UniProtKB - A2ACT4 (A2ACT4_MOUSE)
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Protein
Submitted name:
Neurotensin receptor 1
Gene
Ntsr1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- G-protein coupled neurotensin receptor activity Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein N-terminus binding Source: Ensembl
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- D-aspartate import across plasma membrane Source: Ensembl
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- inositol phosphate catabolic process Source: Ensembl
- learning Source: Ensembl
- L-glutamate import across plasma membrane Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of release of sequestered calcium ion into cytosol Source: Ensembl
- negative regulation of systemic arterial blood pressure Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of arachidonic acid secretion Source: Ensembl
- positive regulation of cation channel activity Source: Ensembl
- positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
- positive regulation of glutamate secretion Source: Ensembl
- positive regulation of inhibitory postsynaptic potential Source: Ensembl
- positive regulation of inositol phosphate biosynthetic process Source: Ensembl
- positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
- regulation of action potential Source: Ensembl
- regulation of membrane depolarization Source: Ensembl
- regulation of respiratory gaseous exchange Source: Ensembl
- regulation of sensory perception of pain Source: Ensembl
- response to lipid Source: Ensembl
- temperature homeostasis Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Neurotensin receptor 1ImportedSubmitted name: Ntsr1 proteinImported |
Gene namesi | Name:Ntsr1Imported ORF Names:mCG_6723Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97386 Ntsr1 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 89 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 101 – 125 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 188 – 209 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 235 – 259 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 308 – 326 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 346 – 368 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneInteractioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein N-terminus binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 369 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 290 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
HOVERGENi | HBG098285 |
KOi | K04211 |
OMAi | VPMLFTM |
OrthoDBi | EOG091G0Q6E |
Family and domain databases
CDDi | cd15355 7tmA_NTSR1, 1 hit |
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003985 NT1_rcpt IPR003984 NT_rcpt |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01479 NEUROTENSINR PR01480 NEUROTENSN1R |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A2ACT4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP
60 70 80 90 100
NSNLDVNTDI YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST
110 120 130 140 150
VHYHLGSLAL SDLLILLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA
160 170 180 190 200
CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA
210 220 230 240 250
VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN TFMSFLFPML
260 270 280 290 300
IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV
310 320 330 340 350
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF
360 370 380 390 400
YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT
410 420
FSRKPNSMSS NHAFSTSATR ETLY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC138630 mRNA Translation: AAI38631.1 BC138633 mRNA Translation: AAI38634.1 CH466626 Genomic DNA Translation: EDL07336.1 |
RefSeqi | NP_061236.1, NM_018766.2 |
UniGenei | Mm.301712 |
Genome annotation databases
GeneIDi | 18216 |
KEGGi | mmu:18216 |
Similar proteinsi
Entry informationi
Entry namei | A2ACT4_MOUSE | |
Accessioni | A2ACT4Primary (citable) accession number: A2ACT4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | April 25, 2018 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |