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A2ACM0

- A2ACM0_MOUSE

UniProt

A2ACM0 - A2ACM0_MOUSE

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Protein
Submitted name: Regulatory-associated protein of mTOR
Gene
Rptor, 4932417H02Rik, mCG_15044
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase III type 1 promoter DNA binding Source: Ensembl
  2. RNA polymerase III type 2 promoter DNA binding Source: Ensembl
  3. RNA polymerase III type 3 promoter DNA binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. TOR signaling Source: Ensembl
  2. cell growth Source: Ensembl
  3. cellular response to amino acid stimulus Source: Ensembl
  4. cellular response to nutrient levels Source: Ensembl
  5. positive regulation of TOR signaling Source: Ensembl
  6. positive regulation of endothelial cell proliferation Source: Ensembl
  7. positive regulation of protein serine/threonine kinase activity Source: Ensembl
  8. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
  9. regulation of cell size Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.

Names & Taxonomyi

Protein namesi
Submitted name:
Regulatory-associated protein of mTORImported
Gene namesi
Name:RptorImported
Synonyms:4932417H02RikImported
ORF Names:mCG_15044Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1921620. Rptor.

Subcellular locationi

GO - Cellular componenti

  1. TORC1 complex Source: MGI
  2. lysosomal membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00640000091541.
HOVERGENiHBG059496.
InParanoidiA2ACM0.
KOiK07204.
OMAiFCDWSAK.
OrthoDBiEOG7QC7V7.
TreeFamiTF105729.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ACM0-1 [UniParc]FASTAAdd to Basket

« Hide

MESEMLQSPL MGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR     50
MKDRMKTVSV ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE 100
TIGANLQKQY ENWQPRARYK QSLDPTVDEV KKLCTSLRRN AKEERVLFHY 150
NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY DLQTWMGSPS IFVYDCSNAG 200
LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC IQLAACEAHE 250
LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG 300
RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF 350
LLAERIMRSY NCTPVSSPRL PPTYMHAMWQ AWDLAVDICL SQLPTIIEEG 400
TAFRHSPFFA EQLTAFQVWL TMGVENRSPP EQLPIVLQVL LSQVHRLRAL 450
DLLGRFLDLG PWAVSLALSV GIFPYVLKLL QSSARELRPL LVFIWAKILA 500
VDSSCQADLV KDNGHKYFLS VLADPYMPAE HRTMTAFILA VIVNSYTTGQ 550
EACLQGNLIA ICLEQLSDPH PLLRQWVAIC LGRIWQNFDS ARWCGVRDSA 600
HEKLYSLLSD PIPEVRCAAV FALGTFVGNS AERTDHSTTI DHNVAMMLAQ 650
LINDGSPMVR KELVVALSHL VVQYESNFCT VALQFMEEEK NYPLPSPAAT 700
EGGSLTPVRD SPCTPRLRSV SSYGNIRAVT TARNLNKSLQ NLSLTEESGS 750
SVAFSPGNLS TSSSASSTLG SPENEEYILS FETIDKMRRV SSYSALNSLI 800
GVSFNSVYTQ IWRVLLHLAA DPYPDVSDLA MKVLNSIAYK ATVNARPQRI 850
LDTSSLTQSA PASPTNKGMH MHQVGGSPPA SSTSSCSLTN DVAKQTVSRD 900
LPSSRPGTAG PTGAQYTPHS HQFPRTRKMF DKGPDQTTDD ADDAAGHKSF 950
ICASMQTGFC DWSARYFAQP VMKIPEEHDL ESQIRKEREW RFLRNTRVRK 1000
QAQQVIQKGI TRLDDQIFLN RNPGVPSVVK FHPFTPCIAV ADKDSICFWD 1050
WEKGEKLDYF HNGNPRYTRV TAMEYLNGQD CSLLLTATDD GAIRVWKNFA 1100
DLEKNPEMVT AWQGLSDMLP TTRGAGMVVD WEQETGLLMS SGDVRIVRIW 1150
DTDRETKVQD IPTGADSCVT SLSCDSHRSL IVAGLGDGSI RVYDRRMALS 1200
ECRVMTYREH TAWVVKAYLQ KHPEGHIVSV SVNGDVRFFD PRMPESVNVM 1250
QIVKGLTALD IHPQANLIAC GSMNQFTAIY NGNGELINNI KYYDGFMGQR 1300
VGAISCLAFH PHWPHLAVGS NDYYISVYSV EKRVR 1335
Length:1,335
Mass (Da):149,497
Last modified:February 20, 2007 - v1
Checksum:iED1A91924F7ED6A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL669881 Genomic DNA. No translation available.
AL928989 Genomic DNA. No translation available.
AL929234 Genomic DNA. No translation available.
BX248132 Genomic DNA. No translation available.
CH466558 Genomic DNA. Translation: EDL34715.1.
RefSeqiNP_083174.2. NM_028898.2.
UniGeneiMm.209933.

Genome annotation databases

EnsembliENSMUST00000026671; ENSMUSP00000026671; ENSMUSG00000025583.
GeneIDi74370.
KEGGimmu:74370.
UCSCiuc007mqz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL669881 Genomic DNA. No translation available.
AL928989 Genomic DNA. No translation available.
AL929234 Genomic DNA. No translation available.
BX248132 Genomic DNA. No translation available.
CH466558 Genomic DNA. Translation: EDL34715.1 .
RefSeqi NP_083174.2. NM_028898.2.
UniGenei Mm.209933.

3D structure databases

ModBasei Search...

Protocols and materials databases

DNASUi 74370.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026671 ; ENSMUSP00000026671 ; ENSMUSG00000025583 .
GeneIDi 74370.
KEGGi mmu:74370.
UCSCi uc007mqz.1. mouse.

Organism-specific databases

CTDi 57521.
MGIi MGI:1921620. Rptor.

Phylogenomic databases

GeneTreei ENSGT00640000091541.
HOVERGENi HBG059496.
InParanoidi A2ACM0.
KOi K07204.
OMAi FCDWSAK.
OrthoDBi EOG7QC7V7.
TreeFami TF105729.

Enzyme and pathway databases

Reactomei REACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.

Miscellaneous databases

ChiTaRSi RPTOR. mouse.
NextBioi 340575.
SOURCEi Search...

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR12848. PTHR12848. 1 hit.
Pfami PF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2ACM0_MOUSE
AccessioniPrimary (citable) accession number: A2ACM0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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