Ntsr1

Functionⁱ

GO - Molecular functionⁱ

G-protein coupled neurotensin receptor activity Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
protein N-terminus binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

adult locomotory behavior Source: Ensembl
D-aspartate import Source: Ensembl
detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
inositol phosphate catabolic process Source: Ensembl
learning Source: Ensembl
L-glutamate import across plasma membrane Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of release of sequestered calcium ion into cytosol Source: Ensembl
negative regulation of systemic arterial blood pressure Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of arachidonic acid secretion Source: Ensembl
positive regulation of cation channel activity Source: Ensembl
positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
positive regulation of glutamate secretion Source: Ensembl
positive regulation of inhibitory postsynaptic potential Source: Ensembl
positive regulation of inositol phosphate biosynthetic process Source: Ensembl
positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
regulation of action potential Source: Ensembl
regulation of membrane depolarization Source: Ensembl
regulation of respiratory gaseous exchange Source: Ensembl
regulation of sensory perception of pain Source: Ensembl
response to lipid Source: Ensembl
temperature homeostasis Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Neurotensin receptor 1Imported Submitted name: Ntsr1 proteinImported
Gene namesⁱ	Name:Ntsr1Imported ORF Names:mCG_6723Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:97386. Ntsr1.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	64 – 89	HelicalSequence analysisAdd BLAST	26
Transmembraneⁱ	101 – 125	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	188 – 209	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	235 – 259	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	308 – 326	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	346 – 368	HelicalSequence analysisAdd BLAST	23

GO - Cellular componentⁱ

cell surface Source: Ensembl
cytoplasmic side of plasma membrane Source: Ensembl
dendritic shaft Source: Ensembl
dendritic spine Source: Ensembl
endoplasmic reticulum Source: Ensembl
Golgi apparatus Source: Ensembl
integral component of plasma membrane Source: Ensembl
membrane raft Source: Ensembl
mitochondrion Source: Ensembl
perikaryon Source: Ensembl
symmetric synapse Source: Ensembl
terminal bouton Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027568.
ExpressionAtlasⁱ	A2ACT4. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
protein N-terminus binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	A2ACT4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	80 – 369	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		290

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
HOVERGENⁱ	HBG098285.
KEGG Orthology (KO) More...KOⁱ	K04211.
OMAⁱ	VPMLFTM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q6E.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003985. NT1_rcpt. IPR003984. NT_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR01479. NEUROTENSINR. PR01480. NEUROTENSN1R.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A2ACT4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP 
        60         70         80         90        100
NSNLDVNTDI YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST 
       110        120        130        140        150
VHYHLGSLAL SDLLILLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA 
       160        170        180        190        200
CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA 
       210        220        230        240        250
VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN TFMSFLFPML 
       260        270        280        290        300
IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV 
       310        320        330        340        350
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF 
       360        370        380        390        400
YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT 
       410        420 
FSRKPNSMSS NHAFSTSATR ETLY

Length:424

Mass (Da):47,217

Last modified:February 20, 2007 - v1

Checksum:ⁱ8E9A723171A48711

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC138630 mRNA. Translation: AAI38631.1. BC138633 mRNA. Translation: AAI38634.1. CH466626 Genomic DNA. Translation: EDL07336.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_061236.1. NM_018766.2.
UniGeneⁱ	Mm.301712.

Genome annotation databases

GeneIDⁱ	18216.
KEGGⁱ	mmu:18216.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC138630 mRNA. Translation: AAI38631.1. BC138633 mRNA. Translation: AAI38634.1. CH466626 Genomic DNA. Translation: EDL07336.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_061236.1. NM_018766.2.
UniGeneⁱ	Mm.301712.

3D structure databases

SMRⁱ	A2ACT4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	18216.
KEGGⁱ	mmu:18216.

Organism-specific databases

CTDⁱ	4923.
MGIⁱ	MGI:97386. Ntsr1.

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
HOVERGENⁱ	HBG098285.
KEGG Orthology (KO) More...KOⁱ	K04211.
OMAⁱ	VPMLFTM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q6E.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027568.
ExpressionAtlasⁱ	A2ACT4. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003985. NT1_rcpt. IPR003984. NT_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR01479. NEUROTENSINR. PR01480. NEUROTENSN1R.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2ACT4_MOUSE
Accessionⁱ	A2ACT4Primary (citable) accession number: A2ACT4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	July 5, 2017
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2ACT4 (A2ACT4_MOUSE)

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Neurotensin receptor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ