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A2ACM0

- A2ACM0_MOUSE

UniProt

A2ACM0 - A2ACM0_MOUSE

Protein
Submitted name:

Regulatory-associated protein of mTOR

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA polymerase III type 1 promoter DNA binding Source: Ensembl
    2. RNA polymerase III type 2 promoter DNA binding Source: Ensembl
    3. RNA polymerase III type 3 promoter DNA binding Source: Ensembl

    GO - Biological processi

    1. cell growth Source: Ensembl
    2. cellular response to amino acid stimulus Source: Ensembl
    3. cellular response to nutrient levels Source: Ensembl
    4. positive regulation of endothelial cell proliferation Source: Ensembl
    5. positive regulation of protein serine/threonine kinase activity Source: Ensembl
    6. positive regulation of TOR signaling Source: Ensembl
    7. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
    8. regulation of cell size Source: Ensembl
    9. TOR signaling Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_213550. HSF1-dependent transactivation.
    REACT_220701. Regulation of AMPK activity via LKB1.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Regulatory-associated protein of mTORImported
    Gene namesi
    Name:RptorImported
    Synonyms:4932417H02RikImported
    ORF Names:mCG_15044Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1921620. Rptor.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: Ensembl
    2. TORC1 complex Source: MGI

    Family & Domainsi

    Keywords - Domaini

    RepeatUniRule annotation, WD repeatUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00640000091541.
    HOVERGENiHBG059496.
    InParanoidiA2ACM0.
    KOiK07204.
    OMAiFCDWSAK.
    OrthoDBiEOG7QC7V7.
    TreeFamiTF105729.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    2.130.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR004083. Raptor.
    IPR029347. Raptor_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR12848. PTHR12848. 1 hit.
    PfamiPF14538. Raptor_N. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2ACM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESEMLQSPL MGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR     50
    MKDRMKTVSV ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE 100
    TIGANLQKQY ENWQPRARYK QSLDPTVDEV KKLCTSLRRN AKEERVLFHY 150
    NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY DLQTWMGSPS IFVYDCSNAG 200
    LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC IQLAACEAHE 250
    LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG 300
    RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF 350
    LLAERIMRSY NCTPVSSPRL PPTYMHAMWQ AWDLAVDICL SQLPTIIEEG 400
    TAFRHSPFFA EQLTAFQVWL TMGVENRSPP EQLPIVLQVL LSQVHRLRAL 450
    DLLGRFLDLG PWAVSLALSV GIFPYVLKLL QSSARELRPL LVFIWAKILA 500
    VDSSCQADLV KDNGHKYFLS VLADPYMPAE HRTMTAFILA VIVNSYTTGQ 550
    EACLQGNLIA ICLEQLSDPH PLLRQWVAIC LGRIWQNFDS ARWCGVRDSA 600
    HEKLYSLLSD PIPEVRCAAV FALGTFVGNS AERTDHSTTI DHNVAMMLAQ 650
    LINDGSPMVR KELVVALSHL VVQYESNFCT VALQFMEEEK NYPLPSPAAT 700
    EGGSLTPVRD SPCTPRLRSV SSYGNIRAVT TARNLNKSLQ NLSLTEESGS 750
    SVAFSPGNLS TSSSASSTLG SPENEEYILS FETIDKMRRV SSYSALNSLI 800
    GVSFNSVYTQ IWRVLLHLAA DPYPDVSDLA MKVLNSIAYK ATVNARPQRI 850
    LDTSSLTQSA PASPTNKGMH MHQVGGSPPA SSTSSCSLTN DVAKQTVSRD 900
    LPSSRPGTAG PTGAQYTPHS HQFPRTRKMF DKGPDQTTDD ADDAAGHKSF 950
    ICASMQTGFC DWSARYFAQP VMKIPEEHDL ESQIRKEREW RFLRNTRVRK 1000
    QAQQVIQKGI TRLDDQIFLN RNPGVPSVVK FHPFTPCIAV ADKDSICFWD 1050
    WEKGEKLDYF HNGNPRYTRV TAMEYLNGQD CSLLLTATDD GAIRVWKNFA 1100
    DLEKNPEMVT AWQGLSDMLP TTRGAGMVVD WEQETGLLMS SGDVRIVRIW 1150
    DTDRETKVQD IPTGADSCVT SLSCDSHRSL IVAGLGDGSI RVYDRRMALS 1200
    ECRVMTYREH TAWVVKAYLQ KHPEGHIVSV SVNGDVRFFD PRMPESVNVM 1250
    QIVKGLTALD IHPQANLIAC GSMNQFTAIY NGNGELINNI KYYDGFMGQR 1300
    VGAISCLAFH PHWPHLAVGS NDYYISVYSV EKRVR 1335
    Length:1,335
    Mass (Da):149,497
    Last modified:February 20, 2007 - v1
    Checksum:iED1A91924F7ED6A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL669881 Genomic DNA. No translation available.
    AL928989 Genomic DNA. No translation available.
    AL929234 Genomic DNA. No translation available.
    BX248132 Genomic DNA. No translation available.
    CH466558 Genomic DNA. Translation: EDL34715.1.
    RefSeqiNP_083174.2. NM_028898.2.
    UniGeneiMm.209933.

    Genome annotation databases

    EnsembliENSMUST00000026671; ENSMUSP00000026671; ENSMUSG00000025583.
    GeneIDi74370.
    KEGGimmu:74370.
    UCSCiuc007mqz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL669881 Genomic DNA. No translation available.
    AL928989 Genomic DNA. No translation available.
    AL929234 Genomic DNA. No translation available.
    BX248132 Genomic DNA. No translation available.
    CH466558 Genomic DNA. Translation: EDL34715.1 .
    RefSeqi NP_083174.2. NM_028898.2.
    UniGenei Mm.209933.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 74370.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026671 ; ENSMUSP00000026671 ; ENSMUSG00000025583 .
    GeneIDi 74370.
    KEGGi mmu:74370.
    UCSCi uc007mqz.1. mouse.

    Organism-specific databases

    CTDi 57521.
    MGIi MGI:1921620. Rptor.

    Phylogenomic databases

    GeneTreei ENSGT00640000091541.
    HOVERGENi HBG059496.
    InParanoidi A2ACM0.
    KOi K07204.
    OMAi FCDWSAK.
    OrthoDBi EOG7QC7V7.
    TreeFami TF105729.

    Enzyme and pathway databases

    Reactomei REACT_213550. HSF1-dependent transactivation.
    REACT_220701. Regulation of AMPK activity via LKB1.

    Miscellaneous databases

    ChiTaRSi RPTOR. mouse.
    NextBioi 340575.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    2.130.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR004083. Raptor.
    IPR029347. Raptor_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR12848. PTHR12848. 1 hit.
    Pfami PF14538. Raptor_N. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiA2ACM0_MOUSE
    AccessioniPrimary (citable) accession number: A2ACM0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3