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Protein

Tetratricopeptide repeat protein 39A

Gene

Ttc39a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 39A
Short name:
TPR repeat protein 39A
Gene namesi
Name:Ttc39a
Synonyms:Kiaa0452
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2444350. Ttc39a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Tetratricopeptide repeat protein 39APRO_0000291997Add
BLAST

Proteomic databases

EPDiA2ACP1.
MaxQBiA2ACP1.
PaxDbiA2ACP1.
PRIDEiA2ACP1.

Expressioni

Gene expression databases

BgeeiA2ACP1.
ExpressionAtlasiA2ACP1. baseline and differential.
GenevisibleiA2ACP1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102229.

Structurei

3D structure databases

ProteinModelPortaliA2ACP1.
SMRiA2ACP1. Positions 470-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati280 – 31334TPR 1Add
BLAST
Repeati470 – 50334TPR 2Add
BLAST
Repeati511 – 54434TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the TTC39 family.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3783. Eukaryota.
ENOG410XS7D. LUCA.
GeneTreeiENSGT00390000009763.
HOVERGENiHBG057941.
InParanoidiA2ACP1.
OMAiMYHALTY.
OrthoDBiEOG75QR3N.
PhylomeDBiA2ACP1.
TreeFamiTF313761.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019412. OMP_Iml2/TPR_39.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR030416. TTC39A/B.
[Graphical view]
PANTHERiPTHR31859:SF3. PTHR31859:SF3. 1 hit.
PfamiPF10300. DUF3808. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2ACP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQKGHKDSL YDCKGSPVSS LHEALDQCMT ALDLFLTNQF SEALSYLKPR
60 70 80 90 100
TKESMYHSLT YATILEMQAM MTFDPQDILL AGNMMKEAQS LCQRHRRKSS
110 120 130 140 150
MTDSFSNLVH RPTIDQFTEE EIHAEVCYAE CLLQRAALTF LQDENMVSFI
160 170 180 190 200
KGGIKVRNSY QTYKELDSLV QSSQYSKGES HRHFEGGVKL GVGAFNLTLS
210 220 230 240 250
MLPTRILRLL EFVGFSGNKD YGLLQLEEGA TGHSFRAVLC VMLLLCYHTF
260 270 280 290 300
LTFVLGTGNV NIEEAEKLLK PYLNRYPKGA IFLFFAGRIE AIKGNIDAAV
310 320 330 340 350
RRFEECCEAQ QHWKQFHHMC YWELMWCFTY KGQWKMAYFY ADLLSKENSW
360 370 380 390 400
SKATYIYMKA AYLSMFGKED YKPFGDNEVE LFRAVPGLKL KIAGKSLPTE
410 420 430 440 450
KFAIRKSRRY LSPNPISLPI PALEMMYIWN GYAVIGKQPT LTDGMLEVIT
460 470 480 490 500
KAEEMLAMGP ENEYSADDDC LVKLLKGLCL KYLGRIQEAE ENFRSISANE
510 520 530 540 550
KKIKYDHYLI PNALLELALL FMEQGRNEEA IKLLESAKQN YKNYSMESRT
560 570
HFRIQAATLQ ARSSLEDGNR SLVSSVSL
Length:578
Mass (Da):66,126
Last modified:February 20, 2007 - v1
Checksum:i32F06E2C07910FC8
GO
Isoform 2 (identifier: A2ACP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGQKGHKDSLYDCK → MTTASGPGDLPA

Show »
Length:576
Mass (Da):65,634
Checksum:i39024F7753DACDA2
GO

Sequence cautioni

The sequence BAC36475.1 differs from that shown. Reason: Frameshift at positions 384 and 474. Curated
The sequence CAM13655.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM13658.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM13659.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM13660.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti552 – 5521F → L in AAH23883 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MGQKG…LYDCK → MTTASGPGDLPA in isoform 2. 3 PublicationsVSP_026354Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048659 mRNA. Translation: BAC33414.1.
AK076772 mRNA. Translation: BAC36475.1. Frameshift.
AL669905 Genomic DNA. Translation: CAM13655.1. Sequence problems.
AL669905 Genomic DNA. Translation: CAM13656.1.
AL669905 Genomic DNA. Translation: CAM13657.1.
AL669905 Genomic DNA. Translation: CAM13658.1. Sequence problems.
AL669905 Genomic DNA. Translation: CAM13659.1. Sequence problems.
AL669905 Genomic DNA. Translation: CAM13660.1. Sequence problems.
BC023883 mRNA. Translation: AAH23883.1.
BC026660 mRNA. Translation: AAH26660.1.
AK172951 mRNA. Translation: BAD32229.1.
CCDSiCCDS18463.1. [A2ACP1-2]
CCDS51260.1. [A2ACP1-1]
RefSeqiNP_001139420.1. NM_001145948.1. [A2ACP1-1]
NP_700441.2. NM_153392.2. [A2ACP1-2]
UniGeneiMm.33091.

Genome annotation databases

EnsembliENSMUST00000064129; ENSMUSP00000066334; ENSMUSG00000028555. [A2ACP1-2]
ENSMUST00000106618; ENSMUSP00000102229; ENSMUSG00000028555. [A2ACP1-1]
GeneIDi230603.
KEGGimmu:230603.
UCSCiuc008ucj.2. mouse. [A2ACP1-2]
uc008uck.2. mouse. [A2ACP1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048659 mRNA. Translation: BAC33414.1.
AK076772 mRNA. Translation: BAC36475.1. Frameshift.
AL669905 Genomic DNA. Translation: CAM13655.1. Sequence problems.
AL669905 Genomic DNA. Translation: CAM13656.1.
AL669905 Genomic DNA. Translation: CAM13657.1.
AL669905 Genomic DNA. Translation: CAM13658.1. Sequence problems.
AL669905 Genomic DNA. Translation: CAM13659.1. Sequence problems.
AL669905 Genomic DNA. Translation: CAM13660.1. Sequence problems.
BC023883 mRNA. Translation: AAH23883.1.
BC026660 mRNA. Translation: AAH26660.1.
AK172951 mRNA. Translation: BAD32229.1.
CCDSiCCDS18463.1. [A2ACP1-2]
CCDS51260.1. [A2ACP1-1]
RefSeqiNP_001139420.1. NM_001145948.1. [A2ACP1-1]
NP_700441.2. NM_153392.2. [A2ACP1-2]
UniGeneiMm.33091.

3D structure databases

ProteinModelPortaliA2ACP1.
SMRiA2ACP1. Positions 470-540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102229.

Proteomic databases

EPDiA2ACP1.
MaxQBiA2ACP1.
PaxDbiA2ACP1.
PRIDEiA2ACP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064129; ENSMUSP00000066334; ENSMUSG00000028555. [A2ACP1-2]
ENSMUST00000106618; ENSMUSP00000102229; ENSMUSG00000028555. [A2ACP1-1]
GeneIDi230603.
KEGGimmu:230603.
UCSCiuc008ucj.2. mouse. [A2ACP1-2]
uc008uck.2. mouse. [A2ACP1-1]

Organism-specific databases

CTDi22996.
MGIiMGI:2444350. Ttc39a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3783. Eukaryota.
ENOG410XS7D. LUCA.
GeneTreeiENSGT00390000009763.
HOVERGENiHBG057941.
InParanoidiA2ACP1.
OMAiMYHALTY.
OrthoDBiEOG75QR3N.
PhylomeDBiA2ACP1.
TreeFamiTF313761.

Miscellaneous databases

ChiTaRSiTtc39a. mouse.
PROiA2ACP1.
SOURCEiSearch...

Gene expression databases

BgeeiA2ACP1.
ExpressionAtlasiA2ACP1. baseline and differential.
GenevisibleiA2ACP1. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019412. OMP_Iml2/TPR_39.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR030416. TTC39A/B.
[Graphical view]
PANTHERiPTHR31859:SF3. PTHR31859:SF3. 1 hit.
PfamiPF10300. DUF3808. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Head and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-578 (ISOFORM 2).
    Tissue: Pancreatic islet.

Entry informationi

Entry nameiTT39A_MOUSE
AccessioniPrimary (citable) accession number: A2ACP1
Secondary accession number(s): A2ACN9
, A2ACP2, A2ACP3, A2ACP4, Q6A067, Q8C612, Q8CFL5, Q8K1A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.