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Protein
Submitted name:

Regulatory-associated protein of mTOR

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 14-3-3 protein binding Source: MGI
  2. protein complex binding Source: MGI
  3. protein kinase binding Source: MGI
  4. RNA polymerase III type 1 promoter DNA binding Source: MGI
  5. RNA polymerase III type 2 promoter DNA binding Source: MGI
  6. RNA polymerase III type 3 promoter DNA binding Source: MGI
  7. TFIIIC-class transcription factor binding Source: MGI

GO - Biological processi

  1. cell growth Source: MGI
  2. cellular response to amino acid stimulus Source: MGI
  3. cellular response to nutrient levels Source: MGI
  4. positive regulation of endothelial cell proliferation Source: Ensembl
  5. positive regulation of protein serine/threonine kinase activity Source: MGI
  6. positive regulation of TOR signaling Source: MGI
  7. positive regulation of transcription from RNA polymerase III promoter Source: MGI
  8. regulation of cell size Source: MGI
  9. TOR signaling Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Names & Taxonomyi

Protein namesi
Submitted name:
Regulatory-associated protein of mTORImported
Gene namesi
Name:RptorImported
Synonyms:4932417H02RikImported
ORF Names:mCG_15044Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1921620. Rptor.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. dendrite Source: Ensembl
  3. intracellular membrane-bounded organelle Source: MGI
  4. lysosomal membrane Source: MGI
  5. lysosome Source: MGI
  6. neuronal cell body Source: Ensembl
  7. nucleoplasm Source: MGI
  8. TORC1 complex Source: MGI
Complete GO annotation...

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00640000091541.
HOVERGENiHBG059496.
KOiK07204.
OMAiQTIVLCE.
OrthoDBiEOG7QC7V7.
TreeFamiTF105729.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2ACM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEMLQSPL MGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR
60 70 80 90 100
MKDRMKTVSV ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE
110 120 130 140 150
TIGANLQKQY ENWQPRARYK QSLDPTVDEV KKLCTSLRRN AKEERVLFHY
160 170 180 190 200
NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY DLQTWMGSPS IFVYDCSNAG
210 220 230 240 250
LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC IQLAACEAHE
260 270 280 290 300
LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG
310 320 330 340 350
RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF
360 370 380 390 400
LLAERIMRSY NCTPVSSPRL PPTYMHAMWQ AWDLAVDICL SQLPTIIEEG
410 420 430 440 450
TAFRHSPFFA EQLTAFQVWL TMGVENRSPP EQLPIVLQVL LSQVHRLRAL
460 470 480 490 500
DLLGRFLDLG PWAVSLALSV GIFPYVLKLL QSSARELRPL LVFIWAKILA
510 520 530 540 550
VDSSCQADLV KDNGHKYFLS VLADPYMPAE HRTMTAFILA VIVNSYTTGQ
560 570 580 590 600
EACLQGNLIA ICLEQLSDPH PLLRQWVAIC LGRIWQNFDS ARWCGVRDSA
610 620 630 640 650
HEKLYSLLSD PIPEVRCAAV FALGTFVGNS AERTDHSTTI DHNVAMMLAQ
660 670 680 690 700
LINDGSPMVR KELVVALSHL VVQYESNFCT VALQFMEEEK NYPLPSPAAT
710 720 730 740 750
EGGSLTPVRD SPCTPRLRSV SSYGNIRAVT TARNLNKSLQ NLSLTEESGS
760 770 780 790 800
SVAFSPGNLS TSSSASSTLG SPENEEYILS FETIDKMRRV SSYSALNSLI
810 820 830 840 850
GVSFNSVYTQ IWRVLLHLAA DPYPDVSDLA MKVLNSIAYK ATVNARPQRI
860 870 880 890 900
LDTSSLTQSA PASPTNKGMH MHQVGGSPPA SSTSSCSLTN DVAKQTVSRD
910 920 930 940 950
LPSSRPGTAG PTGAQYTPHS HQFPRTRKMF DKGPDQTTDD ADDAAGHKSF
960 970 980 990 1000
ICASMQTGFC DWSARYFAQP VMKIPEEHDL ESQIRKEREW RFLRNTRVRK
1010 1020 1030 1040 1050
QAQQVIQKGI TRLDDQIFLN RNPGVPSVVK FHPFTPCIAV ADKDSICFWD
1060 1070 1080 1090 1100
WEKGEKLDYF HNGNPRYTRV TAMEYLNGQD CSLLLTATDD GAIRVWKNFA
1110 1120 1130 1140 1150
DLEKNPEMVT AWQGLSDMLP TTRGAGMVVD WEQETGLLMS SGDVRIVRIW
1160 1170 1180 1190 1200
DTDRETKVQD IPTGADSCVT SLSCDSHRSL IVAGLGDGSI RVYDRRMALS
1210 1220 1230 1240 1250
ECRVMTYREH TAWVVKAYLQ KHPEGHIVSV SVNGDVRFFD PRMPESVNVM
1260 1270 1280 1290 1300
QIVKGLTALD IHPQANLIAC GSMNQFTAIY NGNGELINNI KYYDGFMGQR
1310 1320 1330
VGAISCLAFH PHWPHLAVGS NDYYISVYSV EKRVR
Length:1,335
Mass (Da):149,497
Last modified:February 20, 2007 - v1
Checksum:iED1A91924F7ED6A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669881 Genomic DNA. No translation available.
AL928989 Genomic DNA. No translation available.
AL929234 Genomic DNA. No translation available.
BX248132 Genomic DNA. No translation available.
CH466558 Genomic DNA. Translation: EDL34715.1.
RefSeqiNP_083174.2. NM_028898.2.
UniGeneiMm.209933.

Genome annotation databases

EnsembliENSMUST00000026671; ENSMUSP00000026671; ENSMUSG00000025583.
GeneIDi74370.
KEGGimmu:74370.
UCSCiuc007mqz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669881 Genomic DNA. No translation available.
AL928989 Genomic DNA. No translation available.
AL929234 Genomic DNA. No translation available.
BX248132 Genomic DNA. No translation available.
CH466558 Genomic DNA. Translation: EDL34715.1.
RefSeqiNP_083174.2. NM_028898.2.
UniGeneiMm.209933.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi74370.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026671; ENSMUSP00000026671; ENSMUSG00000025583.
GeneIDi74370.
KEGGimmu:74370.
UCSCiuc007mqz.1. mouse.

Organism-specific databases

CTDi57521.
MGIiMGI:1921620. Rptor.

Phylogenomic databases

GeneTreeiENSGT00640000091541.
HOVERGENiHBG059496.
KOiK07204.
OMAiQTIVLCE.
OrthoDBiEOG7QC7V7.
TreeFamiTF105729.

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Miscellaneous databases

ChiTaRSiRptor. mouse.
NextBioi340575.
SOURCEiSearch...

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA2ACM0_MOUSE
AccessioniPrimary (citable) accession number: A2ACM0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.