Gm1369
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2686215. Slc25a34.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei112 – 134Helical; Name=3Sequence analysisAdd BLAST23
Transmembranei184 – 205Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei292 – 315Helical; Name=6Sequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917901 – 318Solute carrier family 25 member 34Add BLAST318

Proteomic databases

PaxDbiA2ADF7.
PRIDEiA2ADF7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040740.
CleanExiMM_SLC25A34.
GenevisibleiA2ADF7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039188.

Structurei

3D structure databases

ProteinModelPortaliA2ADF7.
SMRiA2ADF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 111Solcar 1Add BLAST94
Repeati115 – 208Solcar 2Add BLAST94
Repeati218 – 309Solcar 3Add BLAST92

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0755. Eukaryota.
ENOG410XS37. LUCA.
GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
HOVERGENiHBG108440.
InParanoidiA2ADF7.
KOiK15117.
OMAiARGTYPR.
OrthoDBiEOG091G0MCY.
PhylomeDBiA2ADF7.
TreeFamiTF324506.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2ADF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPTQAQMAP AMDSREMVSP AVDLVLGASA CCLACVFTNP LEVVKTRLQL
60 70 80 90 100
QGELQAPGTY PRPYRGFVSS VAAVARADGL WGLQKGLAAG LLYQGLMNGV
110 120 130 140 150
RFYCYSLACQ AGLTQQPGGT VVAGAAAGAL GAFVGSPAYL VKTQLQAQTV
160 170 180 190 200
ATMAVGHQHQ HQGVLSALET IWRQQGMLGL WRGVGGAVPR VTVGSAAQLA
210 220 230 240 250
TFTSAKAWVQ DRQWFLEDSW LVTLAGGMIS SIAVVAVMTP LDVVSTRLYN
260 270 280 290 300
QPVDRAGRGQ LYGGLADCLV KTCQQEGPLA LYKGLGPAYL RLGPHTILSM
310
FFWDELRKLV ARAQHQGT
Length:318
Mass (Da):33,778
Last modified:February 20, 2007 - v1
Checksum:i0FC61CE7065CE4D6
GO
Isoform 2 (identifier: A2ADF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-219: WFLEDS → VRSWEH
     220-318: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):23,042
Checksum:i9C3594C1CB9B63F0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026235214 – 219WFLEDS → VRSWEH in isoform 2. 1 Publication6
Alternative sequenceiVSP_026236220 – 318Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670446 Genomic DNA. Translation: CAM19906.1.
BC089627 mRNA. Translation: AAH89627.2.
CCDSiCCDS18878.1. [A2ADF7-1]
RefSeqiNP_001013802.1. NM_001013780.1. [A2ADF7-1]
UniGeneiMm.295682.

Genome annotation databases

EnsembliENSMUST00000038661; ENSMUSP00000039188; ENSMUSG00000040740. [A2ADF7-1]
GeneIDi384071.
KEGGimmu:384071.
UCSCiuc008vox.1. mouse. [A2ADF7-1]
uc008voy.1. mouse. [A2ADF7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670446 Genomic DNA. Translation: CAM19906.1.
BC089627 mRNA. Translation: AAH89627.2.
CCDSiCCDS18878.1. [A2ADF7-1]
RefSeqiNP_001013802.1. NM_001013780.1. [A2ADF7-1]
UniGeneiMm.295682.

3D structure databases

ProteinModelPortaliA2ADF7.
SMRiA2ADF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039188.

Proteomic databases

PaxDbiA2ADF7.
PRIDEiA2ADF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038661; ENSMUSP00000039188; ENSMUSG00000040740. [A2ADF7-1]
GeneIDi384071.
KEGGimmu:384071.
UCSCiuc008vox.1. mouse. [A2ADF7-1]
uc008voy.1. mouse. [A2ADF7-2]

Organism-specific databases

CTDi284723.
MGIiMGI:2686215. Slc25a34.

Phylogenomic databases

eggNOGiKOG0755. Eukaryota.
ENOG410XS37. LUCA.
GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
HOVERGENiHBG108440.
InParanoidiA2ADF7.
KOiK15117.
OMAiARGTYPR.
OrthoDBiEOG091G0MCY.
PhylomeDBiA2ADF7.
TreeFamiTF324506.

Miscellaneous databases

PROiA2ADF7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040740.
CleanExiMM_SLC25A34.
GenevisibleiA2ADF7. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2534_MOUSE
AccessioniPrimary (citable) accession number: A2ADF7
Secondary accession number(s): Q5FW51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.