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Protein
Submitted name:

Msx2-interacting protein

Gene

Spen

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Msx2-interacting proteinImported
Gene namesi
Name:SpenImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1891706. Spen.

PTM / Processingi

Proteomic databases

MaxQBiA2ADB1.
PaxDbiA2ADB1.
PRIDEiA2ADB1.

Expressioni

Gene expression databases

BgeeiA2ADB1.
ExpressionAtlasiA2ADB1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101412.

Structurei

3D structure databases

ProteinModelPortaliA2ADB1.
SMRiA2ADB1. Positions 337-622, 3452-3620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8176RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini337 – 41074RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini440 – 51576RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini519 – 59173RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini3454 – 3620167SPOCInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1494 – 152128Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410ZT33. LUCA.
GeneTreeiENSGT00530000063730.
HOVERGENiHBG045583.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 4 hits.
PS50917. SPOC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ADB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF
60 70 80 90 100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR
110 120 130 140 150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG
160 170 180 190 200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR
210 220 230 240 250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS
260 270 280 290 300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SSNTDSSDSS
310 320 330 340 350
STASDDSPAR SVQSAAVPAP TSQLLSSLEK DEPRKSFGIK VQNLPVRSTD
360 370 380 390 400
TSLKDGLFHE FKKFGKVTSV QIHGASEERY GLVFFRQQED QEKALTASKG
410 420 430 440 450
KLFFGMQIEV TAWVGPETES ENEFRPLDER IDEFHPKATR TLFIGNLEKT
460 470 480 490 500
TTYHDLRNIF QRFGEIVDID IKKVNGVPQY AFLQYCDIAS VCKAIKKMDG
510 520 530 540 550
EYLGNNRLKL GFGKSMPTNC VWLDGLSSNV SDQYLTRHFC RYGPVVKVVF
560 570 580 590 600
DRLKGMALVL YSEIEDAQAA VKETKGRKIG GNKIKVDFAN RESQLAFYHC
610 620 630 640 650
MEKSGQDMRD FYEMLTERRE ERRGSYEYSQ ERTYYENVRT PGTYPEDSRR
660 670 680 690 700
DYPARGREFY SEWETYQGEY YDSRYYDEPR EYREYRSDPY EQDIREYSYR
710 720 730 740 750
QRERERERER FESDRDHERR PIERSQSPVH LRRPQSPGVS PAHSERLPSD
760 770 780 790 800
SERRLYRRSS ERSGSCSSVS PPRYDKLEKA RLERYTKNEK ADKERTFDPE
810 820 830 840 850
RVERERRIVR KEKGEKDKAE RQKRKGKAHS PSSQPSETEQ ENDREQSPEK
860 870 880 890 900
PRGSTKLSRD RADKEGPAKN RLELVPCVVL TRVKEKEGKV IEHPPPEKLK
910 920 930 940 950
ARLGRDTTKA SALDQKPQAA QGEPAKSDPA RGKALREKVL PSHAEVGEKE
960 970 980 990 1000
GRTKLRKHLK AEQTPELSAL DLEKLEARKR RFADSGLKIE KQKPEIKKTS
1010 1020 1030 1040 1050
PETEDTRILL KKQPDTSRDG VLLREGESER KPVRKEILKR ESKKTKLERL
1060 1070 1080 1090 1100
NSALSPKDCQ DPAAVSAGSG SRPSSDVHAG LGELTHGSVE TQETQPKKAI
1110 1120 1130 1140 1150
PSKPQPKQLQ LLENQGPEKE EVRKNYCRPR EEPAEHRAGQ EKPHGGNAEE
1160 1170 1180 1190 1200
KLGIDIDHTQ SYRKQMEQSR RKQRMEMEIA KAEKFGSPKK DVDDYERRSL
1210 1220 1230 1240 1250
VHEVGKPPQD VTDDSPPSKK RRTDHVDFDI CTKRERNYRS SRQISEDSER
1260 1270 1280 1290 1300
TSCSPSVRHG SFHDDDDPRG SPRLVSVKGS PKGDEKGLPY PNAAVRDDPL
1310 1320 1330 1340 1350
KCNPYDSGKR EQTADTAKIK LSVLNSEGEP SRWDPPMKQD PSRFDVSFPN
1360 1370 1380 1390 1400
SVIKRDSLRK RSVRDLEPGE VPSDSDEDAE HRSQSPRASS FYDSPRLSFL
1410 1420 1430 1440 1450
LRDRDQKLRE RDERLASSLE RNKFYSFALD KTITPDTKAL LERAKSLSSS
1460 1470 1480 1490 1500
REENWSFLDW DSRFANFRNN KDKEKVDSAP RPIPSWYMKK KKIRTDSEGK
1510 1520 1530 1540 1550
LADKKDERRE EEQERQELFA SRFLHSSIFE QDSKRLQHLE RKSEEPDLPP
1560 1570 1580 1590 1600
GGLYGRQASE GANSTSDSVQ EPVVLFHSRF MELTRMQQKE KEKDQKPKEA
1610 1620 1630 1640 1650
EKQEEPETHP KTPEPAAETK EPEPKAPVSA GLPAVTVTVV TPEPASSAPE
1660 1670 1680 1690 1700
KAEEAAEAPS PAGEKPAEPA PVSEETKLVS EPASVPVEQP RQSDVPPGED
1710 1720 1730 1740 1750
SRDSQDSAAL APSAPQESAA TDAVPCVNAE PLTPGTTVSQ VESSVDPKPS
1760 1770 1780 1790 1800
SPQPLSKLTQ RSEEAEEGKV EKPDTTPSTE PDATQNAGVA SEAQPPASED
1810 1820 1830 1840 1850
VEANPPVAAK DRKTNKSKRS KTSVQAAAAS VVEKPVTRKS ERIDREKLKR
1860 1870 1880 1890 1900
SSSPRGEAQK LLELKMEAEK ITRTASKSSG GDTEHPEPSL PLSRSRRRNV
1910 1920 1930 1940 1950
RSVYATMTDH ESRSPAKEPV EQPRVTRKRL ERELQEAVVP PTTPRRGRPP
1960 1970 1980 1990 2000
KTRRRAEEDG EHERKEPAET PRPAEGWRSP RSQKSAAAAG PQGKRGRNEQ
2010 2020 2030 2040 2050
KVEAAAEAGA QASTREGNPK SRGEREAASE PKRDRRDPST DKNGPDTFPV
2060 2070 2080 2090 2100
EVLERKPPEK TYKSKRGRAR STRSAMDRAA HQRSLEMAAR AAGQAADKEA
2110 2120 2130 2140 2150
GPAAASPQES ESPQKGSGSS PQLANNPADP DREAEEESAS ASTAPPEGTQ
2160 2170 2180 2190 2200
LARQIELEQA VQNIAKLPEP SAAAASKGTA TATAASEEPA PEHGHKPAHQ
2210 2220 2230 2240 2250
ASETELAAAI GSIISDASGE PENFSAPPSV PPGSQTHPRE GMEPGLHEAE
2260 2270 2280 2290 2300
SGILETGTAT ESSAPQVSAL DPPEGSADTK ETRGNSGDSV QEAKGSKVEV
2310 2320 2330 2340 2350
TPPRKDKGRQ KTTRRRKRNA NKKVVAITET RASEAEQTQS ESPAAEEATA
2360 2370 2380 2390 2400
ATPEAPQEEK QSEKPPSPPA ECTFDPSKTP PAESLSQENS AAEKTPCKAP
2410 2420 2430 2440 2450
VLPALPPLSQ PALMDDGPQA RFKVHSIIES DPVTPPSDSG IPPPTIPLVT
2460 2470 2480 2490 2500
IAKLPPPVIP GGVPHQSPPP KVTEWITRQE EPRAQSTPSP ALPPDTKASD
2510 2520 2530 2540 2550
MDTSSSTLRK ILMDPKYVSA TGVTSTSVTS AIAEPVSAPC LQEAPAPPCD
2560 2570 2580 2590 2600
PKHPPLEGVS AAAVPNADTQ ASEVPVAADK EKVAPVIAPK ITSVISRMPV
2610 2620 2630 2640 2650
SIDLENSQKI TLAKPAPQTL TGLVSALTGL VNVSLVPVNA LKGPVKGSVA
2660 2670 2680 2690 2700
TLKGLVSTPA GPVNLLKGPV NVLTGPVNVL TTPVSATVGT VNAAPGPVTA
2710 2720 2730 2740 2750
ACGVTATTGT AAVTGAVTAP AAKGKQRASS NENSRFHPGS MSVIDDRPAD
2760 2770 2780 2790 2800
TGSGAGLRVN TSEGVVLLSY SGQKTEGPQR ISAKISQIPP ASAMDIEFQQ
2810 2820 2830 2840 2850
SVSKSQVKAD SITPTQSAPK GPQTPSAFAN VAAHSTLVLT AQTYNASPVI
2860 2870 2880 2890 2900
SSVKTDRPSL EKPEPIHLSV STPVTQGGTV KVLTQGINTP PVLVHNQLVL
2910 2920 2930 2940 2950
TPSIVTTNKK LADPVTLKIE TKVLQPANLG PTLTPHHPPA LPSKLPAEVN
2960 2970 2980 2990 3000
HVPSGPSTPA DRTIAHLATP KPDTHSPRPT GPTPGLFPRP CHPSSTTSTA
3010 3020 3030 3040 3050
LSTNATVMLA AGIPVPQFIS SIHPEQSVIM PPHSITQTVS LGHLSQGEVR
3060 3070 3080 3090 3100
MSTPTLPSIT YSIRPETLHS PRAPLQPQQI EARAPQRVGT PQPATTGVPA
3110 3120 3130 3140 3150
LATQHPPEEE VHYHLPVARA AAPVQSEVLV MQSEYRLHPY TVPRDVRIMV
3160 3170 3180 3190 3200
HPHVTAVSEQ PRATEGVVKV PPANKAPQQL VKEAVKTSDA KAVPAPAPVP
3210 3220 3230 3240 3250
VPVPVPTPAP PPHGEARILT VTPSSQLQGL PLTPPVVVTH GVQIVHSSGE
3260 3270 3280 3290 3300
LFQEYRYGDV RTYHAPAQQL THTQFPVASS ISLASRTKTS AQVPPEGEPL
3310 3320 3330 3340 3350
QSTQSAQPAP STQATQPIPP APPCQPSQLS QPAQPPSGKI PQVSQEAKGT
3360 3370 3380 3390 3400
QTGGVEQTRL PAIPTNRPSE PHAQLQRAPV ETAQPAHPSP VSVSMKPDLP
3410 3420 3430 3440 3450
SPLSSQAAPK QPLFVPANSG PSTPPGLALP HAEVQPAPKQ ESSPHGTPQR
3460 3470 3480 3490 3500
PVDMVQLLKK YPIVWQGLLA LKNDTAAVQL HFVSGNNVLA HRSLPLSEGG
3510 3520 3530 3540 3550
PPLRIAQRMR LEASQLEGVA RRMTVETDYC LLLALPCGRD QEDVVSQTES
3560 3570 3580 3590 3600
LKAAFITYLQ AKQAAGIINV PNPGSNQPAY VLQIFPPCEF SESHLSRLAP
3610 3620
DLLASISNIS PHLMIVIASV
Length:3,620
Mass (Da):395,983
Last modified:February 20, 2007 - v1
Checksum:i7E8F9FDFE34DEF15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670285 Genomic DNA. No translation available.
AL670446 Genomic DNA. No translation available.
RefSeqiXP_006539134.1. XM_006539071.2.
UniGeneiMm.299906.

Genome annotation databases

EnsembliENSMUST00000078886; ENSMUSP00000077925; ENSMUSG00000040761.
GeneIDi56381.
UCSCiuc008vom.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670285 Genomic DNA. No translation available.
AL670446 Genomic DNA. No translation available.
RefSeqiXP_006539134.1. XM_006539071.2.
UniGeneiMm.299906.

3D structure databases

ProteinModelPortaliA2ADB1.
SMRiA2ADB1. Positions 337-622, 3452-3620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101412.

Proteomic databases

MaxQBiA2ADB1.
PaxDbiA2ADB1.
PRIDEiA2ADB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078886; ENSMUSP00000077925; ENSMUSG00000040761.
GeneIDi56381.
UCSCiuc008vom.2. mouse.

Organism-specific databases

CTDi23013.
MGIiMGI:1891706. Spen.

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410ZT33. LUCA.
GeneTreeiENSGT00530000063730.
HOVERGENiHBG045583.

Miscellaneous databases

ChiTaRSiSpen. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiA2ADB1.
ExpressionAtlasiA2ADB1. baseline and differential.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 4 hits.
PS50917. SPOC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2ADB1_MOUSE
AccessioniPrimary (citable) accession number: A2ADB1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.